MOUSE:WWTR1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Wwtr1 (synonyms: Taz)
Protein Name(s)	WW domain-containing transcription regulator protein 1 Transcriptional coactivator with PDZ-binding motif
External Links
UniProt	Q9EPK5
EMBL	AJ299430 AK142299 AK142720 BC004640 BC014727
CCDS	CCDS38434.1 CCDS50912.1
RefSeq	NP_001161753.1 NP_598545.2
UniGene	Mm.405029
PDB	5GN0
PDBsum	5GN0
ProteinModelPortal	Q9EPK5
SMR	Q9EPK5
BioGrid	220584
CORUM	Q9EPK5
DIP	DIP-39476N
ELM	Q9EPK5
IntAct	Q9EPK5
MINT	Q9EPK5
STRING	10090.ENSMUSP00000113040
iPTMnet	Q9EPK5
PhosphoSitePlus	Q9EPK5
PaxDb	Q9EPK5
PeptideAtlas	Q9EPK5
PRIDE	Q9EPK5
Ensembl	ENSMUST00000029380 ENSMUST00000120977
GeneID	97064
KEGG	mmu:97064
UCSC	uc008phb.2 uc012cpt.1
CTD	25937
MGI	MGI:1917649
eggNOG	ENOG410KCVW ENOG4111U1C
GeneTree	ENSGT00510000046760
HOGENOM	HOG000007854
HOVERGEN	HBG002748
InParanoid	Q9EPK5
KO	K16820
OMA	AMSQPNL
OrthoDB	EOG091G095A
PhylomeDB	Q9EPK5
TreeFam	TF326941
Reactome	R-MMU-2028269 R-MMU-2032785 R-MMU-2173796
ChiTaRS	Wwtr1
PRO	PR:Q9EPK5
Proteomes	UP000000589
Bgee	ENSMUSG00000027803
CleanEx	MM_WWTR1
Genevisible	Q9EPK5
GO	GO:0005737 GO:0005829 GO:0016604 GO:0005654 GO:0005634 GO:0005667 GO:0042803 GO:0003713 GO:0003714 GO:0060271 GO:0032835 GO:0003015 GO:0035329 GO:0060993 GO:0048762 GO:0035264 GO:0090090 GO:0045599 GO:0006469 GO:0001933 GO:0000122 GO:0001649 GO:0008284 GO:0010718 GO:0045944 GO:0016567 GO:0060828 GO:0072307 GO:0060390 GO:0006355 GO:0031146 GO:0017145 GO:0001894 GO:0006351
CDD	cd00201
InterPro	IPR001202 IPR036020
Pfam	PF00397
SMART	SM00456
SUPFAM	SSF51045
PROSITE	PS01159 PS50020

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0016567	protein ubiquitination	PMID:21474562^[1]	ECO:0000315			P		Figures 3 and 4	complete CACAO 5933
involved_in	GO:0003015	heart process	PMID:23918388^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001894	tissue homeostasis	PMID:23918388^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0003015) occurs_in:(UBERON:0000948)	Seeded From UniProt	complete
involved_in	GO:0016567	protein ubiquitination	PMID:21474562^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:16332960^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:16332960^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9GZV5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation	PMID:23974041^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103262	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060993	kidney morphogenesis	PMID:17636028^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3759999	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060828	regulation of canonical Wnt signaling pathway	PMID:23974041^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103262	P	regulates_o_occurs_in:(EMAPA:27742) occurs_in:(EMAPA:27742)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060390	regulation of SMAD protein signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9GZV5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060271	cilium assembly	PMID:17251353^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3702742	P	occurs_in:(EMAPA:28407)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048762	mesenchymal cell differentiation	PMID:17636028^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3759999	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16300735^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97487	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:16099986^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99829	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:14970209^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:108067	P	has_regulation_target:(MGI:MGI:109517)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:14970209^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:109517)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045599	negative regulation of fat cell differentiation	PMID:16099986^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97747	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035329	hippo signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9GZV5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035264	multicellular organism growth	PMID:17636028^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3759999	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032835	glomerulus development	PMID:18172001^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3775483	P	results_in_development_of:(EMAPA:17366)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	PMID:17636028^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3759999	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0017145	stem cell division	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9GZV5	P		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9GZV5	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016567	protein ubiquitination	PMID:17636028^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9GZV5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9GZV5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006469	negative regulation of protein kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9GZV5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:14970209^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(MGI:MGI:109517)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9GZV5	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:16099986^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11118213^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9GZV5	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	PMID:14970209^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9GZV5	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19010321^[12]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:17068)\|part_of:(EMAPA:17068)\|part_of:(EMAPA:36504)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:16300735^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:11118213^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9GZV5	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q4V7E6	C		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:16099986^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97747	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9GZV5	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9GZV5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	PMID:16099986^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88177	P	regulates_o_results_in_acquisition_of_features_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001649	osteoblast differentiation	PMID:16099986^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_results_in_acquisition_of_features_of:(CL:0000062)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:16099986^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:97747	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q4V7E6 ensembl:ENSRNOP00000022507	C		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9GZV5 ensembl:ENSP00000419465	P		Seeded From UniProt	complete
involved_in	GO:0060390	regulation of SMAD protein signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9GZV5 ensembl:ENSP00000419465	P		Seeded From UniProt	complete
involved_in	GO:0035329	hippo signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9GZV5 ensembl:ENSP00000419465	P		Seeded From UniProt	complete
involved_in	GO:0017145	stem cell division	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9GZV5 ensembl:ENSP00000419465	P		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9GZV5 ensembl:ENSP00000419465	C		Seeded From UniProt	complete
involved_in	GO:0010718	positive regulation of epithelial to mesenchymal transition	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9GZV5 ensembl:ENSP00000419465	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9GZV5 ensembl:ENSP00000419465	P		Seeded From UniProt	complete
involved_in	GO:0006469	negative regulation of protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9GZV5 ensembl:ENSP00000419465	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9GZV5 ensembl:ENSP00000419465	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9GZV5 ensembl:ENSP00000419465	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9GZV5 ensembl:ENSP00000419465	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9GZV5 ensembl:ENSP00000419465	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9GZV5 ensembl:ENSP00000419465	F		Seeded From UniProt	complete
involved_in	GO:0001933	negative regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9GZV5 ensembl:ENSP00000419465	P		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-MMU-8985233 Reactome:R-MMU-2064924	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Yim, H et al. (2011) Nek1 and TAZ interact to maintain normal levels of polycystin 2. J. Am. Soc. Nephrol. 22 832-7 PubMed GONUTS page
↑ ^2.0 ^2.1 Xin, M et al. (2013) Hippo pathway effector Yap promotes cardiac regeneration. Proc. Natl. Acad. Sci. U.S.A. 110 13839-44 PubMed GONUTS page
↑ ^3.0 ^3.1 Murakami, M et al. (2005) A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc. Natl. Acad. Sci. U.S.A. 102 18034-9 PubMed GONUTS page
↑ ^4.0 ^4.1 Das, A et al. (2013) Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nat. Cell Biol. 15 1035-44 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Tian, Y et al. (2007) TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex. Mol. Cell. Biol. 27 6383-95 PubMed GONUTS page
↑ Hossain, Z et al. (2007) Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1. Proc. Natl. Acad. Sci. U.S.A. 104 1631-6 PubMed GONUTS page
↑ ^7.0 ^7.1 Murakami, M et al. (2006) Transcriptional activity of Pax3 is co-activated by TAZ. Biochem. Biophys. Res. Commun. 339 533-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Hong, JH et al. (2005) TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 309 1074-8 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Park, KS et al. (2004) TAZ interacts with TTF-1 and regulates expression of surfactant protein-C. J. Biol. Chem. 279 17384-90 PubMed GONUTS page
↑ Makita, R et al. (2008) Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ. Am. J. Physiol. Renal Physiol. 294 F542-53 PubMed GONUTS page
↑ ^11.0 ^11.1 Kanai, F et al. (2000) TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J. 19 6778-91 PubMed GONUTS page
↑ Di Palma, T et al. (2009) TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation. Exp. Cell Res. 315 162-75 PubMed GONUTS page

[PMID:21474562-1] 1.0 ^1.1 Yim, H et al. (2011) Nek1 and TAZ interact to maintain normal levels of polycystin 2. J. Am. Soc. Nephrol. 22 832-7 PubMed GONUTS page

[PMID:23918388-2] 2.0 ^2.1 Xin, M et al. (2013) Hippo pathway effector Yap promotes cardiac regeneration. Proc. Natl. Acad. Sci. U.S.A. 110 13839-44 PubMed GONUTS page

[PMID:16332960-3] 3.0 ^3.1 Murakami, M et al. (2005) A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome. Proc. Natl. Acad. Sci. U.S.A. 102 18034-9 PubMed GONUTS page

[PMID:23974041-4] 4.0 ^4.1 Das, A et al. (2013) Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation. Nat. Cell Biol. 15 1035-44 PubMed GONUTS page

[PMID:17636028-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Tian, Y et al. (2007) TAZ promotes PC2 degradation through a SCFbeta-Trcp E3 ligase complex. Mol. Cell. Biol. 27 6383-95 PubMed GONUTS page

[PMID:17251353-6] Hossain, Z et al. (2007) Glomerulocystic kidney disease in mice with a targeted inactivation of Wwtr1. Proc. Natl. Acad. Sci. U.S.A. 104 1631-6 PubMed GONUTS page

[PMID:16300735-7] 7.0 ^7.1 Murakami, M et al. (2006) Transcriptional activity of Pax3 is co-activated by TAZ. Biochem. Biophys. Res. Commun. 339 533-9 PubMed GONUTS page

[PMID:16099986-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 ^8.6 Hong, JH et al. (2005) TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science 309 1074-8 PubMed GONUTS page

[PMID:14970209-9] 9.0 ^9.1 ^9.2 ^9.3 Park, KS et al. (2004) TAZ interacts with TTF-1 and regulates expression of surfactant protein-C. J. Biol. Chem. 279 17384-90 PubMed GONUTS page

[PMID:18172001-10] Makita, R et al. (2008) Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ. Am. J. Physiol. Renal Physiol. 294 F542-53 PubMed GONUTS page

[PMID:11118213-11] 11.0 ^11.1 Kanai, F et al. (2000) TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. EMBO J. 19 6778-91 PubMed GONUTS page

[PMID:19010321-12] Di Palma, T et al. (2009) TAZ is a coactivator for Pax8 and TTF-1, two transcription factors involved in thyroid differentiation. Exp. Cell Res. 315 162-75 PubMed GONUTS page

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MOUSE:WWTR1

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References

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