HUMAN:JAK2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	JAK2
Protein Name(s)	Tyrosine-protein kinase JAK2 Janus kinase 2 JAK-2
External Links
UniProt	O60674
EMBL	AF058925 AF001362 AF005216 AL161450
CCDS	CCDS6457.1
PIR	JW0091
RefSeq	NP_004963.1 XP_005251512.1
UniGene	Hs.656213
PDB	2B7A 2W1I 2XA4 3E62 3E63 3E64 3FUP 3IO7 3IOK 3JY9 3KCK 3KRR 3LPB 3Q32 3RVG 3TJC 3TJD 3UGC 3ZMM 4AQC 4BBE 4BBF 4C61 4C62 4D0W 4D0X 4D1S 4E4M 4E6D 4E6Q 4F08 4F09 4FVP 4FVQ 4FVR 4GFM 4GMY 4HGE 4IVA 4JI9 4JIA
PDBsum	2B7A 2W1I 2XA4 3E62 3E63 3E64 3FUP 3IO7 3IOK 3JY9 3KCK 3KRR 3LPB 3Q32 3RVG 3TJC 3TJD 3UGC 3ZMM 4AQC 4BBE 4BBF 4C61 4C62 4D0W 4D0X 4D1S 4E4M 4E6D 4E6Q 4F08 4F09 4FVP 4FVQ 4FVR 4GFM 4GMY 4HGE 4IVA 4JI9 4JIA
ProteinModelPortal	O60674
SMR	O60674
BioGrid	109920
DIP	DIP-33880N
IntAct	O60674
MINT	MINT-158048
STRING	9606.ENSP00000371067
BindingDB	O60674
ChEMBL	CHEMBL2971
DrugBank	DB08877 DB08895
GuidetoPHARMACOLOGY	2048
PhosphoSite	O60674
MaxQB	O60674
PaxDb	O60674
PRIDE	O60674
DNASU	3717
Ensembl	ENST00000381652
GeneID	3717
KEGG	hsa:3717
UCSC	uc003ziw.3
CTD	3717
GeneCards	GC09P004985
HGNC	HGNC:6192
HPA	CAB013089
MIM	147796 254450 263300 600880 601626 614521
neXtProt	NX_O60674
Orphanet	131 3318 71493 824 729
PharmGKB	PA29989
eggNOG	COG0515
GeneTree	ENSGT00760000118799
HOGENOM	HOG000049158
HOVERGEN	HBG006195
InParanoid	O60674
KO	K04447
OMA	CHGPISM
OrthoDB	EOG7BW0HM
PhylomeDB	O60674
TreeFam	TF327041
BRENDA	2.7.10.2
Reactome	REACT_111040 REACT_111133 REACT_115697 REACT_1183 REACT_1391 REACT_169118 REACT_1695 REACT_19290 REACT_228108 REACT_23837 REACT_23891 REACT_24970 REACT_24980 REACT_25078 REACT_27307
SignaLink	O60674
ChiTaRS	JAK2
EvolutionaryTrace	O60674
GeneWiki	Janus_kinase_2
GenomeRNAi	3717
NextBio	14567
PRO	PR:O60674
Proteomes	UP000005640
Bgee	O60674
CleanEx	HS_JAK2
ExpressionAtlas	O60674
Genevestigator	O60674
GO	GO:0005901 GO:0005737 GO:0005856 GO:0005829 GO:0031904 GO:0045121 GO:0016363 GO:0005634 GO:0005524 GO:0005131 GO:0020037 GO:0042393 GO:0035401 GO:0005143 GO:0004715 GO:0004672 GO:0019901 GO:0004713 GO:0005102 GO:0042169 GO:0030041 GO:0006919 GO:0097296 GO:0042977 GO:0000186 GO:0006915 GO:0031103 GO:0007596 GO:0030154 GO:0006928 GO:0019221 GO:0007167 GO:0030218 GO:0097191 GO:0007186 GO:0060396 GO:0035409 GO:0009755 GO:0034050 GO:0060333 GO:0035722 GO:0035556 GO:0008631 GO:0007259 GO:0060397 GO:0061180 GO:0007498 GO:0031959 GO:0008285 GO:0022408 GO:0043392 GO:0045822 GO:0043524 GO:0018108 GO:0048008 GO:0050867 GO:0045597 GO:0030335 GO:0008284 GO:0010811 GO:0007204 GO:0043388 GO:0060399 GO:0050729 GO:0032024 GO:0032731 GO:0045429 GO:0051770 GO:0050731 GO:0014068 GO:0032516 GO:0033160 GO:0051091 GO:0032760 GO:0042517 GO:0042523 GO:0046777 GO:0006468 GO:0050727 GO:0060334 GO:0046677 GO:0033194 GO:0070671 GO:0032496 GO:0034612 GO:0007165 GO:0007262 GO:0033209 GO:0007260 GO:0042508 GO:0042503 GO:0042506
Gene3D	3.30.505.10
InterPro	IPR019749 IPR019748 IPR000299 IPR011009 IPR000719 IPR017441 IPR001245 IPR000980 IPR008266 IPR020635 IPR016251 IPR020693
Pfam	PF07714 PF00017
PIRSF	PIRSF000636
PRINTS	PR01823 PR01825 PR00109
SMART	SM00295 SM00252 SM00219
SUPFAM	SSF47031 SSF55550 SSF56112
PROSITE	PS50057 PS00107 PS50011 PS00109 PS50001

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0045428	regulation of nitric oxide biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62689	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:0120162	positive regulation of cold-induced thermogenesis	PMID:26515423^[1]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:23061660^[2]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:9670957^[3]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0070671	response to interleukin-12	PMID:7528775^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061180	mammary gland epithelium development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0060399	positive regulation of growth hormone receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0060396	growth hormone receptor signaling pathway	PMID:10925297^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
	GO:0042325	regulation of phosphorylation	PMID:22319590^[6]	ECO:0000314			P		figure 4	complete CACAO 3742
involved_in	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
	GO:0004713	protein tyrosine kinase activity	PMID:23061660^[2]	ECO:0000314			F		Table 3	complete CACAO 5304
involved_in	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	PMID:10925297^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	C		Seeded From UniProt	complete
involved_in	GO:0043392	negative regulation of DNA binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0035722	interleukin-12-mediated signaling pathway	PMID:7528775^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0034612	response to tumor necrosis factor	PMID:8609418^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:8609418^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0030154	cell differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0030041	actin filament polymerization	PMID:10925297^[5]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:10925297^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	PMID:8609418^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0018108	peptidyl-tyrosine phosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0010811	positive regulation of cell-substrate adhesion	PMID:10925297^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0007260	tyrosine phosphorylation of STAT protein	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0007167	enzyme linked receptor protein signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:10502458^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:10502458^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005143	interleukin-12 receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	F		Seeded From UniProt	complete
enables	GO:0005131	growth hormone receptor binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62689	F		Seeded From UniProt	complete
involved_in	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0042976	activation of Janus kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
enables	GO:0042393	histone binding	PMID:19783980^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042169	SH2 domain binding	PMID:9727029^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O15524	F		Seeded From UniProt	complete
involved_in	GO:0035409	histone H3-Y41 phosphorylation	PMID:19783980^[9]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0035401	histone kinase activity (H3-Y41 specific)	PMID:19783980^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
enables	GO:0020037	heme binding	PMID:21036157^[11]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:19783980^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:11201744^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P06800	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q62120	F		Seeded From UniProt	complete
involved_in	GO:0035409	histone H3-Y41 phosphorylation	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001231348 UniProtKB:O60674	P		Seeded From UniProt	complete
enables	GO:0035401	histone kinase activity (H3-Y41 specific)	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001231348 UniProtKB:O60674	F		Seeded From UniProt	complete
involved_in	GO:0030218	erythrocyte differentiation	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96629 PANTHER:PTN002401049	P		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96629 MGI:MGI:99928 PANTHER:PTN002401049 RGD:2940 UniProtKB:O60674	P		Seeded From UniProt	complete
involved_in	GO:0007260	tyrosine phosphorylation of STAT protein	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96629 PANTHER:PTN002401049 RGD:2939	P		Seeded From UniProt	complete
enables	GO:0005131	growth hormone receptor binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001231348 RGD:2939	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:9111318^[14]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:20304997^[15]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:19665053^[16]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:15143187^[17]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0046677	response to antibiotic	PMID:16280321^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:22820988^[19]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60674	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21841788^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60674	F		Seeded From UniProt	complete
part_of	GO:0005925	focal adhesion	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1904707	positive regulation of vascular smooth muscle cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:1904037	positive regulation of epithelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:1902728	positive regulation of growth factor dependent skeletal muscle satellite cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0099527	postsynapse to nucleus signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
part_of	GO:0098978	glutamatergic synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	C		Seeded From UniProt	complete
involved_in	GO:0060548	negative regulation of cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0060333	interferon-gamma-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
enables	GO:0051428	peptide hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	F		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0050867	positive regulation of cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0050804	modulation of chemical synaptic transmission	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0048008	platelet-derived growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0046777	protein autophosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0045822	negative regulation of heart contraction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0045597	positive regulation of cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0045428	regulation of nitric oxide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
enables	GO:0043560	insulin receptor substrate binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	F		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	F		Seeded From UniProt	complete
involved_in	GO:0043524	negative regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0043388	positive regulation of DNA binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0033194	response to hydroperoxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
enables	GO:0033130	acetylcholine receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	F		Seeded From UniProt	complete
involved_in	GO:0032731	positive regulation of interleukin-1 beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0032516	positive regulation of phosphoprotein phosphatase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0031959	mineralocorticoid receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
enables	GO:0031702	type 1 angiotensin receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	F		Seeded From UniProt	complete
involved_in	GO:0031103	axon regeneration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0030335	positive regulation of cell migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0022408	negative regulation of cell-cell adhesion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	C		Seeded From UniProt	complete
involved_in	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0009755	hormone-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
enables	GO:0008022	protein C-terminus binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	F		Seeded From UniProt	complete
involved_in	GO:0007260	tyrosine phosphorylation of STAT protein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0007259	receptor signaling pathway via JAK-STAT	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0007204	positive regulation of cytosolic calcium ion concentration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0007186	G protein-coupled receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
involved_in	GO:0006979	response to oxidative stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	C		Seeded From UniProt	complete
enables	GO:0005131	growth hormone receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	F		Seeded From UniProt	complete
involved_in	GO:0000186	activation of MAPKK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q62689 ensembl:ENSRNOP00000071877	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020635	F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016251 InterPro:IPR020693	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR016251 InterPro:IPR017441 InterPro:IPR020693	F		Seeded From UniProt	complete
part_of	GO:0005856	cytoskeleton	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000299	C		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR001245 InterPro:IPR008266 InterPro:IPR016251 InterPro:IPR020635 InterPro:IPR020693	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016251 InterPro:IPR020693	C		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR016251 InterPro:IPR020693	P		Seeded From UniProt	complete
enables	GO:0042393	histone binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020693	F		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.10.2	F		Seeded From UniProt	complete
involved_in	GO:0035556	intracellular signal transduction	PMID:9590174^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007498	mesoderm development	PMID:9590174^[21]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007259	receptor signaling pathway via JAK-STAT	PMID:9670957^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9670957^[3]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	PMID:9670957^[3] Reactome:R-HSA-879907 Reactome:R-HSA-873922 Reactome:R-HSA-873919 Reactome:R-HSA-873918 Reactome:R-HSA-3215391	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0070757	interleukin-35-mediated signaling pathway	Reactome:R-HSA-8984722	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070106	interleukin-27-mediated signaling pathway	Reactome:R-HSA-9020956	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070102	interleukin-6-mediated signaling pathway	Reactome:R-HSA-1059683	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060397	growth hormone receptor signaling pathway via JAK-STAT	Reactome:R-HSA-982772	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060334	regulation of interferon-gamma-mediated signaling pathway	Reactome:R-HSA-877312	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060333	interferon-gamma-mediated signaling pathway	Reactome:R-HSA-877300	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046579	positive regulation of Ras protein signal transduction	Reactome:R-HSA-9027284	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038155	interleukin-23-mediated signaling pathway	Reactome:R-HSA-9020933	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035722	interleukin-12-mediated signaling pathway	Reactome:R-HSA-9020591	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031904	endosome lumen	Reactome:R-HSA-1170539	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	Reactome:R-HSA-6785807 Reactome:R-HSA-6783589 Reactome:R-HSA-512988 Reactome:R-HSA-451927	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	Reactome:R-HSA-9027276	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	Reactome:R-HSA-109582	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-997237 Reactome:R-HSA-982810 Reactome:R-HSA-982807 Reactome:R-HSA-982792 Reactome:R-HSA-982778 Reactome:R-HSA-982775 Reactome:R-HSA-982768 Reactome:R-HSA-976991 Reactome:R-HSA-921155 Reactome:R-HSA-914182 Reactome:R-HSA-914036 Reactome:R-HSA-913451 Reactome:R-HSA-913424 Reactome:R-HSA-913374 Reactome:R-HSA-913371 Reactome:R-HSA-913370 Reactome:R-HSA-912757 Reactome:R-HSA-912527 Reactome:R-HSA-909738 Reactome:R-HSA-909552 Reactome:R-HSA-9029150 Reactome:R-HSA-9027281 Reactome:R-HSA-9027275 Reactome:R-HSA-9027273 Reactome:R-HSA-9027272 Reactome:R-HSA-9021627 Reactome:R-HSA-9012657 Reactome:R-HSA-8984023 Reactome:R-HSA-8984021 Reactome:R-HSA-8984014 Reactome:R-HSA-8984012 Reactome:R-HSA-8984001 Reactome:R-HSA-8983996 Reactome:R-HSA-8983983 Reactome:R-HSA-8983878 Reactome:R-HSA-8983876 Reactome:R-HSA-8983872 Reactome:R-HSA-8983870 Reactome:R-HSA-8983845 Reactome:R-HSA-8983841 Reactome:R-HSA-8983835 Reactome:R-HSA-8983834 Reactome:R-HSA-8983519 Reactome:R-HSA-8983518 Reactome:R-HSA-8981093 Reactome:R-HSA-8952823 Reactome:R-HSA-8952807 Reactome:R-HSA-8952749 Reactome:R-HSA-8950757 Reactome:R-HSA-8950537 Reactome:R-HSA-8950518 Reactome:R-HSA-8950485 Reactome:R-HSA-8950453 Reactome:R-HSA-8950448 Reactome:R-HSA-8950441 Reactome:R-HSA-8950423 Reactome:R-HSA-8950405 Reactome:R-HSA-8950340 Reactome:R-HSA-8950269 Reactome:R-HSA-8950210 Reactome:R-HSA-8950128 Reactome:R-HSA-879942 Reactome:R-HSA-879934 Reactome:R-HSA-879930 Reactome:R-HSA-879925 Reactome:R-HSA-879910 Reactome:R-HSA-879909 Reactome:R-HSA-879907 Reactome:R-HSA-877269 Reactome:R-HSA-873927 Reactome:R-HSA-873926 Reactome:R-HSA-873924 Reactome:R-HSA-873922 Reactome:R-HSA-873921 Reactome:R-HSA-873919 Reactome:R-HSA-873918 Reactome:R-HSA-6809140 Reactome:R-HSA-6788628 Reactome:R-HSA-6788582 Reactome:R-HSA-6788571 Reactome:R-HSA-6786124 Reactome:R-HSA-6786114 Reactome:R-HSA-6786110 Reactome:R-HSA-6786101 Reactome:R-HSA-6786096 Reactome:R-HSA-6786095 Reactome:R-HSA-6786092 Reactome:R-HSA-6786072 Reactome:R-HSA-6786070 Reactome:R-HSA-6786058 Reactome:R-HSA-6786050 Reactome:R-HSA-6785898 Reactome:R-HSA-6785821 Reactome:R-HSA-6784204 Reactome:R-HSA-6784189 Reactome:R-HSA-6783681 Reactome:R-HSA-6783556 Reactome:R-HSA-6783552 Reactome:R-HSA-6783530 Reactome:R-HSA-6783524 Reactome:R-HSA-5696482 Reactome:R-HSA-5672965 Reactome:R-HSA-508247 Reactome:R-HSA-453111 Reactome:R-HSA-453104 Reactome:R-HSA-450031 Reactome:R-HSA-449976 Reactome:R-HSA-448427 Reactome:R-HSA-447252 Reactome:R-HSA-447226 Reactome:R-HSA-447130 Reactome:R-HSA-1675473 Reactome:R-HSA-1671687 Reactome:R-HSA-1470012 Reactome:R-HSA-1470010 Reactome:R-HSA-1470009 Reactome:R-HSA-1433456 Reactome:R-HSA-1433451 Reactome:R-HSA-1433418 Reactome:R-HSA-1370505 Reactome:R-HSA-1370500 Reactome:R-HSA-1364044 Reactome:R-HSA-1170539 Reactome:R-HSA-1169192 Reactome:R-HSA-1168894 Reactome:R-HSA-1168459 Reactome:R-HSA-1168445 Reactome:R-HSA-1112755 Reactome:R-HSA-1112727 Reactome:R-HSA-1112708 Reactome:R-HSA-1112703 Reactome:R-HSA-1112690 Reactome:R-HSA-1112604 Reactome:R-HSA-1112602 Reactome:R-HSA-1112565 Reactome:R-HSA-1112514 Reactome:R-HSA-1112510 Reactome:R-HSA-1067688 Reactome:R-HSA-1067659 Reactome:R-HSA-1067651	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005654	nucleoplasm	Reactome:R-HSA-3215391	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004715	non-membrane spanning protein tyrosine kinase activity	Reactome:R-HSA-879910 Reactome:R-HSA-6788582 Reactome:R-HSA-1112703 Reactome:R-HSA-1112602	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	Reactome:R-HSA-8983872	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0000165	MAPK cascade	Reactome:R-HSA-5673001	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
enables	GO:0004713	protein tyrosine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0829	F		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
involved_in	GO:0002250	adaptive immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1064	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0006325	chromatin organization	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0156	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0012505	endomembrane system	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0147	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ Shi, SY et al. (2016) JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice. Diabetologia 59 187-96 PubMed GONUTS page
↑ ^2.0 ^2.1 Hanan, EJ et al. (2012) Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors. J. Med. Chem. 55 10090-107 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 Mellado, M et al. (1998) The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor. J. Immunol. 161 805-13 PubMed GONUTS page
↑ ^4.0 ^4.1 Bacon, CM et al. (1995) Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J. Exp. Med. 181 399-404 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 Ryu, H et al. (2000) Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin. J. Immunol. 165 2116-23 PubMed GONUTS page
↑ Looyenga, BD et al. (2012) STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma. PLoS ONE 7 e30820 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 Murata, T et al. (1996) IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling. J. Immunol. 156 2972-8 PubMed GONUTS page
↑ ^8.0 ^8.1 Hellgren, G et al. (1999) The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver. Growth Horm. IGF Res. 9 212-8 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 Dawson, MA et al. (2009) JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461 819-22 PubMed GONUTS page
↑ Dey, BR et al. (1998) Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor. J. Biol. Chem. 273 24095-101 PubMed GONUTS page
↑ Yao, X et al. (2010) Heme controls the regulation of protein tyrosine kinases Jak2 and Src. Biochem. Biophys. Res. Commun. 403 30-5 PubMed GONUTS page
↑ Irie-Sasaki, J et al. (2001) CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature 409 349-54 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Feng, J et al. (1997) Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop. Mol. Cell. Biol. 17 2497-501 PubMed GONUTS page
↑ Argetsinger, LS et al. (2010) Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity. Mol. Endocrinol. 24 1062-76 PubMed GONUTS page
↑ Fukumoto, T et al. (2009) Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells. Cell. Signal. 21 1775-83 PubMed GONUTS page
↑ Argetsinger, LS et al. (2004) Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity. Mol. Cell. Biol. 24 4955-67 PubMed GONUTS page
↑ Shang, L & Tomasi, TB (2006) The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. J. Biol. Chem. 281 1876-84 PubMed GONUTS page
↑ Bandaranayake, RM et al. (2012) Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F. Nat. Struct. Mol. Biol. 19 754-9 PubMed GONUTS page
↑ Ungureanu, D et al. (2011) The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling. Nat. Struct. Mol. Biol. 18 971-6 PubMed GONUTS page
↑ ^21.0 ^21.1 Neubauer, H et al. (1998) Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93 397-409 PubMed GONUTS page

[PMID:26515423-1] Shi, SY et al. (2016) JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice. Diabetologia 59 187-96 PubMed GONUTS page

[PMID:23061660-2] 2.0 ^2.1 Hanan, EJ et al. (2012) Discovery of potent and selective pyrazolopyrimidine janus kinase 2 inhibitors. J. Med. Chem. 55 10090-107 PubMed GONUTS page

[PMID:9670957-3] 3.0 ^3.1 ^3.2 ^3.3 Mellado, M et al. (1998) The chemokine monocyte chemotactic protein 1 triggers Janus kinase 2 activation and tyrosine phosphorylation of the CCR2B receptor. J. Immunol. 161 805-13 PubMed GONUTS page

[PMID:7528775-4] 4.0 ^4.1 Bacon, CM et al. (1995) Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J. Exp. Med. 181 399-404 PubMed GONUTS page

[PMID:10925297-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 Ryu, H et al. (2000) Regulation of neutrophil adhesion by pituitary growth hormone accompanies tyrosine phosphorylation of Jak2, p125FAK, and paxillin. J. Immunol. 165 2116-23 PubMed GONUTS page

[PMID:22319590-6] Looyenga, BD et al. (2012) STAT3 is activated by JAK2 independent of key oncogenic driver mutations in non-small cell lung carcinoma. PLoS ONE 7 e30820 PubMed GONUTS page

[PMID:8609418-7] 7.0 ^7.1 ^7.2 Murata, T et al. (1996) IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling. J. Immunol. 156 2972-8 PubMed GONUTS page

[PMID:10502458-8] 8.0 ^8.1 Hellgren, G et al. (1999) The growth hormone receptor associates with Jak1, Jak2 and Tyk2 in human liver. Growth Horm. IGF Res. 9 212-8 PubMed GONUTS page

[PMID:19783980-9] 9.0 ^9.1 ^9.2 ^9.3 Dawson, MA et al. (2009) JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature 461 819-22 PubMed GONUTS page

[PMID:9727029-10] Dey, BR et al. (1998) Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor. J. Biol. Chem. 273 24095-101 PubMed GONUTS page

[PMID:21036157-11] Yao, X et al. (2010) Heme controls the regulation of protein tyrosine kinases Jak2 and Src. Biochem. Biophys. Res. Commun. 403 30-5 PubMed GONUTS page

[PMID:11201744-12] Irie-Sasaki, J et al. (2001) CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling. Nature 409 349-54 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:9111318-14] Feng, J et al. (1997) Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop. Mol. Cell. Biol. 17 2497-501 PubMed GONUTS page

[PMID:20304997-15] Argetsinger, LS et al. (2010) Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity. Mol. Endocrinol. 24 1062-76 PubMed GONUTS page

[PMID:19665053-16] Fukumoto, T et al. (2009) Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells. Cell. Signal. 21 1775-83 PubMed GONUTS page

[PMID:15143187-17] Argetsinger, LS et al. (2004) Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity. Mol. Cell. Biol. 24 4955-67 PubMed GONUTS page

[PMID:16280321-18] Shang, L & Tomasi, TB (2006) The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. J. Biol. Chem. 281 1876-84 PubMed GONUTS page

[PMID:22820988-19] Bandaranayake, RM et al. (2012) Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F. Nat. Struct. Mol. Biol. 19 754-9 PubMed GONUTS page

[PMID:21841788-20] Ungureanu, D et al. (2011) The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling. Nat. Struct. Mol. Biol. 18 971-6 PubMed GONUTS page

[PMID:9590174-21] 21.0 ^21.1 Neubauer, H et al. (1998) Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93 397-409 PubMed GONUTS page

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HUMAN:JAK2

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