MOUSE:TNFL6

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Faslg (synonyms: Apt1lg1, Cd95l, Fasl, gld, Tnfsf6)
Protein Name(s)	Tumor necrosis factor ligand superfamily member 6 CD95 ligand CD95-L Fas antigen ligand Fas ligand FasL Tumor necrosis factor ligand superfamily member 6, membrane form Tumor necrosis factor ligand superfamily member 6, soluble form Receptor-binding FasL ectodomain Soluble Fas ligand sFasL ADAM10-processed FasL form APL FasL intracellular domain FasL ICD SPPL2A-processed FasL form SPA
External Links
UniProt	P41047
EMBL	U06948 U10984 S76752 U58995 AF119335
CCDS	CCDS15418.1
PIR	A53062
RefSeq	NP_034307.1 XP_006496716.1 XP_006496717.1
UniGene	Mm.3355
ProteinModelPortal	P41047
SMR	P41047
BioGrid	199595
MINT	MINT-1486494
PRIDE	P41047
Ensembl	ENSMUST00000000834
GeneID	14103
KEGG	mmu:14103
UCSC	uc007dfr.2
CTD	14103
MGI	MGI:99255
eggNOG	NOG42315
HOGENOM	HOG000290680
HOVERGEN	HBG055128
InParanoid	P41047
KO	K04389
OMA	WEDTYGI
OrthoDB	EOG7V4B0Q
PhylomeDB	P41047
TreeFam	TF332169
Reactome	REACT_215122 REACT_241657 REACT_243608 REACT_263715
NextBio	285134
PMAP-CutDB	P41047
PRO	PR:P41047
Proteomes	UP000000589
Bgee	P41047
CleanEx	MM_FASL
ExpressionAtlas	P41047
Genevestigator	P41047
GO	GO:0005901 GO:0060205 GO:0009897 GO:0005615 GO:0070062 GO:0016021 GO:0043202 GO:0005634 GO:0048471 GO:0006919 GO:0097190 GO:0030644 GO:0048388 GO:0008625 GO:0006955 GO:0006925 GO:0097527 GO:0016525 GO:0000122 GO:0043065 GO:0008284 GO:2000353 GO:0045742 GO:0043123 GO:0043525 GO:0070848 GO:0032496 GO:0046666 GO:0070231 GO:0006351
Gene3D	2.60.120.40
InterPro	IPR028326 IPR006053 IPR021184 IPR006052 IPR008983
Pfam	PF00229
PRINTS	PR01681 PR01234
SMART	SM00207
SUPFAM	SSF49842
PROSITE	PS00251 PS50049

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0043065	positive regulation of apoptosis	PMID:20100735^[1]	ECO:0000315			P		fig.1	complete
	GO:0010468	regulation of gene expression	PMID:20100735^[1]	ECO:0000315			P		Fig.5A,B	complete
part_of	GO:0009986	cell surface	PMID:20404348^[2]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000746) exists_during:(GO:0071456)	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48023	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P48023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000353	positive regulation of endothelial cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903514	release of sequestered calcium ion into cytosol by endoplasmic reticulum	PMID:26582200^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097527	necroptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097190	apoptotic signaling pathway	PMID:7511063^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097190	apoptotic signaling pathway	PMID:15629131^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097190	apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070266	necroptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070231	T cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48023	P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48023	C		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3880	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0048388	endosomal lumen acidification	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3880	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046666	retinal cell programmed cell death	PMID:14517994^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1856384	P	occurs_in:(EMAPA:17168)\|occurs_in:(EMAPA:16674)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3880	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3880	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3880	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	PMID:14749367^[7]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48023	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3880	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030644	cellular chloride ion homeostasis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3880	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0016525	negative regulation of angiogenesis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48023	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	PMID:16973387^[8]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000624)\|part_of:(CL:0000625)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:15039234^[9]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(EMAPA:32760) regulates_o_occurs_in:(CL:0000097)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:10588860^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:26582200^[3]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48023	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3880	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3880	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006925	inflammatory cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3880	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48023	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3880	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48023	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48023	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48023	C		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3880	F		Seeded From UniProt	complete
enables	GO:0005123	death receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3880	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P48023	P		Seeded From UniProt	complete
involved_in	GO:0010469	regulation of signaling receptor activity	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0005125	P		Seeded From UniProt	complete
involved_in	GO:0070848	response to growth factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36940 ensembl:ENSRNOP00000003998	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36940 ensembl:ENSRNOP00000003998	C		Seeded From UniProt	complete
involved_in	GO:0048388	endosomal lumen acidification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36940 ensembl:ENSRNOP00000003998	P		Seeded From UniProt	complete
involved_in	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36940 ensembl:ENSRNOP00000003998	P		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36940 ensembl:ENSRNOP00000003998	C		Seeded From UniProt	complete
involved_in	GO:0043525	positive regulation of neuron apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36940 ensembl:ENSRNOP00000003998	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36940 ensembl:ENSRNOP00000003998	P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36940 ensembl:ENSRNOP00000003998	C		Seeded From UniProt	complete
involved_in	GO:0030644	cellular chloride ion homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36940 ensembl:ENSRNOP00000003998	P		Seeded From UniProt	complete
involved_in	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36940 ensembl:ENSRNOP00000003998	P		Seeded From UniProt	complete
involved_in	GO:0008284	positive regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36940 ensembl:ENSRNOP00000003998	P		Seeded From UniProt	complete
involved_in	GO:0006925	inflammatory cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36940 ensembl:ENSRNOP00000003998	P		Seeded From UniProt	complete
part_of	GO:0005901	caveola	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36940 ensembl:ENSRNOP00000003998	C		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36940 ensembl:ENSRNOP00000003998	F		Seeded From UniProt	complete
enables	GO:0005123	death receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P36940 ensembl:ENSRNOP00000003998	F		Seeded From UniProt	complete
involved_in	GO:2000353	positive regulation of endothelial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48023 ensembl:ENSP00000356694	P		Seeded From UniProt	complete
involved_in	GO:1903514	release of sequestered calcium ion into cytosol by endoplasmic reticulum	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48023 ensembl:ENSP00000356694	P		Seeded From UniProt	complete
involved_in	GO:0097527	necroptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48023 ensembl:ENSP00000356694	P		Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48023 ensembl:ENSP00000356694	P		Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48023 ensembl:ENSP00000356694	P		Seeded From UniProt	complete
involved_in	GO:0070266	necroptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48023 ensembl:ENSP00000356694	P		Seeded From UniProt	complete
involved_in	GO:0070231	T cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48023 ensembl:ENSP00000356694	P		Seeded From UniProt	complete
part_of	GO:0070062	extracellular exosome	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48023 ensembl:ENSP00000356694	C		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48023 ensembl:ENSP00000356694	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48023 ensembl:ENSP00000356694	P		Seeded From UniProt	complete
involved_in	GO:0016525	negative regulation of angiogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48023 ensembl:ENSP00000356694	P		Seeded From UniProt	complete
involved_in	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48023 ensembl:ENSP00000356694	P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48023 ensembl:ENSP00000356694	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48023 ensembl:ENSP00000356694	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48023 ensembl:ENSP00000356694	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48023 ensembl:ENSP00000356694	C		Seeded From UniProt	complete
involved_in	GO:0000122	negative regulation of transcription by RNA polymerase II	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P48023 ensembl:ENSP00000356694	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q53ZZ1 ensembl:ENSP00000356694	C		Seeded From UniProt	complete
enables	GO:0005164	tumor necrosis factor receptor binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006052 InterPro:IPR006053 InterPro:IPR028326	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR028326	P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006052 InterPro:IPR006053	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR006052 InterPro:IPR006053	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
part_of	GO:0005764	lysosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0458	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
part_of	GO:0005615	extracellular space	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	C		Seeded From UniProt	complete
enables	GO:0005125	cytokine activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0202	F		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0964 UniProtKB-SubCell:SL-0243	C		Seeded From UniProt	complete
part_of	GO:0060205	cytoplasmic vesicle lumen	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0325	C		Seeded From UniProt	complete
part_of	GO:0043202	lysosomal lumen	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0156	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Lin, YC et al. (2010) FasL gene-deficient mice display a limited disruption in spermatogenesis and inhibition of mono-(2-ethylhexyl) phthalate-induced germ cell apoptosis. Toxicol. Sci. 114 335-45 PubMed GONUTS page
↑ Sayed, D et al. (2010) MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand. J. Biol. Chem. 285 20281-90 PubMed GONUTS page
↑ ^3.0 ^3.1 Urresti, J et al. (2016) Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells. J. Biol. Chem. 291 1221-34 PubMed GONUTS page
↑ Takahashi, T et al. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76 969-76 PubMed GONUTS page
↑ Hsu, LJ et al. (2005) Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1. Biochem. Biophys. Res. Commun. 327 415-23 PubMed GONUTS page
↑ Péquignot, MO et al. (2003) Major role of BAX in apoptosis during retinal development and in establishment of a functional postnatal retina. Dev. Dyn. 228 231-8 PubMed GONUTS page
↑ Remy, I & Michnick, SW (2004) Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. Mol. Cell. Biol. 24 1493-504 PubMed GONUTS page
↑ Marie, JC et al. (2006) Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25 441-54 PubMed GONUTS page
↑ Hiatt, K et al. (2004) Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells. Am. J. Pathol. 164 1471-9 PubMed GONUTS page
↑ Estellés, A et al. (1999) The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis. Dev. Biol. 216 16-28 PubMed GONUTS page

[PMID:20100735-1] 1.0 ^1.1 Lin, YC et al. (2010) FasL gene-deficient mice display a limited disruption in spermatogenesis and inhibition of mono-(2-ethylhexyl) phthalate-induced germ cell apoptosis. Toxicol. Sci. 114 335-45 PubMed GONUTS page

[PMID:20404348-2] Sayed, D et al. (2010) MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligand. J. Biol. Chem. 285 20281-90 PubMed GONUTS page

[PMID:26582200-3] 3.0 ^3.1 Urresti, J et al. (2016) Lifeguard Inhibits Fas Ligand-mediated Endoplasmic Reticulum-Calcium Release Mandatory for Apoptosis in Type II Apoptotic Cells. J. Biol. Chem. 291 1221-34 PubMed GONUTS page

[PMID:7511063-4] Takahashi, T et al. (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76 969-76 PubMed GONUTS page

[PMID:15629131-5] Hsu, LJ et al. (2005) Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1. Biochem. Biophys. Res. Commun. 327 415-23 PubMed GONUTS page

[PMID:14517994-6] Péquignot, MO et al. (2003) Major role of BAX in apoptosis during retinal development and in establishment of a functional postnatal retina. Dev. Dyn. 228 231-8 PubMed GONUTS page

[PMID:14749367-7] Remy, I & Michnick, SW (2004) Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt. Mol. Cell. Biol. 24 1493-504 PubMed GONUTS page

[PMID:16973387-8] Marie, JC et al. (2006) Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Immunity 25 441-54 PubMed GONUTS page

[PMID:15039234-9] Hiatt, K et al. (2004) Loss of the nf1 tumor suppressor gene decreases fas antigen expression in myeloid cells. Am. J. Pathol. 164 1471-9 PubMed GONUTS page

[PMID:10588860-10] Estellés, A et al. (1999) The phosphoprotein protein PEA-15 inhibits Fas- but increases TNF-R1-mediated caspase-8 activity and apoptosis. Dev. Biol. 216 16-28 PubMed GONUTS page

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MOUSE:TNFL6

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