name: hippo signaling
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def: "The series of molecular signals mediated by the serine/threonine kinase Hippo or one of its orthologs. In Drosophila, Hippo in complex with the scaffold protein Salvador (Sav), phosphorylates and activates Warts (Wts), which in turn phosphorylates and inactivates the Yorkie (Yki) transcriptional activator. The core fly components hippo, sav, wts and mats are conserved in mammals as STK4/3 (MST1/2), SAV1/WW45, LATS1/2 and MOB1." [PMID:17318211, PMID:18328423]
synonym: "hippo signal transduction" EXACT [GOC:signaling]
synonym: "hippo signaling cascade" RELATED [GOC:signaling]
synonym: "hippo signaling pathway" EXACT 
synonym: "hippo signalling cascade" RELATED [GOC:mah]
synonym: "Salvador-Warts-Hippo signaling pathway" NARROW 
synonym: "SWH pathway" NARROW 
is_a: GO:0035556 ! intracellular signal transduction
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Pages in category "GO:0035329 ! hippo signaling"
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