HUMAN:INAR2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IFNAR2 (synonyms: IFNABR, IFNARB)
Protein Name(s)	Interferon alpha/beta receptor 2 IFN-R-2 IFN-alpha binding protein IFN-alpha/beta receptor 2 Interferon alpha binding protein Type I interferon receptor 2
External Links
UniProt	P48551
EMBL	X77722 L42243 L42238 L42239 L42240 L42323 L42241 L42242 L42243 L42238 L42239 L42240 L42323 L42241 L42243 L42238 L42239 L42240 L42323 L42241 L42242 L41942 L41943 L41944 U29584 X89814 X89772 AY740397 AK293059 CR541817 AP000292 AP000293 AP000294 AP000295 CH471079 CH471079 CH471079 CH471079
CCDS	CCDS13621.1 CCDS13622.1 CCDS74782.1
PIR	I39073 S59501
RefSeq	NP_000865.2 NP_001276054.1 NP_001276055.1 NP_001276057.1 NP_997467.1 NP_997468.1
UniGene	Hs.708195
PDB	1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4
PDBsum	1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4
ProteinModelPortal	P48551
SMR	P48551
BioGrid	109677
DIP	DIP-945N
IntAct	P48551
MINT	MINT-196715
STRING	9606.ENSP00000343957
ChEMBL	CHEMBL2364170
DrugBank	DB00034 DB00105 DB00011 DB00018 DB00069 DB00060 DB00068 DB00008 DB00022
PhosphoSite	P48551
DMDM	1352466
MaxQB	P48551
PaxDb	P48551
PRIDE	P48551
DNASU	3455
Ensembl	ENST00000342101 ENST00000342136 ENST00000382264 ENST00000404220
GeneID	3455
KEGG	hsa:3455
UCSC	uc002yrb.3 uc002yrd.3 uc002yrf.3
CTD	3455
GeneCards	GC21P034602
HGNC	HGNC:5433
HPA	CAB025889
MIM	602376 610424
neXtProt	NX_P48551
PharmGKB	PA29671
eggNOG	NOG41946
GeneTree	ENSGT00510000049322
HOGENOM	HOG000013219
HOVERGEN	HBG053907
InParanoid	P48551
KO	K05131
OMA	AFVEVIH
PhylomeDB	P48551
TreeFam	TF335897
Reactome	REACT_25162 REACT_25216
SignaLink	P48551
ChiTaRS	IFNAR2
EvolutionaryTrace	P48551
GeneWiki	IFNAR2
GenomeRNAi	3455
NextBio	13610
PMAP-CutDB	Q6FHD7
PRO	PR:P48551
Proteomes	UP000005640
Bgee	P48551
CleanEx	HS_IFNAR2
ExpressionAtlas	P48551
Genevestigator	P48551
GO	GO:0005576 GO:0005615 GO:0005887 GO:0005886 GO:0019901 GO:0019962 GO:0004905 GO:0008283 GO:0007166 GO:0019221 GO:0007259 GO:0006357 GO:0060338 GO:0035455 GO:0009615 GO:0060337
Gene3D	2.60.40.10
InterPro	IPR003961 IPR013783 IPR015373
Pfam	PF09294 PF01108
SUPFAM	SSF49265

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
enables	GO:0004905	type I interferon receptor activity	PMID:7665574^[1]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0060337	type I interferon signaling pathway	PMID:7665574^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060337	type I interferon signaling pathway	PMID:26424569^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035456	response to interferon-beta	PMID:26424569^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035455	response to interferon-alpha	PMID:26424569^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	PMID:26424569^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0035455	response to interferon-alpha	PMID:7759950^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:7759950^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P23458	F	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:7759950^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004905	type I interferon receptor activity	PMID:7759950^[3]	ECO:0000314	direct assay evidence used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0060337	type I interferon signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000466380 UniProtKB:P48551	P	Seeded From UniProt	complete
	GO:0035455	response to interferon-alpha	PMID:24478317^[5]	ECO:0000314			P	IFN-alpha was used in the concentrations as stated by the manufacturer in cytokine and chemokine study	complete CACAO 9636
involved_in	GO:0019221	cytokine-mediated signaling pathway	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:3605069 PANTHER:PTN000466212	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000466212 RGD:620138	C	Seeded From UniProt	complete
enables	GO:0004905	type I interferon receptor activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1098243 PANTHER:PTN000466380 UniProtKB:P48551	F	Seeded From UniProt	complete
enables	GO:0004896	cytokine receptor activity	PMID:21873635^[4]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000466212 ZFIN:ZDB-GENE-070905-4	F	Seeded From UniProt	complete
enables	GO:0019962	type I interferon binding	PMID:7759950^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P01563	F	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:7759950^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:7588638^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007259	receptor signaling pathway via JAK-STAT	PMID:7588638^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	PMID:8798579^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:7588638^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:8969169^[8] Reactome:R-HSA-997314 Reactome:R-HSA-997311 Reactome:R-HSA-997309 Reactome:R-HSA-912685 Reactome:R-HSA-909732 Reactome:R-HSA-909730 Reactome:R-HSA-909729 Reactome:R-HSA-909726 Reactome:R-HSA-909724 Reactome:R-HSA-909722 Reactome:R-HSA-909720 Reactome:R-HSA-909719 Reactome:R-HSA-909718	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:7588638^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0004905	type I interferon receptor activity	PMID:8798579^[7]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:0060338	regulation of type I interferon-mediated signaling pathway	Reactome:R-HSA-912694	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0060337	type I interferon signaling pathway	Reactome:R-HSA-909733	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C	Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C	Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C	Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Domanski, P et al. (1995) Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling. J. Biol. Chem. 270 21606-11 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 ^2.3 Duncan, CJ et al. (2015) Human IFNAR2 deficiency: Lessons for antiviral immunity. Sci Transl Med 7 307ra154 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Novick, D et al. (1995) Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor. J. Leukoc. Biol. 57 712-8 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Rivera, J et al. (2014) Platelet-activating factor contributes to Bacillus anthracis lethal toxin-associated damage. J. Biol. Chem. 289 7131-41 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Lutfalla, G et al. (1995) Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. EMBO J. 14 5100-8 PubMed GONUTS page
↑ ^7.0 ^7.1 Platanias, LC et al. (1996) Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor. J. Biol. Chem. 271 23630-3 PubMed GONUTS page
↑ Croze, E et al. (1996) The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein. J. Biol. Chem. 271 33165-8 PubMed GONUTS page

[PMID:7665574-1] 1.0 ^1.1 Domanski, P et al. (1995) Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling. J. Biol. Chem. 270 21606-11 PubMed GONUTS page

[PMID:26424569-2] 2.0 ^2.1 ^2.2 ^2.3 Duncan, CJ et al. (2015) Human IFNAR2 deficiency: Lessons for antiviral immunity. Sci Transl Med 7 307ra154 PubMed GONUTS page

[PMID:7759950-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Novick, D et al. (1995) Soluble and membrane-anchored forms of the human IFN-alpha/beta receptor. J. Leukoc. Biol. 57 712-8 PubMed GONUTS page

[PMID:21873635-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:24478317-5] Rivera, J et al. (2014) Platelet-activating factor contributes to Bacillus anthracis lethal toxin-associated damage. J. Biol. Chem. 289 7131-41 PubMed GONUTS page

[PMID:7588638-6] 6.0 ^6.1 ^6.2 ^6.3 Lutfalla, G et al. (1995) Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. EMBO J. 14 5100-8 PubMed GONUTS page

[PMID:8798579-7] 7.0 ^7.1 Platanias, LC et al. (1996) Differences in interferon alpha and beta signaling. Interferon beta selectively induces the interaction of the alpha and betaL subunits of the type I interferon receptor. J. Biol. Chem. 271 23630-3 PubMed GONUTS page

[PMID:8969169-8] Croze, E et al. (1996) The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein. J. Biol. Chem. 271 33165-8 PubMed GONUTS page

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HUMAN:INAR2

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