HUMAN:YAP1

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	YAP1 (synonyms: YAP65)
Protein Name(s)	Transcriptional coactivator YAP1 Yes-associated protein 1 Protein yorkie homolog Yes-associated protein YAP65 homolog
External Links
UniProt	P46937
EMBL	X80507 AY316529 AB567720 AB567721 AK300414 AK316116 AP000942 AP001527 AP002777 CH471065 CH471065 BC038235 HE864159 HE864160 HE864161 HE864162
CCDS	CCDS44716.1 CCDS53699.1 CCDS53700.1 CCDS60944.1 CCDS73373.1 CCDS73374.1 CCDS8314.2
PIR	A56954
RefSeq	NP_001123617.1 NP_001181973.1 NP_001181974.1 NP_001269026.1 NP_001269027.1 NP_001269028.1 NP_001269029.1 NP_001269030.1
UniGene	Hs.503692
PDB	1JMQ 1K5R 1K9Q 1K9R 2LAW 2LAX 2LAY 2LTV 2LTW 3KYS 3MHR
PDBsum	1JMQ 1K5R 1K9Q 1K9R 2LAW 2LAX 2LAY 2LTV 2LTW 3KYS 3MHR
DisProt	DP00702
ProteinModelPortal	P46937
SMR	P46937
BioGrid	115684
DIP	DIP-40839N
IntAct	P46937
MINT	MINT-110802
STRING	9606.ENSP00000282441
PhosphoSite	P46937
DMDM	294862479
MaxQB	P46937
PaxDb	P46937
PRIDE	P46937
Ensembl	ENST00000282441 ENST00000345877 ENST00000524575 ENST00000526343 ENST00000531439 ENST00000537274 ENST00000615667
GeneID	10413
KEGG	hsa:10413
UCSC	uc001pgt.3 uc001pgu.3
CTD	10413
GeneCards	GC11P102015
HGNC	HGNC:16262
HPA	CAB009370
MIM	120433 606608
neXtProt	NX_P46937
Orphanet	1473
PharmGKB	PA38103
eggNOG	COG5021
GeneTree	ENSGT00510000046760
HOGENOM	HOG000007854
HOVERGEN	HBG002748
InParanoid	P46937
KO	K16687
OMA	LRQSSYE
PhylomeDB	P46937
TreeFam	TF326941
Reactome	REACT_116022 REACT_116145 REACT_118607 REACT_118713
SignaLink	P46937
ChiTaRS	YAP1
EvolutionaryTrace	P46937
GeneWiki	YAP1
GenomeRNAi	10413
NextBio	35497342
PRO	PR:P46937
Proteomes	UP000005640
Bgee	P46937
CleanEx	HS_YAP1
ExpressionAtlas	P46937
Genevestigator	P46937
GO	GO:0005737 GO:0005829 GO:0005654 GO:0005634 GO:0003713 GO:0003714 GO:0044212 GO:0008283 GO:0006974 GO:0071480 GO:0060242 GO:0010467 GO:0035329 GO:1903507 GO:0006355 GO:0006367
InterPro	IPR001202
Pfam	PF00397
SMART	SM00456
SUPFAM	SSF51045
PROSITE	PS01159 PS50020

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
part_of	GO:0005634	nucleus	PMID:28169360^[1]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:25796446^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:25796446^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:25796446^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0050847	progesterone receptor signaling pathway	PMID:16772533^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	PMID:16772533^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	PMID:16772533^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	PMID:20123905^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20123905^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P28347	F		Seeded From UniProt	complete
part_of	GO:0071148	TEAD-1-YAP complex	PMID:20123905^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	PMID:20368466^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0071149	TEAD-2-YAP complex	PMID:20368466^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:20368466^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15562	F		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20368466^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:20123905^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		F	has_input:(UniProtKB:P28347)	Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:20123905^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	PMID:20123905^[4]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P28347	F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:20368466^[5]	ECO:0000314	direct assay evidence used in manual assertion		F	has_input:(UniProtKB:Q15562)	Seeded From UniProt	complete
enables	GO:0033613	activating transcription factor binding	PMID:20368466^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15562	F		Seeded From UniProt	complete
involved_in	GO:0071480	cellular response to gamma radiation	PMID:18280240^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060242	contact inhibition	PMID:17974916^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0044212	transcription regulatory region DNA binding	PMID:18280240^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	PMID:17974916^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	PMID:18280240^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18158288^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:17974916^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18280240^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18158288^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17974916^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:18158288^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:18280240^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:18158288^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0072091	regulation of stem cell proliferation	PMID:25433207^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050767	regulation of neurogenesis	PMID:25433207^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903507	negative regulation of nucleic acid-templated transcription	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003714	P		Seeded From UniProt	complete
involved_in	GO:2001237	negative regulation of extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:2000737	negative regulation of stem cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:1902459	positive regulation of stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0090263	positive regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0072091	regulation of stem cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0071300	cellular response to retinoic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
enables	GO:0070064	proline-rich region binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	F		Seeded From UniProt	complete
involved_in	GO:0061026	cardiac muscle tissue regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0060828	regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0060487	lung epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0060449	bud elongation involved in lung branching	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0060045	positive regulation of cardiac muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0048368	lateral mesoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0048339	paraxial mesoderm development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0046622	positive regulation of organ growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
	GO:0010629	negative regulation of gene expression	PMID:29403552^[10]	ECO:0000315			P		Fig 5 In the YAP siRNA-transfected group the levels of Bax, caspase 3 and p53 were notably increased compared to BL control that did have significant levels of expression. Organism: Human Assay type: western blot analysis	complete CACAO 13068
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
	GO:0050679	positive regulation of epithelial cell proliferation	PMID:29403552^[10]	ECO:0000315			P		“As shown in Fig. 2, compared with the controls, the Eca-109 cell proliferation ability was notably decreased in cells transfected with YAP siRNA. These data indicated that YAP inhibition was able to suppress the proliferation in Eca-109 cells.” Organism: Human Assay type: MTT assay	complete CACAO 13069
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
	GO:1904036	negative regulation of epithelial cell apoptotic process	PMID:29403552^[10]	ECO:0000315			P		“As observed in Fig. 3, the apoptosis rate of Eca-109 cells was significantly increased in the YAP siRNA-transfected group. Thus, these results indicated that YAP inhibition induced cell apoptosis in Eca-109 cells.” Organism: Human Assay type: FCM	complete CACAO 13070
involved_in	GO:0035329	hippo signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
	GO:0010628	positive regulation of gene expression	PMID:29403552^[10]	ECO:0000315			P		Fig 5 In the YAP siRNA-transfected group the levels of Bcl-2 and p-Erk were evidently decreased compared to BL. Organism: Human Assay type: western blot analysis	complete CACAO 13079
involved_in	GO:0035019	somatic stem cell population maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0030903	notochord development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0030857	negative regulation of epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0030216	keratinocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	C		Seeded From UniProt	complete
involved_in	GO:0010837	regulation of keratinocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	F		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	C		Seeded From UniProt	complete
part_of	GO:0005667	transcription factor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	F		Seeded From UniProt	complete
enables	GO:0003682	chromatin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	F		Seeded From UniProt	complete
involved_in	GO:0003143	embryonic heart tube morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0003015	heart process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0001894	tissue homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0001570	vasculogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
enables	GO:0000978	RNA polymerase II proximal promoter sequence-specific DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	F		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P46938 ensembl:ENSMUSP00000069554	P		Seeded From UniProt	complete
involved_in	GO:0035329	hippo signaling	PMID:18158288^[8] Reactome:R-HSA-2028269	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902036	regulation of hematopoietic stem cell differentiation	Reactome:R-HSA-8939236	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006367	transcription initiation from RNA polymerase II promoter	Reactome:R-HSA-2032785	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-2064421 Reactome:R-HSA-2064406 Reactome:R-HSA-2032770 Reactome:R-HSA-2028724 Reactome:R-HSA-2028644 Reactome:R-HSA-2028598 Reactome:R-HSA-2028583 Reactome:R-HSA-1254251 Reactome:R-HSA-1254248	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-8956676 Reactome:R-HSA-8956659 Reactome:R-HSA-8956649 Reactome:R-HSA-8956639 Reactome:R-HSA-8951695 Reactome:R-HSA-8951676 Reactome:R-HSA-8871266 Reactome:R-HSA-8871265 Reactome:R-HSA-8871260 Reactome:R-HSA-2064406 Reactome:R-HSA-2032775 Reactome:R-HSA-2032770 Reactome:R-HSA-1254248	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Liu, J et al. (2017) Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway. Sci Rep 7 42125 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Enzo, E et al. (2015) Aerobic glycolysis tunes YAP/TAZ transcriptional activity. EMBO J. 34 1349-70 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Dhananjayan, SC et al. (2006) WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors. Mol. Endocrinol. 20 2343-54 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Li, Z et al. (2010) Structural insights into the YAP and TEAD complex. Genes Dev. 24 235-40 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Tian, W et al. (2010) Structural and functional analysis of the YAP-binding domain of human TEAD2. Proc. Natl. Acad. Sci. U.S.A. 107 7293-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Levy, D et al. (2008) Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol. Cell 29 350-61 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 Zhao, B et al. (2007) Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 21 2747-61 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Hao, Y et al. (2008) Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J. Biol. Chem. 283 5496-509 PubMed GONUTS page
↑ ^9.0 ^9.1 Serinagaoglu, Y et al. (2015) Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development. Dev. Biol. 398 97-109 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Cui, M & Li, Z (2018) Downregulation of YAP inhibits proliferation and induces apoptosis in Eca-109 cells. Exp Ther Med 15 1048-1052 PubMed GONUTS page

[PMID:28169360-1] Liu, J et al. (2017) Loss of DLG5 promotes breast cancer malignancy by inhibiting the Hippo signaling pathway. Sci Rep 7 42125 PubMed GONUTS page

[PMID:25796446-2] 2.0 ^2.1 ^2.2 Enzo, E et al. (2015) Aerobic glycolysis tunes YAP/TAZ transcriptional activity. EMBO J. 34 1349-70 PubMed GONUTS page

[PMID:16772533-3] 3.0 ^3.1 ^3.2 Dhananjayan, SC et al. (2006) WW domain binding protein-2, an E6-associated protein interacting protein, acts as a coactivator of estrogen and progesterone receptors. Mol. Endocrinol. 20 2343-54 PubMed GONUTS page

[PMID:20123905-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 Li, Z et al. (2010) Structural insights into the YAP and TEAD complex. Genes Dev. 24 235-40 PubMed GONUTS page

[PMID:20368466-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 Tian, W et al. (2010) Structural and functional analysis of the YAP-binding domain of human TEAD2. Proc. Natl. Acad. Sci. U.S.A. 107 7293-8 PubMed GONUTS page

[PMID:18280240-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Levy, D et al. (2008) Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol. Cell 29 350-61 PubMed GONUTS page

[PMID:17974916-7] 7.0 ^7.1 ^7.2 ^7.3 Zhao, B et al. (2007) Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev. 21 2747-61 PubMed GONUTS page

[PMID:18158288-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Hao, Y et al. (2008) Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J. Biol. Chem. 283 5496-509 PubMed GONUTS page

[PMID:25433207-9] 9.0 ^9.1 Serinagaoglu, Y et al. (2015) Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development. Dev. Biol. 398 97-109 PubMed GONUTS page

[PMID:29403552-10] 10.0 ^10.1 ^10.2 ^10.3 Cui, M & Li, Z (2018) Downregulation of YAP inhibits proliferation and induces apoptosis in Eca-109 cells. Exp Ther Med 15 1048-1052 PubMed GONUTS page

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HUMAN:YAP1

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