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PMID:20231902
| Citation |
Kim, D, Shu, S, Coppola, MD, Kaneko, S, Yuan, ZQ and Cheng, JQ (2010) Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway. PLoS ONE 5:e9616 |
|---|---|
| Abstract |
Hippo, a Drosophila serine/threonine kinase, promotes apoptosis and restricts cell growth and proliferation. Its mammalian homolog MST2 has been shown to play similar role and be regulated by Raf-1 via a kinase-independent mechanism and by RASSF family proteins through forming complex with MST2. However, regulation of MST2 by cell survival signal remains largely unknown. |
| Links |
PubMed PMC2834758 Online version:10.1371/journal.pone.0009616 |
| Keywords |
Active Transport, Cell Nucleus; Animals; Breast Neoplasms/pathology; COS Cells; Caspase 3/metabolism; Caspase 7/metabolism; Cell Line; Cercopithecus aethiops; Gene Expression Regulation, Enzymologic; Humans; Insulin-Like Growth Factor I/metabolism; Phosphorylation; Protein-Serine-Threonine Kinases/metabolism; Proto-Oncogene Proteins c-akt/metabolism; Signal Transduction |
| edit table |
Significance
Annotations
| Gene product | Qualifier | GO Term | Evidence Code | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0006468: protein phosphorylation |
ECO:0000314: direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
See also
References
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