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MOUSE:BAX
Contents
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0007283 |
spermatogenesis |
ECO:0000315 |
P |
Fig 2 A, C-J, Fig 3) Bax- mutants were incapable of spermatogenesis. |
complete | |||||
involved_in |
GO:0010917 |
negative regulation of mitochondrial membrane potential |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0051087 |
chaperone binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
happens_during:(GO:0033554) |
Seeded From UniProt |
complete | ||
enables |
GO:0051087 |
chaperone binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
happens_during:(GO:0033554) |
Seeded From UniProt |
complete | ||
enables |
GO:0030544 |
Hsp70 protein binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
happens_during:(GO:0033554) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
exists_during:(GO:0006915) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0097144 |
BAX complex |
ECO:0000353 |
physical interaction evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:2001244 |
positive regulation of intrinsic apoptotic signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:1900103 |
positive regulation of endoplasmic reticulum unfolded protein response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0097144 |
BAX complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0097136 |
Bcl-2 family protein complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0090200 |
positive regulation of release of cytochrome c from mitochondria |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0046930 |
pore complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043653 |
mitochondrial fragmentation involved in apoptotic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043496 |
regulation of protein homodimerization activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032976 |
release of matrix enzymes from mitochondria |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032461 |
positive regulation of protein oligomerization |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032091 |
negative regulation of protein binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0015267 |
channel activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010248 |
establishment or maintenance of transmembrane electrochemical gradient |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0008289 |
lipid binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008053 |
mitochondrial fusion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005757 |
mitochondrial permeability transition pore complex |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097192 |
extrinsic apoptotic signaling pathway in absence of ligand |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:101769 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:88138 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:99702 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1330841 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0015267 |
channel activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000883418 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008630 |
intrinsic apoptotic signaling pathway in response to DNA damage |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0029131 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008053 |
mitochondrial fusion |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:99702 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:88139 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001836 |
release of cytochrome c from mitochondria |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:99702 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:2001244 |
positive regulation of intrinsic apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2158306 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:2001244 |
positive regulation of intrinsic apoptotic signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:2001234 |
negative regulation of apoptotic signaling pathway |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2675387 |
P |
regulates_o_occurs_in:(CL:0000670) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:1990117 |
B cell receptor apoptotic signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1902512 |
positive regulation of apoptotic DNA fragmentation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1902445 |
regulation of mitochondrial membrane permeability involved in programmed necrotic cell death |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3589203 |
P |
regulates_o_occurs_in:(CL:0000057) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:1902263 |
apoptotic process involved in embryonic digit morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1197519 |
P |
occurs_in:(EMAPA:17445)|occurs_in:(EMAPA:17448)|occurs_in:(EMAPA:17451)|occurs_in:(EMAPA:17454)|occurs_in:(EMAPA:17476)|occurs_in:(EMAPA:17479)|occurs_in:(EMAPA:17482)|occurs_in:(EMAPA:17485) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:1902262 |
apoptotic process involved in blood vessel morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1097161 |
P |
occurs_in:(EMAPA:16198)|occurs_in:(EMAPA:32743) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:1902110 |
positive regulation of mitochondrial membrane permeability involved in apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1197519 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:1902108 |
regulation of mitochondrial membrane permeability involved in apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:108093 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:1902108 |
regulation of mitochondrial membrane permeability involved in apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:108093 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:1900103 |
positive regulation of endoplasmic reticulum unfolded protein response |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0097296 |
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0097193 |
intrinsic apoptotic signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0097192 |
extrinsic apoptotic signaling pathway in absence of ligand |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1197519 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0097192 |
extrinsic apoptotic signaling pathway in absence of ligand |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1097161 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0097191 |
extrinsic apoptotic signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0097190 |
apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0097190 |
apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0097190 |
apoptotic signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0097144 |
BAX complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0097136 |
Bcl-2 family protein complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0090200 |
positive regulation of release of cytochrome c from mitochondria |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0072332 |
intrinsic apoptotic signaling pathway by p53 class mediator |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
colocalizes_with |
GO:0071944 |
cell periphery |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0071310 |
cellular response to organic substance |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0070584 |
mitochondrion morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:88139 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0070242 |
thymocyte apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1197519 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0070059 |
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1097161 |
P |
occurs_in:(CL:0000057) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0070059 |
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1097161 |
P |
occurs_in:(CL:0000057) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0070059 |
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0060068 |
vagina development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1097161 |
P |
results_in_development_of:(EMAPA:18986) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0060058 |
positive regulation of apoptotic process involved in mammary gland involution |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0060041 |
retina development in camera-type eye |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0060011 |
Sertoli cell proliferation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1857389 |
P |
Seeded From UniProt |
complete | ||
NOT|acts_upstream_of_or_within |
GO:0051881 |
regulation of mitochondrial membrane potential |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051726 |
regulation of cell cycle |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1097161 |
P |
occurs_in:(CL:0000236) |
Seeded From UniProt |
complete | |
enables |
GO:0051434 |
BH3 domain binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051402 |
neuron apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:95819 |
P |
occurs_in:(EMAPA:35883) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0051402 |
neuron apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:97321 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0051402 |
neuron apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:88138 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0051402 |
neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0051402 |
neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051402 |
neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0051402 |
neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0051402 |
neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051402 |
neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0051400 |
BH domain binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2192 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0051281 |
positive regulation of release of sequestered calcium ion into cytosol |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0051260 |
protein homooligomerization |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051260 |
protein homooligomerization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0051259 |
protein complex oligomerization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0051087 |
chaperone binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2192 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0048873 |
homeostasis of number of cells within a tissue |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857249 |
P |
occurs_in:(EMAPA:35169)|occurs_in:(EMAPA:35421) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0048873 |
homeostasis of number of cells within a tissue |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0048872 |
homeostasis of number of cells |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1097161 |
P |
regulates_o_occurs_in:(EMAPA:32679) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0048872 |
homeostasis of number of cells |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
regulates_o_occurs_in:(EMAPA:35850) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0048678 |
response to axon injury |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0048597 |
post-embryonic camera-type eye morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1097161 |
P |
has_participant:(EMAPA:16198)|has_participant:(EMAPA:32743) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0048515 |
spermatid differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
|
Seeded From UniProt |
complete | |
part_of |
GO:0048471 |
perinuclear region of cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2192 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0048147 |
negative regulation of fibroblast proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0048087 |
positive regulation of developmental pigmentation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:99702 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2192 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0046930 |
pore complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0046666 |
retinal cell programmed cell death |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
occurs_in:(EMAPA:17168)|occurs_in:(EMAPA:16674) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0045333 |
cellular respiration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2192 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045136 |
development of secondary sexual characteristics |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0044877 |
protein-containing complex binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2192 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043653 |
mitochondrial fragmentation involved in apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:88139 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:95813 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:95824 |
P |
occurs_in:(EMAPA:19037) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:107202 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
occurs_in:(EMAPA:16668)|occurs_in:(EMAPA:16668)|occurs_in:(EMAPA:16668)|occurs_in:(EMAPA:16797)|occurs_in:(EMAPA:16797)|occurs_in:(EMAPA:16797)|occurs_in:(EMAPA:16797)|occurs_in:(EMAPA:16797)|occurs_in:(EMAPA:16797)|occurs_in:(EMAPA:16797)|occurs_in:(EMAPA:16797)|occurs_in:(EMAPA:17571)|occurs_in:(EMAPA:17571)|occurs_in:(EMAPA:17571)|occurs_in:(EMAPA:17571)|occurs_in:(EMAPA:17571)|occurs_in:(EMAPA:32769)|occurs_in:(EMAPA:32770) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
occurs_in:(EMAPA:35338) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
regulates_o_occurs_in:(CL:0000101)|regulates_o_occurs_in:(CL:0000100) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2158306 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2158306 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
regulates_o_occurs_in:(EMAPA:16797)|regulates_o_occurs_in:(EMAPA:17155) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
regulates_o_occurs_in:(CL:0000540) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043523 |
regulation of neuron apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043497 |
regulation of protein heterodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043496 |
regulation of protein homodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043281 |
regulation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:98834 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:88139 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:96974 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:102845 |
P |
occurs_in:(EMAPA:18323) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
occurs_in:(EMAPA:17023) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
regulates_o_occurs_in:(CL:0000540) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
occurs_in:(EMAPA:16039) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2192 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0042475 |
odontogenesis of dentin-containing tooth |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1197519 |
P |
has_participant:(EMAPA:32889) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0035234 |
ectopic germ cell programmed cell death |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:96974 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0035234 |
ectopic germ cell programmed cell death |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:96677 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0035234 |
ectopic germ cell programmed cell death |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0035108 |
limb morphogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1097161 |
P |
has_participant:(EMAPA:32722) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0034644 |
cellular response to UV |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:98834 |
P |
occurs_in:(CL:0000057) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0033599 |
regulation of mammary gland epithelial cell proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0033137 |
negative regulation of peptidyl-serine phosphorylation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1097161 |
P |
regulates_o_has_input:(MGI:MGI:96623) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0032976 |
release of matrix enzymes from mitochondria |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0032471 |
negative regulation of endoplasmic reticulum calcium ion concentration |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1097161 |
P |
regulates_o_occurs_in:(CL:0000057) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0032461 |
positive regulation of protein oligomerization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0032091 |
negative regulation of protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0031966 |
mitochondrial membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0031966 |
mitochondrial membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0031966 |
mitochondrial membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0031966 |
mitochondrial membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2192 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0031072 |
heat shock protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2192 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0021987 |
cerebral cortex development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
results_in_development_of:(EMAPA:35169) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0021854 |
hypothalamus development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
results_in_development_of:(EMAPA:35421) |
Seeded From UniProt |
complete | |
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
Missing: with/from | |||
enables |
GO:0015267 |
channel activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0010917 |
negative regulation of mitochondrial membrane potential |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0010524 |
positive regulation of calcium ion transport into cytosol |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1097161 |
P |
regulates_o_occurs_in:(CL:0000057) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0010332 |
response to gamma radiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
occurs_in:(EMAPA:17023) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0010248 |
establishment or maintenance of transmembrane electrochemical gradient |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0010212 |
response to ionizing radiation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:107202 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0010212 |
response to ionizing radiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0009791 |
post-embryonic development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:88138 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0009651 |
response to salt stress |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:102845 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0009636 |
response to toxic substance |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0009636 |
response to toxic substance |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0009611 |
response to wounding |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0009566 |
fertilization |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2176699 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008637 |
apoptotic mitochondrial changes |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0008637 |
apoptotic mitochondrial changes |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0008635 |
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008635 |
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0008635 |
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0008630 |
intrinsic apoptotic signaling pathway in response to DNA damage |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1197519 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0008630 |
intrinsic apoptotic signaling pathway in response to DNA damage |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1097161 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008630 |
intrinsic apoptotic signaling pathway in response to DNA damage |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008625 |
extrinsic apoptotic signaling pathway via death domain receptors |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0008584 |
male gonad development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:88138 |
P |
results_in_development_of:(EMAPA:31476) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0008584 |
male gonad development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
results_in_development_of:(EMAPA:17972) |
Seeded From UniProt |
complete | |
enables |
GO:0008289 |
lipid binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008283 |
cell population proliferation |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:88138 |
P |
acts_on_population_of:(CL:0000540) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0008283 |
cell population proliferation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008053 |
mitochondrial fusion |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008053 |
mitochondrial fusion |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008053 |
mitochondrial fusion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007548 |
sex differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
has_participant:(EMAPA:35169)|has_participant:(EMAPA:35421) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0007399 |
nervous system development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2387665 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007283 |
spermatogenesis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2176699 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007283 |
spermatogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007283 |
spermatogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007281 |
germ cell development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2176699 |
P |
results_in_development_of:(CL:0000020) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0007008 |
outer mitochondrial membrane organization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2192 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007007 |
inner mitochondrial membrane organization |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2192 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
occurs_in:(CL:0000540) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0006974 |
cellular response to DNA damage stimulus |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1097161 |
P |
has_regulation_target:(MGI:MGI:1312922) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1097161 |
P |
has_regulation_target:(MGI:MGI:1312922) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
regulates_o_occurs_in:(EMAPA:17606) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:2158306 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006915 |
apoptotic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0006915 |
apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006915 |
apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0006915 |
apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2192 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0006808 |
regulation of nitrogen utilization |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:88138 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0006687 |
glycosphingolipid metabolic process |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
occurs_in:(EMAPA:17972) |
Seeded From UniProt |
complete | |
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2192 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005757 |
mitochondrial permeability transition pore complex |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2192 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:16846)|part_of:(EMAPA:16894)|part_of:(EMAPA:17373) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000084) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2192 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000057) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(CL:0000084) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:35836) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
|
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:17331) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2192 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0002904 |
positive regulation of B cell apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:97250 |
P |
regulates_o_occurs_in:(CL:0000236) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0002358 |
B cell homeostatic proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0002352 |
B cell negative selection |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1097161 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0002262 |
myeloid cell homeostasis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1197519 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001974 |
blood vessel remodeling |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1097161 |
P |
has_participant:(EMAPA:16198)|has_participant:(EMAPA:32743) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0001844 |
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001836 |
release of cytochrome c from mitochondria |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:108093 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001836 |
release of cytochrome c from mitochondria |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:98834 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001836 |
release of cytochrome c from mitochondria |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0001836 |
release of cytochrome c from mitochondria |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0001836 |
release of cytochrome c from mitochondria |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0001836 |
release of cytochrome c from mitochondria |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0001836 |
release of cytochrome c from mitochondria |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0001822 |
kidney development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:88138 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001783 |
B cell apoptotic process |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1097161 |
P |
occurs_in:(CL:0000236) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0001783 |
B cell apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0001782 |
B cell homeostasis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1197519 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001782 |
B cell homeostasis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001777 |
T cell homeostatic proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
acts_on_population_of:(CL:0000051) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0001777 |
T cell homeostatic proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001776 |
leukocyte homeostasis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1197519 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001776 |
leukocyte homeostasis |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1097161 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0001764 |
neuron migration |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0001541 |
ovarian follicle development |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:2176699 |
P |
results_in_development_of:(EMAPA:30755) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0001541 |
ovarian follicle development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:1857429 |
P |
results_in_development_of:(EMAPA:35627) |
Seeded From UniProt |
complete | |
involved_in |
GO:2001244 |
positive regulation of intrinsic apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1990117 |
B cell receptor apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1902512 |
positive regulation of apoptotic DNA fragmentation |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:1900103 |
positive regulation of endoplasmic reticulum unfolded protein response |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097193 |
intrinsic apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097191 |
extrinsic apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0097190 |
apoptotic signaling pathway |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0097144 |
BAX complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0097136 |
Bcl-2 family protein complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0090200 |
positive regulation of release of cytochrome c from mitochondria |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0071944 |
cell periphery |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0070059 |
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0051434 |
BH3 domain binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051260 |
protein homooligomerization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0051259 |
protein complex oligomerization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0046930 |
pore complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043653 |
mitochondrial fragmentation involved in apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043525 |
positive regulation of neuron apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043497 |
regulation of protein heterodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043496 |
regulation of protein homodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0042802 |
identical protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032976 |
release of matrix enzymes from mitochondria |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032461 |
positive regulation of protein oligomerization |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0032091 |
negative regulation of protein binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0015267 |
channel activity |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0010248 |
establishment or maintenance of transmembrane electrochemical gradient |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0009636 |
response to toxic substance |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008637 |
apoptotic mitochondrial changes |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008635 |
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008289 |
lipid binding |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0008053 |
mitochondrial fusion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005829 |
cytosol |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005789 |
endoplasmic reticulum membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005783 |
endoplasmic reticulum |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005757 |
mitochondrial permeability transition pore complex |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005635 |
nuclear envelope |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005634 |
nucleus |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
C |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001836 |
release of cytochrome c from mitochondria |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0001783 |
B cell apoptotic process |
ECO:0000265 |
sequence orthology evidence used in automatic assertion |
UniProtKB:Q07812 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0042981 |
regulation of apoptotic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR020717 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:2001241 |
positive regulation of extrinsic apoptotic signaling pathway in absence of ligand |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042802 |
identical protein binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005741 |
mitochondrial outer membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016032 |
viral process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005739 |
mitochondrion |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0016021 |
integral component of membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006915 |
apoptotic process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 Knudson, CM et al. (1995) Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270 96-9 PubMed GONUTS page
- ↑ Llambi, F et al. (2016) BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation. Cell 165 421-33 PubMed GONUTS page
- ↑ D'Orsi, B et al. (2016) Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury. J. Neurosci. 36 4564-78 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 Gotoh, T et al. (2004) hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria. Cell Death Differ. 11 390-402 PubMed GONUTS page
- ↑ Ekholm-Reed, S et al. (2013) Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1. Mol. Cell. Biol. 33 3627-43 PubMed GONUTS page
- ↑ Tan, KO et al. (2001) MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains. J. Biol. Chem. 276 2802-7 PubMed GONUTS page
- ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ 8.0 8.1 8.2 Young, C et al. (2003) Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain. Cell Death Differ. 10 1148-55 PubMed GONUTS page
- ↑ Suzuki, H et al. (2008) Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways. Dev. Biol. 318 133-42 PubMed GONUTS page
- ↑ Whelan, RS et al. (2012) Bax regulates primary necrosis through mitochondrial dynamics. Proc. Natl. Acad. Sci. U.S.A. 109 6566-71 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 11.4 11.5 11.6 11.7 11.8 Hutcheson, J et al. (2005) Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis. J. Exp. Med. 201 1949-60 PubMed GONUTS page
- ↑ 12.0 12.1 12.2 Hahn, P et al. (2005) Persistent fetal ocular vasculature in mice deficient in bax and bak. Arch. Ophthalmol. 123 797-802 PubMed GONUTS page
- ↑ Shamas-Din, A et al. (2013) tBid undergoes multiple conformational changes at the membrane required for Bax activation. J. Biol. Chem. 288 22111-27 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Chipuk, JE et al. (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303 1010-4 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 Cregan, SP et al. (1999) Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons. J. Neurosci. 19 7860-9 PubMed GONUTS page
- ↑ Lum, JJ et al. (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120 237-48 PubMed GONUTS page
- ↑ 17.0 17.1 17.2 Dong, H et al. (2003) Enhanced oligodendrocyte survival after spinal cord injury in Bax-deficient mice and mice with delayed Wallerian degeneration. J. Neurosci. 23 8682-91 PubMed GONUTS page
- ↑ 18.0 18.1 18.2 18.3 18.4 18.5 Valentijn, AJ et al. (2003) Spatial and temporal changes in Bax subcellular localization during anoikis. J. Cell Biol. 162 599-612 PubMed GONUTS page
- ↑ Mu, J et al. (2003) Apoptosis and related proteins in placenta of intrauterine fetal death in prostaglandin f receptor-deficient mice. Biol. Reprod. 68 1968-74 PubMed GONUTS page
- ↑ 20.0 20.1 Cleland, MM et al. (2011) Bcl-2 family interaction with the mitochondrial morphogenesis machinery. Cell Death Differ. 18 235-47 PubMed GONUTS page
- ↑ 21.0 21.1 Ruiz-Vela, A et al. (2005) Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep. 6 379-85 PubMed GONUTS page
- ↑ 22.0 22.1 22.2 22.3 22.4 Zong, WX et al. (2003) Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J. Cell Biol. 162 59-69 PubMed GONUTS page
- ↑ 23.0 23.1 23.2 23.3 Lindsten, T et al. (2000) The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol. Cell 6 1389-99 PubMed GONUTS page
- ↑ 24.0 24.1 Schorr, K et al. (1999) Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo. Cancer Res. 59 2541-5 PubMed GONUTS page
- ↑ 25.0 25.1 Mosinger Ogilvie, J et al. (1998) Suppression of developmental retinal cell death but not of photoreceptor degeneration in Bax-deficient mice. Invest. Ophthalmol. Vis. Sci. 39 1713-20 PubMed GONUTS page
- ↑ Ross, AJ et al. (2001) BCLW mediates survival of postmitotic Sertoli cells by regulating BAX activity. Dev. Biol. 239 295-308 PubMed GONUTS page
- ↑ 27.0 27.1 27.2 Heimlich, G et al. (2004) Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6. Biochem. J. 378 247-55 PubMed GONUTS page
- ↑ 28.0 28.1 28.2 28.3 Takeuchi, O et al. (2005) Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc. Natl. Acad. Sci. U.S.A. 102 11272-7 PubMed GONUTS page
- ↑ de Rivero Vaccari, JC et al. (2006) NMDA receptors promote survival in somatosensory relay nuclei by inhibiting Bax-dependent developmental cell death. Proc. Natl. Acad. Sci. U.S.A. 103 16971-6 PubMed GONUTS page
- ↑ Laforet, GA et al. (2001) Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease. J. Neurosci. 21 9112-23 PubMed GONUTS page
- ↑ 31.0 31.1 31.2 31.3 Middleton, G et al. (2000) Differences in bcl-2- and bax-independent function in regulating apoptosis in sensory neuron populations. Eur. J. Neurosci. 12 819-27 PubMed GONUTS page
- ↑ Weiner, JA et al. (2005) Gamma protocadherins are required for synaptic development in the spinal cord. Proc. Natl. Acad. Sci. U.S.A. 102 8-14 PubMed GONUTS page
- ↑ 33.0 33.1 Potts, PR et al. (2003) Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis. J. Cell Biol. 163 789-99 PubMed GONUTS page
- ↑ Sun, W et al. (2003) Neuromuscular development after the prevention of naturally occurring neuronal death by Bax deletion. J. Neurosci. 23 7298-310 PubMed GONUTS page
- ↑ 35.0 35.1 35.2 Vila, M et al. (2001) Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Proc. Natl. Acad. Sci. U.S.A. 98 2837-42 PubMed GONUTS page
- ↑ Roth, KA et al. (2000) Epistatic and independent functions of caspase-3 and Bcl-X(L) in developmental programmed cell death. Proc. Natl. Acad. Sci. U.S.A. 97 466-71 PubMed GONUTS page
- ↑ 37.0 37.1 Shi, J et al. (2005) Bax limits adult neural stem cell persistence through caspase and IP3 receptor activation. Cell Death Differ. 12 1601-12 PubMed GONUTS page
- ↑ 38.0 38.1 38.2 38.3 Forger, NG et al. (2004) Deletion of Bax eliminates sex differences in the mouse forebrain. Proc. Natl. Acad. Sci. U.S.A. 101 13666-71 PubMed GONUTS page
- ↑ Fan, H et al. (2001) Elimination of Bax expression in mice increases cerebellar purkinje cell numbers but not the number of granule cells. J. Comp. Neurol. 436 82-91 PubMed GONUTS page
- ↑ 40.0 40.1 Zeng, Q et al. (2000) Gustatory innervation and bax-dependent caspase-2: participants in the life and death pathways of mouse taste receptor cells. J. Comp. Neurol. 424 640-50 PubMed GONUTS page
- ↑ 41.0 41.1 Libby, RT et al. (2005) Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage. PLoS Genet. 1 17-26 PubMed GONUTS page
- ↑ 42.0 42.1 Coultas, L et al. (2005) Concomitant loss of proapoptotic BH3-only Bcl-2 antagonists Bik and Bim arrests spermatogenesis. EMBO J. 24 3963-73 PubMed GONUTS page
- ↑ 43.0 43.1 43.2 43.3 Shibue, T et al. (2003) Integral role of Noxa in p53-mediated apoptotic response. Genes Dev. 17 2233-8 PubMed GONUTS page
- ↑ 44.0 44.1 44.2 44.3 44.4 44.5 44.6 Knudson, CM & Korsmeyer, SJ (1997) Bcl-2 and Bax function independently to regulate cell death. Nat. Genet. 16 358-63 PubMed GONUTS page
- ↑ Wang, K et al. (1996) BID: a novel BH3 domain-only death agonist. Genes Dev. 10 2859-69 PubMed GONUTS page
- ↑ 46.0 46.1 Simonian, PL et al. (1996) Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL. J. Biol. Chem. 271 22764-72 PubMed GONUTS page
- ↑ Yang, E et al. (1995) Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80 285-91 PubMed GONUTS page
- ↑ Chao, DT et al. (1995) Bcl-XL and Bcl-2 repress a common pathway of cell death. J. Exp. Med. 182 821-8 PubMed GONUTS page
- ↑ Péquignot, MO et al. (2003) Major role of BAX in apoptosis during retinal development and in establishment of a functional postnatal retina. Dev. Dyn. 228 231-8 PubMed GONUTS page
- ↑ 50.0 50.1 Jacob, DA et al. (2005) Effects of Bax gene deletion on muscle and motoneuron degeneration in a sexually dimorphic neuromuscular system. J. Neurosci. 25 5638-44 PubMed GONUTS page
- ↑ Shindler, KS et al. (1997) Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice. J. Neurosci. 17 3112-9 PubMed GONUTS page
- ↑ Selimi, F et al. (2000) Bax inactivation in lurcher mutants rescues cerebellar granule cells but not purkinje cells or inferior olivary neurons. J. Neurosci. 20 5339-45 PubMed GONUTS page
- ↑ Almeida, OF et al. (2000) Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate. FASEB J. 14 779-90 PubMed GONUTS page
- ↑ 54.0 54.1 Chong, MJ et al. (2000) Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system. Proc. Natl. Acad. Sci. U.S.A. 97 889-94 PubMed GONUTS page
- ↑ White, FA et al. (1998) Widespread elimination of naturally occurring neuronal death in Bax-deficient mice. J. Neurosci. 18 1428-39 PubMed GONUTS page
- ↑ Deckwerth, TL et al. (1996) BAX is required for neuronal death after trophic factor deprivation and during development. Neuron 17 401-11 PubMed GONUTS page
- ↑ Buss, RR et al. (2006) Neuromuscular development in the absence of programmed cell death: phenotypic alteration of motoneurons and muscle. J. Neurosci. 26 13413-27 PubMed GONUTS page
- ↑ Guo, H et al. (2005) Development of pontine noradrenergic A5 neurons requires brain-derived neurotrophic factor. Eur. J. Neurosci. 21 2019-23 PubMed GONUTS page
- ↑ 59.0 59.1 Sun, W et al. (2004) Programmed cell death of adult-generated hippocampal neurons is mediated by the proapoptotic gene Bax. J. Neurosci. 24 11205-13 PubMed GONUTS page
- ↑ Zaidi, AU et al. (2001) Bcl-X(L)-caspase-9 interactions in the developing nervous system: evidence for multiple death pathways. J. Neurosci. 21 169-75 PubMed GONUTS page
- ↑ Werth, JL et al. (2000) Reversible physiological alterations in sympathetic neurons deprived of NGF but protected from apoptosis by caspase inhibition or Bax deletion. Exp. Neurol. 161 203-11 PubMed GONUTS page
- ↑ Middleton, G et al. (1996) Bax promotes neuronal survival and antagonises the survival effects of neurotrophic factors. Development 122 695-701 PubMed GONUTS page
- ↑ Prasad, T et al. (2008) A differential developmental pattern of spinal interneuron apoptosis during synaptogenesis: insights from genetic analyses of the protocadherin-gamma gene cluster. Development 135 4153-64 PubMed GONUTS page
- ↑ Popper, P et al. (1997) TRPM-2 expression and tunel staining in neurodegenerative diseases: studies in wobbler and rd mice. Exp. Neurol. 143 246-54 PubMed GONUTS page
- ↑ 65.0 65.1 Runyan, C et al. (2006) Steel factor controls midline cell death of primordial germ cells and is essential for their normal proliferation and migration. Development 133 4861-9 PubMed GONUTS page
- ↑ 66.0 66.1 Fan, H et al. (2006) Susceptibility to metanephric apoptosis in bradykinin B2 receptor null mice via the p53-Bax pathway. Am. J. Physiol. Renal Physiol. 291 F670-82 PubMed GONUTS page
- ↑ Perez, GI et al. (1999) Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency. Nat. Genet. 21 200-3 PubMed GONUTS page
- ↑ 68.0 68.1 Przemeck, SM et al. (2007) Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2. Am. J. Physiol. Gastrointest. Liver Physiol. 292 G620-7 PubMed GONUTS page
- ↑ 69.0 69.1 Tessner, TG et al. (2004) Prostaglandin E2 reduces radiation-induced epithelial apoptosis through a mechanism involving AKT activation and bax translocation. J. Clin. Invest. 114 1676-85 PubMed GONUTS page
- ↑ 70.0 70.1 Russell, LD et al. (2002) Bax-dependent spermatogonia apoptosis is required for testicular development and spermatogenesis. Biol. Reprod. 66 950-8 PubMed GONUTS page
- ↑ Dargusch, R et al. (2001) The role of Bax in glutamate-induced nerve cell death. J. Neurochem. 76 295-301 PubMed GONUTS page
- ↑ Chi, MM et al. (2000) Decreased glucose transporter expression triggers BAX-dependent apoptosis in the murine blastocyst. J. Biol. Chem. 275 40252-7 PubMed GONUTS page
- ↑ Li, A & Harris, DA (2005) Mammalian prion protein suppresses Bax-induced cell death in yeast. J. Biol. Chem. 280 17430-4 PubMed GONUTS page
- ↑ 74.0 74.1 Zha, H et al. (1996) Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2. J. Biol. Chem. 271 7440-4 PubMed GONUTS page
- ↑ Vukosavic, S et al. (1999) Bax and Bcl-2 interaction in a transgenic mouse model of familial amyotrophic lateral sclerosis. J. Neurochem. 73 2460-8 PubMed GONUTS page
- ↑ 76.0 76.1 Stallock, J et al. (2003) The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo. Development 130 6589-97 PubMed GONUTS page
- ↑ 77.0 77.1 77.2 Oakes, SA et al. (2005) Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc. Natl. Acad. Sci. U.S.A. 102 105-10 PubMed GONUTS page
- ↑ 78.0 78.1 Putcha, GV et al. (2002) Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. J. Cell Biol. 157 441-53 PubMed GONUTS page
- ↑ 79.0 79.1 79.2 Zhao, Y et al. (2001) Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury. J. Biol. Chem. 276 27432-40 PubMed GONUTS page
- ↑ 80.0 80.1 Oltvai, ZN et al. (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74 609-19 PubMed GONUTS page
- ↑ 81.0 81.1 Xiang, H et al. (1998) Bax involvement in p53-mediated neuronal cell death. J. Neurosci. 18 1363-73 PubMed GONUTS page
- ↑ 82.0 82.1 82.2 82.3 Rucker, EB 3rd et al. (2000) Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis. Mol. Endocrinol. 14 1038-52 PubMed GONUTS page
- ↑ Degenhardt, K et al. (2002) Bax and Bak independently promote cytochrome C release from mitochondria. J. Biol. Chem. 277 14127-34 PubMed GONUTS page
- ↑ 84.0 84.1 84.2 Jürgensmeier, JM et al. (1998) Bax directly induces release of cytochrome c from isolated mitochondria. Proc. Natl. Acad. Sci. U.S.A. 95 4997-5002 PubMed GONUTS page
- ↑ Willis, SN et al. (2005) Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev. 19 1294-305 PubMed GONUTS page
- ↑ Lee, JH et al. (1999) Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene 18 6183-90 PubMed GONUTS page
- ↑ Tzung, SP et al. (1997) Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene. Am. J. Pathol. 150 1985-95 PubMed GONUTS page
- ↑ Karbowski, M et al. (2006) Role of Bax and Bak in mitochondrial morphogenesis. Nature 443 658-62 PubMed GONUTS page
- ↑ Pardo, J et al. (2006) The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice. J. Cell Biol. 174 509-19 PubMed GONUTS page
- ↑ Ma, L et al. (2003) Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons. Development 130 3525-34 PubMed GONUTS page
- ↑ Robinson, AM et al. (2003) Olfactory neurons in bax knockout mice are protected from bulbectomy-induced apoptosis. Neuroreport 14 1891-4 PubMed GONUTS page
- ↑ Hotchkiss, RS et al. (1999) Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J. Immunol. 162 4148-56 PubMed GONUTS page
- ↑ Rabionet, M et al. (2008) Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3. J. Biol. Chem. 283 13357-69 PubMed GONUTS page
- ↑ Hsu, YT & Youle, RJ (1998) Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations. J. Biol. Chem. 273 10777-83 PubMed GONUTS page
- ↑ 95.0 95.1 Wang, X et al. (2009) Mitochondrial degeneration and not apoptosis is the primary cause of embryonic lethality in ceramide transfer protein mutant mice. J. Cell Biol. 184 143-58 PubMed GONUTS page
- ↑ 96.0 96.1 Takahashi, Y et al. (2005) Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol. Cell. Biol. 25 9369-82 PubMed GONUTS page
- ↑ Yuan, X et al. (2005) Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol. Cell 19 77-87 PubMed GONUTS page
- ↑ 98.0 98.1 Chae, HJ et al. (2004) BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress. Mol. Cell 15 355-66 PubMed GONUTS page
- ↑ 99.0 99.1 Karpinich, NO et al. (2002) The course of etoposide-induced apoptosis from damage to DNA and p53 activation to mitochondrial release of cytochrome c. J. Biol. Chem. 277 16547-52 PubMed GONUTS page
- ↑ Zhou, Z et al. (2003) Cidea-deficient mice have lean phenotype and are resistant to obesity. Nat. Genet. 35 49-56 PubMed GONUTS page
- ↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
- ↑ Mootha, VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell 115 629-40 PubMed GONUTS page
- ↑ 103.0 103.1 Lakhani, SA et al. (2006) Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science 311 847-51 PubMed GONUTS page
- ↑ 104.0 104.1 Parikh, N et al. (2004) The Bax N terminus is required for negative regulation by the mitogen-activated protein kinase kinase and Akt signaling pathways in T cells. J. Immunol. 173 6220-7 PubMed GONUTS page
- ↑ Abdelwahid, E et al. (1999) Apoptosis in the pattern formation of the ventricular wall during mouse heart organogenesis. Anat. Rec. 256 208-17 PubMed GONUTS page
- ↑ Zeng, Q & Oakley, B (1999) p53 and Bax: putative death factors in taste cell turnover. J. Comp. Neurol. 413 168-80 PubMed GONUTS page
- ↑ Eischen, CM et al. (2001) Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis. Mol. Cell. Biol. 21 7653-62 PubMed GONUTS page
- ↑ Walensky, LD et al. (2006) A stapled BID BH3 helix directly binds and activates BAX. Mol. Cell 24 199-210 PubMed GONUTS page
- ↑ Greenfeld, CR et al. (2007) BAX is involved in regulating follicular growth, but is dispensable for follicle atresia in adult mouse ovaries. Reproduction 133 107-16 PubMed GONUTS page
- ↑ Dziarmaga, A et al. (2006) Neuronal apoptosis inhibitory protein is expressed in developing kidney and is regulated by PAX2. Am. J. Physiol. Renal Physiol. 291 F913-20 PubMed GONUTS page
- ↑ Sung, TC et al. (2015) Solution Structure of Apoptotic BAX Oligomer: Oligomerization Likely Precedes Membrane Insertion. Structure 23 1878-1888 PubMed GONUTS page
a
b
- GO:0097144 ! BAX complex
- GO:0097136 ! Bcl-2 family protein complex
- GO:0051434 ! BH3 domain binding
- GO:0051400 ! BH domain binding
- GO:0001974 ! blood vessel remodeling
- GO:0001783 ! B cell apoptotic process
- GO:0001782 ! B cell homeostasis
- GO:0002358 ! B cell homeostatic proliferation
- GO:0002352 ! B cell negative selection
- GO:1990117 ! B cell receptor apoptotic signaling pathway
c
- GO:0033554 ! cellular response to stress
- GO:0045333 ! cellular respiration
- GO:0034644 ! cellular response to UV
- GO:0071944 ! cell periphery
- GO:0008283 ! cell population proliferation
- GO:0021987 ! cerebral cortex development
- GO:0015267 ! channel activity
- Chordata
- Craniata
- GO:0005737 ! cytoplasm
- GO:0005829 ! cytosol
e
- GO:0035234 ! ectopic germ cell programmed cell death
- GO:0005789 ! endoplasmic reticulum membrane
- GO:0005783 ! endoplasmic reticulum
- GO:0010248 ! establishment or maintenance of transmembrane electrochemical gradient
- Euarchontoglires
- Eukaryota
- Euteleostomi
- Eutheria
- GO:0097191 ! extrinsic apoptotic signaling pathway
- GO:0008625 ! extrinsic apoptotic signaling pathway via death domain receptors
- GO:0097192 ! extrinsic apoptotic signaling pathway in absence of ligand
h
i
- GO:0042802 ! identical protein binding
- GO:0007007 ! inner mitochondrial membrane organization
- GO:0016021 ! integral component of membrane
- GO:0008630 ! intrinsic apoptotic signaling pathway in response to DNA damage
- GO:0072332 ! intrinsic apoptotic signaling pathway by p53 class mediator
- GO:0097193 ! intrinsic apoptotic signaling pathway
- GO:0070059 ! intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
m
- GO:0008584 ! male gonad development
- Mammalia
- GO:0016020 ! membrane
- Metazoa
- GO:0031966 ! mitochondrial membrane
- GO:0005757 ! mitochondrial permeability transition pore complex
- GO:0043653 ! mitochondrial fragmentation involved in apoptotic process
- GO:0005741 ! mitochondrial outer membrane
- GO:0008053 ! mitochondrial fusion
- GO:0005739 ! mitochondrion
- Muridae
- Murinae
- Muroidea
- Mus
- Mus musculus
- GO:0002262 ! myeloid cell homeostasis
n
- GO:0033137 ! negative regulation of peptidyl-serine phosphorylation
- GO:0032471 ! negative regulation of endoplasmic reticulum calcium ion concentration
- GO:0008285 ! negative regulation of cell population proliferation
- GO:0043524 ! negative regulation of neuron apoptotic process
- GO:0032091 ! negative regulation of protein binding
- GO:0010917 ! negative regulation of mitochondrial membrane potential
- GO:2001234 ! negative regulation of apoptotic signaling pathway
- GO:0048147 ! negative regulation of fibroblast proliferation
- GO:0007399 ! nervous system development
- GO:0051402 ! neuron apoptotic process
- GO:0001764 ! neuron migration
- GO:0005635 ! nuclear envelope
- GO:0005634 ! nucleus
o
- GO:0006919 ! obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process
- GO:0008635 ! obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
- GO:0097296 ! obsolete activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
- GO:0071310 ! obsolete cellular response to organic substance
- GO:0070584 ! obsolete mitochondrion morphogenesis
- GO:0001844 ! obsolete protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
- GO:0043497 ! obsolete regulation of protein heterodimerization activity
- GO:0043281 ! obsolete regulation of cysteine-type endopeptidase activity involved in apoptotic process
- GO:0042475 ! odontogenesis of dentin-containing tooth
- GO:0007008 ! outer mitochondrial membrane organization
- GO:0001541 ! ovarian follicle development
p
- GO:0048471 ! perinuclear region of cytoplasm
- GO:0046930 ! pore complex
- GO:0010524 ! positive regulation of calcium ion transport into cytosol
- GO:0002904 ! positive regulation of B cell apoptotic process
- GO:0060058 ! positive regulation of apoptotic process involved in mammary gland involution
- GO:1902110 ! positive regulation of mitochondrial membrane permeability involved in apoptotic process
- GO:1902512 ! positive regulation of apoptotic DNA fragmentation
- GO:0048087 ! positive regulation of developmental pigmentation
- GO:0043525 ! positive regulation of neuron apoptotic process
- GO:2001241 ! positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
- GO:0051281 ! positive regulation of release of sequestered calcium ion into cytosol
- GO:0032461 ! positive regulation of protein oligomerization
- GO:2001244 ! positive regulation of intrinsic apoptotic signaling pathway
- GO:0090200 ! positive regulation of release of cytochrome c from mitochondria
- GO:1900103 ! positive regulation of endoplasmic reticulum unfolded protein response
- GO:0043065 ! positive regulation of apoptotic process
- GO:0048597 ! post-embryonic camera-type eye morphogenesis
- GO:0009791 ! post-embryonic development
- GO:0044877 ! protein-containing complex binding
- GO:0051087 ! protein-folding chaperone binding
- GO:0051259 ! protein complex oligomerization
- GO:0046982 ! protein heterodimerization activity
- GO:0042803 ! protein homodimerization activity
- GO:0051260 ! protein homooligomerization
r
- GO:0043523 ! regulation of neuron apoptotic process
- GO:0051726 ! regulation of cell cycle
- GO:0051881 ! regulation of mitochondrial membrane potential
- GO:0042981 ! regulation of apoptotic process
- GO:1902445 ! regulation of mitochondrial membrane permeability involved in programmed necrotic cell death
- GO:0043496 ! regulation of protein homodimerization activity
- GO:1902108 ! regulation of mitochondrial membrane permeability involved in apoptotic process
- GO:0006808 ! regulation of nitrogen utilization
- GO:0033599 ! regulation of mammary gland epithelial cell proliferation
- GO:0001836 ! release of cytochrome c from mitochondria
- GO:0032976 ! release of matrix enzymes from mitochondria
- GO:0010212 ! response to ionizing radiation
- GO:0009611 ! response to wounding
- GO:0009636 ! response to toxic substance
- GO:0048678 ! response to axon injury
- GO:0009651 ! response to salt stress
- GO:0010332 ! response to gamma radiation
- GO:0046666 ! retinal cell programmed cell death
- GO:0060041 ! retina development in camera-type eye
- Rodentia
s