MOUSE:K1C18

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Krt18 (synonyms: Kerd, Krt1-18)
Protein Name(s)	Keratin, type I cytoskeletal 18 Cytokeratin endo B Keratin D Cytokeratin-18 CK-18 Keratin-18 K18
External Links
UniProt	P05784
EMBL	M11686 M36376 M22832 AK145413 AK167072 AK167265 AK167432 AK167469 AK167676 BC089022 Y00217
CCDS	CCDS27869.1
PIR	I59463
RefSeq	NP_034794.2
UniGene	Mm.22479
ProteinModelPortal	P05784
SMR	P05784
BioGrid	201023
IntAct	P05784
MINT	MINT-1866927
PhosphoSite	P05784
SWISS-2DPAGE	P05784
MaxQB	P05784
PaxDb	P05784
PRIDE	P05784
Ensembl	ENSMUST00000023803
GeneID	16668
KEGG	mmu:16668
UCSC	uc007xuj.2
CTD	3875
MGI	MGI:96692
eggNOG	NOG150427
GeneTree	ENSGT00760000119046
HOGENOM	HOG000230975
HOVERGEN	HBG013015
InParanoid	P05784
KO	K07604
OMA	RAKYEKM
OrthoDB	EOG7V1FR3
PhylomeDB	P05784
TreeFam	TF332742
ChiTaRS	Krt18
NextBio	290387
PRO	PR:P05784
Proteomes	UP000000589
Bgee	P05784
CleanEx	MM_KRT18
Genevestigator	P05784
GO	GO:0071944 GO:0034451 GO:0070062 GO:0005882 GO:0045095 GO:0016363 GO:0005730 GO:0044822 GO:0005198 GO:0097191 GO:0043000 GO:0097284 GO:0045104 GO:0043066 GO:0033209
InterPro	IPR001664 IPR018039 IPR027695 IPR002957
PANTHER	PTHR23239 PTHR23239:SF35
Pfam	PF00038
PRINTS	PR01248
PROSITE	PS00226

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
acts_upstream_of_or_within	GO:0097284	hepatocyte apoptotic process	PMID:10747083^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178045	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097191	extrinsic apoptotic signaling pathway	PMID:10747083^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2178045	P	Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05783	F	Seeded From UniProt	complete
part_of	GO:0071944	cell periphery	PMID:23284756^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045104	intermediate filament cytoskeleton organization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05783	P	Seeded From UniProt	complete
part_of	GO:0045095	keratin filament	PMID:21930775^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0045095	keratin filament	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05783	C	Seeded From UniProt	complete
part_of	GO:0045095	keratin filament	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:619935	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043066	negative regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05783	P	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043000	Golgi to plasma membrane CFTR protein transport	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05783	P	Seeded From UniProt	complete
part_of	GO:0034451	centriolar satellite	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05783	C	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:10747083^[1]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:96705	P	Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	PMID:10747083^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05783	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05783	C	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05783	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P05783	C	Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05783 ensembl:ENSP00000373489	F	Seeded From UniProt	complete
involved_in	GO:0045104	intermediate filament cytoskeleton organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05783 ensembl:ENSP00000373489	P	Seeded From UniProt	complete
part_of	GO:0045095	keratin filament	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05783 ensembl:ENSP00000373489	C	Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05783 ensembl:ENSP00000373489	P	Seeded From UniProt	complete
involved_in	GO:0043000	Golgi to plasma membrane CFTR protein transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05783 ensembl:ENSP00000373489	P	Seeded From UniProt	complete
part_of	GO:0034451	centriolar satellite	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05783 ensembl:ENSP00000373489	C	Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05783 ensembl:ENSP00000373489	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05783 ensembl:ENSP00000373489	C	Seeded From UniProt	complete
part_of	GO:0005815	microtubule organizing center	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05783 ensembl:ENSP00000373489	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P05783 ensembl:ENSP00000373489	C	Seeded From UniProt	complete
part_of	GO:0045095	keratin filament	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q5BJY9 ensembl:ENSRNOP00000067234	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024RAY2 ensembl:ENSP00000373489	C	Seeded From UniProt	complete
enables	GO:0005198	structural molecule activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001664 InterPro:IPR002957	F	Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001664	C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539	C	Seeded From UniProt	complete
part_of	GO:0005882	intermediate filament	GO_REF:0000037 GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0416 UniProtKB-KW:KW-0403	C	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
part_of	GO:0016363	nuclear matrix	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0181	C	Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0188	C	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Caulin, C et al. (2000) Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis. J. Cell Biol. 149 17-22 PubMed GONUTS page
↑ Krolewski, RC et al. (2012) Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium. PLoS ONE 7 e51737 PubMed GONUTS page
↑ Fessing, MY et al. (2011) p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis. J. Cell Biol. 194 825-39 PubMed GONUTS page

[PMID:10747083-1] 1.0 ^1.1 ^1.2 ^1.3 Caulin, C et al. (2000) Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis. J. Cell Biol. 149 17-22 PubMed GONUTS page

[PMID:23284756-2] Krolewski, RC et al. (2012) Ascl1 (Mash1) knockout perturbs differentiation of nonneuronal cells in olfactory epithelium. PLoS ONE 7 e51737 PubMed GONUTS page

[PMID:21930775-3] Fessing, MY et al. (2011) p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis. J. Cell Biol. 194 825-39 PubMed GONUTS page

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MOUSE:K1C18

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Notes

References

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