HUMAN:GSK3A

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	GSK3A
Protein Name(s)	Glycogen synthase kinase-3 alpha GSK-3 alpha Serine/threonine-protein kinase GSK3A
External Links
UniProt	P49840
EMBL	L40027 D63424 AC006486 BC027984 BC051865
CCDS	CCDS12599.1
RefSeq	NP_063937.2
UniGene	Hs.466828
PDB	2DFM
PDBsum	2DFM
ProteinModelPortal	P49840
SMR	P49840
BioGrid	109186
IntAct	P49840
MINT	MINT-1688290
STRING	9606.ENSP00000222330
BindingDB	P49840
ChEMBL	CHEMBL2850
GuidetoPHARMACOLOGY	2029
PhosphoSite	P49840
BioMuta	GSK3A
DMDM	12644292
MaxQB	P49840
PaxDb	P49840
PeptideAtlas	P49840
PRIDE	P49840
DNASU	2931
Ensembl	ENST00000222330 ENST00000453535
GeneID	2931
KEGG	hsa:2931
UCSC	uc002otb.1
CTD	2931
GeneCards	GC19M042734
HGNC	HGNC:4616
HPA	CAB004422 HPA028423
MIM	606784
neXtProt	NX_P49840
PharmGKB	PA29008
eggNOG	COG0515
GeneTree	ENSGT00520000055635
HOGENOM	HOG000233017
HOVERGEN	HBG014652
InParanoid	P49840
KO	K08822
OMA	FDELRCP
OrthoDB	EOG7TF78V
PhylomeDB	P49840
TreeFam	TF101104
Reactome	REACT_12564 REACT_18273 REACT_355468
SignaLink	P49840
ChiTaRS	GSK3A
GeneWiki	GSK3A
GenomeRNAi	2931
NextBio	11615
PRO	PR:P49840
Proteomes	UP000005640
Bgee	P49840
CleanEx	HS_GSK3A
ExpressionAtlas	P49840
Genevisible	P49840
GO	GO:0030877 GO:0005829 GO:0005524 GO:0034236 GO:0004674 GO:0050321 GO:0003214 GO:0016477 GO:0044267 GO:0032869 GO:0036016 GO:0071285 GO:0071407 GO:0030968 GO:0007173 GO:0097192 GO:0038095 GO:0008543 GO:0005977 GO:0044027 GO:0045087 GO:0008286 GO:0036498 GO:0090090 GO:0061052 GO:0046325 GO:2000466 GO:0045719 GO:1904227 GO:0046627 GO:0032007 GO:2000077 GO:0010905 GO:0007399 GO:0048011 GO:0048015 GO:0071879 GO:0030819 GO:2000467 GO:0045823 GO:1901030 GO:0033138 GO:0010800 GO:0045732 GO:1903955 GO:0045944 GO:0043161 GO:0006468 GO:0006349 GO:1903146 GO:0003073 GO:0016055
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0018107	peptidyl-threonine phosphorylation	PMID:25897075^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(UniProtKB:Q6R327)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:28386764^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F	has_input:(UniProtKB:P10636)	Seeded From UniProt	complete
involved_in	GO:0031398	positive regulation of protein ubiquitination	PMID:25897075^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q6R327)	Seeded From UniProt	complete
involved_in	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:25897075^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q6R327)	Seeded From UniProt	complete
enables	GO:0048156	tau protein binding	PMID:28386764^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	PMID:28386764^[2]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2NL51	P		Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2NL51	P	part_of:(GO:0071549)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2NL51	P	regulates_expression_of:(ENSEMBL:ENSG00000113580)	Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:20371704^[3]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P04150	F		Seeded From UniProt	complete
part_of	GO:0097440	apical dendrite	PMID:8725894^[4]	ECO:0000303	author statement without traceable support used in manual assertion		C	part_of:(UBERON:0001953) part_of:(GO:1990635)	Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	PMID:8725894^[4]	ECO:0000303	author statement without traceable support used in manual assertion		C	part_of:(UBERON:0001953)	Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:8725894^[4]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	PMID:21711983^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902004	positive regulation of amyloid-beta formation	PMID:12761548^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000540) occurs_in:(CL:0000540)	Seeded From UniProt	complete
involved_in	GO:1902004	positive regulation of amyloid-beta formation	PMID:12761548^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P49841	P		Seeded From UniProt	complete
part_of	GO:1990635	proximal dendrite	PMID:8725894^[4]	ECO:0000303	author statement without traceable support used in manual assertion		C	part_of:(UBERON:0001953) part_of:(GO:0097440)	Seeded From UniProt	complete
involved_in	GO:1903146	regulation of autophagy of mitochondrion	PMID:24912190^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903955	positive regulation of protein targeting to mitochondrion	PMID:24912190^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O60260)	Seeded From UniProt	complete
involved_in	GO:2000467	positive regulation of glycogen (starch) synthase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2NL51	P		Seeded From UniProt	complete
involved_in	GO:0071879	positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2NL51	P		Seeded From UniProt	complete
involved_in	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2NL51	P		Seeded From UniProt	complete
involved_in	GO:1904227	negative regulation of glycogen synthase activity, transferring glucose-1-phosphate	PMID:17569761^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046627	negative regulation of insulin receptor signaling pathway	PMID:17569761^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046325	negative regulation of glucose import	PMID:17569761^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045823	positive regulation of heart contraction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2NL51	P		Seeded From UniProt	complete
involved_in	GO:0045732	positive regulation of protein catabolic process	PMID:19759537^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0034236	protein kinase A catalytic subunit binding	PMID:11035810^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P17612	F		Seeded From UniProt	complete
involved_in	GO:0032869	cellular response to insulin stimulus	PMID:17569761^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032007	negative regulation of TOR signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2NL51	P		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:19759537^[9]	ECO:0000303	author statement without traceable support used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0106071	positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2NL51	P		Seeded From UniProt	complete
involved_in	GO:0008286	insulin receptor signaling pathway	PMID:18285345^[11]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2NL51	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:11035810^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:11035810^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0003214	cardiac left ventricle morphogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2NL51	P		Seeded From UniProt	complete
involved_in	GO:0003073	regulation of systemic arterial blood pressure	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2NL51	P		Seeded From UniProt	complete
involved_in	GO:0007212	dopamine receptor signaling pathway	PMID:21711983^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P	part_of:(GO:0099565)	Seeded From UniProt	complete
involved_in	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2NL51	P		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2NL51	P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2NL51	P		Seeded From UniProt	complete
involved_in	GO:0036016	cellular response to interleukin-3	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q2NL51	P		Seeded From UniProt	complete
involved_in	GO:0010905	negative regulation of UDP-glucose catabolic process	PMID:11035810^[10]	ECO:0000305	curator inference used in manual assertion	GO:0004674	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:1901030	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0060079	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.26	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11035810^[10] Reactome:R-HSA-2399966 Reactome:R-HSA-1791054	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000466	negative regulation of glycogen (starch) synthase activity	PMID:19366350^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000077	negative regulation of type B pancreatic cell development	PMID:19366350^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090090	negative regulation of canonical Wnt signaling pathway	PMID:19366350^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0050321	tau-protein kinase activity	PMID:19366350^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045719	negative regulation of glycogen biosynthetic process	PMID:19366350^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030877	beta-catenin destruction complex	PMID:19366350^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0036498	IRE1-mediated unfolded protein response	Reactome:R-HSA-381070	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
involved_in	GO:0016055	Wnt signaling pathway	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0879	P		Seeded From UniProt	complete
involved_in	GO:0007399	nervous system development	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0524	P		Seeded From UniProt	complete
involved_in	GO:0005977	glycogen metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0321	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
involved_in	GO:0005975	carbohydrate metabolic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0119	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0009968	negative regulation of signal transduction	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0734	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Koo, J et al. (2015) Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation. J. Biol. Chem. 290 14120-9 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page
↑ Spokoini, R et al. (2010) Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis. Mol. Endocrinol. 24 1136-50 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Harr, SD et al. () Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles. Neurobiol. Aging 17 343-8 PubMed GONUTS page
↑ ^5.0 ^5.1 Beaulieu, JM (2012) A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health. J Psychiatry Neurosci 37 7-16 PubMed GONUTS page
↑ ^6.0 ^6.1 Phiel, CJ et al. (2003) GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature 423 435-9 PubMed GONUTS page
↑ ^7.0 ^7.1 Ivatt, RM et al. (2014) Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy. Proc. Natl. Acad. Sci. U.S.A. 111 8494-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Ciaraldi, TP et al. (2007) Role of glycogen synthase kinase-3 alpha in insulin action in cultured human skeletal muscle cells. Endocrinology 148 4393-9 PubMed GONUTS page
↑ ^9.0 ^9.1 Huang, SM et al. (2009) Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461 614-20 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Fang, X et al. (2000) Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc. Natl. Acad. Sci. U.S.A. 97 11960-5 PubMed GONUTS page
↑ Waraich, RS et al. (2008) Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells. J. Biol. Chem. 283 11226-33 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Rayasam, GV et al. (2009) Glycogen synthase kinase 3: more than a namesake. Br. J. Pharmacol. 156 885-98 PubMed GONUTS page

[PMID:25897075-1] 1.0 ^1.1 ^1.2 Koo, J et al. (2015) Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation. J. Biol. Chem. 290 14120-9 PubMed GONUTS page

[PMID:28386764-2] 2.0 ^2.1 ^2.2 Guo, T et al. (2017) Roles of tau protein in health and disease. Acta Neuropathol. 133 665-704 PubMed GONUTS page

[PMID:20371704-3] Spokoini, R et al. (2010) Glycogen synthase kinase-3 plays a central role in mediating glucocorticoid-induced apoptosis. Mol. Endocrinol. 24 1136-50 PubMed GONUTS page

[PMID:8725894-4] 4.0 ^4.1 ^4.2 ^4.3 Harr, SD et al. () Glycogen synthase kinase 3 alpha and 3 beta do not colocalize with neurofibrillary tangles. Neurobiol. Aging 17 343-8 PubMed GONUTS page

[PMID:21711983-5] 5.0 ^5.1 Beaulieu, JM (2012) A role for Akt and glycogen synthase kinase-3 as integrators of dopamine and serotonin neurotransmission in mental health. J Psychiatry Neurosci 37 7-16 PubMed GONUTS page

[PMID:12761548-6] 6.0 ^6.1 Phiel, CJ et al. (2003) GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature 423 435-9 PubMed GONUTS page

[PMID:24912190-7] 7.0 ^7.1 Ivatt, RM et al. (2014) Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy. Proc. Natl. Acad. Sci. U.S.A. 111 8494-9 PubMed GONUTS page

[PMID:17569761-8] 8.0 ^8.1 ^8.2 ^8.3 Ciaraldi, TP et al. (2007) Role of glycogen synthase kinase-3 alpha in insulin action in cultured human skeletal muscle cells. Endocrinology 148 4393-9 PubMed GONUTS page

[PMID:19759537-9] 9.0 ^9.1 Huang, SM et al. (2009) Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461 614-20 PubMed GONUTS page

[PMID:11035810-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Fang, X et al. (2000) Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A. Proc. Natl. Acad. Sci. U.S.A. 97 11960-5 PubMed GONUTS page

[PMID:18285345-11] Waraich, RS et al. (2008) Phosphorylation of Ser357 of rat insulin receptor substrate-1 mediates adverse effects of protein kinase C-delta on insulin action in skeletal muscle cells. J. Biol. Chem. 283 11226-33 PubMed GONUTS page

[PMID:19366350-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 Rayasam, GV et al. (2009) Glycogen synthase kinase 3: more than a namesake. Br. J. Pharmacol. 156 885-98 PubMed GONUTS page

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HUMAN:GSK3A

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