GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
PMID:16300735
| Citation |
Murakami, M, Tominaga, J, Makita, R, Uchijima, Y, Kurihara, Y, Nakagawa, O, Asano, T and Kurihara, H (2006) Transcriptional activity of Pax3 is co-activated by TAZ. Biochem. Biophys. Res. Commun. 339:533-9 |
|---|---|
| Abstract |
Pax3 is a transcription factor which functions in embryonic development and human diseases. In a yeast two-hybrid screen with full-length Pax3 as bait, we isolated a clone encoding transcriptional co-activator with PDZ-binding motif (TAZ) from an E10.5 mouse embryo cDNA library. Co-immunoprecipitation and nuclear co-localization of TAZ with Pax3 suggest that their association is functionally relevant. In situ hybridization revealed TAZ and Pax3 expression to partially overlap in the paraxial mesoderm, limb buds, and the neural tube. In C2C12 myoblast cells and NIH3T3 cells, TAZ enhanced the transcriptional activity of Pax3 on artificial and microphthalmia-associated transcription factor promoter-luciferase constructs, suggesting that TAZ can function as a co-activator of Pax3. Functional interaction between Pax3 and TAZ may provide a clue to clarifying the mechanism by which Pax3 serves as a transcriptional activator during embryogenesis. |
| Links |
PubMed Online version:10.1016/j.bbrc.2005.10.214 |
| Keywords |
Animals; Cell Nucleus/metabolism; Gene Expression Regulation, Developmental; Humans; Mice; Mutation/genetics; Paired Box Transcription Factors/genetics; Paired Box Transcription Factors/metabolism; Protein Binding; Proteins/genetics; Proteins/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism; Transcription, Genetic/genetics |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
|---|---|---|---|---|---|---|---|---|
| edit table |
See also
References
See Help:References for how to manage references in GONUTS.
