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PMID:9492004
| Citation |
Liljedahl, M, Winqvist, O, Surh, CD, Wong, P, Ngo, K, Teyton, L, Peterson, PA, Brunmark, A, Rudensky, AY, Fung-Leung, WP and Karlsson, L (1998) Altered antigen presentation in mice lacking H2-O. Immunity 8:233-43 |
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| Abstract |
HLA-DM catalyzes the release of MHC class II-associated invariant chain-derived peptides (CLIP) from class II molecules. Recent evidence has suggested that HLA-DO is a negative regulator of HLA-DM in B cells, but the physiological function of HLA-DO remains unclear. Analysis of antigen presentation by B cells from mice lacking H2-O (the mouse equivalent of HLA-DO), together with biochemical analysis using purified HLA-DO and HLA-DM molecules, suggests that HLA-DO/H2-O influences the peptide loading of class II molecules by limiting the pH range in which HLA-DM is active. This effect may serve to decrease the presentation of antigens internalized by fluid-phase endocytosis, thus concentrating the B cell-mediated antigen presentation to antigens internalized by membrane immunoglobulin. |
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| Keywords |
Animals; Antigen Presentation; Antigen-Presenting Cells/immunology; Antigens, Differentiation, B-Lymphocyte/analysis; B-Lymphocytes/immunology; Fluorescent Antibody Technique; Gene Targeting; HLA-D Antigens/genetics; HLA-D Antigens/immunology; Histocompatibility Antigens Class II/analysis; Hydrogen-Ion Concentration; Immunoglobulin G/blood; Lymph Nodes/cytology; Lymph Nodes/immunology; Mice; Mice, Mutant Strains; Peptides/immunology; Precipitin Tests; Spleen/cytology; Spleen/immunology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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