PMID:8557033

Citation	Strasser, A, Harris, AW, Huang, DC, Krammer, PH and Cory, S (1995) Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J. 14:6136-47
Abstract	Activation of the cell surface receptor Fas/APO-1 (CD95) induces apoptosis in lymphocytes and regulates immune responses. The cytoplasmic membrane protein Bcl-2 inhibits lymphocyte killing by diverse cytotoxic agents, but we found it provided little protection against Fas/APO-1-transduced apoptosis in B lymphoid cell lines, thymocytes and activated T cells. In contrast, the cowpox virus protease inhibitor CrmA blocked Fas/APO-1-transduced apoptosis, but did not affect cell death induced by gamma-radiation or serum deprivation. Signalling through Fas/APO-1 did not down-regulate Bcl-2 or induce its antagonists Bax and Bcl-xS. In Fas/APO-1-deficient lpr mice, Bcl-2 transgenes markedly augmented the survival of antigen-activated T cells and the abnormal accumulation of lymphocytes (although they did not interfere with deletion of auto-reactive cells in the thymus). These data raise the possibility that Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.
Links	PubMed PMC394738
Keywords	Animals; Antigens, CD95/genetics; Antigens, CD95/physiology; Apoptosis/genetics; Apoptosis/immunology; Apoptosis/physiology; Autoimmunity; Base Sequence; Cell Line; DNA Primers/genetics; Gene Expression; Humans; Lymphatic Diseases/etiology; Lymphocyte Activation; Lymphocytes/cytology; Lymphocytes/immunology; Lymphocytes/physiology; Mice; Mice, Transgenic; Molecular Sequence Data; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/physiology; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogenes; Serpins/physiology; Signal Transduction/physiology; T-Lymphocytes/immunology; Viral Proteins
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