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HUMAN:LATS2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) LATS2 (ECO:0000312 with EMBL:BAA92381.1) (synonyms: KPM)
Protein Name(s) Serine/threonine-protein kinase LATS2

Kinase phosphorylated during mitosis protein Large tumor suppressor homolog 2 Serine/threonine-protein kinase kpm Warts-like kinase

External Links
UniProt Q9NRM7
EMBL AF207547
AK314235
AL161613
AL356285
AL356285
AL161613
CH471075
AB028019
CCDS CCDS9294.1
RefSeq NP_055387.2
XP_005266399.1
UniGene Hs.78960
ProteinModelPortal Q9NRM7
SMR Q9NRM7
BioGrid 117727
IntAct Q9NRM7
MINT MINT-1772003
STRING 9606.ENSP00000372035
BindingDB Q9NRM7
ChEMBL CHEMBL5907
GuidetoPHARMACOLOGY 1516
PhosphoSite Q9NRM7
DMDM 212276441
MaxQB Q9NRM7
PaxDb Q9NRM7
PRIDE Q9NRM7
DNASU 26524
Ensembl ENST00000382592
GeneID 26524
KEGG hsa:26524
UCSC uc001unr.4
CTD 26524
GeneCards GC13M021547
H-InvDB HIX0022357
HGNC HGNC:6515
HPA HPA039191
MIM 604861
neXtProt NX_Q9NRM7
PharmGKB PA30302
eggNOG COG0515
GeneTree ENSGT00760000118994
HOGENOM HOG000040002
HOVERGEN HBG052311
InParanoid Q9NRM7
KO K08791
OMA YGVQRSP
OrthoDB EOG7BZVS1
PhylomeDB Q9NRM7
TreeFam TF351549
Reactome REACT_118607
SignaLink Q9NRM7
ChiTaRS LATS2
GeneWiki LATS2
GenomeRNAi 26524
NextBio 48850
PRO PR:Q9NRM7
Proteomes UP000005640
Bgee Q9NRM7
CleanEx HS_LATS2
ExpressionAtlas Q9NRM7
Genevestigator Q9NRM7
GO GO:0005829
GO:0005815
GO:0005634
GO:0000922
GO:0005524
GO:0046872
GO:0004674
GO:0034613
GO:0000082
GO:0035329
GO:0009755
GO:0035556
GO:0030216
GO:0007067
GO:0090090
GO:0045736
GO:0006468
GO:0046620
InterPro IPR000961
IPR011009
IPR028742
IPR017892
IPR000719
IPR017441
IPR002290
IPR008271
IPR009060
IPR015940
PANTHER PTHR24356:SF149
Pfam PF00069
PF00433
SMART SM00133
SM00220
SUPFAM SSF46934
SSF56112
PROSITE PS51285
PS00107
PS50011
PS00108
PS50030

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0090090

negative regulation of canonical Wnt signaling pathway

PMID:20412773[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035329

hippo signaling

PMID:20412773[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045736

negative regulation of cyclin-dependent protein serine/threonine kinase activity

PMID:12853976[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:10871863[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0009755

hormone-mediated signaling pathway

PMID:15131260[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

PMID:10871863[3]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10673337[5]

ECO:0000303

author statement without traceable support used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

PMID:10871863[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:10871863[3]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

PMID:12853976[2]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0000082

G1/S transition of mitotic cell cycle

PMID:12853976[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046620

regulation of organ growth

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1354386
PANTHER:PTN002390470

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0011739
PANTHER:PTN002390470

P

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003744
FB:FBgn0010379
MGI:MGI:97601
PANTHER:PTN000683254
PomBase:SPAC1B9.02c
PomBase:SPAC22E12.14c
PomBase:SPAPB18E9.02c
RGD:3395
RGD:3399
RGD:61925
RGD:620968
RGD:67383
SGD:S000000201
UniProtKB:O15530
UniProtKB:P31749
UniProtKB:Q15208
UniProtKB:Q9NRM7
UniProtKB:Q9Y2H1

P

Seeded From UniProt

complete

involved_in

GO:0035329

hippo signaling

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1333883
MGI:MGI:1354386
PANTHER:PTN002390470
UniProtKB:O95835
UniProtKB:Q9NRM7

P

Seeded From UniProt

complete

involved_in

GO:0018105

peptidyl-serine phosphorylation

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:87986
PANTHER:PTN000683254
RGD:2081
RGD:3395
RGD:3399
RGD:3668
RGD:61925
SGD:S000001609
SGD:S000001861
SGD:S000002898
SGD:S000005460
UniProtKB:A0A1D5PUY5
UniProtKB:P31749
UniProtKB:P41743
UniProtKB:Q02156
UniProtKB:Q05513
UniProtKB:Q05655
WB:WBGene00000102
WB:WBGene00000103
WB:WBGene00004033
WB:WBGene00004034
WB:WBGene00004789
WB:WBGene00006599

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000500077
UniProtKB:Q9NRM7

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0003091
FB:FBgn0003744
FB:FBgn0010379
FB:FBgn0260399
FB:FBgn0261854
MGI:MGI:104874
MGI:MGI:2182368
MGI:MGI:87986
MGI:MGI:894676
MGI:MGI:97595
MGI:MGI:97596
MGI:MGI:97599
MGI:MGI:97602
PANTHER:PTN000683254
PomBase:SPAC1B9.02c
PomBase:SPAC22E12.14c
PomBase:SPAC24B11.11c
PomBase:SPAC821.12
PomBase:SPAPB18E9.02c
PomBase:SPCC576.15c
RGD:2081
RGD:2082
RGD:3399
RGD:3668
RGD:620146
RGD:620968
RGD:62390
SGD:S000001248
SGD:S000001609
SGD:S000001861
SGD:S000002898
SGD:S000003324
SGD:S000005105
SGD:S000005460
SGD:S000006315
TAIR:locus:2088515
UniProtKB:O15530
UniProtKB:O95835
UniProtKB:P05771
UniProtKB:P17252
UniProtKB:P31749
UniProtKB:P31751
UniProtKB:P41743
UniProtKB:Q02156
UniProtKB:Q04759
UniProtKB:Q05513
UniProtKB:Q05655
UniProtKB:Q09013
UniProtKB:Q15208
UniProtKB:Q16512
UniProtKB:Q16513
UniProtKB:Q96GX5
UniProtKB:Q9NRM7
UniProtKB:Q9XF67
UniProtKB:Q9Y243
UniProtKB:Q9Y2H1
WB:WBGene00000102
WB:WBGene00000103
WB:WBGene00004034
WB:WBGene00004789
WB:WBGene00006599
dictyBase:DDB_G0268620

F

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1354386
PANTHER:PTN000500077
UniProtKB:Q9NRM7

C

Seeded From UniProt

complete

involved_in

GO:0000082

G1/S transition of mitotic cell cycle

PMID:21873635[6]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1354386
PANTHER:PTN002390470
UniProtKB:Q9NRM7

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:10673337[5]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR008271

F

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000961
InterPro:IPR017892

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR017441
InterPro:IPR017892

F

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR000961
InterPro:IPR008271
InterPro:IPR017892

P

Seeded From UniProt

complete

involved_in

GO:0035329

hippo signaling

Reactome:R-HSA-2028269

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-2059926
Reactome:R-HSA-2038398
Reactome:R-HSA-2028679
Reactome:R-HSA-2028673
Reactome:R-HSA-2028661
Reactome:R-HSA-2028626
Reactome:R-HSA-2028589
Reactome:R-HSA-2028583
Reactome:R-HSA-2028555

ECO:0000304

author statement supported by traceable reference used in manual assertion









C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

Reactome:R-HSA-2028661
Reactome:R-HSA-2028583

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0206

C

Seeded From UniProt

complete

enables

GO:0004674

protein serine/threonine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0723

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0051301

cell division

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0132

P

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

involved_in

GO:0007049

cell cycle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0131

P

Seeded From UniProt

complete

part_of

GO:0000922

spindle pole

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0448

C

Seeded From UniProt

complete

part_of

GO:0005815

microtubule organizing center

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0048

C

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 Varelas, X et al. (2010) The Hippo pathway regulates Wnt/beta-catenin signaling. Dev. Cell 18 579-91 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 Li, Y et al. (2003) Lats2, a putative tumor suppressor, inhibits G1/S transition. Oncogene 22 4398-405 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Hori, T et al. (2000) Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor. Oncogene 19 3101-9 PubMed GONUTS page
  4. ↑ Powzaniuk, M et al. (2004) The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor. Mol. Endocrinol. 18 2011-23 PubMed GONUTS page
  5. ↑ 5.0 5.1 Yabuta, N et al. (2000) Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts. Genomics 63 263-70 PubMed GONUTS page
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 6.7 6.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
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