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PMID:19033381

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Citation

Evdokimov, E, Sharma, P, Lockett, SJ, Lualdi, M and Kuehn, MR (2008) Loss of SUMO1 in mice affects RanGAP1 localization and formation of PML nuclear bodies, but is not lethal as it can be compensated by SUMO2 or SUMO3. J. Cell. Sci. 121:4106-13

Abstract

Conjugation of the small ubiquitin-like modifier (SUMO) to target proteins regulates numerous biological processes and has been implicated in tumorigenesis and metastasis. The three SUMO isoforms in vertebrates, SUMO1 and the highly similar SUMO2 and SUMO3, can be conjugated to unique as well as overlapping subsets of target proteins. Yet, it is still not clear whether roles for each family member are distinct or whether redundancy exists. Here we describe a mutant mouse line that completely lacks SUMO1, but surprisingly is viable and lacks any overt phenotype. Our study points to compensatory utilization of SUMO2 and/or SUMO3 for sumoylation of SUMO1 targets. The ability of SUMO isoforms to substitute for one another has important implications for rational targeting of the SUMO pathway.

Links

PubMed Online version:10.1242/jcs.038570

Keywords

Animals; Cells, Cultured; Fibroblasts/metabolism; Fibroblasts/ultrastructure; GTPase-Activating Proteins/metabolism; Mice; Mice, Mutant Strains; Nuclear Proteins/metabolism; SUMO-1 Protein/genetics; SUMO-1 Protein/metabolism; Small Ubiquitin-Related Modifier Proteins/genetics; Small Ubiquitin-Related Modifier Proteins/metabolism; Transcription Factors/metabolism; Tumor Suppressor Proteins/metabolism; Ubiquitins/genetics; Ubiquitins/metabolism

Significance

Annotations

Gene product Qualifier GO Term Evidence Code with/from Aspect Extension Notes Status

MOUSE:SUMO1

acts_upstream_of_or_within

GO:0030578: PML body organization

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3819343

P

Seeded From UniProt

complete

MOUSE:SUMO1

acts_upstream_of_or_within

GO:0016925: protein sumoylation

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3819343

P

Seeded From UniProt

complete

MOUSE:SUMO1

acts_upstream_of_or_within

GO:0090204: protein localization to nuclear pore

ECO:0000315: mutant phenotype evidence used in manual assertion

MGI:MGI:3819343

P

Seeded From UniProt

complete

MOUSE:PML

located_in

GO:0016605: PML body

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

MOUSE:PML

part_of

GO:0016605: PML body

ECO:0000314: direct assay evidence used in manual assertion

C

Seeded From UniProt

complete


See also

References

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