MOUSE:IL33

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Il33
Protein Name(s)	Interleukin-33 IL-33 Interleukin-33(102-266) Interleukin-33(109-266)
External Links
UniProt	Q8BVZ5
EMBL	AY905582 AK075849 AK163464 BC003847
CCDS	CCDS29740.1
RefSeq	NP_001158196.1 NP_598536.2 XP_006527526.1
UniGene	Mm.182359
ProteinModelPortal	Q8BVZ5
SMR	Q8BVZ5
BioGrid	218533
IntAct	Q8BVZ5
PhosphoSite	Q8BVZ5
PRIDE	Q8BVZ5
Ensembl	ENSMUST00000025724 ENSMUST00000120388
GeneID	77125
KEGG	mmu:77125
UCSC	uc008hec.2
CTD	90865
MGI	MGI:1924375
eggNOG	NOG41297
GeneTree	ENSGT00390000005185
HOGENOM	HOG000070215
HOVERGEN	HBG081791
InParanoid	Q8BVZ5
KO	K12967
OMA	DPGVFIG
OrthoDB	EOG7TQV1R
PhylomeDB	Q8BVZ5
TreeFam	TF338120
NextBio	346526
PRO	PR:Q8BVZ5
Proteomes	UP000000589
Bgee	Q8BVZ5
CleanEx	MM_IL33
ExpressionAtlas	Q8BVZ5
Genevestigator	Q8BVZ5
GO	GO:0005694 GO:0005615 GO:0005634 GO:0030133 GO:0005125 GO:0051607 GO:0097191 GO:0051025 GO:0032689 GO:0002686 GO:0002826 GO:0090197 GO:0010628 GO:0051024 GO:0050729 GO:0032736 GO:0032753 GO:0032754 GO:0032755 GO:0043032 GO:0032436 GO:0045944 GO:0002830 GO:0006351
InterPro	IPR026145
PANTHER	PTHR21114
Pfam	PF15095

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0002281	macrophage activation involved in immune response	PMID:21494550^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0061518	microglial cell proliferation	PMID:21349253^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002282	microglial cell activation involved in immune response	PMID:21349253^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090197	positive regulation of chemokine secretion	PMID:19841166^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051025	negative regulation of immunoglobulin secretion	PMID:18268038^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08226	P		Seeded From UniProt	complete
involved_in	GO:0051024	positive regulation of immunoglobulin secretion	PMID:18268038^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08226	P		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:19841166^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:19841166^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043032	positive regulation of macrophage activation	PMID:19841166^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:18268038^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08226	P		Seeded From UniProt	complete
involved_in	GO:0032754	positive regulation of interleukin-5 production	PMID:18268038^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08226	P		Seeded From UniProt	complete
involved_in	GO:0032753	positive regulation of interleukin-4 production	PMID:18268038^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08226	P		Seeded From UniProt	complete
involved_in	GO:0032736	positive regulation of interleukin-13 production	PMID:18268038^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08226	P		Seeded From UniProt	complete
involved_in	GO:0032689	negative regulation of interferon-gamma production	PMID:18268038^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08226	P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:19841166^[3]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002830	positive regulation of type 2 immune response	PMID:18268038^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08226	P		Seeded From UniProt	complete
involved_in	GO:0002826	negative regulation of T-helper 1 type immune response	PMID:18268038^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08226	P		Seeded From UniProt	complete
involved_in	GO:0002686	negative regulation of leukocyte migration	PMID:18268038^[4]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P08226	P		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1924375 PANTHER:PTN000473807	P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:21873635^[5]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1924375 PANTHER:PTN000473807 UniProtKB:O95760	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097191	extrinsic apoptotic signaling pathway	PMID:22660580^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99695	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090197	positive regulation of chemokine secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95760	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051607	defense response to virus	PMID:23630360^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043032	positive regulation of macrophage activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95760	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:22660580^[6]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1861437 MGI:MGI:3039600	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	PMID:22660580^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	PMID:19666510^[8]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000546) has_regulation_target:(MGI:MGI:96541)\|regulates_o_occurs_in(CL:0000546) has_regulation_target:(MGI:MGI:95663)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:12819012^[9]	ECO:0000266	sequence orthology evidence used in manual assertion	EMBL:AB024518	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	PMID:17623648^[10]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P14719-1 UniProtKB:P14719-2	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O95760	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002830	positive regulation of type 2 immune response	PMID:23630360^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0090197	positive regulation of chemokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95760 ensembl:ENSP00000370842	P		Seeded From UniProt	complete
involved_in	GO:0043032	positive regulation of macrophage activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95760 ensembl:ENSP00000370842	P		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O95760 ensembl:ENSP00000370842	F		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR026145	F		Seeded From UniProt	complete
part_of	GO:0005694	chromosome	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0158 UniProtKB-SubCell:SL-0468	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0030133	transport vesicle	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0244	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Ohno, T et al. (2011) Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation. PLoS ONE 6 e18404 PubMed GONUTS page
↑ ^2.0 ^2.1 Yasuoka, S et al. (2011) Production and functions of IL-33 in the central nervous system. Brain Res. 1385 8-17 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Kurowska-Stolarska, M et al. (2009) IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation. J. Immunol. 183 6469-77 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Miller, AM et al. (2008) IL-33 reduces the development of atherosclerosis. J. Exp. Med. 205 339-46 PubMed GONUTS page
↑ ^5.0 ^5.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Zhao, J et al. (2012) F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation. Nat. Immunol. 13 651-8 PubMed GONUTS page
↑ ^7.0 ^7.1 Liang, Y et al. (2013) IL-33 induces nuocytes and modulates liver injury in viral hepatitis. J. Immunol. 190 5666-75 PubMed GONUTS page
↑ Guo, L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc. Natl. Acad. Sci. U.S.A. 106 13463-8 PubMed GONUTS page
↑ Baekkevold, ES et al. (2003) Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules. Am. J. Pathol. 163 69-79 PubMed GONUTS page
↑ Hayakawa, H et al. (2007) Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation. J. Biol. Chem. 282 26369-80 PubMed GONUTS page

[PMID:21494550-1] Ohno, T et al. (2011) Paracrine IL-33 stimulation enhances lipopolysaccharide-mediated macrophage activation. PLoS ONE 6 e18404 PubMed GONUTS page

[PMID:21349253-2] 2.0 ^2.1 Yasuoka, S et al. (2011) Production and functions of IL-33 in the central nervous system. Brain Res. 1385 8-17 PubMed GONUTS page

[PMID:19841166-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Kurowska-Stolarska, M et al. (2009) IL-33 amplifies the polarization of alternatively activated macrophages that contribute to airway inflammation. J. Immunol. 183 6469-77 PubMed GONUTS page

[PMID:18268038-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 ^4.8 ^4.9 Miller, AM et al. (2008) IL-33 reduces the development of atherosclerosis. J. Exp. Med. 205 339-46 PubMed GONUTS page

[PMID:21873635-5] 5.0 ^5.1 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22660580-6] 6.0 ^6.1 ^6.2 Zhao, J et al. (2012) F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation. Nat. Immunol. 13 651-8 PubMed GONUTS page

[PMID:23630360-7] 7.0 ^7.1 Liang, Y et al. (2013) IL-33 induces nuocytes and modulates liver injury in viral hepatitis. J. Immunol. 190 5666-75 PubMed GONUTS page

[PMID:19666510-8] Guo, L et al. (2009) IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells. Proc. Natl. Acad. Sci. U.S.A. 106 13463-8 PubMed GONUTS page

[PMID:12819012-9] Baekkevold, ES et al. (2003) Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules. Am. J. Pathol. 163 69-79 PubMed GONUTS page

[PMID:17623648-10] Hayakawa, H et al. (2007) Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation. J. Biol. Chem. 282 26369-80 PubMed GONUTS page

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MOUSE:IL33

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