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PMID:16996265

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Citation

Willecke, M, Hamaratoglu, F, Kango-Singh, M, Udan, R, Chen, CL, Tao, C, Zhang, X and Halder, G (2006) The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr. Biol. 16:2090-100

Abstract

The Hippo tumor-suppressor pathway has emerged as a key signaling pathway that controls tissue size in Drosophila. Merlin, the Drosophila homolog of the human Neurofibromatosis type-2 (NF2) tumor-suppressor gene, and the related protein Expanded are the most upstream components of the Hippo pathway identified so far. However, components acting upstream of Expanded and Merlin, such as transmembrane receptors, have not yet been identified.

Links

PubMed Online version:10.1016/j.cub.2006.09.005

Keywords

Animals; Cadherins/genetics; Cadherins/physiology; Cell Adhesion Molecules/genetics; Cell Adhesion Molecules/physiology; Cell Proliferation; Drosophila/embryology; Drosophila/genetics; Drosophila/physiology; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila Proteins/physiology; Eye/embryology; Eye/ultrastructure; Intracellular Signaling Peptides and Proteins; Membrane Proteins/metabolism; Neurofibromin 2/metabolism; Nuclear Proteins/metabolism; Phenotype; Protein Kinases/metabolism; Protein-Serine-Threonine Kinases/metabolism; Signal Transduction; Trans-Activators/metabolism; Wing/anatomy & histology

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

DROME:FAT

involved_in

GO:0035332: positive regulation of hippo signaling

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0261456

P

Seeded From UniProt

complete

DROME:FAT

involved_in

GO:0043065: positive regulation of apoptotic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:FAT

involved_in

GO:0008285: negative regulation of cell population proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:FAT

involved_in

GO:0035332: positive regulation of hippo signaling

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:EXPA

involved_in

GO:0035332: positive regulation of hippo signaling

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0001075

P

Seeded From UniProt

complete

DROME:EXPA

involved_in

GO:0043065: positive regulation of apoptotic process

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:MERH

involved_in

GO:0008285: negative regulation of cell population proliferation

ECO:0000315: mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

DROME:HIPPO

involved_in

GO:0035329: hippo signaling

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0001075

P

Seeded From UniProt

complete

DROME:WARTS

involved_in

GO:0035329: hippo signaling

ECO:0000316: genetic interaction evidence used in manual assertion

FB:FBgn0001075

P

Seeded From UniProt

complete


See also

References

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