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HUMAN:PA1B2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PAFAH1B2 (synonyms: PAFAHB)
Protein Name(s) Platelet-activating factor acetylhydrolase IB subunit beta

PAF acetylhydrolase 30 kDa subunit PAF-AH 30 kDa subunit PAF-AH subunit beta PAFAH subunit beta

External Links
UniProt P68402
EMBL D63390
DQ836738
DQ836739
DQ836740
DQ836741
DQ836742
DQ836743
AK292973
CR456736
EF445007
AP005018
CH471065
BC000398
BC019301
CCDS CCDS53713.1
CCDS53714.1
CCDS53715.1
CCDS8380.1
PIR JC5409
RefSeq NP_001171675.1
NP_001171676.1
NP_001171677.1
NP_002563.1
UniGene Hs.728488
PDB 1VYH
PDBsum 1VYH
ProteinModelPortal P68402
SMR P68402
BioGrid 111086
IntAct P68402
MINT MINT-5002700
STRING 9606.ENSP00000304006
ChEMBL CHEMBL4463
PhosphoSite P68402
DMDM 55977294
REPRODUCTION-2DPAGE IPI00026546
MaxQB P68402
PaxDb P68402
PeptideAtlas P68402
PRIDE P68402
Ensembl ENST00000419197
ENST00000527958
ENST00000529887
ENST00000530272
GeneID 5049
KEGG hsa:5049
UCSC uc001pqe.2
uc009yzk.2
CTD 5049
GeneCards GC11P117014
H-InvDB HIX0022939
HGNC HGNC:8575
HPA HPA051836
MIM 602508
neXtProt NX_P68402
PharmGKB PA32906
eggNOG NOG69837
GeneTree ENSGT00390000016520
HOGENOM HOG000232143
HOVERGEN HBG053477
InParanoid P68402
KO K16795
OMA RTENVIW
OrthoDB EOG7HB5BS
PhylomeDB P68402
TreeFam TF323955
ChiTaRS PAFAH1B2
EvolutionaryTrace P68402
GeneWiki PAFAH1B2
GenomeRNAi 5049
NextBio 19456
PRO PR:P68402
Proteomes UP000005640
Bgee P68402
CleanEx HS_PAFAH1B2
ExpressionAtlas P68402
Genevestigator P68402
GO GO:0005737
GO:0005829
GO:0070062
GO:0005730
GO:0005886
GO:0003847
GO:0007420
GO:0016042
GO:0006629
GO:0016239
GO:0007283
Gene3D 3.40.50.1110
InterPro IPR013831

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0016239

positive regulation of macroautophagy

PMID:24478317[1]

ECO:0000315

P

Figure 1. Compared PAF measurements in vivo following LeTx injection.

complete
CACAO 9634

part_of

GO:0070062

extracellular exosome

PMID:19056867[2]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(UBERON:0001088)

Seeded From UniProt

complete

involved_in

GO:0016239

positive regulation of macroautophagy

PMID:22354037[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0047179

platelet-activating factor acetyltransferase activity

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001724533
RGD:620332
RGD:620333

F

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001724533
RGD:620332
RGD:620333

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[4]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:108414
MGI:MGI:108415
PANTHER:PTN001724533

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005730

nucleolus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0001650

fibrillar center

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0047179

platelet-activating factor acetyltransferase activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35264
ensembl:ENSRNOP00000068672

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35264
ensembl:ENSRNOP00000068672

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35264
ensembl:ENSRNOP00000068672

F

Seeded From UniProt

complete

involved_in

GO:0007420

brain development

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35264
ensembl:ENSRNOP00000068672

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:O35264
ensembl:ENSRNOP00000068672

C

Seeded From UniProt

complete

involved_in

GO:0007283

spermatogenesis

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61206
ensembl:ENSMUSP00000127851

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q61206
ensembl:ENSMUSP00000127851

C

Seeded From UniProt

complete

enables

GO:0003847

1-alkyl-2-acetylglycerophosphocholine esterase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:3.1.1.47

F

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

PMID:9144386[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:16130169[6]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:1904813

ficolin-1-rich granule lumen

Reactome:R-HSA-6800434

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0034774

secretory granule lumen

Reactome:R-HSA-6798748

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-8848484

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005576

extracellular region

Reactome:R-HSA-6800434
Reactome:R-HSA-6798748

ECO:0000304

author statement supported by traceable reference used in manual assertion


C

Seeded From UniProt

complete

involved_in

GO:0006629

lipid metabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0443

P

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0016042

lipid catabolic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0442

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Rivera, J et al. (2014) Platelet-activating factor contributes to Bacillus anthracis lethal toxin-associated damage. J. Biol. Chem. 289 7131-41 PubMed GONUTS page
  2. Gonzales, PA et al. (2009) Large-scale proteomics and phosphoproteomics of urinary exosomes. J. Am. Soc. Nephrol. 20 363-79 PubMed GONUTS page
  3. McKnight, NC et al. (2012) Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC. EMBO J. 31 1931-46 PubMed GONUTS page
  4. 4.0 4.1 4.2 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  5. Adachi, H et al. (1997) Differential tissue distribution of the beta- and gamma-subunits of human cytosolic platelet-activating factor acetylhydrolase (isoform I). Biochem. Biophys. Res. Commun. 233 10-3 PubMed GONUTS page
  6. Bruneel, A et al. (2005) Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis. Proteomics 5 3876-84 PubMed GONUTS page