MOUSE:PML

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pml
Protein Name(s)	Protein PML
External Links
UniProt	Q60953
EMBL	AK028044 BC020990 U33626
CCDS	CCDS23239.1 CCDS23240.2
RefSeq	NP_032910.3 NP_835188.2
UniGene	Mm.392123
ProteinModelPortal	Q60953
SMR	Q60953
BioGrid	202265
DIP	DIP-29279N
IntAct	Q60953
MINT	MINT-4108085
PhosphoSite	Q60953
MaxQB	Q60953
PaxDb	Q60953
PRIDE	Q60953
Ensembl	ENSMUST00000085673 ENSMUST00000114136
GeneID	18854
KEGG	mmu:18854
UCSC	uc009pwp.2 uc009pwq.2
CTD	5371
MGI	MGI:104662
eggNOG	NOG326718
GeneTree	ENSGT00510000048454
HOGENOM	HOG000115586
HOVERGEN	HBG000552
InParanoid	Q60953
KO	K10054
OMA	KFRVLIQ
OrthoDB	EOG7M98FM
PhylomeDB	Q60953
TreeFam	TF336434
Reactome	REACT_198660
NextBio	295230
PRO	PR:Q60953
Proteomes	UP000000589
Bgee	Q60953
CleanEx	MM_PML
ExpressionAtlas	Q60953
Genevestigator	Q60953
GO	GO:0005829 GO:0031901 GO:0042406 GO:0016363 GO:0031965 GO:0005730 GO:0005654 GO:0005634 GO:0016605 GO:0050897 GO:0003677 GO:0046332 GO:0003713 GO:0008270 GO:0006919 GO:0060444 GO:0007569 GO:0007050 GO:0045165 GO:0071353 GO:0090398 GO:0032922 GO:0007182 GO:0051607 GO:0006977 GO:0032469 GO:0043153 GO:0097191 GO:0045087 GO:0072332 GO:0008630 GO:0042771 GO:0070059 GO:0008631 GO:0051457 GO:0030099 GO:0016525 GO:0030308 GO:0008285 GO:2000059 GO:0051974 GO:0032211 GO:0045892 GO:0032938 GO:1902187 GO:0030578 GO:0060058 GO:2001235 GO:0002230 GO:2001238 GO:0031065 GO:0043161 GO:0006461 GO:0050821 GO:0006605 GO:0010522 GO:0042752 GO:2000779 GO:0045343 GO:0001932 GO:0006355 GO:0010332 GO:0001666 GO:0009411 GO:0048384 GO:0007184 GO:0006351 GO:0007179 GO:0016032
Gene3D	3.30.40.10
InterPro	IPR021978 IPR000315 IPR001841 IPR013083 IPR017907
Pfam	PF12126 PF00643
SMART	SM00336 SM00184
PROSITE	PS50119 PS00518 PS50089

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0030155	regulation of cell adhesion	PMID:23555679^[1]	ECO:0000315			P		figure 3	complete CACAO 7525
	GO:0048146	positive regulation of fibroblast proliferation	PMID:23555679^[1]	ECO:0000315			P		figure 4	complete CACAO 7526
	GO:0010761	fibroblast migration	PMID:23555679^[1]	ECO:0000315			P		figure 5	complete CACAO 7527
involved_in	GO:0050711	negative regulation of interleukin-1 secretion	PMID:24407287^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050713	negative regulation of interleukin-1 beta secretion	PMID:24407287^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010761	fibroblast migration	PMID:23555679^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048146	positive regulation of fibroblast proliferation	PMID:23555679^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030155	regulation of cell adhesion	PMID:23555679^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1902187	negative regulation of viral release from host cell	PMID:18248090^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:18248090^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
colocalizes_with	GO:0000792	heterochromatin	PMID:17081986^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:17081986^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000779	regulation of double-strand break repair	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
involved_in	GO:0090398	cellular senescence	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29590-4	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
involved_in	GO:0043153	entrainment of circadian clock by photoperiod	PMID:22274616^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:15626733^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042752	regulation of circadian rhythm	PMID:22274616^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0042406	extrinsic component of endoplasmic reticulum membrane	PMID:21030605^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032922	circadian regulation of gene expression	PMID:22274616^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032469	endoplasmic reticulum calcium ion homeostasis	PMID:21030605^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031065	positive regulation of histone deacetylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29590-5	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
part_of	GO:0016605	PML body	PMID:10779416^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion		C		Seeded From UniProt	complete
colocalizes_with	GO:0016605	PML body	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29590	C		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
involved_in	GO:0010522	regulation of calcium ion transport into cytosol	PMID:21030605^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007569	cell aging	PMID:10910364^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:10910364^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	PMID:15626733^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006605	protein targeting	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29590-5	P		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21030605^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29590	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29590	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:22274616^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21030605^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001932	regulation of protein phosphorylation	PMID:21030605^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
involved_in	GO:1902187	negative regulation of viral release from host cell	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104662 PANTHER:PTN002379290 UniProtKB:P29590	P		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104662 PANTHER:PTN002379290	F		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104662 PANTHER:PTN002379290 UniProtKB:P29590	P		Seeded From UniProt	complete
enables	GO:0032183	SUMO binding	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002379290 UniProtKB:P29590	F		Seeded From UniProt	complete
involved_in	GO:0030578	PML body organization	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104662 PANTHER:PTN002379290 UniProtKB:P29590	P		Seeded From UniProt	complete
part_of	GO:0016605	PML body	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104662 PANTHER:PTN002379290 UniProtKB:P29590	C		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104662 PANTHER:PTN002379290 UniProtKB:P29590	C		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104662 PANTHER:PTN002379290 UniProtKB:P29590	P		Seeded From UniProt	complete
involved_in	GO:0007050	cell cycle arrest	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104662 PANTHER:PTN002379290 UniProtKB:P29590	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:104662 PANTHER:PTN002379290 UniProtKB:P29590	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002379290 UniProtKB:P29590	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002379290 UniProtKB:P29590	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030578	PML body organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030308	negative regulation of cell growth	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030099	myeloid cell differentiation	PMID:9488655^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429949	P		Seeded From UniProt	complete
part_of	GO:0016605	PML body	PMID:22904064^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	PMID:19033381^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	PMID:16461359^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016525	negative regulation of angiogenesis	PMID:16915281^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016525	negative regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	PMID:15252119^[16]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010332	response to gamma radiation	PMID:9806545^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010332	response to gamma radiation	PMID:11025664^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:104662	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009411	response to UV	PMID:15626733^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:104662	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	PMID:21030605^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:9806545^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:15626733^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:104662	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	PMID:9488655^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007182	common-partner SMAD protein phosphorylation	PMID:15356634^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007179	transforming growth factor beta receptor signaling pathway	PMID:15356634^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007050	cell cycle arrest	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:9806545^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006606	protein import into nucleus	PMID:15356634^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006605	protein targeting	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19416967^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10716735^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	C		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002230	positive regulation of defense response to virus by host	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	PMID:16915281^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001666	response to hypoxia	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001235	positive regulation of apoptotic signaling pathway	PMID:10684855^[22]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1197015	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001235	positive regulation of apoptotic signaling pathway	PMID:10684855^[22]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000779	regulation of double-strand break repair	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1990830	cellular response to leukemia inhibitory factor	PMID:20439489^[23]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904816	positive regulation of protein localization to chromosome, telomeric region	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902187	negative regulation of viral release from host cell	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097191	extrinsic apoptotic signaling pathway	PMID:9806545^[17]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429949	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090398	cellular senescence	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	PMID:14992722^[24]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071353	cellular response to interleukin-4	PMID:9798653^[25]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	PMID:21030605^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0065003	protein-containing complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060444	branching involved in mammary gland duct morphogenesis	PMID:19261859^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429949	P	has_participant:(EMAPA:35538)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060058	positive regulation of apoptotic process involved in mammary gland involution	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051974	negative regulation of telomerase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051457	maintenance of protein location in nucleus	PMID:17332504^[27]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
enables	GO:0050897	cobalt ion binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050821	protein stabilization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048384	retinoic acid receptor signaling pathway	PMID:9488655^[11]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429949	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	F		Seeded From UniProt	complete
enables	GO:0046332	SMAD binding	PMID:15356634^[19]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045930	negative regulation of mitotic cell cycle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045165	cell fate commitment	PMID:19261859^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2429949	P	occurs_in:(EMAPA:17760)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045087	innate immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034097	response to cytokine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032938	negative regulation of translation in response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032211	negative regulation of telomere maintenance via telomerase	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032206	positive regulation of telomere maintenance	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
enables	GO:0032183	SUMO binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	F		Seeded From UniProt	complete
part_of	GO:0031965	nuclear membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	C		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031065	positive regulation of histone deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P29590	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030578	PML body organization	PMID:12529400^[28]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1903508	positive regulation of nucleic acid-templated transcription	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003713	P		Seeded From UniProt	complete
involved_in	GO:1903508	positive regulation of nucleic acid-templated transcription	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003713	P		Seeded From UniProt	complete
involved_in	GO:1903508	positive regulation of nucleic acid-templated transcription	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0003713	P		Seeded From UniProt	complete
involved_in	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	P		Seeded From UniProt	complete
involved_in	GO:2000779	regulation of double-strand break repair	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	P		Seeded From UniProt	complete
involved_in	GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	P		Seeded From UniProt	complete
involved_in	GO:1902187	negative regulation of viral release from host cell	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	P		Seeded From UniProt	complete
involved_in	GO:0090398	cellular senescence	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	P		Seeded From UniProt	complete
involved_in	GO:0065003	protein-containing complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	P		Seeded From UniProt	complete
involved_in	GO:0051457	maintenance of protein location in nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	P		Seeded From UniProt	complete
involved_in	GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	F		Seeded From UniProt	complete
involved_in	GO:0034097	response to cytokine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	P		Seeded From UniProt	complete
involved_in	GO:0032206	positive regulation of telomere maintenance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	P		Seeded From UniProt	complete
enables	GO:0032183	SUMO binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	F		Seeded From UniProt	complete
involved_in	GO:0030578	PML body organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	P		Seeded From UniProt	complete
involved_in	GO:0030308	negative regulation of cell growth	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	P		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	C		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	P		Seeded From UniProt	complete
involved_in	GO:0006355	regulation of transcription, DNA-templated	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	P		Seeded From UniProt	complete
part_of	GO:0000784	nuclear chromosome, telomeric region	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P29590 ensembl:ENSP00000268058	C		Seeded From UniProt	complete
enables	GO:0008270	zinc ion binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000315	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045343	regulation of MHC class I biosynthetic process	PMID:9845074^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:9845074^[29]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0003713	transcription coactivator activity	PMID:15626733^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
involved_in	GO:0048511	rhythmic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0090	P		Seeded From UniProt	complete
enables	GO:0003677	DNA binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0238	F		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256	C		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0051	P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0190	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C		Seeded From UniProt	complete
part_of	GO:0005789	endoplasmic reticulum membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0097	C		Seeded From UniProt	complete
part_of	GO:0031901	early endosome membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0093	C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0465	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Tang, MK et al. (2013) Promyelocytic leukemia (PML) protein plays important roles in regulating cell adhesion, morphology, proliferation and migration. PLoS ONE 8 e59477 PubMed GONUTS page
↑ ^2.0 ^2.1 Dowling, JK et al. (2014) Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation. J. Biol. Chem. 289 6429-37 PubMed GONUTS page
↑ ^3.0 ^3.1 Uchil, PD et al. (2008) TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. PLoS Pathog. 4 e16 PubMed GONUTS page
↑ ^4.0 ^4.1 Lin, DY et al. (2006) Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. Mol. Cell 24 341-54 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 Miki, T et al. (2012) PML regulates PER2 nuclear localization and circadian function. EMBO J. 31 1427-39 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Salomoni, P et al. (2005) The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage. Blood 105 3686-90 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Giorgi, C et al. (2010) PML regulates apoptosis at endoplasmic reticulum by modulating calcium release. Science 330 1247-51 PubMed GONUTS page
↑ Zhong, S et al. (2000) Role of SUMO-1-modified PML in nuclear body formation. Blood 95 2748-52 PubMed GONUTS page
↑ ^9.0 ^9.1 Pearson, M et al. (2000) PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 406 207-10 PubMed GONUTS page
↑ ^10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^11.0 ^11.1 ^11.2 Wang, ZG et al. (1998) Role of PML in cell growth and the retinoic acid pathway. Science 279 1547-51 PubMed GONUTS page
↑ Neault, M et al. (2012) Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor. Nucleic Acids Res. 40 9513-21 PubMed GONUTS page
↑ Evdokimov, E et al. (2008) Loss of SUMO1 in mice affects RanGAP1 localization and formation of PML nuclear bodies, but is not lethal as it can be compensated by SUMO2 or SUMO3. J. Cell. Sci. 121 4106-13 PubMed GONUTS page
↑ Qin, Q et al. (2006) A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein. J. Cell Biol. 172 497-504 PubMed GONUTS page
↑ ^15.0 ^15.1 Bernardi, R et al. (2006) PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature 442 779-85 PubMed GONUTS page
↑ Ishov, AM et al. (2004) Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRX. J. Cell. Sci. 117 3807-20 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Wang, ZG et al. (1998) PML is essential for multiple apoptotic pathways. Nat. Genet. 20 266-72 PubMed GONUTS page
↑ Guo, A et al. (2000) The function of PML in p53-dependent apoptosis. Nat. Cell Biol. 2 730-6 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 Lin, HK et al. (2004) Cytoplasmic PML function in TGF-beta signalling. Nature 431 205-11 PubMed GONUTS page
↑ Cho, G et al. (2009) SUMO interaction motifs in Sizn1 are required for promyelocytic leukemia protein nuclear body localization and for transcriptional activation. J. Biol. Chem. 284 19592-600 PubMed GONUTS page
↑ Misawa, K et al. (2000) A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc. Natl. Acad. Sci. U.S.A. 97 3062-6 PubMed GONUTS page
↑ ^22.0 ^22.1 Zhong, S et al. (2000) Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. J. Exp. Med. 191 631-40 PubMed GONUTS page
↑ Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page
↑ de Stanchina, E et al. (2004) PML is a direct p53 target that modulates p53 effector functions. Mol. Cell 13 523-35 PubMed GONUTS page
↑ Chu, CC & Paul, WE (1998) Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol. Immunol. 35 487-502 PubMed GONUTS page
↑ ^26.0 ^26.1 Li, W et al. (2009) PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool. Proc. Natl. Acad. Sci. U.S.A. 106 4725-30 PubMed GONUTS page
↑ Takahashi, K et al. (2007) Dynamic regulation of p53 subnuclear localization and senescence by MORC3. Mol. Biol. Cell 18 1701-9 PubMed GONUTS page
↑ Ecsedy, JA et al. (2003) Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. Mol. Cell. Biol. 23 950-60 PubMed GONUTS page
↑ ^29.0 ^29.1 Zheng, P et al. (1998) Proto-oncogene PML controls genes devoted to MHC class I antigen presentation. Nature 396 373-6 PubMed GONUTS page

[PMID:23555679-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 Tang, MK et al. (2013) Promyelocytic leukemia (PML) protein plays important roles in regulating cell adhesion, morphology, proliferation and migration. PLoS ONE 8 e59477 PubMed GONUTS page

[PMID:24407287-2] 2.0 ^2.1 Dowling, JK et al. (2014) Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation. J. Biol. Chem. 289 6429-37 PubMed GONUTS page

[PMID:18248090-3] 3.0 ^3.1 Uchil, PD et al. (2008) TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. PLoS Pathog. 4 e16 PubMed GONUTS page

[PMID:17081986-4] 4.0 ^4.1 Lin, DY et al. (2006) Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. Mol. Cell 24 341-54 PubMed GONUTS page

[PMID:22274616-5] 5.0 ^5.1 ^5.2 ^5.3 Miki, T et al. (2012) PML regulates PER2 nuclear localization and circadian function. EMBO J. 31 1427-39 PubMed GONUTS page

[PMID:15626733-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Salomoni, P et al. (2005) The promyelocytic leukemia protein PML regulates c-Jun function in response to DNA damage. Blood 105 3686-90 PubMed GONUTS page

[PMID:21030605-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 ^7.7 Giorgi, C et al. (2010) PML regulates apoptosis at endoplasmic reticulum by modulating calcium release. Science 330 1247-51 PubMed GONUTS page

[PMID:10779416-8] Zhong, S et al. (2000) Role of SUMO-1-modified PML in nuclear body formation. Blood 95 2748-52 PubMed GONUTS page

[PMID:10910364-9] 9.0 ^9.1 Pearson, M et al. (2000) PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature 406 207-10 PubMed GONUTS page

[PMID:21873635-10] 10.00 ^10.01 ^10.02 ^10.03 ^10.04 ^10.05 ^10.06 ^10.07 ^10.08 ^10.09 ^10.10 ^10.11 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9488655-11] 11.0 ^11.1 ^11.2 Wang, ZG et al. (1998) Role of PML in cell growth and the retinoic acid pathway. Science 279 1547-51 PubMed GONUTS page

[PMID:22904064-12] Neault, M et al. (2012) Ablation of PRMT6 reveals a role as a negative transcriptional regulator of the p53 tumor suppressor. Nucleic Acids Res. 40 9513-21 PubMed GONUTS page

[PMID:19033381-13] Evdokimov, E et al. (2008) Loss of SUMO1 in mice affects RanGAP1 localization and formation of PML nuclear bodies, but is not lethal as it can be compensated by SUMO2 or SUMO3. J. Cell. Sci. 121 4106-13 PubMed GONUTS page

[PMID:16461359-14] Qin, Q et al. (2006) A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein. J. Cell Biol. 172 497-504 PubMed GONUTS page

[PMID:16915281-15] 15.0 ^15.1 Bernardi, R et al. (2006) PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature 442 779-85 PubMed GONUTS page

[PMID:15252119-16] Ishov, AM et al. (2004) Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRX. J. Cell. Sci. 117 3807-20 PubMed GONUTS page

[PMID:9806545-17] 17.0 ^17.1 ^17.2 ^17.3 Wang, ZG et al. (1998) PML is essential for multiple apoptotic pathways. Nat. Genet. 20 266-72 PubMed GONUTS page

[PMID:11025664-18] Guo, A et al. (2000) The function of PML in p53-dependent apoptosis. Nat. Cell Biol. 2 730-6 PubMed GONUTS page

[PMID:15356634-19] 19.0 ^19.1 ^19.2 ^19.3 Lin, HK et al. (2004) Cytoplasmic PML function in TGF-beta signalling. Nature 431 205-11 PubMed GONUTS page

[PMID:19416967-20] Cho, G et al. (2009) SUMO interaction motifs in Sizn1 are required for promyelocytic leukemia protein nuclear body localization and for transcriptional activation. J. Biol. Chem. 284 19592-600 PubMed GONUTS page

[PMID:10716735-21] Misawa, K et al. (2000) A method to identify cDNAs based on localization of green fluorescent protein fusion products. Proc. Natl. Acad. Sci. U.S.A. 97 3062-6 PubMed GONUTS page

[PMID:10684855-22] 22.0 ^22.1 Zhong, S et al. (2000) Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis. J. Exp. Med. 191 631-40 PubMed GONUTS page

[PMID:20439489-23] Tarantino, C et al. (2010) miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. FASEB J. 24 3255-63 PubMed GONUTS page

[PMID:14992722-24] Stanchina, E et al. (2004) PML is a direct p53 target that modulates p53 effector functions. Mol. Cell 13 523-35 PubMed GONUTS page

[PMID:9798653-25] Chu, CC & Paul, WE (1998) Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol. Immunol. 35 487-502 PubMed GONUTS page

[PMID:19261859-26] 26.0 ^26.1 Li, W et al. (2009) PML depletion disrupts normal mammary gland development and skews the composition of the mammary luminal cell progenitor pool. Proc. Natl. Acad. Sci. U.S.A. 106 4725-30 PubMed GONUTS page

[PMID:17332504-27] Takahashi, K et al. (2007) Dynamic regulation of p53 subnuclear localization and senescence by MORC3. Mol. Biol. Cell 18 1701-9 PubMed GONUTS page

[PMID:12529400-28] Ecsedy, JA et al. (2003) Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. Mol. Cell. Biol. 23 950-60 PubMed GONUTS page

[PMID:9845074-29] 29.0 ^29.1 Zheng, P et al. (1998) Proto-oncogene PML controls genes devoted to MHC class I antigen presentation. Nature 396 373-6 PubMed GONUTS page

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