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PMID:19484742

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Citation

Hergovich, A and Hemmings, BA Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling. Biofactors 35:338-45

Abstract

The NDR/LATS family of kinases is a subgroup of the AGC group of protein kinases and is conserved from lower eukaryotes to humans. Like other AGC kinases, NDR/LATS kinases require phosphorylation of conserved Ser/Thr residues for activation. On the one hand, binding of the coactivator MOB to NDR/LATS allows autophosphorylation. On the other hand, MST kinases directly phosphorylate NDR/LATS kinases. In addition to our understanding of the molecular activation mechanisms, recent studies have shown that LATS kinases play a central role in Hippo/SWH (Salvador/Warts/Hippo) tumor suppressor pathways, which coordinate cell proliferation and apoptosis by regulating proto-oncogenes, such as YAP and TAZ. In this review, we summarize current knowledge of Merlin/MST/SAV/MOB/LATS/NDR/YAP/TAZ networks (also termed mammalian Hippo signaling) and their roles in mammalian cellular transformation.

Links

PubMed Online version:10.1002/biof.47

Keywords

Adaptor Proteins, Signal Transducing/physiology; Animals; Cell Cycle Proteins/physiology; Drosophila Proteins/physiology; Gene Expression Regulation; Genes, Tumor Suppressor/physiology; Humans; Intracellular Signaling Peptides and Proteins/physiology; Neurofibromin 2/physiology; Nuclear Proteins/physiology; Protein-Serine-Threonine Kinases/physiology; Signal Transduction/physiology; Transcription Factors/physiology; Tumor Suppressor Proteins/physiology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

HUMAN:STK4

involved_in

GO:0035329: hippo signaling

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

HUMAN:STK3

involved_in

GO:0035329: hippo signaling

ECO:0000304: author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete


See also

References

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