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HUMAN:PIDD

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) PIDD (synonyms: LRDD)
Protein Name(s) p53-induced protein with a death domain

Leucine-rich repeat and death domain-containing protein

External Links
UniProt Q9HB75
EMBL AF229178
AF274972
AF465246
AK074893
AB208832
AB208949
AB209529
AL833849
BC014904
RefSeq NP_665893.2
NP_665894.2
UniGene Hs.592290
PDB 2OF5
PDBsum 2OF5
ProteinModelPortal Q9HB75
SMR Q9HB75
BioGrid 120645
IntAct Q9HB75
MINT MINT-1474528
MEROPS S68.001
PhosphoSite Q9HB75
DMDM 116242715
PaxDb Q9HB75
PRIDE Q9HB75
DNASU 55367
Ensembl ENST00000347755
ENST00000411829
GeneID 55367
KEGG hsa:55367
UCSC uc001lrk.2
uc001lrl.1
uc001lrm.1
uc001lrp.2
CTD 55367
GeneCards GC11M000799
H-InvDB HIX0021767
HGNC HGNC:16491
HPA CAB012647
HPA055473
MIM 605247
neXtProt NX_Q9HB75
PharmGKB PA30445
eggNOG NOG310879
HOVERGEN HBG066762
InParanoid Q9HB75
KO K10130
OMA VPHFSWF
OrthoDB EOG7BP81T
PhylomeDB Q9HB75
TreeFam TF331183
SignaLink Q9HB75
ChiTaRS PIDD
EvolutionaryTrace Q9HB75
GeneWiki LRDD
GenomeRNAi 55367
NextBio 59757
PRO PR:Q9HB75
ArrayExpress Q9HB75
Bgee Q9HB75
Genevestigator Q9HB75
GO GO:0005737
GO:0005634
GO:0005123
GO:0005515
GO:0006919
GO:0006974
GO:0006977
GO:0043066
GO:0043065
GO:1902043
GO:0051092
GO:0007165
Gene3D 1.10.533.10
InterPro IPR011029
IPR000488
IPR001611
IPR003591
IPR019502
IPR000906
Pfam PF00531
PF00560
PF13855
PF10461
PF00791
SMART SM00005
SM00369
SUPFAM SSF47986
PROSITE PS50017
PS51450
PS51145

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0006915

apoptotic process

PMID:17159900[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:17159900[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:17159900[1]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:17159900[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0016540

protein autoprocessing

PMID:17159900[1]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0004175

endopeptidase activity

PMID:17159900[1]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043122

regulation of I-kappaB kinase/NF-kappaB signaling

PMID:17159900[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043066

negative regulation of apoptotic process

PMID:21726810[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

part_of:(GO:0006974)

Seeded From UniProt

complete

involved_in

GO:0006977

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

PMID:21726810[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

PMID:21726810[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21726810[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:21726810[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0098656

anion transmembrane transport

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001140629
UniProtKB:Q6NSJ5
UniProtKB:Q6P9F7
UniProtKB:Q7L1W4
UniProtKB:Q8TDW0

P

Seeded From UniProt

complete

part_of

GO:0034702

ion channel complex

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001140629
UniProtKB:Q8IWT6

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1889507
PANTHER:PTN001140629
UniProtKB:Q6NSJ5
UniProtKB:Q6P9F7
UniProtKB:Q7L1W4
UniProtKB:Q8TDW0
UniProtKB:Q9HB75

C

Seeded From UniProt

complete

enables

GO:0005225

volume-sensitive anion channel activity

PMID:21873635[3]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001140629
RGD:1311690
UniProtKB:Q6NSJ5
UniProtKB:Q7L1W4
UniProtKB:Q8IWT6
UniProtKB:Q8TDW0

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

GO_REF:0000052

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0015698

inorganic anion transport

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0005225

P

Seeded From UniProt

complete

involved_in

GO:0097191

extrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERV7
ensembl:ENSMUSP00000026580

P

Seeded From UniProt

complete

involved_in

GO:0097190

apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERV7
ensembl:ENSMUSP00000026580

P

Seeded From UniProt

complete

involved_in

GO:0008625

extrinsic apoptotic signaling pathway via death domain receptors

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERV7
ensembl:ENSMUSP00000026580

P

Seeded From UniProt

complete

involved_in

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERV7
ensembl:ENSMUSP00000026580

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q9ERV7
ensembl:ENSMUSP00000026580

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019502

P

Seeded From UniProt

complete

involved_in

GO:0006974

cellular response to DNA damage stimulus

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR019502

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000488

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:10825539[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0005123

death receptor binding

PMID:10825539[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:18309324[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:18309324[5]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

Reactome:R-HSA-5633008

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-HSA-6800798
Reactome:R-HSA-6800797
Reactome:R-HSA-6800794
Reactome:R-HSA-6800793

ECO:0000304

author statement supported by traceable reference used in manual assertion




C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

Reactome:R-HSA-6800793
Reactome:R-HSA-6800490
Reactome:R-HSA-6800396

ECO:0000304

author statement supported by traceable reference used in manual assertion



C

Seeded From UniProt

complete

enables

GO:0016787

hydrolase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0378

F

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

edit table

Notes

References

See Help:References for how to manage references in GONUTS.

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Tinel, A et al. (2007) Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. EMBO J. 26 197-208 PubMed GONUTS page
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Oliver, TG et al. (2011) Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Mol. Cell 43 57-71 PubMed GONUTS page
  3. ↑ 3.0 3.1 3.2 3.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  4. ↑ 4.0 4.1 Telliez, JB et al. (2000) LRDD, a novel leucine rich repeat and death domain containing protein. Biochim. Biophys. Acta 1478 280-8 PubMed GONUTS page
  5. ↑ 5.0 5.1 Galluzzi, L et al. (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15 1113-23 PubMed GONUTS page
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