PMID:18199416

Citation	Haraldsson, MK, Louis-Dit-Sully, CA, Lawson, BR, Sternik, G, Santiago-Raber, ML, Gascoigne, NR, Theofilopoulos, AN and Kono, DH (2008) The lupus-related Lmb3 locus contains a disease-suppressing Coronin-1A gene mutation. Immunity 28:40-51
Abstract	Here, we show that a lupus-suppressing locus is caused by a nonsense mutation of the filamentous actin-inhibiting Coronin-1A gene. This mutation was associated with developmental and functional alterations in T cells including reduced migration, survival, activation, and Ca2+ flux. T-dependent humoral responses were impaired, but no intrinsic B cell defects were detected. By transfer of T cells, it was shown that suppression of autoimmunity could be accounted for by the presence of the Coro1a(Lmb3) mutation in T cells. Our results demonstrate that Coronin-1A is required for the development of systemic lupus and identify actin-cytoskeleton regulatory proteins as potential targets for modulating autoimmune diseases.
Links	PubMed PMC2274909 Online version:10.1016/j.immuni.2007.11.023
Keywords	Actins/metabolism; Adoptive Transfer; Animals; Apoptosis/physiology; Autoantibodies/blood; Autoantibodies/immunology; B-Lymphocytes/immunology; Cell Proliferation; Chemotaxis, Leukocyte/immunology; Codon, Nonsense; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Genetic Predisposition to Disease; Immunoglobulin G/blood; Immunoglobulin G/immunology; Immunohistochemistry; Lupus Erythematosus, Systemic/genetics; Lupus Erythematosus, Systemic/immunology; Lymphocyte Activation/immunology; Mice; Microfilament Proteins/genetics; Polymerase Chain Reaction; T-Lymphocytes/immunology; Transfection
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