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MOUSE:STK3
Contents
Species (Taxon ID) | Mus musculus (Mouse). (10090) | |
Gene Name(s) | Stk3 (synonyms: Mess1, Mst2) | |
Protein Name(s) | Serine/threonine-protein kinase 3
Mammalian STE20-like protein kinase 2 MST-2 STE20-like kinase MST2 Serine/threonine-protein kinase 3 36kDa subunit MST2/N Serine/threonine-protein kinase 3 20kDa subunit MST2/C | |
External Links | ||
UniProt | Q9JI10 | |
EMBL | AF271361 U28726 AY058922 BC037440 BC049123 | |
CCDS | CCDS37059.1 | |
RefSeq | NP_062609.2 | |
UniGene | Mm.262330 | |
ProteinModelPortal | Q9JI10 | |
SMR | Q9JI10 | |
BioGrid | 207869 | |
IntAct | Q9JI10 | |
STRING | 10090.ENSMUSP00000018476 | |
BindingDB | Q9JI10 | |
ChEMBL | CHEMBL4310 | |
PhosphoSite | Q9JI10 | |
MaxQB | Q9JI10 | |
PaxDb | Q9JI10 | |
PRIDE | Q9JI10 | |
Ensembl | ENSMUST00000018476 ENSMUST00000067033 | |
GeneID | 56274 | |
KEGG | mmu:56274 | |
UCSC | uc007vlz.1 uc011zrz.1 | |
CTD | 6788 | |
MGI | MGI:1928487 | |
eggNOG | COG0515 | |
GeneTree | ENSGT00800000124019 | |
HOGENOM | HOG000234203 | |
HOVERGEN | HBG108518 | |
InParanoid | Q9JI10 | |
KO | K04412 | |
OMA | XDEDELD | |
OrthoDB | EOG7TF79T | |
PhylomeDB | Q9JI10 | |
TreeFam | TF354217 | |
Reactome | R-MMU-2028269 | |
ChiTaRS | Stk3 | |
NextBio | 312160 | |
PRO | PR:Q9JI10 | |
Proteomes | UP000000589 | |
Bgee | Q9JI10 | |
CleanEx | MM_STK3 | |
ExpressionAtlas | Q9JI10 | |
Genevisible | Q9JI10 | |
GO | GO:0005737 GO:0005634 GO:0005524 GO:0000287 GO:0004709 GO:0046983 GO:0004674 GO:0000186 GO:0060706 GO:0007417 GO:0003157 GO:0097284 GO:0035329 GO:0035556 GO:0000165 GO:0090090 GO:0008285 GO:0046621 GO:0001841 GO:0043065 GO:1902043 GO:0045600 GO:0046330 GO:0032092 GO:0051897 GO:0051091 GO:0060215 GO:0006468 GO:0050821 GO:0060800 GO:0007346 GO:0023014 GO:0031098 | |
InterPro | IPR011009 IPR024205 IPR000719 IPR017441 IPR011524 IPR002290 | |
Pfam | PF11629 PF00069 | |
SMART | SM00220 | |
SUPFAM | SSF56112 | |
PROSITE | PS00107 PS50011 PS50951 |
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046983 |
protein dimerization activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035329 |
hippo signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035329 |
hippo signaling |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1928487 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032147 |
activation of protein kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1919399 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0031098 |
stress-activated protein kinase signaling cascade |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000684825 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0023014 |
signal transduction by protein phosphorylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000684825 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0023083 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0023083 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:1902043 |
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1928487 |
P |
regulates_o_occurs_in:(EMAPA:16846) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:1902043 |
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:104798 |
P |
regulates_o_occurs_in:(EMAPA:16846) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:1902043 |
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:104798 |
P |
regulates_o_occurs_in:(CL:0000182) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0097284 |
hepatocyte apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:104798 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1929004 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0060800 |
regulation of cell differentiation involved in embryonic placenta development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1929004 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0060706 |
cell differentiation involved in embryonic placenta development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1929004 |
P |
occurs_in:(EMAPA:16042) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0060215 |
primitive hemopoiesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1929004 |
P |
occurs_in:(EMAPA:16042) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0051897 |
positive regulation of protein kinase B signaling |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:104798 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0050821 |
protein stabilization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0046621 |
negative regulation of organ growth |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1929004 |
P |
regulates_o_occurs_in:(EMAPA:16846)|regulates_o_occurs_in:(EMAPA:18767)|regulates_o_occurs_in:(EMAPA:17021)|regulates_o_occurs_in:(EMAPA:16105) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0046330 |
positive regulation of JNK cascade |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:104798 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0045600 |
positive regulation of fat cell differentiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1929004 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1929004 |
P |
|
Seeded From UniProt |
complete | |
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0035556 |
intracellular signal transduction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0035329 |
hippo signaling |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0032092 |
positive regulation of protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1929004 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1929004 |
P |
regulates_o_occurs_in:(EMAPA:16042) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0007417 |
central nervous system development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1929004 |
P |
results_in_development_of:(EMAPA:16470) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0006468 |
protein phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004672 |
protein kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0003157 |
endocardium development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1929004 |
P |
results_in_development_of:(EMAPA:16105) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0001841 |
neural tube formation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1929004 |
P |
results_in_formation_of:(EMAPA:16164) |
Seeded From UniProt |
complete | |
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q13188 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004672 |
protein kinase activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q13188 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0000287 |
magnesium ion binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q13188 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090090 |
negative regulation of canonical Wnt signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q13188 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q13188 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0050821 |
protein stabilization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q13188 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042802 |
identical protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q13188 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q13188 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0035329 |
hippo signaling |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q13188 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0032991 |
protein-containing complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q13188 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032092 |
positive regulation of protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q13188 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q13188 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q13188 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005524 |
ATP binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q13188 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007165 |
signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Lu, L et al. (2010) Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc. Natl. Acad. Sci. U.S.A. 107 1437-42 PubMed GONUTS page
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 3.0 3.1 3.2 3.3 3.4 3.5 3.6 3.7 3.8 3.9 Song, H et al. (2010) Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc. Natl. Acad. Sci. U.S.A. 107 1431-6 PubMed GONUTS page
- ↑ Du, X et al. (2014) Mst1 and mst2 are essential regulators of trophoblast differentiation and placenta morphogenesis. PLoS ONE 9 e90701 PubMed GONUTS page
- ↑ 5.0 5.1 5.2 5.3 5.4 5.5 Oh, S et al. (2009) Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol. Cell. Biol. 29 6309-20 PubMed GONUTS page
- ↑ 6.0 6.1 6.2 6.3 Park, BH et al. (2012) Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPARγ. PLoS ONE 7 e30983 PubMed GONUTS page
- ↑ Song, H et al. (2010) Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity. Biochem. Biophys. Res. Commun. 391 969-73 PubMed GONUTS page
- ↑ Lee, KK & Yonehara, S (2002) Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST). J. Biol. Chem. 277 12351-8 PubMed GONUTS page
a
c
g
m
n
p
- GO:0016310 ! phosphorylation
- GO:0051897 ! positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
- GO:0043065 ! positive regulation of apoptotic process
- GO:0045600 ! positive regulation of fat cell differentiation
- GO:0046330 ! positive regulation of JNK cascade
- GO:1902043 ! positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
- GO:0051091 ! positive regulation of DNA-binding transcription factor activity
- GO:0032092 ! positive regulation of protein binding
- GO:0060215 ! primitive hemopoiesis
- GO:0032991 ! protein-containing complex
- GO:0046983 ! protein dimerization activity
- GO:0004672 ! protein kinase activity
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
- GO:0050821 ! protein stabilization
r
s