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PMID:10485657
| Citation |
Moriggl, R, Sexl, V, Piekorz, R, Topham, D and Ihle, JN (1999) Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. Immunity 11:225-30 |
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| Abstract |
The activation and subsequent proliferation of peripheral T cells requires the engagement of the T cell and a cytokine receptor, typically the IL-2 or IL-4 receptors. Critical to understanding the regulation of peripheral T cells is the knowledge of the unique contributions of each receptor to full T cell activation and cell cycle progression. Mice deficient in Stat5a and Stat5b have demonstrated the essential role that these highly related proteins play in cell cycle progression following peripheral T cell activation. Here we demonstrate that activation of the Stat5 proteins by tyrosine phosphorylation is uniquely contributed by cytokine receptor signaling and specifically does not occur through the T cell receptor complex. |
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| Keywords |
Animals; Antigens, CD3/immunology; Cytokines/pharmacology; DNA/metabolism; DNA-Binding Proteins/metabolism; Interleukin-2/pharmacology; Interleukin-4/pharmacology; Mice; Milk Proteins; Phosphorylation; Receptors, Antigen, T-Cell/physiology; Receptors, Interleukin-2/physiology; Receptors, Interleukin-4/physiology; STAT5 Transcription Factor; T-Lymphocytes/physiology; Trans-Activators/metabolism |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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