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PMID:7595210
| Citation |
Hughes, DP and Crispe, IN (1995) A naturally occurring soluble isoform of murine Fas generated by alternative splicing. J. Exp. Med. 182:1395-401 |
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| Abstract |
We report a soluble isoform of mouse Fas, which is generated by alternative splicing of Fas mRNA to a newly identified exon located between exons 2 and 3 of the previously published Fas sequence. This splicing event creates a novel Fas transcript, Fas beta, with the potential to encode a truncated form of the extracellular domain, termed Fas B. In vitro, P815 mastocytoma cells transfected with Fas B become resistant to Fas ligand-induced apoptosis, and the resistance is mediated by a secreted product of the transfected cells. In vivo, Fas beta mRNA expression is correlated inversely with apoptosis among subsets of intrahepatic T lymphocytes, a cell population in which activation-induced T cell apoptosis occurs. We propose that Fas B is a new cytokine that acts physiologically to limit apoptosis induced by Fas ligand. |
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| Keywords |
Amino Acid Sequence; Animals; Antigens, CD95/chemistry; Antigens, CD95/genetics; Apoptosis/drug effects; Base Sequence; Exons/genetics; Fas Ligand Protein; Liver/immunology; Lymphocyte Activation; Lymphoproliferative Disorders/genetics; Mast-Cell Sarcoma/pathology; Membrane Glycoproteins/pharmacology; Mice; Mice, Inbred C57BL; Molecular Sequence Data; RNA Splicing; RNA, Messenger/genetics; RNA, Messenger/metabolism; Recombinant Proteins/metabolism; Solubility; Transfection; Tumor Cells, Cultured |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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