MOUSE:IL2

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Il2 (synonyms: Il-2)
Protein Name(s)	Interleukin-2 IL-2 T-cell growth factor TCGF
External Links
UniProt	P04351
EMBL	X01663 X01664 X01665 X01772 K02292 M16762 M16760 M16761 AF195956 AF065914 AL662823 X66058 L07574 L07576
CCDS	CCDS17316.1
PIR	A93550 I54512 I68871
RefSeq	NP_032392.1
UniGene	Mm.14190
ProteinModelPortal	P04351
SMR	P04351
IntAct	P04351
BindingDB	P04351
ChEMBL	CHEMBL2466
PhosphoSite	P04351
PRIDE	P04351
Ensembl	ENSMUST00000029275
GeneID	16183
KEGG	mmu:16183
UCSC	uc008pai.3
CTD	3558
MGI	MGI:96548
eggNOG	NOG41211
GeneTree	ENSGT00390000003555
HOGENOM	HOG000048727
HOVERGEN	HBG007496
InParanoid	P04351
KO	K05429
OMA	LMSNINV
OrthoDB	EOG72RN13
PhylomeDB	P04351
TreeFam	TF338200
Reactome	REACT_210793 REACT_220092 REACT_223974 REACT_261365
NextBio	289069
PRO	PR:P04351
Proteomes	UP000000589
Bgee	P04351
CleanEx	MM_IL2
ExpressionAtlas	P04351
Genevestigator	P04351
GO	GO:0005615 GO:0030246 GO:0005125 GO:0043208 GO:0005134 GO:0097192 GO:0006955 GO:0002903 GO:0045822 GO:0050728 GO:0050672 GO:0001933 GO:0042104 GO:0030890 GO:0007204 GO:0060999 GO:0051024 GO:0032729 GO:0032740 GO:0048304 GO:0045591 GO:0042102 GO:0045944 GO:0042523 GO:0007205 GO:0046013
Gene3D	1.20.1250.10
InterPro	IPR009079 IPR012351 IPR000779
PANTHER	PTHR11443
Pfam	PF00715
PRINTS	PR00265
ProDom	PD003649
SMART	SM00189
SUPFAM	SSF47266
PROSITE	PS00424

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0042104	positive regulation of activated T cell proliferation	PMID:24478317^[1]	ECO:0000315			P		Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Figure 2 shows an evidentiary correlation between IL-2 and T-cell activities in mice.	complete CACAO 9667
involved_in	GO:2000320	negative regulation of T-helper 17 cell differentiation	PMID:25642768^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	RNAcentral:URS000039ED8D_10090	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:12082633^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060999	positive regulation of dendritic spine development	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051024	positive regulation of immunoglobulin secretion	PMID:1830926^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857191	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050728	negative regulation of inflammatory response	PMID:8402910^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857191	P	regulates_o_has_participant:(EMAPA:18939)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050728	negative regulation of inflammatory response	PMID:7589135^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857191	P	regulates_o_has_participant:(EMAPA:18939)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050672	negative regulation of lymphocyte proliferation	PMID:16227984^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857191	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048304	positive regulation of isotype switching to IgG isotypes	PMID:1830926^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857191	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046013	regulation of T cell homeostatic proliferation	PMID:16227984^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857191	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:10485657^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045822	negative regulation of heart contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045591	positive regulation of regulatory T cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045582	positive regulation of T cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045471	response to ethanol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620047	P		Seeded From UniProt	complete
enables	GO:0043208	glycosphingolipid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620047	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	PMID:10485657^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000084)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60568	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042104	positive regulation of activated T cell proliferation	PMID:1830926^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857191	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042104	positive regulation of activated T cell proliferation	PMID:7584142^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042104	positive regulation of activated T cell proliferation	PMID:10485657^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042104	positive regulation of activated T cell proliferation	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60568	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042102	positive regulation of T cell proliferation	PMID:22968459^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857191	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042102	positive regulation of T cell proliferation	PMID:1588041^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042102	positive regulation of T cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032740	positive regulation of interleukin-17 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60568	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032729	positive regulation of interferon-gamma production	PMID:17213291^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0031851	kappa-type opioid receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620047	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030890	positive regulation of B cell proliferation	PMID:9184696^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60568	P		Seeded From UniProt	complete
enables	GO:0030246	carbohydrate binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620047	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620047	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:9492004^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:8612131^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:7688139^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000084)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:23395675^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:19139201^[18]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35770)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:1830926^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16769892^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15087456^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:12874832^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11728336^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10072077^[23]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620047	C		Seeded From UniProt	complete
enables	GO:0005134	interleukin-2 receptor binding	PMID:8262055^[24]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005134	interleukin-2 receptor binding	PMID:7584142^[9]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000084)	Seeded From UniProt	complete
enables	GO:0005134	interleukin-2 receptor binding	PMID:1588041^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000084)	Seeded From UniProt	complete
enables	GO:0005134	interleukin-2 receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620047	F		Seeded From UniProt	complete
enables	GO:0005134	interleukin-2 receptor binding	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60568	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:12874832^[21]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0000084)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:23395675^[17]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:1588041^[11]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000084)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:10485657^[8]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000084)	Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620047	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60568	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002903	negative regulation of B cell apoptotic process	PMID:9184696^[13]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60568	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002366	leukocyte activation involved in immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P60568	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620047	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620047	P		Seeded From UniProt	complete
part_of	GO:0005623	cell	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0007204	C		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008083	P		Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60568 ensembl:ENSP00000226730	P		Seeded From UniProt	complete
involved_in	GO:0042104	positive regulation of activated T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60568 ensembl:ENSP00000226730	P		Seeded From UniProt	complete
involved_in	GO:0032740	positive regulation of interleukin-17 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60568 ensembl:ENSP00000226730	P		Seeded From UniProt	complete
involved_in	GO:0030890	positive regulation of B cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60568 ensembl:ENSP00000226730	P		Seeded From UniProt	complete
enables	GO:0005134	interleukin-2 receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60568 ensembl:ENSP00000226730	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60568 ensembl:ENSP00000226730	F		Seeded From UniProt	complete
involved_in	GO:0002903	negative regulation of B cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60568 ensembl:ENSP00000226730	P		Seeded From UniProt	complete
involved_in	GO:0002366	leukocyte activation involved in immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P60568 ensembl:ENSP00000226730	P		Seeded From UniProt	complete
enables	GO:0005134	interleukin-2 receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000779	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000779	C		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000779	P		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000779	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
enables	GO:0008083	growth factor activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0339	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Rivera, J et al. (2014) Platelet-activating factor contributes to Bacillus anthracis lethal toxin-associated damage. J. Biol. Chem. 289 7131-41 PubMed GONUTS page
↑ Murugaiyan, G et al. (2015) MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis. J. Clin. Invest. 125 1069-80 PubMed GONUTS page
↑ Fleischer, A et al. (2002) Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2. Oncogene 21 3181-9 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Schorle, H et al. (1991) Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352 621-4 PubMed GONUTS page
↑ Sadlack, B et al. (1993) Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75 253-61 PubMed GONUTS page
↑ Simpson, SJ et al. (1995) Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur. J. Immunol. 25 2618-25 PubMed GONUTS page
↑ ^7.0 ^7.1 Fontenot, JD et al. (2005) A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6 1142-51 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Moriggl, R et al. (1999) Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Immunity 11 225-30 PubMed GONUTS page
↑ ^9.0 ^9.1 Willerford, DM et al. (1995) Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3 521-30 PubMed GONUTS page
↑ Vigne, S et al. (2012) IL-36 signaling amplifies Th1 responses by enhancing proliferation and Th1 polarization of naive CD4+ T cells. Blood 120 3478-87 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Casey, LS et al. (1992) IL-4 induces IL-2 receptor p75 beta-chain gene expression and IL-2-dependent proliferation in mouse T lymphocytes. J. Immunol. 148 3418-26 PubMed GONUTS page
↑ Wilson, TJ et al. (2007) FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection. Blood 109 3786-93 PubMed GONUTS page
↑ ^13.0 ^13.1 Li, L et al. (1997) The apoptosis and proliferation of SAC-activated B cells by IL-10 are associated with changes in Bcl-2, Bcl-xL, and Mcl-1 expression. Cell. Immunol. 178 33-41 PubMed GONUTS page
↑ Liljedahl, M et al. (1998) Altered antigen presentation in mice lacking H2-O. Immunity 8 233-43 PubMed GONUTS page
↑ Sant'Angelo, DB et al. (1996) The specificity and orientation of a TCR to its peptide-MHC class II ligands. Immunity 4 367-76 PubMed GONUTS page
↑ Shahinian, A et al. (1993) Differential T cell costimulatory requirements in CD28-deficient mice. Science 261 609-12 PubMed GONUTS page
↑ ^17.0 ^17.1 Zheng, Y et al. (2013) Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation. Immunity 38 285-95 PubMed GONUTS page
↑ Deshmukh, HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect. Immun. 77 1376-82 PubMed GONUTS page
↑ Chae, WJ et al. (2006) The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc. Natl. Acad. Sci. U.S.A. 103 9631-6 PubMed GONUTS page
↑ Yamashita, M et al. (2004) Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J. Biol. Chem. 279 26983-90 PubMed GONUTS page
↑ ^21.0 ^21.1 Butler, JJ et al. (2003) Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways. J. Cell. Biochem. 89 975-91 PubMed GONUTS page
↑ Allenspach, EJ et al. (2001) ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 15 739-50 PubMed GONUTS page
↑ Moriggl, R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10 249-59 PubMed GONUTS page
↑ Zurawski, SM et al. (1993) Definition and spatial location of mouse interleukin-2 residues that interact with its heterotrimeric receptor. EMBO J. 12 5113-9 PubMed GONUTS page

[PMID:24478317-1] Rivera, J et al. (2014) Platelet-activating factor contributes to Bacillus anthracis lethal toxin-associated damage. J. Biol. Chem. 289 7131-41 PubMed GONUTS page

[PMID:25642768-2] Murugaiyan, G et al. (2015) MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis. J. Clin. Invest. 125 1069-80 PubMed GONUTS page

[PMID:12082633-3] Fleischer, A et al. (2002) Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2. Oncogene 21 3181-9 PubMed GONUTS page

[PMID:1830926-4] 4.0 ^4.1 ^4.2 ^4.3 Schorle, H et al. (1991) Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 352 621-4 PubMed GONUTS page

[PMID:8402910-5] Sadlack, B et al. (1993) Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 75 253-61 PubMed GONUTS page

[PMID:7589135-6] Simpson, SJ et al. (1995) Evidence that CD4+, but not CD8+ T cells are responsible for murine interleukin-2-deficient colitis. Eur. J. Immunol. 25 2618-25 PubMed GONUTS page

[PMID:16227984-7] 7.0 ^7.1 Fontenot, JD et al. (2005) A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6 1142-51 PubMed GONUTS page

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