MOUSE:BAD

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Bad (synonyms: Bbc6)
Protein Name(s)	Bcl2-associated agonist of cell death BAD Bcl-2-binding component 6 Bcl-xL/Bcl-2-associated death promoter Bcl2 antagonist of cell death
External Links
UniProt	Q61337
EMBL	L37296 BC006762
CCDS	CCDS29513.1
PIR	A55671
RefSeq	NP_031548.1
UniGene	Mm.4387
PDB	2BZW
PDBsum	2BZW
DisProt	DP00563
ProteinModelPortal	Q61337
SMR	Q61337
BioGrid	198296
DIP	DIP-273N
IntAct	Q61337
MINT	MINT-202237
BindingDB	Q61337
ChEMBL	CHEMBL5385
PhosphoSite	Q61337
MaxQB	Q61337
PaxDb	Q61337
PRIDE	Q61337
DNASU	12015
Ensembl	ENSMUST00000025910
GeneID	12015
KEGG	mmu:12015
UCSC	uc008gjn.1
CTD	572
MGI	MGI:1096330
eggNOG	NOG43412
GeneTree	ENSGT00390000010740
HOGENOM	HOG000095169
HOVERGEN	HBG001653
InParanoid	Q61337
KO	K02158
OMA	GEAGHQQ
OrthoDB	EOG7MD4RF
PhylomeDB	Q61337
TreeFam	TF102001
Reactome	REACT_196588 REACT_209641 REACT_220918 REACT_223399
EvolutionaryTrace	Q61337
NextBio	280229
PMAP-CutDB	Q61337
PRO	PR:Q61337
Proteomes	UP000000589
Bgee	Q61337
CleanEx	MM_BAD
ExpressionAtlas	Q61337
Genevestigator	Q61337
GO	GO:0005737 GO:0005829 GO:0005741 GO:0005739 GO:0008656 GO:0008289 GO:0005543 GO:0046982 GO:0019903 GO:0006919 GO:0046031 GO:0097190 GO:0046034 GO:0008283 GO:0060154 GO:0071247 GO:0071456 GO:0071396 GO:0071260 GO:0071316 GO:0071310 GO:0019221 GO:0097192 GO:0008625 GO:0006007 GO:0042593 GO:0097193 GO:0008630 GO:0046931 GO:0043065 GO:0060139 GO:0045579 GO:0043280 GO:0050679 GO:0033133 GO:0032024 GO:0035774 GO:0010918 GO:1901216 GO:0090200 GO:0045582 GO:2000078 GO:0042981 GO:0043281 GO:0046902 GO:0001836 GO:0043200 GO:0051592 GO:0042493 GO:0032355 GO:0045471 GO:0051384 GO:0009749 GO:0042542 GO:0034201 GO:0032570 GO:0033574 GO:0019050 GO:0044342
InterPro	IPR018868
Pfam	PF10514

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0005739	mitochondrion	PMID:22072718^[1]	ECO:0000314			C		Fig. 6A	complete CACAO 3002
	GO:0016310	phosphorylation	PMID:16396982^[2]	ECO:0000314			P		FIgure 9	complete CACAO 6525
involved_in	GO:1902220	positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	PMID:21716255^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:21716255^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21716255^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21546903^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:2000078	positive regulation of type B pancreatic cell development	PMID:18223655^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097193	intrinsic apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q92934	P		Seeded From UniProt	complete
involved_in	GO:0071396	cellular response to lipid	PMID:18223655^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071316	cellular response to nicotine	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q92934	P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q92934	P		Seeded From UniProt	complete
involved_in	GO:0046931	pore complex assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q92934	P		Seeded From UniProt	complete
involved_in	GO:0046902	regulation of mitochondrial membrane permeability	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q92934	P		Seeded From UniProt	complete
involved_in	GO:0046034	ATP metabolic process	PMID:18223655^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046031	ADP metabolic process	PMID:18223655^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044342	type B pancreatic cell proliferation	PMID:18223655^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q92934	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:21095239^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	PMID:18223655^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	PMID:18223655^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0033133	positive regulation of glucokinase activity	PMID:18223655^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	PMID:18223655^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010918	positive regulation of mitochondrial membrane potential	PMID:18223655^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	PMID:19915011^[7]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q92934	F		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:19915011^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q92934	C		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q92934	F		Seeded From UniProt	complete
involved_in	GO:0097202	activation of cysteine-type endopeptidase activity	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002004008 UniProtKB:Q92934	P		Seeded From UniProt	complete
involved_in	GO:0097193	intrinsic apoptotic signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002004008 UniProtKB:Q92934	P		Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002004008 UniProtKB:Q92934	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002004008 UniProtKB:Q92934	P		Seeded From UniProt	complete
involved_in	GO:0046902	regulation of mitochondrial membrane permeability	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002004008 UniProtKB:Q92934	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096330 PANTHER:PTN002004008	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002004008 UniProtKB:Q92934	F		Seeded From UniProt	complete
enables	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096330 PANTHER:PTN002004008 UniProtKB:Q92934	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096330 PANTHER:PTN002004008 RGD:620103 UniProtKB:Q92934	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096330 PANTHER:PTN002004008 RGD:620103 UniProtKB:Q92934	C		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	PMID:21873635^[8]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096330 PANTHER:PTN002004008	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904710	positive regulation of granulosa cell apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620103	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901216	positive regulation of neuron death	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620103	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097202	activation of cysteine-type endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097193	intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:12431371^[9]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1890081	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:14967141^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000826)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:12944463^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	PMID:12115603^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097190	apoptotic signaling pathway	PMID:12931191^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2675966 MGI:MGI:3029528	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097190	apoptotic signaling pathway	PMID:15231831^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097190	apoptotic signaling pathway	PMID:11717309^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090200	positive regulation of release of cytochrome c from mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92934	P		Seeded From UniProt	complete
enables	GO:0071889	14-3-3 protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620103	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071316	cellular response to nicotine	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071310	cellular response to organic substance	PMID:12727206^[16]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:A7MCM4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060154	cellular process regulating host cell cycle in response to virus	PMID:15231831^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060139	positive regulation of apoptotic process by virus	PMID:15231831^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92934	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:7834748^[17]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10417 UniProtKB:Q64373	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046931	pore complex assembly	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046902	regulation of mitochondrial membrane permeability	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045862	positive regulation of proteolysis	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045582	positive regulation of T cell differentiation	PMID:12431371^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3029528	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045579	positive regulation of B cell differentiation	PMID:12431371^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3029528	P		Seeded From UniProt	complete
enables	GO:0043422	protein kinase B binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620103	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:14967141^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000826)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	PMID:12727206^[16]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:A7MCM4	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	PMID:7834748^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042593	glucose homeostasis	PMID:12931191^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2675966 MGI:MGI:3029528	P		Seeded From UniProt	complete
enables	GO:0030346	protein phosphatase 2B binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620103	F		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:12944463^[11]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q76MZ3	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92934	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019221	cytokine-mediated signaling pathway	PMID:14967141^[10]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000826)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019050	suppression by virus of host apoptotic process	PMID:15231831^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2675966	P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0019050	suppression by virus of host apoptotic process	PMID:15231831^[14]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000540)	Seeded From UniProt	complete
enables	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92934	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:12431371^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3029528	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:15231831^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	PMID:12431371^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3029528	P		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92934	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0008283	cell population proliferation	PMID:9176392^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(EMAPA:16846) acts_on_population_of:(CL:0000182)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92934	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006007	glucose catabolic process	PMID:12931191^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2675966 MGI:MGI:3029528	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:12142566^[19]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11980919^[20]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16985) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:12727206^[16]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:A7MCM4	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92934	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620103	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92934	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[21]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:12931191^[13]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92934	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620103	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:11146504^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q92934	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001836	release of cytochrome c from mitochondria	PMID:12431371^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3029528	P		Seeded From UniProt	complete
involved_in	GO:1904710	positive regulation of granulosa cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
enables	GO:0071889	14-3-3 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	F		Seeded From UniProt	complete
involved_in	GO:0071247	cellular response to chromate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
enables	GO:0043422	protein kinase B binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	F		Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0034201	response to oleic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0033574	response to testosterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
enables	GO:0030346	protein phosphatase 2B binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	F		Seeded From UniProt	complete
involved_in	GO:0021987	cerebral cortex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0097202	activation of cysteine-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	P		Seeded From UniProt	complete
involved_in	GO:0097193	intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	P		Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	P		Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	P		Seeded From UniProt	complete
involved_in	GO:0071316	cellular response to nicotine	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	P		Seeded From UniProt	complete
involved_in	GO:0046931	pore complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	P		Seeded From UniProt	complete
involved_in	GO:0046902	regulation of mitochondrial membrane permeability	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	P		Seeded From UniProt	complete
involved_in	GO:0045862	positive regulation of proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	F		Seeded From UniProt	complete
enables	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	F		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	F		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	C		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q92934 ensembl:ENSP00000378040	F		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:A0A024R562 ensembl:ENSP00000378040	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018868	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-NUL-3139045	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Niture, SK & Jaiswal, AK (2011) Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis. J. Biol. Chem. 286 44542-56 PubMed GONUTS page
↑ Ohta, T et al. (2006) Inhibition of phosphatidylinositol 3-kinase increases efficacy of cisplatin in in vivo ovarian cancer models. Endocrinology 147 1761-9 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Küper, C et al. (2011) Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells. Kidney Int. 80 938-945 PubMed GONUTS page
↑ Torii, S et al. (2011) Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins. Cell Death Differ. 18 1711-25 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Danial, NN et al. (2008) Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat. Med. 14 144-53 PubMed GONUTS page
↑ Deng, H et al. (2011) Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells. Int. J. Biochem. Cell Biol. 43 409-15 PubMed GONUTS page
↑ ^7.0 ^7.1 Quoyer, J et al. (2010) GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells. J. Biol. Chem. 285 1989-2002 PubMed GONUTS page
↑ ^8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Datta, SR et al. (2002) Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev. Cell 3 631-43 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 Yu, C et al. (2004) JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol. Cell 13 329-40 PubMed GONUTS page
↑ ^11.0 ^11.1 Chiang, CW et al. (2003) Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. Mol. Cell. Biol. 23 6350-62 PubMed GONUTS page
↑ Ayllón, V et al. (2002) The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad. Eur. J. Immunol. 32 1847-55 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 Danial, NN et al. (2003) BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 424 952-6 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Seo, SY et al. (2004) BAD is a pro-survival factor prior to activation of its pro-apoptotic function. J. Biol. Chem. 279 42240-9 PubMed GONUTS page
↑ Dramsi, S et al. (2002) Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity. J. Biol. Chem. 277 6399-405 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 Hsieh, YC et al. (2003) Cloning of zebrafish BAD, a BH3-only proapoptotic protein, whose overexpression leads to apoptosis in COS-1 cells and zebrafish embryos. Biochem. Biophys. Res. Commun. 304 667-75 PubMed GONUTS page
↑ ^17.0 ^17.1 Yang, E et al. (1995) Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80 285-91 PubMed GONUTS page
↑ Tzung, SP et al. (1997) Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene. Am. J. Pathol. 150 1985-95 PubMed GONUTS page
↑ Shibata, M et al. (2002) Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice. J. Cereb. Blood Flow Metab. 22 810-20 PubMed GONUTS page
↑ Putcha, GV et al. (2002) Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. J. Cell Biol. 157 441-53 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
↑ Dominov, JA et al. (2001) Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis. Dev. Dyn. 220 18-26 PubMed GONUTS page

[PMID:22072718-1] Niture, SK & Jaiswal, AK (2011) Inhibitor of Nrf2 (INrf2 or Keap1) protein degrades Bcl-xL via phosphoglycerate mutase 5 and controls cellular apoptosis. J. Biol. Chem. 286 44542-56 PubMed GONUTS page

[PMID:16396982-2] Ohta, T et al. (2006) Inhibition of phosphatidylinositol 3-kinase increases efficacy of cisplatin in in vivo ovarian cancer models. Endocrinology 147 1761-9 PubMed GONUTS page

[PMID:21716255-3] 3.0 ^3.1 ^3.2 Küper, C et al. (2011) Cyclooxygenase-2-dependent phosphorylation of the pro-apoptotic protein Bad inhibits tonicity-induced apoptosis in renal medullary cells. Kidney Int. 80 938-945 PubMed GONUTS page

[PMID:21546903-4] Torii, S et al. (2011) Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins. Cell Death Differ. 18 1711-25 PubMed GONUTS page

[PMID:18223655-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 ^5.8 ^5.9 Danial, NN et al. (2008) Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat. Med. 14 144-53 PubMed GONUTS page

[PMID:21095239-6] Deng, H et al. (2011) Phosphorylation of Bcl-associated death protein (Bad) by erythropoietin-activated c-Jun N-terminal protein kinase 1 contributes to survival of erythropoietin-dependent cells. Int. J. Biochem. Cell Biol. 43 409-15 PubMed GONUTS page

[PMID:19915011-7] 7.0 ^7.1 Quoyer, J et al. (2010) GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells. J. Biol. Chem. 285 1989-2002 PubMed GONUTS page

[PMID:21873635-8] 8.00 ^8.01 ^8.02 ^8.03 ^8.04 ^8.05 ^8.06 ^8.07 ^8.08 ^8.09 ^8.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:12431371-9] 9.0 ^9.1 ^9.2 ^9.3 ^9.4 ^9.5 Datta, SR et al. (2002) Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Dev. Cell 3 631-43 PubMed GONUTS page

[PMID:14967141-10] 10.0 ^10.1 ^10.2 Yu, C et al. (2004) JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol. Cell 13 329-40 PubMed GONUTS page

[PMID:12944463-11] 11.0 ^11.1 Chiang, CW et al. (2003) Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis. Mol. Cell. Biol. 23 6350-62 PubMed GONUTS page

[PMID:12115603-12] Ayllón, V et al. (2002) The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad. Eur. J. Immunol. 32 1847-55 PubMed GONUTS page

[PMID:12931191-13] 13.0 ^13.1 ^13.2 ^13.3 Danial, NN et al. (2003) BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 424 952-6 PubMed GONUTS page

[PMID:15231831-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 Seo, SY et al. (2004) BAD is a pro-survival factor prior to activation of its pro-apoptotic function. J. Biol. Chem. 279 42240-9 PubMed GONUTS page

[PMID:11717309-15] Dramsi, S et al. (2002) Identification of a novel phosphorylation site, Ser-170, as a regulator of bad pro-apoptotic activity. J. Biol. Chem. 277 6399-405 PubMed GONUTS page

[PMID:12727206-16] 16.0 ^16.1 ^16.2 Hsieh, YC et al. (2003) Cloning of zebrafish BAD, a BH3-only proapoptotic protein, whose overexpression leads to apoptosis in COS-1 cells and zebrafish embryos. Biochem. Biophys. Res. Commun. 304 667-75 PubMed GONUTS page

[PMID:7834748-17] 17.0 ^17.1 Yang, E et al. (1995) Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80 285-91 PubMed GONUTS page

[PMID:9176392-18] Tzung, SP et al. (1997) Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene. Am. J. Pathol. 150 1985-95 PubMed GONUTS page

[PMID:12142566-19] Shibata, M et al. (2002) Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice. J. Cereb. Blood Flow Metab. 22 810-20 PubMed GONUTS page

[PMID:11980919-20] Putcha, GV et al. (2002) Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. J. Cell Biol. 157 441-53 PubMed GONUTS page

[PMID:18614015-21] Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page

[PMID:11146504-22] Dominov, JA et al. (2001) Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis. Dev. Dyn. 220 18-26 PubMed GONUTS page

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MOUSE:BAD

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