HUMAN:STK3

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	STK3 (synonyms: KRS1, MST2)
Protein Name(s)	Serine/threonine-protein kinase 3 Mammalian STE20-like protein kinase 2 MST-2 STE20-like kinase MST2 Serine/threonine-protein kinase Krs-1 Serine/threonine-protein kinase 3 36kDa subunit MST2/N Serine/threonine-protein kinase 3 20kDa subunit MST2/C
External Links
UniProt	Q13188
EMBL	U26424 U60206 AK131363 AK291837 AC016877 AP002087 AP003355 AP003467 AP003551 CH471060 BC010640 Z25422
CCDS	CCDS47900.1 CCDS59108.1
PIR	I38212
RefSeq	NP_001243241.1 NP_006272.2 XP_011515550.1
UniGene	Hs.492333 Hs.738869
PDB	3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM
PDBsum	3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM
ProteinModelPortal	Q13188
SMR	Q13188
BioGrid	112664
DIP	DIP-36128N
IntAct	Q13188
MINT	MINT-3027356
STRING	9606.ENSP00000390500
BindingDB	Q13188
ChEMBL	CHEMBL4708
GuidetoPHARMACOLOGY	2219
PhosphoSite	Q13188
BioMuta	STK3
DMDM	46577700
OGP	Q13188
MaxQB	Q13188
PaxDb	Q13188
PRIDE	Q13188
DNASU	6788
Ensembl	ENST00000419617 ENST00000523601
GeneID	6788
KEGG	hsa:6788
UCSC	uc003yip.4
CTD	6788
GeneCards	STK3
HGNC	HGNC:11406
HPA	CAB025316 HPA007120
MIM	605030
neXtProt	NX_Q13188
PharmGKB	PA36213
eggNOG	COG0515
GeneTree	ENSGT00810000125395
HOGENOM	HOG000234203
HOVERGEN	HBG108518
InParanoid	Q13188
KO	K04412
OMA	XDEDELD
OrthoDB	EOG7TF79T
PhylomeDB	Q13188
TreeFam	TF354217
BRENDA	2.7.11.1
Reactome	R-HSA-2028269
SignaLink	Q13188
ChiTaRS	STK3
GeneWiki	STK3
GenomeRNAi	6788
NextBio	26504
PMAP-CutDB	Q13188
PRO	PR:Q13188
Proteomes	UP000005640
Bgee	Q13188
CleanEx	HS_STK3
ExpressionAtlas	Q13188
Genevisible	Q13188
GO	GO:0005737 GO:0005829 GO:0005634 GO:0043234 GO:0005524 GO:0000287 GO:0004709 GO:0046983 GO:0004672 GO:0043539 GO:0004674 GO:0000186 GO:0006915 GO:0060706 GO:0007417 GO:0003157 GO:0097284 GO:0035329 GO:0035556 GO:0000165 GO:0090090 GO:0008285 GO:0046621 GO:0001841 GO:0043065 GO:1902043 GO:0045600 GO:0046330 GO:0032092 GO:0051897 GO:0071902 GO:0051091 GO:0060215 GO:0006468 GO:0050821 GO:0042981 GO:0060800 GO:0007346 GO:0007165 GO:0023014 GO:0031098
InterPro	IPR011009 IPR024205 IPR000719 IPR017441 IPR011524 IPR002290
Pfam	PF11629 PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS50951

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
enables	GO:0004672	protein kinase activity	PMID:28087714^[1]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:19525978^[2]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P50749)	Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:20412773^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035329	hippo signaling	PMID:20412773^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13043	F		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13043	P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:8566796^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:20231902^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:20086174^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:8566796^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19525978^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:8566796^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:19525978^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18362890^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18328708^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:8566796^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	PMID:8566796^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035329	hippo signaling	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1928487 MGI:MGI:1929004 PANTHER:PTN001554629 UniProtKB:Q13043 UniProtKB:Q13188	P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919399 PANTHER:PTN000684825 RGD:727905 UniProtKB:Q7RTN6 UniProtKB:Q9C0K7	P		Seeded From UniProt	complete
involved_in	GO:0031098	stress-activated protein kinase signaling cascade	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 UniProtKB:A0A1D8PKE2 UniProtKB:A0A1D8PM87	P		Seeded From UniProt	complete
involved_in	GO:0023014	signal transduction by protein phosphorylation	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 TAIR:locus:2205523 UniProtKB:Q9UEW8	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0267698 MGI:MGI:1339975 MGI:MGI:1344404 MGI:MGI:1346867 MGI:MGI:1346875 MGI:MGI:1891638 MGI:MGI:1928487 MGI:MGI:1929004 PANTHER:PTN000684825 PomBase:SPAC1F3.02c PomBase:SPBC17F3.02 PomBase:SPBC1D7.05 PomBase:SPBC409.07c PomBase:SPBC543.07 RGD:3780 RGD:620966 RGD:621643 SGD:S000000999 SGD:S000002318 SGD:S000002931 SGD:S000003664 SGD:S000004354 SGD:S000005757 SGD:S000006061 TAIR:locus:2017662 TAIR:locus:2074835 TAIR:locus:2087130 TAIR:locus:2170578 UniProtKB:A0A0B4KGS4 UniProtKB:O00506 UniProtKB:O95819 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q57Y61 UniProtKB:Q7RTN6 UniProtKB:Q8N4C8 UniProtKB:Q96PY6 UniProtKB:Q9C0K7 UniProtKB:Q9H2G2 UniProtKB:Q9P289 UniProtKB:Q9S7U9 UniProtKB:Q9UKE5 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 UniProtKB:Q9Y6R4 WB:WBGene00002177 WB:WBGene00002201 WB:WBGene00003368 WB:WBGene00013355 dictyBase:DDB_G0284181 dictyBase:DDB_G0286359	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[9]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0031030 FB:FBgn0035001 FB:FBgn0261456 FB:FBgn0267698 MGI:MGI:1344404 MGI:MGI:1346882 MGI:MGI:1349394 MGI:MGI:1355329 MGI:MGI:1858416 MGI:MGI:1917378 MGI:MGI:1920334 PANTHER:PTN000684825 PomBase:SPBC1604.14c PomBase:SPBC21.06c RGD:3250 RGD:3251 RGD:621643 RGD:708455 RGD:727905 SGD:S000005242 TAIR:locus:2035989 TAIR:locus:2045658 TAIR:locus:2080394 TAIR:locus:2116417 TAIR:locus:2133559 TAIR:locus:2174969 TAIR:locus:2205523 TAIR:locus:2206885 UniProtKB:A0A0B4KGS4 UniProtKB:C0H4N8 UniProtKB:O75914 UniProtKB:O94804 UniProtKB:O95747 UniProtKB:O95819 UniProtKB:O96013 UniProtKB:Q02750 UniProtKB:Q12851 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q13233 UniProtKB:Q8IVH8 UniProtKB:Q8N4C8 UniProtKB:Q92918 UniProtKB:Q99558 UniProtKB:Q9H2G2 UniProtKB:Q9H2K8 UniProtKB:Q9UEW8 UniProtKB:Q9UKE5 UniProtKB:Q9UL54 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 WB:WBGene00013355 WB:WBGene00017472 dictyBase:DDB_G0276459 dictyBase:DDB_G0286359	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:16930133^[10]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:15688006^[11]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:15109305^[12]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11278283^[13]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	PMID:22292086^[14]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9H4B6	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	PMID:22292086^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:19962960^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	PMID:22292086^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23972470^[16]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13188	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:20562859^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q13188	F		Seeded From UniProt	complete
involved_in	GO:0071902	positive regulation of protein serine/threonine kinase activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0043539	P		Seeded From UniProt	complete
involved_in	GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JI10 ensembl:ENSMUSP00000018476	P		Seeded From UniProt	complete
involved_in	GO:0097284	hepatocyte apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JI10 ensembl:ENSMUSP00000018476	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JI10 ensembl:ENSMUSP00000018476	P		Seeded From UniProt	complete
involved_in	GO:0060800	regulation of cell differentiation involved in embryonic placenta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JI10 ensembl:ENSMUSP00000018476	P		Seeded From UniProt	complete
involved_in	GO:0060706	cell differentiation involved in embryonic placenta development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JI10 ensembl:ENSMUSP00000018476	P		Seeded From UniProt	complete
involved_in	GO:0060215	primitive hemopoiesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JI10 ensembl:ENSMUSP00000018476	P		Seeded From UniProt	complete
involved_in	GO:0051897	positive regulation of protein kinase B signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JI10 ensembl:ENSMUSP00000018476	P		Seeded From UniProt	complete
involved_in	GO:0046621	negative regulation of organ growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JI10 ensembl:ENSMUSP00000018476	P		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JI10 ensembl:ENSMUSP00000018476	P		Seeded From UniProt	complete
involved_in	GO:0045600	positive regulation of fat cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JI10 ensembl:ENSMUSP00000018476	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JI10 ensembl:ENSMUSP00000018476	P		Seeded From UniProt	complete
involved_in	GO:0035329	hippo signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JI10 ensembl:ENSMUSP00000018476	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JI10 ensembl:ENSMUSP00000018476	P		Seeded From UniProt	complete
involved_in	GO:0007417	central nervous system development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JI10 ensembl:ENSMUSP00000018476	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JI10 ensembl:ENSMUSP00000018476	C		Seeded From UniProt	complete
involved_in	GO:0003157	endocardium development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JI10 ensembl:ENSMUSP00000018476	P		Seeded From UniProt	complete
involved_in	GO:0001841	neural tube formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JI10 ensembl:ENSMUSP00000018476	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024205	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011524	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:8816758^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:10840030^[19] PMID:8816758^[18]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0043539	protein serine/threonine kinase activator activity	PMID:20412773^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0035329	hippo signaling	PMID:19484742^[20] Reactome:R-HSA-2028269	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:11278283^[13]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-2028697 Reactome:R-HSA-2028675 Reactome:R-HSA-2028673 Reactome:R-HSA-2028635 Reactome:R-HSA-2028591 Reactome:R-HSA-2028589	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Kwan, J et al. (2016) DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. Genes Dev. 30 2696-2709 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Cooper, WN et al. (2009) RASSF2 associates with and stabilizes the proapoptotic kinase MST2. Oncogene 28 2988-98 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Varelas, X et al. (2010) The Hippo pathway regulates Wnt/beta-catenin signaling. Dev. Cell 18 579-91 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 Creasy, CL & Chernoff, J (1995) Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene 167 303-6 PubMed GONUTS page
↑ Kim, D et al. (2010) Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway. PLoS ONE 5 e9616 PubMed GONUTS page
↑ Romano, D et al. (2010) Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt. Cancer Res. 70 1195-203 PubMed GONUTS page
↑ Hirabayashi, S et al. (2008) Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. Oncogene 27 4281-92 PubMed GONUTS page
↑ Praskova, M et al. (2008) MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr. Biol. 18 311-21 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Callus, BA et al. (2006) Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. FEBS J. 273 4264-76 PubMed GONUTS page
↑ Chan, EH et al. (2005) The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene 24 2076-86 PubMed GONUTS page
↑ Praskova, M et al. (2004) Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. Biochem. J. 381 453-62 PubMed GONUTS page
↑ ^13.0 ^13.1 Lee, KK et al. (2001) MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. J. Biol. Chem. 276 19276-85 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 Park, BH et al. (2012) Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPARγ. PLoS ONE 7 e30983 PubMed GONUTS page
↑ Song, H et al. (2010) Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity. Biochem. Biophys. Res. Commun. 391 969-73 PubMed GONUTS page
↑ Ni, L et al. (2013) Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5. Structure 21 1757-68 PubMed GONUTS page
↑ Behrends, C et al. (2010) Network organization of the human autophagy system. Nature 466 68-76 PubMed GONUTS page
↑ ^18.0 ^18.1 Taylor, LK et al. (1996) Newly identified stress-responsive protein kinases, Krs-1 and Krs-2. Proc. Natl. Acad. Sci. U.S.A. 93 10099-104 PubMed GONUTS page
↑ Wang, HC & Fecteau, KA (2000) Detection of a novel quiescence-dependent protein kinase. J. Biol. Chem. 275 25850-7 PubMed GONUTS page
↑ Hergovich, A & Hemmings, BA () Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling. Biofactors 35 338-45 PubMed GONUTS page

[PMID:28087714-1] Kwan, J et al. (2016) DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2. Genes Dev. 30 2696-2709 PubMed GONUTS page

[PMID:19525978-2] 2.0 ^2.1 ^2.2 Cooper, WN et al. (2009) RASSF2 associates with and stabilizes the proapoptotic kinase MST2. Oncogene 28 2988-98 PubMed GONUTS page

[PMID:20412773-3] 3.0 ^3.1 ^3.2 Varelas, X et al. (2010) The Hippo pathway regulates Wnt/beta-catenin signaling. Dev. Cell 18 579-91 PubMed GONUTS page

[PMID:8566796-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 Creasy, CL & Chernoff, J (1995) Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene 167 303-6 PubMed GONUTS page

[PMID:20231902-5] Kim, D et al. (2010) Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway. PLoS ONE 5 e9616 PubMed GONUTS page

[PMID:20086174-6] Romano, D et al. (2010) Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt. Cancer Res. 70 1195-203 PubMed GONUTS page

[PMID:18362890-7] Hirabayashi, S et al. (2008) Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1. Oncogene 27 4281-92 PubMed GONUTS page

[PMID:18328708-8] Praskova, M et al. (2008) MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr. Biol. 18 311-21 PubMed GONUTS page

[PMID:21873635-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:16930133-10] Callus, BA et al. (2006) Association of mammalian sterile twenty kinases, Mst1 and Mst2, with hSalvador via C-terminal coiled-coil domains, leads to its stabilization and phosphorylation. FEBS J. 273 4264-76 PubMed GONUTS page

[PMID:15688006-11] Chan, EH et al. (2005) The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1. Oncogene 24 2076-86 PubMed GONUTS page

[PMID:15109305-12] Praskova, M et al. (2004) Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. Biochem. J. 381 453-62 PubMed GONUTS page

[PMID:11278283-13] 13.0 ^13.1 Lee, KK et al. (2001) MST, a physiological caspase substrate, highly sensitizes apoptosis both upstream and downstream of caspase activation. J. Biol. Chem. 276 19276-85 PubMed GONUTS page

[PMID:22292086-14] 14.0 ^14.1 ^14.2 Park, BH et al. (2012) Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPARγ. PLoS ONE 7 e30983 PubMed GONUTS page

[PMID:19962960-15] Song, H et al. (2010) Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity. Biochem. Biophys. Res. Commun. 391 969-73 PubMed GONUTS page

[PMID:23972470-16] Ni, L et al. (2013) Structural basis for autoactivation of human Mst2 kinase and its regulation by RASSF5. Structure 21 1757-68 PubMed GONUTS page

[PMID:20562859-17] Behrends, C et al. (2010) Network organization of the human autophagy system. Nature 466 68-76 PubMed GONUTS page

[PMID:8816758-18] 18.0 ^18.1 Taylor, LK et al. (1996) Newly identified stress-responsive protein kinases, Krs-1 and Krs-2. Proc. Natl. Acad. Sci. U.S.A. 93 10099-104 PubMed GONUTS page

[PMID:10840030-19] Wang, HC & Fecteau, KA (2000) Detection of a novel quiescence-dependent protein kinase. J. Biol. Chem. 275 25850-7 PubMed GONUTS page

[PMID:19484742-20] Hergovich, A & Hemmings, BA () Mammalian NDR/LATS protein kinases in hippo tumor suppressor signaling. Biofactors 35 338-45 PubMed GONUTS page

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