HUMAN:CASP3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	CASP3 (synonyms: CPP32)
Protein Name(s)	Caspase-3 CASP-3 Apopain Cysteine protease CPP32 CPP-32 Protein Yama SREBP cleavage activity 1 SCA-1 Caspase-3 subunit p17 Caspase-3 subunit p12
External Links
UniProt	P42574
EMBL	U13737 U13738 U26943 AJ413269 AK291337 AY219866 CH471056 CH471056 CH471056 BC016926
CCDS	CCDS3836.1
PIR	A55315
RefSeq	NP_004337.2 NP_116786.1
UniGene	Hs.141125
PDB	1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2H5I 2H5J 2H65 2J30 2J31 2J32 2J33 2XYG 2XYH 2XYP 2XZD 2XZT 2Y0B 3DEH 3DEI 3DEJ 3DEK 3EDQ 3GJQ 3GJR 3GJS 3GJT 3H0E 3ITN 3KJF 3PCX 3PD0 3PD1 4DCJ 4DCO 4DCP 4EHA 4EHD 4EHF 4EHH 4EHK 4EHL 4EHN 4JJE 4JQY 4JQZ 4JR0 4QTY 4QU0 4QU5 4QU9 4QUA 4QUB 4QUD 4QUE 4QUG 4QUH 4QUI 4QUJ 4QUL
PDBsum	1CP3 1GFW 1I3O 1NME 1NMQ 1NMS 1PAU 1QX3 1RE1 1RHJ 1RHK 1RHM 1RHQ 1RHR 1RHU 2C1E 2C2K 2C2M 2C2O 2CDR 2CJX 2CJY 2CNK 2CNL 2CNN 2CNO 2DKO 2H5I 2H5J 2H65 2J30 2J31 2J32 2J33 2XYG 2XYH 2XYP 2XZD 2XZT 2Y0B 3DEH 3DEI 3DEJ 3DEK 3EDQ 3GJQ 3GJR 3GJS 3GJT 3H0E 3ITN 3KJF 3PCX 3PD0 3PD1 4DCJ 4DCO 4DCP 4EHA 4EHD 4EHF 4EHH 4EHK 4EHL 4EHN 4JJE 4JQY 4JQZ 4JR0 4QTY 4QU0 4QU5 4QU9 4QUA 4QUB 4QUD 4QUE 4QUG 4QUH 4QUI 4QUJ 4QUL
ProteinModelPortal	P42574
SMR	P42574
BioGrid	107286
DIP	DIP-268N
IntAct	P42574
MINT	MINT-147180
STRING	9606.ENSP00000311032
BindingDB	P42574
ChEMBL	CHEMBL2334
DrugBank	DB01017
GuidetoPHARMACOLOGY	1619
MEROPS	C14.003
PhosphoSite	P42574
DMDM	77416852
OGP	P42574
MaxQB	P42574
PaxDb	P42574
PeptideAtlas	P42574
PRIDE	P42574
DNASU	836
Ensembl	ENST00000308394 ENST00000523916
GeneID	836
KEGG	hsa:836
UCSC	uc003iwh.3
CTD	836
GeneCards	GC04M185548
HGNC	HGNC:1504
HPA	CAB000091 CAB008381 HPA002643
MIM	600636
neXtProt	NX_P42574
PharmGKB	PA26087
eggNOG	NOG279444
GeneTree	ENSGT00760000118912
HOGENOM	HOG000231878
HOVERGEN	HBG050802
InParanoid	P42574
KO	K02187
OMA	DDDMACH
OrthoDB	EOG7TTQ7K
PhylomeDB	P42574
TreeFam	TF102023
BRENDA	3.4.22.56
Reactome	REACT_107 REACT_118572 REACT_118607 REACT_13462 REACT_13526 REACT_13532 REACT_13541 REACT_13579 REACT_22128 REACT_607
SABIO-RK	P42574
EvolutionaryTrace	P42574
GeneWiki	Caspase_3
GenomeRNAi	836
NextBio	3478
PMAP-CutDB	P42574
PRO	PR:P42574
Proteomes	UP000005640
Bgee	P42574
CleanEx	HS_CASP3
ExpressionAtlas	P42574
Genevestigator	P42574
GO	GO:0005829 GO:0005654 GO:0005634 GO:0005886 GO:0004190 GO:0004861 GO:0004197 GO:0097153 GO:0097200 GO:0008233 GO:0008635 GO:0006309 GO:0006915 GO:0097190 GO:0001782 GO:0045165 GO:0006921 GO:0006974 GO:0030218 GO:0097194 GO:0022617 GO:0030198 GO:0097192 GO:0008625 GO:0034349 GO:0007507 GO:0035329 GO:0097193 GO:0008631 GO:0030216 GO:0046007 GO:0043066 GO:0030889 GO:0045736 GO:0051402 GO:0030182 GO:0048011 GO:0030220 GO:0043065 GO:0043525 GO:0006508 GO:1902510 GO:0042981 GO:0043281 GO:0001836 GO:0034612 GO:0009411 GO:0009611 GO:0007605 GO:0043029
Gene3D	3.40.50.1460
InterPro	IPR029030 IPR015470 IPR011600 IPR001309 IPR016129 IPR002138 IPR015917
PANTHER	PTHR10454:SF30
Pfam	PF00656
PRINTS	PR00376
SMART	SM00115
PROSITE	PS01122 PS01121 PS50207 PS50208

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0031647	regulation of protein stability	PMID:17553422^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902004	positive regulation of amyloid-beta formation	PMID:17553422^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:17553422^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway	PMID:21980415^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	occurs_in:(CL:0010003)	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:15565177^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:16920334^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:19740745^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:Q15185)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:22253444^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	PMID:22253444^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0072734	cellular response to staurosporine	PMID:22253444^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	PMID:23729654^[7]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P06396)	Seeded From UniProt	complete
involved_in	GO:0097194	execution phase of apoptosis	PMID:11350920^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:17823127^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	PMID:17559062^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_input:(UniProtKB:Q14126)	Seeded From UniProt	complete
involved_in	GO:0097194	execution phase of apoptosis	PMID:8689682^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	PMID:10921886^[12]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_direct_input:(UniProtKB:P07949-2)	Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	PMID:17167422^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:17167422^[13]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:P15976) happens_during:(GO:0043065)\|has_direct_input(UniProtKB:P09874)	Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	PMID:12888622^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:17167422^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0030218)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17167422^[13]	ECO:0000314	direct assay evidence used in manual assertion		C	exists_during:(GO:0030218)	Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:19240112^[15]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q13177)\|happens_during(GO:2001238)	Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:21726810^[16]	ECO:0000314	direct assay evidence used in manual assertion		F	has_direct_input:(UniProtKB:Q00987)	Seeded From UniProt	complete
enables	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019972 MGI:MGI:107739 MGI:MGI:109383 MGI:MGI:1261423 MGI:MGI:97295 PANTHER:PTN000047947 UniProtKB:P42574 UniProtKB:Q14790	F		Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000048337 UniProtKB:P42574	P		Seeded From UniProt	complete
involved_in	GO:0030216	keratinocyte differentiation	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107739 PANTHER:PTN000048337	P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000048337 RGD:2275	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010501 FB:FBgn0020381 FB:FBgn0026404 FB:FBgn0028381 FB:FBgn0033659 MGI:MGI:107739 MGI:MGI:109383 MGI:MGI:1261423 MGI:MGI:1277950 MGI:MGI:1312922 PANTHER:PTN000047947 RGD:2274 RGD:2275 RGD:61867 RGD:620945 RGD:69274 UniProtKB:O15519 UniProtKB:P42574 UniProtKB:P55210 UniProtKB:P55211 UniProtKB:Q14790 WB:WBGene00000417	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[17]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019972 FB:FBgn0020381 FB:FBgn0026404 FB:FBgn0028381 FB:FBgn0033051 MGI:MGI:107739 MGI:MGI:1261423 MGI:MGI:1336166 MGI:MGI:97295 PANTHER:PTN000047947 RGD:2274 RGD:2275 RGD:61867 RGD:620945 RGD:70967 UniProtKB:O15519 UniProtKB:P31944 UniProtKB:Q95ND5 UniProtKB:Q9ULZ3 WB:WBGene00000417	C		Seeded From UniProt	complete
involved_in	GO:0048011	neurotrophin TRK receptor signaling pathway	PMID:23954828^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	PMID:9353287^[19]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q61144-2	P		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	PMID:9353287^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016005	P		Seeded From UniProt	complete
involved_in	GO:1902004	positive regulation of amyloid-beta formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0071887	leukocyte apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0051146	striated muscle cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0046677	response to antibiotic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	C		Seeded From UniProt	complete
enables	GO:0044877	protein-containing complex binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	F		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	C		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0042060	wound healing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0035094	response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0034349	glial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0032025	response to cobalt ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
part_of	GO:0031264	death-inducing signaling complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	C		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0021766	hippocampus development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
enables	GO:0016005	phospholipase A2 activator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	F		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0010165	response to X-ray	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0010038	response to metal ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	F		Seeded From UniProt	complete
involved_in	GO:0007611	learning or memory	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0007413	axonal fasciculation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	C		Seeded From UniProt	complete
enables	GO:0005123	death receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	F		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
involved_in	GO:0001554	luteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55213 ensembl:ENSRNOP00000014096	P		Seeded From UniProt	complete
enables	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	F		Seeded From UniProt	complete
involved_in	GO:0097194	execution phase of apoptosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
enables	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	F		Seeded From UniProt	complete
involved_in	GO:0071310	cellular response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
involved_in	GO:0051402	neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
involved_in	GO:0046007	negative regulation of activated T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
involved_in	GO:0045786	negative regulation of cell cycle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
involved_in	GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
involved_in	GO:0045165	cell fate commitment	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
involved_in	GO:0043029	T cell homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
involved_in	GO:0034349	glial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
involved_in	GO:0030889	negative regulation of B cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
involved_in	GO:0030216	keratinocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
involved_in	GO:0009611	response to wounding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
involved_in	GO:0009411	response to UV	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
involved_in	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	F		Seeded From UniProt	complete
involved_in	GO:0007605	sensory perception of sound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
involved_in	GO:0007507	heart development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	C		Seeded From UniProt	complete
enables	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	F		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	F		Seeded From UniProt	complete
enables	GO:0004190	aspartic-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	F		Seeded From UniProt	complete
involved_in	GO:0001782	B cell homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P70677 ensembl:ENSMUSP00000147767	P		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001309 InterPro:IPR002138 InterPro:IPR002398	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001309 InterPro:IPR002138 InterPro:IPR002398	P		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR015917	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:7983002^[20]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	PMID:10942389^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	PMID:10521396^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034612	response to tumor necrosis factor	PMID:10521396^[22]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0016241	regulation of macroautophagy	PMID:19549685^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030220	platelet formation	PMID:18309324^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	PMID:18309324^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097194	execution phase of apoptosis	Reactome:R-HSA-75153	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	Reactome:R-HSA-418889	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035329	hippo signaling	Reactome:R-HSA-2028269	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-449836	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006309	apoptotic DNA fragmentation	Reactome:R-HSA-140342	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-211643 Reactome:R-HSA-9627104 Reactome:R-HSA-449073 Reactome:R-HSA-418845 Reactome:R-HSA-373705 Reactome:R-HSA-351913 Reactome:R-HSA-351901 Reactome:R-HSA-351877 Reactome:R-HSA-351876 Reactome:R-HSA-351871 Reactome:R-HSA-351849 Reactome:R-HSA-350651 Reactome:R-HSA-212552 Reactome:R-HSA-211219 Reactome:R-HSA-205117 Reactome:R-HSA-202969 Reactome:R-HSA-202967 Reactome:R-HSA-202966 Reactome:R-HSA-202960 Reactome:R-HSA-202947 Reactome:R-HSA-202939 Reactome:R-HSA-202917 Reactome:R-HSA-2028697 Reactome:R-HSA-2028692 Reactome:R-HSA-201640 Reactome:R-HSA-201639 Reactome:R-HSA-201636 Reactome:R-HSA-201631 Reactome:R-HSA-201630 Reactome:R-HSA-201629 Reactome:R-HSA-201628 Reactome:R-HSA-201622 Reactome:R-HSA-201611 Reactome:R-HSA-201608 Reactome:R-HSA-201603 Reactome:R-HSA-201595 Reactome:R-HSA-114252	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-211219 Reactome:R-HSA-211190 Reactome:R-HSA-211186	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008234	cysteine-type peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0788	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016787	hydrolase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0378	F		Seeded From UniProt	complete
enables	GO:0008233	peptidase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0645	F		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Tesco, G et al. (2007) Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron 54 721-37 PubMed GONUTS page
↑ Zhang, Y et al. (2011) Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway. PLoS ONE 6 e25284 PubMed GONUTS page
↑ Stanelle, J et al. (2005) A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53. Cell Death Differ. 12 347-57 PubMed GONUTS page
↑ Wang, X et al. (2006) Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death. Biochim. Biophys. Acta 1762 742-54 PubMed GONUTS page
↑ Woo, SH et al. (2009) A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function. J. Biol. Chem. 284 30871-80 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Iglesias-Guimarais, V et al. (2012) Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease. J. Biol. Chem. 287 7766-79 PubMed GONUTS page
↑ Mileo, AM et al. (2013) The human papillomavirus-16 E7 oncoprotein exerts antiapoptotic effects via its physical interaction with the actin-binding protein gelsolin. Carcinogenesis 34 2424-33 PubMed GONUTS page
↑ Kagawa, S et al. (2001) Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death. Clin. Cancer Res. 7 1474-80 PubMed GONUTS page
↑ Chandra, D et al. (2007) Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release: evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase-3. J. Biol. Chem. 282 31289-301 PubMed GONUTS page
↑ Cirillo, N et al. (2008) The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery. J. Cell. Biochem. 103 598-606 PubMed GONUTS page
↑ Liu, X et al. (1996) Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86 147-57 PubMed GONUTS page
↑ Bordeaux, MC et al. (2000) The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease. EMBO J. 19 4056-63 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Ribeil, JA et al. (2007) Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1. Nature 445 102-5 PubMed GONUTS page
↑ Gamblin, TC et al. (2003) Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 100 10032-7 PubMed GONUTS page
↑ Luo, S & Rubinsztein, DC (2009) Huntingtin promotes cell survival by preventing Pak2 cleavage. J. Cell. Sci. 122 875-85 PubMed GONUTS page
↑ Oliver, TG et al. (2011) Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Mol. Cell 43 57-71 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Pan, Y et al. (2013) Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis. Neurosci. Lett. 553 46-51 PubMed GONUTS page
↑ ^19.0 ^19.1 Vito, P et al. (1997) Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage. J. Biol. Chem. 272 28315-20 PubMed GONUTS page
↑ Fernandes-Alnemri, T et al. (1994) CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J. Biol. Chem. 269 30761-4 PubMed GONUTS page
↑ Ullrich, CK et al. (2000) HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases. Blood 96 1438-42 PubMed GONUTS page
↑ ^22.0 ^22.1 Lin, Y et al. (1999) Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev. 13 2514-26 PubMed GONUTS page
↑ Betin, VM & Lane, JD (2009) Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. J. Cell. Sci. 122 2554-66 PubMed GONUTS page
↑ ^24.0 ^24.1 Galluzzi, L et al. (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15 1113-23 PubMed GONUTS page

[PMID:17553422-1] 1.0 ^1.1 ^1.2 Tesco, G et al. (2007) Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron 54 721-37 PubMed GONUTS page

[PMID:21980415-2] Zhang, Y et al. (2011) Identification of a conserved anti-apoptotic protein that modulates the mitochondrial apoptosis pathway. PLoS ONE 6 e25284 PubMed GONUTS page

[PMID:15565177-3] Stanelle, J et al. (2005) A novel mitochondrial protein DIP mediates E2F1-induced apoptosis independently of p53. Cell Death Differ. 12 347-57 PubMed GONUTS page

[PMID:16920334-4] Wang, X et al. (2006) Protective role of Cop in Rip2/caspase-1/caspase-4-mediated HeLa cell death. Biochim. Biophys. Acta 1762 742-54 PubMed GONUTS page

[PMID:19740745-5] Woo, SH et al. (2009) A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function. J. Biol. Chem. 284 30871-80 PubMed GONUTS page

[PMID:22253444-6] 6.0 ^6.1 ^6.2 Iglesias-Guimarais, V et al. (2012) Apoptotic DNA degradation into oligonucleosomal fragments, but not apoptotic nuclear morphology, relies on a cytosolic pool of DFF40/CAD endonuclease. J. Biol. Chem. 287 7766-79 PubMed GONUTS page

[PMID:23729654-7] Mileo, AM et al. (2013) The human papillomavirus-16 E7 oncoprotein exerts antiapoptotic effects via its physical interaction with the actin-binding protein gelsolin. Carcinogenesis 34 2424-33 PubMed GONUTS page

[PMID:11350920-8] Kagawa, S et al. (2001) Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death. Clin. Cancer Res. 7 1474-80 PubMed GONUTS page

[PMID:17823127-9] Chandra, D et al. (2007) Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release: evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase-3. J. Biol. Chem. 282 31289-301 PubMed GONUTS page

[PMID:17559062-10] Cirillo, N et al. (2008) The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery. J. Cell. Biochem. 103 598-606 PubMed GONUTS page

[PMID:8689682-11] Liu, X et al. (1996) Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86 147-57 PubMed GONUTS page

[PMID:10921886-12] Bordeaux, MC et al. (2000) The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease. EMBO J. 19 4056-63 PubMed GONUTS page

[PMID:17167422-13] 13.0 ^13.1 ^13.2 ^13.3 Ribeil, JA et al. (2007) Hsp70 regulates erythropoiesis by preventing caspase-3-mediated cleavage of GATA-1. Nature 445 102-5 PubMed GONUTS page

[PMID:12888622-14] Gamblin, TC et al. (2003) Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 100 10032-7 PubMed GONUTS page

[PMID:19240112-15] Luo, S & Rubinsztein, DC (2009) Huntingtin promotes cell survival by preventing Pak2 cleavage. J. Cell. Sci. 122 875-85 PubMed GONUTS page

[PMID:21726810-16] Oliver, TG et al. (2011) Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Mol. Cell 43 57-71 PubMed GONUTS page

[PMID:21873635-17] 17.0 ^17.1 ^17.2 ^17.3 ^17.4 ^17.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23954828-18] Pan, Y et al. (2013) Dok5 is involved in the signaling pathway of neurotrophin-3 against TrkC-induced apoptosis. Neurosci. Lett. 553 46-51 PubMed GONUTS page

[PMID:9353287-19] 19.0 ^19.1 Vito, P et al. (1997) Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage. J. Biol. Chem. 272 28315-20 PubMed GONUTS page

[PMID:7983002-20] Fernandes-Alnemri, T et al. (1994) CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J. Biol. Chem. 269 30761-4 PubMed GONUTS page

[PMID:10942389-21] Ullrich, CK et al. (2000) HIV-1 gp120- and gp160-induced apoptosis in cultured endothelial cells is mediated by caspases. Blood 96 1438-42 PubMed GONUTS page

[PMID:10521396-22] 22.0 ^22.1 Lin, Y et al. (1999) Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev. 13 2514-26 PubMed GONUTS page

[PMID:19549685-23] Betin, VM & Lane, JD (2009) Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. J. Cell. Sci. 122 2554-66 PubMed GONUTS page

[PMID:18309324-24] 24.0 ^24.1 Galluzzi, L et al. (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15 1113-23 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

[13]

[14]

[15]

[16]

[17]

[18]

[19]

[20]

[21]

[22]

[23]

[24]

HUMAN:CASP3

Contents

Annotations

Notes

References

a

b

c

d

e

g

h

i

k

l

m

n

o

p

r

s

t

v

w

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools