MOUSE:STK4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Stk4 (synonyms: Mst1)
Protein Name(s)	Serine/threonine-protein kinase 4 Mammalian STE20-like protein kinase 1 MST-1 STE20-like kinase MST1 Serine/threonine-protein kinase 4 37kDa subunit MST1/N Serine/threonine-protein kinase 4 18kDa subunit MST1/C
External Links
UniProt	Q9JI11
EMBL	AF271360 AK028838 BC054521
CCDS	CCDS17021.1
RefSeq	NP_067395.1
UniGene	Mm.234472
ProteinModelPortal	Q9JI11
SMR	Q9JI11
BioGrid	208405
IntAct	Q9JI11
STRING	10090.ENSMUSP00000018353
PhosphoSite	Q9JI11
MaxQB	Q9JI11
PaxDb	Q9JI11
PRIDE	Q9JI11
Ensembl	ENSMUST00000018353
GeneID	58231
KEGG	mmu:58231
UCSC	uc008ntt.1
CTD	6789
MGI	MGI:1929004
eggNOG	COG0515
GeneTree	ENSGT00800000124019
HOGENOM	HOG000234203
HOVERGEN	HBG108518
InParanoid	Q9JI11
KO	K04411
OMA	PFVRSAK
PhylomeDB	Q9JI11
TreeFam	TF354217
Reactome	R-MMU-2028269
NextBio	314257
PRO	PR:Q9JI11
Proteomes	UP000000589
Bgee	Q9JI11
CleanEx	MM_STK4
ExpressionAtlas	Q9JI11
Genevisible	Q9JI11
GO	GO:0005737 GO:0005654 GO:0005634 GO:0005524 GO:0042802 GO:0000287 GO:0004709 GO:0046983 GO:0042803 GO:0004674 GO:0008134 GO:0000186 GO:0006915 GO:0060706 GO:0000902 GO:0007417 GO:0003157 GO:0097284 GO:0035329 GO:0035556 GO:0030216 GO:0000165 GO:0090090 GO:0008285 GO:0046621 GO:0001841 GO:0001569 GO:0018105 GO:0043065 GO:1902043 GO:0045600 GO:0032092 GO:0060215 GO:0046777 GO:0006468 GO:0060800 GO:0007346 GO:0023014 GO:0031098
InterPro	IPR011009 IPR024205 IPR000719 IPR017441 IPR011524 IPR002290
Pfam	PF11629 PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS50951

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:1904237	positive regulation of substrate-dependent cell migration, cell attachment to substrate	PMID:19073936^[1]	ECO:0000315			P		Figure 4	complete CACAO 11065
involved_in	GO:0035329	hippo signaling	PMID:20080689^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13043	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q13043	F		Seeded From UniProt	complete
involved_in	GO:0035329	hippo signaling	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1928487 MGI:MGI:1929004 PANTHER:PTN001554629 UniProtKB:Q13043 UniProtKB:Q13188	P		Seeded From UniProt	complete
involved_in	GO:0032147	activation of protein kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1919399 PANTHER:PTN000684825 RGD:727905 UniProtKB:Q7RTN6 UniProtKB:Q9C0K7	P		Seeded From UniProt	complete
involved_in	GO:0031098	stress-activated protein kinase signaling cascade	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 UniProtKB:A0A1D8PKE2 UniProtKB:A0A1D8PM87	P		Seeded From UniProt	complete
involved_in	GO:0023014	signal transduction by protein phosphorylation	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000684825 TAIR:locus:2205523 UniProtKB:Q9UEW8	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0267698 MGI:MGI:1339975 MGI:MGI:1344404 MGI:MGI:1346867 MGI:MGI:1346875 MGI:MGI:1891638 MGI:MGI:1928487 MGI:MGI:1929004 PANTHER:PTN000684825 PomBase:SPAC1F3.02c PomBase:SPBC17F3.02 PomBase:SPBC1D7.05 PomBase:SPBC409.07c PomBase:SPBC543.07 RGD:3780 RGD:620966 RGD:621643 SGD:S000000999 SGD:S000002318 SGD:S000002931 SGD:S000003664 SGD:S000004354 SGD:S000005757 SGD:S000006061 TAIR:locus:2017662 TAIR:locus:2074835 TAIR:locus:2087130 TAIR:locus:2170578 UniProtKB:A0A0B4KGS4 UniProtKB:O00506 UniProtKB:O95819 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q57Y61 UniProtKB:Q7RTN6 UniProtKB:Q8N4C8 UniProtKB:Q96PY6 UniProtKB:Q9C0K7 UniProtKB:Q9H2G2 UniProtKB:Q9P289 UniProtKB:Q9S7U9 UniProtKB:Q9UKE5 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 UniProtKB:Q9Y6R4 WB:WBGene00002177 WB:WBGene00002201 WB:WBGene00003368 WB:WBGene00013355 dictyBase:DDB_G0284181 dictyBase:DDB_G0286359	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0023083 FB:FBgn0025743 FB:FBgn0031030 FB:FBgn0035001 FB:FBgn0261456 FB:FBgn0267698 MGI:MGI:1344404 MGI:MGI:1346882 MGI:MGI:1349394 MGI:MGI:1355329 MGI:MGI:1858416 MGI:MGI:1917378 MGI:MGI:1920334 PANTHER:PTN000684825 PomBase:SPBC1604.14c PomBase:SPBC21.06c RGD:3250 RGD:3251 RGD:621643 RGD:708455 RGD:727905 SGD:S000005242 TAIR:locus:2035989 TAIR:locus:2045658 TAIR:locus:2080394 TAIR:locus:2116417 TAIR:locus:2133559 TAIR:locus:2174969 TAIR:locus:2205523 TAIR:locus:2206885 UniProtKB:A0A0B4KGS4 UniProtKB:C0H4N8 UniProtKB:O75914 UniProtKB:O94804 UniProtKB:O95747 UniProtKB:O95819 UniProtKB:O96013 UniProtKB:Q02750 UniProtKB:Q12851 UniProtKB:Q13043 UniProtKB:Q13153 UniProtKB:Q13177 UniProtKB:Q13188 UniProtKB:Q13233 UniProtKB:Q8IVH8 UniProtKB:Q8N4C8 UniProtKB:Q92918 UniProtKB:Q99558 UniProtKB:Q9H2G2 UniProtKB:Q9H2K8 UniProtKB:Q9UEW8 UniProtKB:Q9UKE5 UniProtKB:Q9UL54 UniProtKB:Q9Y4K4 UniProtKB:Q9Y6E0 WB:WBGene00013355 WB:WBGene00017472 dictyBase:DDB_G0276459 dictyBase:DDB_G0286359	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:1312035	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	PMID:20080598^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1928487	P	regulates_o_occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	PMID:20080598^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104798 MGI:MGI:1928487	P	regulates_o_occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors	PMID:20080598^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104798	P	regulates_o_occurs_in:(CL:0000182)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097284	hepatocyte apoptotic process	PMID:20080598^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104798	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:20080598^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1928487	P	regulates_o_occurs_in:(EMAPA:16846) regulates_o_occurs_in:(CL:0000182)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060800	regulation of cell differentiation involved in embryonic placenta development	PMID:24595170^[5]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1928487	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060706	cell differentiation involved in embryonic placenta development	PMID:19786569^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1928487	P	occurs_in:(EMAPA:16042)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060215	primitive hemopoiesis	PMID:19786569^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1928487	P	occurs_in:(EMAPA:16042)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	PMID:19962960^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:4414818	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	PMID:19962960^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046777	protein autophosphorylation	PMID:11805089^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046621	negative regulation of organ growth	PMID:20080598^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1928487	P	regulates_o_occurs_in:(EMAPA:16846)\|regulates_o_occurs_in:(EMAPA:18767)\|regulates_o_occurs_in:(EMAPA:17021)\|regulates_o_occurs_in:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045600	positive regulation of fat cell differentiation	PMID:22292086^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1928487	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	PMID:20080598^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1928487	P	occurs_in:(EMAPA:35415) regulates_o_occurs_in:(CL:0000743)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	PMID:20080598^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1928487	P	occurs_in:(EMAPA:16846) regulates_o_occurs_in:(CL:0000182)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:11805089^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035556	intracellular signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035329	hippo signaling	PMID:18369314^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103262 MGI:MGI:1333883 MGI:MGI:1354386 MGI:MGI:1927144 MGI:MGI:1929004	P	occurs_in:(CL:0000312)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0035329	hippo signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033138	positive regulation of peptidyl-serine phosphorylation	PMID:19962960^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	PMID:19962960^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032092	positive regulation of protein binding	PMID:22292086^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030216	keratinocyte differentiation	PMID:18369314^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:103262 MGI:MGI:1333883 MGI:MGI:1354386 MGI:MGI:1927144 MGI:MGI:1929004	P	results_in_acquisition_of_features_of:(CL:0000312)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	P		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:20080598^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1928487	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:19786569^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1928487	P	regulates_o_occurs_in:(EMAPA:16042)	Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007417	central nervous system development	PMID:19786569^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1928487	P	results_in_development_of:(EMAPA:16470)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	PMID:11805089^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006468	protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18369314^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000312)	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12384512^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11805089^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18369314^[10]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000312)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12384512^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11805089^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:19962960^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0003157	endocardium development	PMID:19786569^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1928487	P	results_in_development_of:(EMAPA:16105)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	PMID:19962960^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001841	neural tube formation	PMID:19786569^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1928487	P	results_in_formation_of:(EMAPA:16164)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001569	branching involved in blood vessel morphogenesis	PMID:19786569^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1928487	P	occurs_in:(EMAPA:16370)\|occurs_in:(EMAPA:16104)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000902	cell morphogenesis	PMID:11805089^[8]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	P		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q13043	F		Seeded From UniProt	complete
involved_in	GO:1905461	positive regulation of vascular associated smooth muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:D4A648 ensembl:ENSRNOP00000061873	P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	P		Seeded From UniProt	complete
involved_in	GO:0050821	protein stabilization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	F		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	P		Seeded From UniProt	complete
involved_in	GO:0035329	hippo signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	P		Seeded From UniProt	complete
involved_in	GO:0033138	positive regulation of peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	C		Seeded From UniProt	complete
involved_in	GO:0032092	positive regulation of protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	P		Seeded From UniProt	complete
part_of	GO:0016604	nuclear body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	C		Seeded From UniProt	complete
enables	GO:0008134	transcription factor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	P		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	P		Seeded From UniProt	complete
enables	GO:0000287	magnesium ion binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q13043 ensembl:ENSP00000361892	F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR024205	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR011524	P		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Zhou, D et al. (2008) The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc. Natl. Acad. Sci. U.S.A. 105 20321-6 PubMed GONUTS page
↑ Lu, L et al. (2010) Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc. Natl. Acad. Sci. U.S.A. 107 1437-42 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Song, H et al. (2010) Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc. Natl. Acad. Sci. U.S.A. 107 1431-6 PubMed GONUTS page
↑ Du, X et al. (2014) Mst1 and mst2 are essential regulators of trophoblast differentiation and placenta morphogenesis. PLoS ONE 9 e90701 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Oh, S et al. (2009) Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol. Cell. Biol. 29 6309-20 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Song, H et al. (2010) Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity. Biochem. Biophys. Res. Commun. 391 969-73 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Lee, KK & Yonehara, S (2002) Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST). J. Biol. Chem. 277 12351-8 PubMed GONUTS page
↑ ^9.0 ^9.1 Park, BH et al. (2012) Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPARγ. PLoS ONE 7 e30983 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Lee, JH et al. (2008) A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J. 27 1231-42 PubMed GONUTS page
↑ ^11.0 ^11.1 Lin, Y et al. (2002) Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. J. Biol. Chem. 277 47991-8001 PubMed GONUTS page

[PMID:19073936-1] Zhou, D et al. (2008) The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells. Proc. Natl. Acad. Sci. U.S.A. 105 20321-6 PubMed GONUTS page

[PMID:20080689-2] Lu, L et al. (2010) Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc. Natl. Acad. Sci. U.S.A. 107 1437-42 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:20080598-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 Song, H et al. (2010) Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc. Natl. Acad. Sci. U.S.A. 107 1431-6 PubMed GONUTS page

[PMID:24595170-5] Du, X et al. (2014) Mst1 and mst2 are essential regulators of trophoblast differentiation and placenta morphogenesis. PLoS ONE 9 e90701 PubMed GONUTS page

[PMID:19786569-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Oh, S et al. (2009) Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse. Mol. Cell. Biol. 29 6309-20 PubMed GONUTS page

[PMID:19962960-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 Song, H et al. (2010) Role of the tumor suppressor RASSF2 in regulation of MST1 kinase activity. Biochem. Biophys. Res. Commun. 391 969-73 PubMed GONUTS page

[PMID:11805089-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 ^8.5 Lee, KK & Yonehara, S (2002) Phosphorylation and dimerization regulate nucleocytoplasmic shuttling of mammalian STE20-like kinase (MST). J. Biol. Chem. 277 12351-8 PubMed GONUTS page

[PMID:22292086-9] 9.0 ^9.1 Park, BH et al. (2012) Mammalian ste20-like kinase and SAV1 promote 3T3-L1 adipocyte differentiation by activation of PPARγ. PLoS ONE 7 e30983 PubMed GONUTS page

[PMID:18369314-10] 10.0 ^10.1 ^10.2 ^10.3 Lee, JH et al. (2008) A crucial role of WW45 in developing epithelial tissues in the mouse. EMBO J. 27 1231-42 PubMed GONUTS page

[PMID:12384512-11] 11.0 ^11.1 Lin, Y et al. (2002) Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis. J. Biol. Chem. 277 47991-8001 PubMed GONUTS page

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MOUSE:STK4

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