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PMID:7584142
| Citation |
Willerford, DM, Chen, J, Ferry, JA, Davidson, L, Ma, A and Alt, FW (1995) Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 3:521-30 |
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| Abstract |
Interleukin-2 receptor alpha chain (IL-2R alpha) expression occurs at specific stages of early T and B lymphocyte development and is induced upon activation of mature lymphocytes. Young mice that lack IL-2R alpha have phenotypically normal development of T and B cells. However, as adults, these mice develop massive enlargement of peripheral lymphoid organs associated with polyclonal T and B cell expansion, which, for T cells, is correlated with impaired activation-induced cell death in vivo. Older IL-2R alpha-deficient mice also develop autoimmune disorders, including hemolytic anemia and inflammatory bowel disease. Thus, IL-2R alpha is essential for regulation of both the size and content of the peripheral lymphoid compartment, probably by influencing the balance between clonal expansion and cell death following lymphocyte activation. |
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| Keywords |
Animals; Apoptosis; B-Lymphocytes/immunology; Cell Differentiation; Female; Lymphoid Tissue/embryology; Lymphoid Tissue/immunology; Lymphoid Tissue/pathology; Mice; Mice, Transgenic; Pregnancy; Receptors, Interleukin-2/deficiency; Receptors, Interleukin-2/genetics; Receptors, Interleukin-2/immunology; T-Lymphocytes/immunology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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