MOUSE:IFNG

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ifng
Protein Name(s)	Interferon gamma IFN-gamma
External Links
UniProt	P01580
EMBL	K00083 AK089574 BC119063 BC119065
CCDS	CCDS24200.1
PIR	A01844
RefSeq	NP_032363.1
UniGene	Mm.240327
ProteinModelPortal	P01580
SMR	P01580
IntAct	P01580
STRING	10090.ENSMUSP00000063800
PhosphoSite	P01580
PRIDE	P01580
Ensembl	ENSMUST00000068592
GeneID	15978
KEGG	mmu:15978
UCSC	uc007hdy.1
CTD	3458
MGI	MGI:107656
eggNOG	NOG45353
GeneTree	ENSGT00390000007831
HOGENOM	HOG000254784
HOVERGEN	HBG056912
InParanoid	P01580
KO	K04687
OMA	KEYFNAS
OrthoDB	EOG7VHSZM
PhylomeDB	P01580
TreeFam	TF336308
Reactome	REACT_198645 REACT_198660
NextBio	288760
PRO	PR:P01580
Proteomes	UP000000589
Bgee	P01580
CleanEx	MM_IFNG
ExpressionAtlas	P01580
Genevestigator	P01580
GO	GO:0009897 GO:0005615 GO:0005125 GO:0002250 GO:0019882 GO:0002302 GO:0007050 GO:0071351 GO:0071222 GO:0042742 GO:0042832 GO:0051607 GO:0030968 GO:0097191 GO:0006959 GO:0006925 GO:0044130 GO:0044146 GO:0032700 GO:0003340 GO:0072308 GO:0031642 GO:0048662 GO:0000122 GO:0001781 GO:0030593 GO:0060559 GO:0045785 GO:0045080 GO:0060550 GO:0060552 GO:0050718 GO:0045084 GO:0032735 GO:0032747 GO:0045410 GO:0048304 GO:0051712 GO:0051044 GO:0002053 GO:0045348 GO:0045666 GO:0045429 GO:0045672 GO:0033141 GO:0034393 GO:0032224 GO:0042102 GO:0045944 GO:0045893 GO:2000309 GO:0032760 GO:0042511 GO:0000060 GO:2000345 GO:0050776 GO:0050796 GO:0098908 GO:0002026 GO:0006355 GO:0042493 GO:0009615 GO:0050954
Gene3D	1.20.1250.10
InterPro	IPR009079 IPR012351 IPR002069
PANTHER	PTHR11419
Pfam	PF00714
PIRSF	PIRSF001936
ProDom	PD002435
SUPFAM	SSF47266

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0060333	interferon-gamma-mediated signaling pathway	PMID:23629966^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045892	negative regulation of transcription, DNA-templated	PMID:23629966^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:24784232^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050691	regulation of defense response to virus by host	PMID:24784232^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
involved_in	GO:0090312	positive regulation of protein deacetylation	PMID:23629966^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045348	positive regulation of MHC class II biosynthetic process	PMID:2493384^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045348	positive regulation of MHC class II biosynthetic process	PMID:2502420^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045348	positive regulation of MHC class II biosynthetic process	PMID:1845803^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:2502420^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:1845803^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006959	humoral immune response	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107656 PANTHER:PTN000892718	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107656 PANTHER:PTN000892718 RGD:2866 UniProtKB:P07353 UniProtKB:P49708	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107656 PANTHER:PTN000892718	F		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:107656 PANTHER:PTN000892718	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010629	negative regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010508	positive regulation of autophagy	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21709260^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21613615^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21606376^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:21217760^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:20956546^[11]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:20399120^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:19838199^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:17658279^[14]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:16177108^[15]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009615	response to virus	PMID:16280321^[16]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007050	cell cycle arrest	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006959	humoral immune response	PMID:17277142^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006925	inflammatory cell apoptotic process	PMID:11457893^[18]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006355	regulation of transcription, DNA-templated	PMID:12050152^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:9348310^[20]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:21460847^[21]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:20706986^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:19139201^[23]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35770)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:18997793^[24]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:17277142^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:17082577^[25]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16769892^[26]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:16275384^[27]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:35770)	Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15843532^[28]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15240714^[29]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15220916^[30]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:15087456^[31]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11894098^[32]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11728336^[33]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:11057672^[34]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	PMID:10072077^[35]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:15240719^[36]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:12925700^[37]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:11911824^[38]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:11027433^[39]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response	PMID:17277142^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002250	adaptive immune response	PMID:17277142^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002026	regulation of the force of heart contraction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001781	neutrophil apoptotic process	PMID:12925700^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000345	regulation of hepatocyte proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000309	positive regulation of tumor necrosis factor (ligand) superfamily member 11 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904798	positive regulation of core promoter binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0098908	regulation of neuronal action potential	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090312	positive regulation of protein deacetylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072125	negative regulation of glomerular mesangial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071902	positive regulation of protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071351	cellular response to interleukin-18	PMID:19666510^[40]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000899)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:18791161^[41]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060559	positive regulation of calcidiol 1-monooxygenase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060557	positive regulation of vitamin D biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060552	positive regulation of fructose 1,6-bisphosphate metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060550	positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060333	interferon-gamma-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060251	regulation of glial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051712	positive regulation of killing of cells of other organism	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051607	defense response to virus	PMID:25268627^[42]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2384409	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051607	defense response to virus	PMID:25268627^[42]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051607	defense response to virus	PMID:20064371^[43]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050954	sensory perception of mechanical stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050852	T cell receptor signaling pathway	PMID:21444916^[44]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050796	regulation of insulin secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050776	regulation of immune response	PMID:12882831^[45]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050718	positive regulation of interleukin-1 beta secretion	PMID:12925700^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048662	negative regulation of smooth muscle cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048304	positive regulation of isotype switching to IgG isotypes	PMID:12882831^[45]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048147	negative regulation of fibroblast proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18025219^[46]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:104798	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:18025219^[46]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045893	positive regulation of transcription, DNA-templated	PMID:14568984^[47]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045892	negative regulation of transcription, DNA-templated	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045785	positive regulation of cell adhesion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045672	positive regulation of osteoclast differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045671	negative regulation of osteoclast differentiation	PMID:17442941^[48]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0002476)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:11168643^[49]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000581)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045410	positive regulation of interleukin-6 biosynthetic process	PMID:12925700^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045410	positive regulation of interleukin-6 biosynthetic process	PMID:12925700^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045348	positive regulation of MHC class II biosynthetic process	PMID:11027433^[39]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045084	positive regulation of interleukin-12 biosynthetic process	PMID:14568984^[47]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045080	positive regulation of chemokine biosynthetic process	PMID:12925700^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045080	positive regulation of chemokine biosynthetic process	PMID:12925700^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044146	negative regulation of growth of symbiont involved in interaction with host	PMID:9348310^[20]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_has_participant:(CL:0000581)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0044130	negative regulation of growth of symbiont in host	PMID:9348310^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857184	P	regulates_o_occurs_in:(EMAPA:16138)	Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042832	defense response to protozoan	PMID:9348310^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042832	defense response to protozoan	PMID:19050265^[50]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042742	defense response to bacterium	PMID:15240719^[36]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	PMID:16280321^[16]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042307	positive regulation of protein import into nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042102	positive regulation of T cell proliferation	PMID:16280321^[16]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034393	positive regulation of smooth muscle cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	PMID:16280321^[16]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032834	positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032747	positive regulation of interleukin-23 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032735	positive regulation of interleukin-12 production	PMID:9348310^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032735	positive regulation of interleukin-12 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032700	negative regulation of interleukin-17 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032224	positive regulation of synaptic transmission, cholinergic	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031642	negative regulation of myelination	PMID:15911877^[51]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031334	positive regulation of protein complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030968	endoplasmic reticulum unfolded protein response	PMID:15911877^[51]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030857	negative regulation of epithelial cell differentiation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:2866	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030593	neutrophil chemotaxis	PMID:12925700^[37]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857184	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030593	neutrophil chemotaxis	PMID:12925700^[37]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019882	antigen processing and presentation	PMID:15356141^[52]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010835	regulation of protein ADP-ribosylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010634	positive regulation of epithelial cell migration	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P01579	P		Seeded From UniProt	complete
involved_in	GO:2000345	regulation of hepatocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
involved_in	GO:1904783	positive regulation of NMDA glutamate receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
involved_in	GO:0098908	regulation of neuronal action potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
involved_in	GO:0072125	negative regulation of glomerular mesangial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
involved_in	GO:0060251	regulation of glial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
involved_in	GO:0050954	sensory perception of mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
involved_in	GO:0048147	negative regulation of fibroblast proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
involved_in	GO:0045785	positive regulation of cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
involved_in	GO:0045666	positive regulation of neuron differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
involved_in	GO:0045348	positive regulation of MHC class II biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
part_of	GO:0043204	perikaryon	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	C		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
part_of	GO:0043005	neuron projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	C		Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
involved_in	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
involved_in	GO:0032224	positive regulation of synaptic transmission, cholinergic	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
involved_in	GO:0030857	negative regulation of epithelial cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	C		Seeded From UniProt	complete
involved_in	GO:0002026	regulation of the force of heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
involved_in	GO:0001774	microglial cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P01581 ensembl:ENSRNOP00000009917	P		Seeded From UniProt	complete
enables	GO:0005133	interferon-gamma receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002069	F		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002069	C		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002069	P		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
involved_in	GO:0040008	regulation of growth	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0341	P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0051	P		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 Contreras, AU et al. (2013) Deacetylation of p53 induces autophagy by suppressing Bmf expression. J. Cell Biol. 201 427-37 PubMed GONUTS page
↑ ^2.0 ^2.1 Marchant, DJ et al. (2014) A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity. Nat. Med. 20 493-502 PubMed GONUTS page
↑ Celada, A & Maki, RA (1989) The expression of I-A correlates with the uptake of interferon-gamma by macrophages. Eur. J. Immunol. 19 205-8 PubMed GONUTS page
↑ ^4.0 ^4.1 Celada, A et al. (1989) Interferon-gamma activates multiple pathways to regulate the expression of the genes for major histocompatibility class II I-A beta, tumor necrosis factor and complement component C3 in mouse macrophages. Eur. J. Immunol. 19 1103-9 PubMed GONUTS page
↑ ^5.0 ^5.1 Celada, A & Maki, RA (1991) IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway. J. Immunol. 146 114-20 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Sharma, S et al. (2011) Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc. Natl. Acad. Sci. U.S.A. 108 11381-6 PubMed GONUTS page
↑ Stellato, C et al. (2011) Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR. J. Immunol. 187 441-9 PubMed GONUTS page
↑ Day, EB et al. (2011) Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses. Proc. Natl. Acad. Sci. U.S.A. 108 9536-41 PubMed GONUTS page
↑ Li, Z et al. (2011) ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). Nat. Immunol. 12 178-85 PubMed GONUTS page
↑ Onodera, A et al. (2010) STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J. Exp. Med. 207 2493-506 PubMed GONUTS page
↑ Yagi, R et al. (2010) The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity 32 507-17 PubMed GONUTS page
↑ Du, C et al. (2009) MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat. Immunol. 10 1252-9 PubMed GONUTS page
↑ Amsen, D et al. (2007) Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity 27 89-99 PubMed GONUTS page
↑ Nishimura, H et al. (2005) A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells. J. Immunol. 175 4627-34 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 Shang, L & Tomasi, TB (2006) The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. J. Biol. Chem. 281 1876-84 PubMed GONUTS page
↑ ^17.0 ^17.1 ^17.2 ^17.3 Hervas-Stubbs, S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J. Immunol. 178 2361-9 PubMed GONUTS page
↑ Collazo, CM et al. (2001) Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. J. Exp. Med. 194 181-8 PubMed GONUTS page
↑ Hu, J et al. (2002) A novel transactivating factor that regulates interferon-gamma-dependent gene expression. J. Biol. Chem. 277 30253-63 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 ^20.4 Scharton-Kersten, T et al. (1997) Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. J. Exp. Med. 186 1523-34 PubMed GONUTS page
↑ Motomura, Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat. Immunol. 12 450-9 PubMed GONUTS page
↑ Wang, L et al. (2010) The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells. Eur. J. Immunol. 40 2385-90 PubMed GONUTS page
↑ Deshmukh, HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect. Immun. 77 1376-82 PubMed GONUTS page
↑ Dardalhon, V et al. (2008) IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat. Immunol. 9 1347-55 PubMed GONUTS page
↑ Kim, PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J. Immunol. 177 6650-9 PubMed GONUTS page
↑ Chae, WJ et al. (2006) The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc. Natl. Acad. Sci. U.S.A. 103 9631-6 PubMed GONUTS page
↑ Lin, W et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J. Allergy Clin. Immunol. 116 1106-15 PubMed GONUTS page
↑ Cheung, H et al. (2005) Accessory protein-like is essential for IL-18-mediated signaling. J. Immunol. 174 5351-7 PubMed GONUTS page
↑ McKee, AS & Pearce, EJ (2004) CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J. Immunol. 173 1224-31 PubMed GONUTS page
↑ Watanabe, T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat. Immunol. 5 800-8 PubMed GONUTS page
↑ Yamashita, M et al. (2004) Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J. Biol. Chem. 279 26983-90 PubMed GONUTS page
↑ Kobayashi, K et al. (2002) RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416 194-9 PubMed GONUTS page
↑ Allenspach, EJ et al. (2001) ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 15 739-50 PubMed GONUTS page
↑ Chen, Q et al. (2000) Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 407 916-20 PubMed GONUTS page
↑ Moriggl, R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10 249-59 PubMed GONUTS page
↑ ^36.0 ^36.1 Schiavoni, G et al. (2004) Type I IFN protects permissive macrophages from Legionella pneumophila infection through an IFN-gamma-independent pathway. J. Immunol. 173 1266-75 PubMed GONUTS page
↑ ^37.0 ^37.1 ^37.2 ^37.3 ^37.4 ^37.5 ^37.6 ^37.7 ^37.8 McLoughlin, RM et al. (2003) Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J. Clin. Invest. 112 598-607 PubMed GONUTS page
↑ Ioan-Facsinay, A et al. (2002) FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity 16 391-402 PubMed GONUTS page
↑ ^39.0 ^39.1 Walter, W et al. (2000) MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance? Br. J. Cancer 83 1192-201 PubMed GONUTS page
↑ Guo, L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc. Natl. Acad. Sci. U.S.A. 106 13463-8 PubMed GONUTS page
↑ Dai, R et al. (2008) Suppression of LPS-induced Interferon-gamma and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: a novel mechanism of immune modulation. Blood 112 4591-7 PubMed GONUTS page
↑ ^42.0 ^42.1 Liao, J et al. (2014) An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse. PLoS ONE 9 e108777 PubMed GONUTS page
↑ Brass, AL et al. (2009) The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell 139 1243-54 PubMed GONUTS page
↑ Iborra, S et al. (2011) H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity. Blood 117 5102-11 PubMed GONUTS page
↑ ^45.0 ^45.1 Gerth, AJ et al. (2003) T-bet regulates T-independent IgG2a class switching. Int. Immunol. 15 937-44 PubMed GONUTS page
↑ ^46.0 ^46.1 Degrandi, D et al. (2007) Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. J. Immunol. 179 7729-40 PubMed GONUTS page
↑ ^47.0 ^47.1 Liu, J et al. (2003) Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1. J. Exp. Med. 198 1265-76 PubMed GONUTS page
↑ Kim, K et al. (2007) Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor. J. Immunol. 178 5588-94 PubMed GONUTS page
↑ Bune, AJ et al. (2001) Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus. Immunology 102 103-13 PubMed GONUTS page
↑ Yarovinsky, F et al. (2008) Recognition of Toxoplasma gondii by TLR11 prevents parasite-induced immunopathology. J. Immunol. 181 8478-84 PubMed GONUTS page
↑ ^51.0 ^51.1 Lin, W et al. (2005) Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma. J. Cell Biol. 169 603-12 PubMed GONUTS page
↑ Basler, M et al. (2004) Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus. J. Immunol. 173 3925-34 PubMed GONUTS page

[PMID:23629966-1] 1.0 ^1.1 ^1.2 Contreras, AU et al. (2013) Deacetylation of p53 induces autophagy by suppressing Bmf expression. J. Cell Biol. 201 427-37 PubMed GONUTS page

[PMID:24784232-2] 2.0 ^2.1 Marchant, DJ et al. (2014) A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity. Nat. Med. 20 493-502 PubMed GONUTS page

[PMID:2493384-3] Celada, A & Maki, RA (1989) The expression of I-A correlates with the uptake of interferon-gamma by macrophages. Eur. J. Immunol. 19 205-8 PubMed GONUTS page

[PMID:2502420-4] 4.0 ^4.1 Celada, A et al. (1989) Interferon-gamma activates multiple pathways to regulate the expression of the genes for major histocompatibility class II I-A beta, tumor necrosis factor and complement component C3 in mouse macrophages. Eur. J. Immunol. 19 1103-9 PubMed GONUTS page

[PMID:1845803-5] 5.0 ^5.1 Celada, A & Maki, RA (1991) IFN-gamma induces the expression of the genes for MHC class II I-A beta and tumor necrosis factor through a protein kinase C-independent pathway. J. Immunol. 146 114-20 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:21709260-7] Sharma, S et al. (2011) Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex. Proc. Natl. Acad. Sci. U.S.A. 108 11381-6 PubMed GONUTS page

[PMID:21613615-8] Stellato, C et al. (2011) Coordinate regulation of GATA-3 and Th2 cytokine gene expression by the RNA-binding protein HuR. J. Immunol. 187 441-9 PubMed GONUTS page

[PMID:21606376-9] Day, EB et al. (2011) Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses. Proc. Natl. Acad. Sci. U.S.A. 108 9536-41 PubMed GONUTS page

[PMID:21217760-10] Li, Z et al. (2011) ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1). Nat. Immunol. 12 178-85 PubMed GONUTS page

[PMID:20956546-11] Onodera, A et al. (2010) STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells. J. Exp. Med. 207 2493-506 PubMed GONUTS page

[PMID:20399120-12] Yagi, R et al. (2010) The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. Immunity 32 507-17 PubMed GONUTS page

[PMID:19838199-13] Du, C et al. (2009) MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat. Immunol. 10 1252-9 PubMed GONUTS page

[PMID:17658279-14] Amsen, D et al. (2007) Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity 27 89-99 PubMed GONUTS page

[PMID:16177108-15] Nishimura, H et al. (2005) A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells. J. Immunol. 175 4627-34 PubMed GONUTS page

[PMID:16280321-16] 16.0 ^16.1 ^16.2 ^16.3 Shang, L & Tomasi, TB (2006) The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. J. Biol. Chem. 281 1876-84 PubMed GONUTS page

[PMID:17277142-17] 17.0 ^17.1 ^17.2 ^17.3 Hervas-Stubbs, S et al. (2007) Insect baculoviruses strongly potentiate adaptive immune responses by inducing type I IFN. J. Immunol. 178 2361-9 PubMed GONUTS page

[PMID:11457893-18] Collazo, CM et al. (2001) Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. J. Exp. Med. 194 181-8 PubMed GONUTS page

[PMID:12050152-19] Hu, J et al. (2002) A novel transactivating factor that regulates interferon-gamma-dependent gene expression. J. Biol. Chem. 277 30253-63 PubMed GONUTS page

[PMID:9348310-20] 20.0 ^20.1 ^20.2 ^20.3 ^20.4 Scharton-Kersten, T et al. (1997) Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction. J. Exp. Med. 186 1523-34 PubMed GONUTS page

[PMID:21460847-21] Motomura, Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat. Immunol. 12 450-9 PubMed GONUTS page

[PMID:20706986-22] Wang, L et al. (2010) The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells. Eur. J. Immunol. 40 2385-90 PubMed GONUTS page

[PMID:19139201-23] Deshmukh, HS et al. (2009) Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. Infect. Immun. 77 1376-82 PubMed GONUTS page

[PMID:18997793-24] Dardalhon, V et al. (2008) IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat. Immunol. 9 1347-55 PubMed GONUTS page

[PMID:17082577-25] Kim, PJ et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J. Immunol. 177 6650-9 PubMed GONUTS page

[PMID:16769892-26] Chae, WJ et al. (2006) The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Proc. Natl. Acad. Sci. U.S.A. 103 9631-6 PubMed GONUTS page

[PMID:16275384-27] Lin, W et al. (2005) Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. J. Allergy Clin. Immunol. 116 1106-15 PubMed GONUTS page

[PMID:15843532-28] Cheung, H et al. (2005) Accessory protein-like is essential for IL-18-mediated signaling. J. Immunol. 174 5351-7 PubMed GONUTS page

[PMID:15240714-29] McKee, AS & Pearce, EJ (2004) CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J. Immunol. 173 1224-31 PubMed GONUTS page

[PMID:15220916-30] Watanabe, T et al. (2004) NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses. Nat. Immunol. 5 800-8 PubMed GONUTS page

[PMID:15087456-31] Yamashita, M et al. (2004) Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J. Biol. Chem. 279 26983-90 PubMed GONUTS page

[PMID:11894098-32] Kobayashi, K et al. (2002) RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature 416 194-9 PubMed GONUTS page

[PMID:11728336-33] Allenspach, EJ et al. (2001) ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 15 739-50 PubMed GONUTS page

[PMID:11057672-34] Chen, Q et al. (2000) Development of Th1-type immune responses requires the type I cytokine receptor TCCR. Nature 407 916-20 PubMed GONUTS page

[PMID:10072077-35] Moriggl, R et al. (1999) Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10 249-59 PubMed GONUTS page

[PMID:15240719-36] 36.0 ^36.1 Schiavoni, G et al. (2004) Type I IFN protects permissive macrophages from Legionella pneumophila infection through an IFN-gamma-independent pathway. J. Immunol. 173 1266-75 PubMed GONUTS page

[PMID:12925700-37] 37.0 ^37.1 ^37.2 ^37.3 ^37.4 ^37.5 ^37.6 ^37.7 ^37.8 McLoughlin, RM et al. (2003) Interplay between IFN-gamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J. Clin. Invest. 112 598-607 PubMed GONUTS page

[PMID:11911824-38] Ioan-Facsinay, A et al. (2002) FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity 16 391-402 PubMed GONUTS page

[PMID:11027433-39] 39.0 ^39.1 Walter, W et al. (2000) MHC class II antigen presentation pathway in murine tumours: tumour evasion from immunosurveillance? Br. J. Cancer 83 1192-201 PubMed GONUTS page

[PMID:19666510-40] Guo, L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc. Natl. Acad. Sci. U.S.A. 106 13463-8 PubMed GONUTS page

[PMID:18791161-41] Dai, R et al. (2008) Suppression of LPS-induced Interferon-gamma and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: a novel mechanism of immune modulation. Blood 112 4591-7 PubMed GONUTS page

[PMID:25268627-42] 42.0 ^42.1 Liao, J et al. (2014) An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse. PLoS ONE 9 e108777 PubMed GONUTS page

[PMID:20064371-43] Brass, AL et al. (2009) The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus. Cell 139 1243-54 PubMed GONUTS page

[PMID:21444916-44] Iborra, S et al. (2011) H-ras and N-ras are dispensable for T-cell development and activation but critical for protective Th1 immunity. Blood 117 5102-11 PubMed GONUTS page

[PMID:12882831-45] 45.0 ^45.1 Gerth, AJ et al. (2003) T-bet regulates T-independent IgG2a class switching. Int. Immunol. 15 937-44 PubMed GONUTS page

[PMID:18025219-46] 46.0 ^46.1 Degrandi, D et al. (2007) Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. J. Immunol. 179 7729-40 PubMed GONUTS page

[PMID:14568984-47] 47.0 ^47.1 Liu, J et al. (2003) Differential regulation of interleukin (IL)-12 p35 and p40 gene expression and interferon (IFN)-gamma-primed IL-12 production by IFN regulatory factor 1. J. Exp. Med. 198 1265-76 PubMed GONUTS page

[PMID:17442941-48] Kim, K et al. (2007) Protein inhibitor of activated STAT 3 modulates osteoclastogenesis by down-regulation of NFATc1 and osteoclast-associated receptor. J. Immunol. 178 5588-94 PubMed GONUTS page

[PMID:11168643-49] Bune, AJ et al. (2001) Mice lacking tartrate-resistant acid phosphatase (Acp 5) have disordered macrophage inflammatory responses and reduced clearance of the pathogen, Staphylococcus aureus. Immunology 102 103-13 PubMed GONUTS page

[PMID:19050265-50] Yarovinsky, F et al. (2008) Recognition of Toxoplasma gondii by TLR11 prevents parasite-induced immunopathology. J. Immunol. 181 8478-84 PubMed GONUTS page

[PMID:15911877-51] 51.0 ^51.1 Lin, W et al. (2005) Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma. J. Cell Biol. 169 603-12 PubMed GONUTS page

[PMID:15356141-52] Basler, M et al. (2004) Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus. J. Immunol. 173 3925-34 PubMed GONUTS page

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MOUSE:IFNG

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