PMID:16996265

Citation	Willecke, M, Hamaratoglu, F, Kango-Singh, M, Udan, R, Chen, CL, Tao, C, Zhang, X and Halder, G (2006) The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr. Biol. 16:2090-100
Abstract	The Hippo tumor-suppressor pathway has emerged as a key signaling pathway that controls tissue size in Drosophila. Merlin, the Drosophila homolog of the human Neurofibromatosis type-2 (NF2) tumor-suppressor gene, and the related protein Expanded are the most upstream components of the Hippo pathway identified so far. However, components acting upstream of Expanded and Merlin, such as transmembrane receptors, have not yet been identified.
Links	PubMed Online version:10.1016/j.cub.2006.09.005
Keywords	Animals; Cadherins/genetics; Cadherins/physiology; Cell Adhesion Molecules/genetics; Cell Adhesion Molecules/physiology; Cell Proliferation; Drosophila/embryology; Drosophila/genetics; Drosophila/physiology; Drosophila Proteins/genetics; Drosophila Proteins/metabolism; Drosophila Proteins/physiology; Eye/embryology; Eye/ultrastructure; Intracellular Signaling Peptides and Proteins; Membrane Proteins/metabolism; Neurofibromin 2/metabolism; Nuclear Proteins/metabolism; Phenotype; Protein Kinases/metabolism; Protein-Serine-Threonine Kinases/metabolism; Signal Transduction; Trans-Activators/metabolism; Wing/anatomy & histology
edit table

Annotations

Gene product	Qualifier	GO Term	Evidence Code	with/from	Aspect	Extension	Notes	Status
DROME:FAT	involved_in	GO:0035332: positive regulation of hippo signaling	ECO:0000316: genetic interaction evidence used in manual assertion	FB:FBgn0261456	P		Seeded From UniProt	complete
DROME:FAT	involved_in	GO:0043065: positive regulation of apoptotic process	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:FAT	involved_in	GO:0008285: negative regulation of cell population proliferation	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:FAT	involved_in	GO:0035332: positive regulation of hippo signaling	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:EXPA	involved_in	GO:0035332: positive regulation of hippo signaling	ECO:0000316: genetic interaction evidence used in manual assertion	FB:FBgn0001075	P		Seeded From UniProt	complete
DROME:EXPA	involved_in	GO:0043065: positive regulation of apoptotic process	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:MERH	involved_in	GO:0008285: negative regulation of cell population proliferation	ECO:0000315: mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
DROME:HIPPO	involved_in	GO:0035329: hippo signaling	ECO:0000316: genetic interaction evidence used in manual assertion	FB:FBgn0001075	P		Seeded From UniProt	complete
DROME:WARTS	involved_in	GO:0035329: hippo signaling	ECO:0000316: genetic interaction evidence used in manual assertion	FB:FBgn0001075	P		Seeded From UniProt	complete

References

See Help:References for how to manage references in GONUTS.