MOUSE:HIPK1

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Hipk1 (synonyms: Kiaa0630, Myak, Nbak2)
Protein Name(s)	Homeodomain-interacting protein kinase 1 Nuclear body-associated kinase 2 Protein kinase Myak
External Links
UniProt	O88904
EMBL	AF077658 AF071070 AF071071 AF170303 AF170304 BC145697 BC145699 AK122333
CCDS	CCDS38576.1
PIR	T14357
RefSeq	NP_001288233.1 NP_001288235.1 NP_034562.2
UniGene	Mm.20827
ProteinModelPortal	O88904
SMR	O88904
BioGrid	200306
IntAct	O88904
MINT	MINT-8308057
PhosphoSite	O88904
MaxQB	O88904
PaxDb	O88904
PRIDE	O88904
Ensembl	ENSMUST00000029438 ENSMUST00000106845 ENSMUST00000118317 ENSMUST00000137078
GeneID	15257
KEGG	mmu:15257
UCSC	uc008qtg.2 uc012cve.1
CTD	204851
MGI	MGI:1314873
eggNOG	COG0515
GeneTree	ENSGT00760000119032
HOGENOM	HOG000231785
HOVERGEN	HBG051908
InParanoid	O88904
KO	K08826
OMA	NQIKSPF
OrthoDB	EOG7034GK
PhylomeDB	O88904
TreeFam	TF105417
Reactome	REACT_196516
NextBio	287873
PRO	PR:O88904
Proteomes	UP000000589
Bgee	O88904
CleanEx	MM_HIPK1
ExpressionAtlas	O88904
Genevestigator	O88904
GO	GO:0005737 GO:0016607 GO:0005634 GO:0016605 GO:0005524 GO:0004672 GO:0004674 GO:0003714 GO:0009952 GO:0048596 GO:0060059 GO:0072577 GO:0097191 GO:0042771 GO:0061072 GO:0060235 GO:0000122 GO:0030182 GO:0008284 GO:0043388 GO:0016926 GO:0006468 GO:0010803 GO:0010842 GO:0007224 GO:0006351
InterPro	IPR011009 IPR000719 IPR017441 IPR002290 IPR008271
Pfam	PF00069
SMART	SM00220
SUPFAM	SSF56112
PROSITE	PS00107 PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0061072	iris morphogenesis	PMID:9748262^[1]	ECO:0000315			P		figure 2 , figure 3	complete CACAO 3484
	GO:0034333	adherens junction assembly	PMID:23565059^[2]	ECO:0000315			P		Figure 1(I-J') shows that HIPK1 -/- mice showed a reduced size and density of adherens junctions as compared to the control group.	complete CACAO 7439
involved_in	GO:0034333	adherens junction assembly	PMID:23565059^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061072	iris morphogenesis	PMID:20579985^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060235	lens induction in camera-type eye	PMID:20579985^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060059	embryonic retina morphogenesis in camera-type eye	PMID:20579985^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0048596	embryonic camera-type eye morphogenesis	PMID:20579985^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030182	neuron differentiation	PMID:20579985^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010842	retina layer formation	PMID:20579985^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:20579985^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0043388	positive regulation of DNA binding	PMID:9748262^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QZR5	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9748262^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QZR5	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:9748262^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QZR5	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:9748262^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QZR5	F		Seeded From UniProt	complete
enables	GO:0003714	transcription corepressor activity	PMID:9748262^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QZR5	F		Seeded From UniProt	complete
NOT\|enables	GO:0003677	DNA binding	PMID:9748262^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QZR5	F		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	PMID:9748262^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QZR5	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86Z02	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072577	endothelial cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86Z02	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	PMID:16537918^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1314872 MGI:MGI:98834	P	occurs_in:(CL:0000057)	Seeded From UniProt	complete
part_of	GO:0016607	nuclear speck	PMID:12529400^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016605	PML body	PMID:12529400^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86Z02	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009952	anterior/posterior pattern specification	PMID:16537918^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1314872	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	PMID:16537918^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1314872	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007224	smoothened signaling pathway	PMID:16537918^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1314872	P	occurs_in:(EMAPA:16183) occurs_in:(CL:0000222)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86Z02	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86Z02	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:12529400^[5]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86Z02	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86Z02	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q86Z02	C		Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86Z02 ensembl:ENSP00000407442	P		Seeded From UniProt	complete
involved_in	GO:0072577	endothelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86Z02 ensembl:ENSP00000407442	P		Seeded From UniProt	complete
involved_in	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86Z02 ensembl:ENSP00000407442	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86Z02 ensembl:ENSP00000407442	C		Seeded From UniProt	complete
part_of	GO:0005813	centrosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86Z02 ensembl:ENSP00000407442	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86Z02 ensembl:ENSP00000407442	C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86Z02 ensembl:ENSP00000407442	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q86Z02 ensembl:ENSP00000407442	C		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR017441	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Kim, YH et al. (1998) Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J. Biol. Chem. 273 25875-9 PubMed GONUTS page
↑ ^2.0 ^2.1 Shang, Y et al. (2013) Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism. PLoS Biol. 11 e1001527 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Inoue, T et al. (2010) Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. FEBS Lett. 584 3233-8 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 Isono, K et al. (2006) Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol. Cell. Biol. 26 2758-71 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Ecsedy, JA et al. (2003) Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. Mol. Cell. Biol. 23 950-60 PubMed GONUTS page

[PMID:9748262-1] 1.0 ^1.1 ^1.2 ^1.3 ^1.4 ^1.5 ^1.6 ^1.7 Kim, YH et al. (1998) Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J. Biol. Chem. 273 25875-9 PubMed GONUTS page

[PMID:23565059-2] 2.0 ^2.1 Shang, Y et al. (2013) Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism. PLoS Biol. 11 e1001527 PubMed GONUTS page

[PMID:20579985-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 ^3.6 Inoue, T et al. (2010) Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. FEBS Lett. 584 3233-8 PubMed GONUTS page

[PMID:16537918-4] 4.0 ^4.1 ^4.2 ^4.3 Isono, K et al. (2006) Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals. Mol. Cell. Biol. 26 2758-71 PubMed GONUTS page

[PMID:12529400-5] 5.0 ^5.1 ^5.2 Ecsedy, JA et al. (2003) Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. Mol. Cell. Biol. 23 950-60 PubMed GONUTS page

[1]

[2]

[3]

[4]

[5]

MOUSE:HIPK1

Contents

Annotations

Notes

References

a

c

d

e

g

i

k

l

m

n

p

r

s

t

v

Navigation menu

Personal tools

Namespaces

Variants

Views

More

Search

Navigation

Cacao

Links

Tools