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MOUSE:BAX

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Bax
Protein Name(s) Apoptosis regulator BAX
External Links
UniProt Q07813
EMBL L22472
BC018228
BC053380
CCDS CCDS21246.1
PIR D47538
RefSeq NP_031553.1
UniGene Mm.19904
PDB 2XA0
PDBsum 2XA0
ProteinModelPortal Q07813
SMR Q07813
BioGrid 198304
DIP DIP-29541N
DIP-357N
IntAct Q07813
MINT MINT-1517262
PhosphoSite Q07813
MaxQB Q07813
PaxDb Q07813
PRIDE Q07813
Ensembl ENSMUST00000033093
GeneID 12028
KEGG mmu:12028
UCSC uc009gvh.1
CTD 581
MGI MGI:99702
eggNOG NOG46695
HOGENOM HOG000095178
HOVERGEN HBG003606
InParanoid Q07813
KO K02159
OMA ADMFADG
OrthoDB EOG70GMGD
PhylomeDB Q07813
TreeFam TF315834
Reactome REACT_202639
ChiTaRS Bax
NextBio 280259
PRO PR:Q07813
Proteomes UP000000589
Bgee Q07813
CleanEx MM_BAX
ExpressionAtlas Q07813
Genevestigator Q07813
GO GO:0097144
GO:0097136
GO:0005737
GO:0005829
GO:0005783
GO:0005789
GO:0070062
GO:0016021
GO:0005622
GO:0031966
GO:0005741
GO:0005757
GO:0005739
GO:0005634
GO:0046930
GO:0015267
GO:0008289
GO:0046982
GO:0042803
GO:0006919
GO:0008635
GO:0097296
GO:0008637
GO:0006915
GO:1902263
GO:1902262
GO:0097190
GO:0001783
GO:0001782
GO:0002358
GO:0002352
GO:1990117
GO:0001974
GO:0008283
GO:0006974
GO:0071310
GO:0034644
GO:0021987
GO:0045136
GO:0035234
GO:0010248
GO:0097192
GO:0008625
GO:0009566
GO:0007281
GO:0006687
GO:0048872
GO:0048873
GO:0021854
GO:0072332
GO:0008630
GO:0070059
GO:0001822
GO:0001776
GO:0035108
GO:0008584
GO:0043653
GO:0008053
GO:0070584
GO:0002262
GO:2001234
GO:0008285
GO:0032471
GO:0048147
GO:0043524
GO:0033137
GO:0032091
GO:0007399
GO:0051402
GO:0001764
GO:0042475
GO:0001541
GO:1902512
GO:0043065
GO:0060058
GO:0002904
GO:0010524
GO:0048087
GO:1900103
GO:2001241
GO:2001244
GO:1902110
GO:0043525
GO:0032461
GO:0090200
GO:0051281
GO:0048597
GO:0009791
GO:0051260
GO:0001844
GO:0051726
GO:0043281
GO:0033599
GO:1902108
GO:1902445
GO:0043523
GO:0006808
GO:0043497
GO:0043496
GO:0001836
GO:0032976
GO:0048678
GO:0010332
GO:0010212
GO:0009651
GO:0009636
GO:0009611
GO:0060041
GO:1990009
GO:0046666
GO:0060011
GO:0007548
GO:0048515
GO:0007283
GO:0001777
GO:0070242
GO:0006927
GO:0060068
InterPro IPR026304
IPR002475
IPR020717
IPR020726
IPR020728
IPR026298
PANTHER PTHR11256
PTHR11256:SF8
Pfam PF00452
PRINTS PR01862
PROSITE PS50062
PS01080
PS01258
PS01259

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0007283

spermatogenesis

PMID:7569956[1]

ECO:0000315

P

Fig 2 A, C-J, Fig 3) Bax- mutants were incapable of spermatogenesis.

complete

involved_in

GO:0010917

negative regulation of mitochondrial membrane potential

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:26949185[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0043525

positive regulation of neuron apoptotic process

PMID:27098698[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

PMID:14752510[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P63037

F

happens_during:(GO:0033554)

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

PMID:14752510[4]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q99LX0

F

happens_during:(GO:0033554)

Seeded From UniProt

complete

enables

GO:0030544

Hsp70 protein binding

PMID:14752510[4]

ECO:0000314

direct assay evidence used in manual assertion

F

happens_during:(GO:0033554)

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:14752510[4]

ECO:0000314

direct assay evidence used in manual assertion

C

exists_during:(GO:0006915)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:14752510[4]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:23858059[5]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(CL:0000530)
  • part_of:(UBERON:0000955)

Seeded From UniProt

complete

part_of

GO:0097144

BAX complex

PMID:11060313[6]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q07817

C

Seeded From UniProt

complete

involved_in

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:1900103

positive regulation of endoplasmic reticulum unfolded protein response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

part_of

GO:0097144

BAX complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

part_of

GO:0097136

Bcl-2 family protein complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

involved_in

GO:0090200

positive regulation of release of cytochrome c from mitochondria

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

part_of

GO:0046930

pore complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

involved_in

GO:0043653

mitochondrial fragmentation involved in apoptotic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0043496

regulation of protein homodimerization activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0032976

release of matrix enzymes from mitochondria

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0032461

positive regulation of protein oligomerization

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

involved_in

GO:0032091

negative regulation of protein binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

enables

GO:0015267

channel activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

F

Seeded From UniProt

complete

involved_in

GO:0010248

establishment or maintenance of transmembrane electrochemical gradient

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

enables

GO:0008289

lipid binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

F

Seeded From UniProt

complete

involved_in

GO:0008053

mitochondrial fusion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

part_of

GO:0005757

mitochondrial permeability transition pore complex

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

involved_in

GO:0097192

extrinsic apoptotic signaling pathway in absence of ligand

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:101769
MGI:MGI:108052
MGI:MGI:1097161
MGI:MGI:88138
MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648
UniProtKB:Q07820

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88138
MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648
RGD:2192
RGD:2199
RGD:2200
RGD:620525
RGD:620621
RGD:620717
RGD:621635
RGD:70984
UniProtKB:P10415
UniProtKB:Q07812
UniProtKB:Q07820
UniProtKB:Q16611
UniProtKB:Q92843
ZFIN:ZDB-GENE-000511-7
ZFIN:ZDB-GENE-030825-1
ZFIN:ZDB-GENE-051012-1

F

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:99702
PANTHER:PTN000883418
RGD:2192
UniProtKB:Q07812
ZFIN:ZDB-GENE-000511-6

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:1330841
MGI:MGI:1858494
MGI:MGI:99702
PANTHER:PTN000135648
RGD:621635
UniProtKB:P10415
UniProtKB:Q07812
UniProtKB:Q16611

F

Seeded From UniProt

complete

enables

GO:0015267

channel activity

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000883418
UniProtKB:Q07812

F

Seeded From UniProt

complete

involved_in

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

FB:FBgn0029131
MGI:MGI:101769
MGI:MGI:1097161
MGI:MGI:88138
MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648

P

Seeded From UniProt

complete

involved_in

GO:0008053

mitochondrial fusion

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:99702
PANTHER:PTN000883418
UniProtKB:Q07812

P

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:88139
MGI:MGI:99702
PANTHER:PTN000135648
RGD:2192
RGD:2200
UniProtKB:P10415
UniProtKB:Q07817
WB:WBGene00000423

C

Seeded From UniProt

complete

involved_in

GO:0001836

release of cytochrome c from mitochondria

PMID:21873635[7]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:99702
PANTHER:PTN000883418
UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

PMID:14502238[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158306

P

  • regulates_o_occurs_in:(EMAPA:35667)
  • regulates_o_occurs_in:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001234

negative regulation of apoptotic signaling pathway

PMID:18436203[9]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2675387

P

regulates_o_occurs_in:(CL:0000670)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1990117

B cell receptor apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902512

positive regulation of apoptotic DNA fragmentation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902445

regulation of mitochondrial membrane permeability involved in programmed necrotic cell death

PMID:22493254[10]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3589203

P

regulates_o_occurs_in:(CL:0000057)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902263

apoptotic process involved in embryonic digit morphogenesis

PMID:15967824[11]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

occurs_in:(EMAPA:17445)|occurs_in:(EMAPA:17448)|occurs_in:(EMAPA:17451)|occurs_in:(EMAPA:17454)|occurs_in:(EMAPA:17476)|occurs_in:(EMAPA:17479)|occurs_in:(EMAPA:17482)|occurs_in:(EMAPA:17485)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902262

apoptotic process involved in blood vessel morphogenesis

PMID:15955981[12]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161

P

occurs_in:(EMAPA:16198)|occurs_in:(EMAPA:32743)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902110

positive regulation of mitochondrial membrane permeability involved in apoptotic process

PMID:15967824[11]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902108

regulation of mitochondrial membrane permeability involved in apoptotic process

PMID:23744079[13]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:108093
MGI:MGI:1929260

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902108

regulation of mitochondrial membrane permeability involved in apoptotic process

PMID:14963330[14]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:108093
MGI:MGI:98834

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1900103

positive regulation of endoplasmic reticulum unfolded protein response

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097296

activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

PMID:10479688[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097193

intrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097192

extrinsic apoptotic signaling pathway in absence of ligand

PMID:15967824[11]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

  • occurs_in:(EMAPA:18768)
  • occurs_in:(CL:0000893)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097192

extrinsic apoptotic signaling pathway in absence of ligand

PMID:15680329[16]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097191

extrinsic apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097190

apoptotic signaling pathway

PMID:14507967[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097190

apoptotic signaling pathway

PMID:12925707[18]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097190

apoptotic signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

part_of

GO:0097144

BAX complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

part_of

GO:0097136

Bcl-2 family protein complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0090200

positive regulation of release of cytochrome c from mitochondria

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0072332

intrinsic apoptotic signaling pathway by p53 class mediator

PMID:10479688[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

colocalizes_with

GO:0071944

cell periphery

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071310

cellular response to organic substance

PMID:12606450[19]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070584

mitochondrion morphogenesis

PMID:20671748[20]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88139

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070242

thymocyte apoptotic process

PMID:15967824[11]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

PMID:15776018[21]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161
UniProtKB:P10415

P

occurs_in:(CL:0000057)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

PMID:12847083[22]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161

P

occurs_in:(CL:0000057)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060068

vagina development

PMID:11163212[23]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161

P

results_in_development_of:(EMAPA:18986)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060058

positive regulation of apoptotic process involved in mammary gland involution

PMID:10363969[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

  • regulates_o_occurs_in:(EMAPA:17759)
  • regulates_o_occurs_in:(CL:0000066)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060041

retina development in camera-type eye

PMID:9699561[25]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060011

Sertoli cell proliferation

PMID:11784036[26]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1857389
MGI:MGI:1857429

P

Seeded From UniProt

complete

NOT|acts_upstream_of_or_within

GO:0051881

regulation of mitochondrial membrane potential

PMID:14614769[27]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051726

regulation of cell cycle

PMID:16055554[28]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161

P

occurs_in:(CL:0000236)

Seeded From UniProt

complete

enables

GO:0051434

BH3 domain binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051402

neuron apoptotic process

PMID:17077143[29]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95819

P

occurs_in:(EMAPA:35883)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051402

neuron apoptotic process

PMID:11717344[30]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97321
MGI:MGI:97383

P

  • occurs_in:(EMAPA:18441)
  • occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051402

neuron apoptotic process

PMID:10762311[31]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88138

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051402

neuron apoptotic process

PMID:15574493[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

  • occurs_in:(EMAPA:17577)
  • occurs_in:(CL:0000099)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051402

neuron apoptotic process

PMID:14623868[33]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051402

neuron apoptotic process

PMID:12917363[34]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

  • occurs_in:(EMAPA:17577)
  • occurs_in:(CL:0000100)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051402

neuron apoptotic process

PMID:11226327[35]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051402

neuron apoptotic process

PMID:10618441[36]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051402

neuron apoptotic process

PMID:10479688[15]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0051400

BH domain binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2192

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

PMID:15947791[37]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

  • regulates_o_occurs_in:(EMAPA:32804)
  • regulates_o_occurs_in:(CL:0000723)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051260

protein homooligomerization

PMID:12925707[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051260

protein homooligomerization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051259

protein complex oligomerization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

enables

GO:0051087

chaperone binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2192

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048873

homeostasis of number of cells within a tissue

PMID:15342910[38]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857249

P

occurs_in:(EMAPA:35169)|occurs_in:(EMAPA:35421)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048873

homeostasis of number of cells within a tissue

PMID:11413548[39]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048872

homeostasis of number of cells

PMID:11163212[23]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161

P

regulates_o_occurs_in:(EMAPA:32679)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048872

homeostasis of number of cells

PMID:10931486[40]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

regulates_o_occurs_in:(EMAPA:35850)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048678

response to axon injury

PMID:16103918[41]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048597

post-embryonic camera-type eye morphogenesis

PMID:15955981[12]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161

P

has_participant:(EMAPA:16198)|has_participant:(EMAPA:32743)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048515

spermatid differentiation

PMID:16270031[42]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

  • occurs_in:(EMAPA:31476)
  • results_in_acquisition_of_features_of:(CL:0000018)

Seeded From UniProt

complete

part_of

GO:0048471

perinuclear region of cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2192

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048147

negative regulation of fibroblast proliferation

PMID:12952892[43]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048087

positive regulation of developmental pigmentation

PMID:9241272[44]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:99702

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:8918887[45]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P70444

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:8798452[46]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q64373-1

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:7834748[47]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q64373

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:7650488[48]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q64373

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:11226327[35]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P10417

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

F

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2192

F

Seeded From UniProt

complete

part_of

GO:0046930

pore complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046666

retinal cell programmed cell death

PMID:14517994[49]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

occurs_in:(EMAPA:17168)|occurs_in:(EMAPA:16674)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045333

cellular respiration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2192

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045136

development of secondary sexual characteristics

PMID:15944391[50]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

enables

GO:0044877

protein-containing complex binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2192

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043653

mitochondrial fragmentation involved in apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:9096145[51]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88139

P

  • occurs_in:(EMAPA:16910)
  • regulates_o_occurs_in:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:10884318[52]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95813

P

  • occurs_in:(EMAPA:17787)
  • regulates_o_occurs_in:(CL:0000120)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:10744634[53]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:95824

P

occurs_in:(EMAPA:19037)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:10639175[54]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:107202

P

  • occurs_in:(EMAPA:19037)
  • regulates_o_occurs_in:(CL:0000117)|occurs_in(EMAPA:17787)
  • regulates_o_occurs_in:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:9699561[25]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

  • occurs_in:(EMAPA:17575)
  • regulates_o_occurs_in:(CL:0000540)|occurs_in(EMAPA:19155)
  • regulates_o_occurs_in:(CL:0000540)|occurs_in(EMAPA:35739)
  • regulates_o_occurs_in:(CL:0000740)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:9454852[55]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

occurs_in:(EMAPA:16668)|occurs_in:(EMAPA:16668)|occurs_in:(EMAPA:16668)|occurs_in:(EMAPA:16797)|occurs_in:(EMAPA:16797)|occurs_in:(EMAPA:16797)|occurs_in:(EMAPA:16797)|occurs_in:(EMAPA:16797)|occurs_in:(EMAPA:16797)|occurs_in:(EMAPA:16797)|occurs_in:(EMAPA:16797)|occurs_in:(EMAPA:17571)|occurs_in:(EMAPA:17571)|occurs_in:(EMAPA:17571)|occurs_in:(EMAPA:17571)|occurs_in:(EMAPA:17571)|occurs_in:(EMAPA:32769)|occurs_in:(EMAPA:32770)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:8816704[56]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

occurs_in:(EMAPA:35338)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:17192424[57]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

regulates_o_occurs_in:(CL:0000101)|regulates_o_occurs_in:(CL:0000100)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:16103918[41]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

  • occurs_in:(EMAPA:35739)
  • regulates_o_occurs_in:(CL:0000740)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:15947791[37]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

  • occurs_in:(EMAPA:35609)
  • regulates_o_occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:15944391[50]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

  • occurs_in:(EMAPA:17577)
  • regulates_o_occurs_in:(CL:0000100)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:15869495[58]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

  • occurs_in:(EMAPA:17563)
  • regulates_o_occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:15590937[59]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

  • occurs_in:(EMAPA:19037)
  • regulates_o_occurs_in:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:14502238[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158306

P

  • occurs_in:(EMAPA:35667)
  • regulates_o_occurs_in:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:11150333[60]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158306

P

  • occurs_in:(EMAPA:16910)
  • regulates_o_occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:10762311[31]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

regulates_o_occurs_in:(EMAPA:16797)|regulates_o_occurs_in:(EMAPA:17155)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

PMID:10683286[61]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

  • occurs_in:(EMAPA:18441)
  • regulates_o_occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043525

positive regulation of neuron apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

PMID:8625820[62]

ECO:0000314

direct assay evidence used in manual assertion

P

regulates_o_occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043523

regulation of neuron apoptotic process

PMID:19029045[63]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043497

regulation of protein heterodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043496

regulation of protein homodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043281

regulation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:14507967[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

PMID:9056387[64]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:98834

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

PMID:8798452[46]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88139

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

PMID:17107997[65]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96974

P

  • occurs_in:(EMAPA:16578)
  • regulates_o_occurs_in:(CL:0000670)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

PMID:16571598[66]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:102845
MGI:MGI:98834

P

occurs_in:(EMAPA:18323)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

PMID:9988273[67]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

  • occurs_in:(EMAPA:35627)
  • regulates_o_occurs_in:(CL:0000477)|occurs_in(EMAPA:35627)
  • regulates_o_occurs_in:(CL:0000023)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

PMID:9241272[44]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

PMID:17068116[68]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

occurs_in:(EMAPA:17023)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

PMID:15578100[69]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

  • occurs_in:(EMAPA:35266)
  • regulates_o_occurs_in:(CL:0000723)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

PMID:11906913[70]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

PMID:11146002[71]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

regulates_o_occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

PMID:10995754[72]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

occurs_in:(EMAPA:16039)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

PMID:15753097[73]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2192

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:8631771[74]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q07813

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:10582606[75]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P10417

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

PMID:8631771[74]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0042475

odontogenesis of dentin-containing tooth

PMID:15967824[11]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

has_participant:(EMAPA:32889)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035234

ectopic germ cell programmed cell death

PMID:17107997[65]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96974

P

  • occurs_in:(EMAPA:16578)
  • occurs_in:(CL:0000670)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035234

ectopic germ cell programmed cell death

PMID:14660547[76]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:96677

P

  • occurs_in:(EMAPA:16859)
  • occurs_in:(CL:0000670)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035234

ectopic germ cell programmed cell death

PMID:14660547[76]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

  • occurs_in:(EMAPA:16859)
  • occurs_in:(CL:0000670)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035108

limb morphogenesis

PMID:11163212[23]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161

P

has_participant:(EMAPA:32722)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034644

cellular response to UV

PMID:14963330[14]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:98834

P

occurs_in:(CL:0000057)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033599

regulation of mammary gland epithelial cell proliferation

PMID:10363969[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033137

negative regulation of peptidyl-serine phosphorylation

PMID:15613488[77]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161

P

regulates_o_has_input:(MGI:MGI:96623)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032976

release of matrix enzymes from mitochondria

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032471

negative regulation of endoplasmic reticulum calcium ion concentration

PMID:15613488[77]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161

P

regulates_o_occurs_in:(CL:0000057)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032461

positive regulation of protein oligomerization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032091

negative regulation of protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

part_of

GO:0031966

mitochondrial membrane

PMID:14614769[27]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0031966

mitochondrial membrane

PMID:11980919[78]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16985)
  • part_of:(CL:0000540)

Seeded From UniProt

complete

part_of

GO:0031966

mitochondrial membrane

PMID:11369777[79]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16846)
  • part_of:(CL:0000182)

Seeded From UniProt

complete

part_of

GO:0031966

mitochondrial membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2192

C

Seeded From UniProt

complete

enables

GO:0031072

heat shock protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2192

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021987

cerebral cortex development

PMID:15342910[38]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

results_in_development_of:(EMAPA:35169)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0021854

hypothalamus development

PMID:15342910[38]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

results_in_development_of:(EMAPA:35421)

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

PMID:8358790[80]

ECO:0000250

sequence similarity evidence used in manual assertion

C

Seeded From UniProt

Missing: with/from

enables

GO:0015267

channel activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010917

negative regulation of mitochondrial membrane potential

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010524

positive regulation of calcium ion transport into cytosol

PMID:15613488[77]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161

P

regulates_o_occurs_in:(CL:0000057)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010332

response to gamma radiation

PMID:17068116[68]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

occurs_in:(EMAPA:17023)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010248

establishment or maintenance of transmembrane electrochemical gradient

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010212

response to ionizing radiation

PMID:10639175[54]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:107202

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010212

response to ionizing radiation

PMID:15578100[69]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009791

post-embryonic development

PMID:9241272[44]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88138

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009651

response to salt stress

PMID:16571598[66]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:102845
MGI:MGI:98834

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009636

response to toxic substance

PMID:9454845[81]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009636

response to toxic substance

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009611

response to wounding

PMID:14507967[17]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009566

fertilization

PMID:10894153[82]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2176699

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008637

apoptotic mitochondrial changes

PMID:12925707[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008637

apoptotic mitochondrial changes

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008635

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

PMID:11836241[83]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008635

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

PMID:9560217[84]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008635

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:15967824[11]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

  • occurs_in:(EMAPA:18768)
  • occurs_in:(CL:0000893)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:15901672[85]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008630

intrinsic apoptotic signaling pathway in response to DNA damage

PMID:12952892[43]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008625

extrinsic apoptotic signaling pathway via death domain receptors

PMID:10597216[86]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008584

male gonad development

PMID:9241272[44]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88138

P

results_in_development_of:(EMAPA:31476)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008584

male gonad development

PMID:16270031[42]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

results_in_development_of:(EMAPA:17972)

Seeded From UniProt

complete

enables

GO:0008289

lipid binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

PMID:10762311[31]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008283

cell population proliferation

PMID:10762311[31]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88138

P

acts_on_population_of:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008283

cell population proliferation

PMID:9176392[87]

ECO:0000314

direct assay evidence used in manual assertion

P

  • occurs_in:(EMAPA:16846)
  • acts_on_population_of:(CL:0000182)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008053

mitochondrial fusion

PMID:17035996[88]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1857429
MGI:MGI:2159364

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008053

mitochondrial fusion

PMID:16893972[89]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1857429
MGI:MGI:2159364

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008053

mitochondrial fusion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007548

sex differentiation

PMID:15342910[38]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

has_participant:(EMAPA:35169)|has_participant:(EMAPA:35421)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007399

nervous system development

PMID:12810599[90]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2387665

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007283

spermatogenesis

PMID:10894153[82]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2176699

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007283

spermatogenesis

PMID:7569956[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007283

spermatogenesis

PMID:11906913[70]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007281

germ cell development

PMID:10894153[82]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2176699

P

results_in_development_of:(CL:0000020)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007008

outer mitochondrial membrane organization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2192

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007007

inner mitochondrial membrane organization

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2192

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006974

cellular response to DNA damage stimulus

PMID:9454845[81]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

occurs_in:(CL:0000540)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006974

cellular response to DNA damage stimulus

PMID:12952892[43]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:15776018[21]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161

P

has_regulation_target:(MGI:MGI:1312922)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:12847083[22]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161

P

has_regulation_target:(MGI:MGI:1312922)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:14561915[91]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

regulates_o_occurs_in:(EMAPA:17606)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:14502238[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:2158306

P

  • regulates_o_occurs_in:(EMAPA:35667)
  • regulates_o_occurs_in:(CL:0000117)
  • has_regulation_target:(MGI:MGI:107739)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006915

apoptotic process

PMID:10201940[92]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006915

apoptotic process

PMID:9560217[84]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006915

apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006915

apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2192

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006808

regulation of nitrogen utilization

PMID:9241272[44]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88138

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006687

glycosphingolipid metabolic process

PMID:18308723[93]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

occurs_in:(EMAPA:17972)

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:9553144[94]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:19139267[95]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:16227588[96]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:15989966[97]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:15304216[98]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:12925707[18]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:12847083[22]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000057)

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:11980919[78]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16985)
  • part_of:(CL:0000540)

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:11864976[99]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

PMID:11369777[79]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16846)
  • part_of:(CL:0000182)

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2192

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

PMID:12847083[22]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000057)

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

part_of

GO:0005757

mitochondrial permeability transition pore complex

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

PMID:16227588[96]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

PMID:12925707[18]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

PMID:12910269[100]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2192

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:18614015[101]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:14651853[102]

ECO:0007005

high throughput direct assay evidence used in manual assertion

C

part_of:(EMAPA:16846)|part_of:(EMAPA:16894)|part_of:(EMAPA:17373)

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:20671748[20]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:19139267[95]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:16469926[103]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000057)

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:15528359[104]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000084)

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:15304216[98]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:12847083[22]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000057)

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:11864976[99]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

PMID:11369777[79]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:16846)
  • part_of:(CL:0000182)

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2192

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:16469926[103]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000057)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:15528359[104]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(CL:0000084)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:11226327[35]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:35836)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:10931486[40]

ECO:0000314

direct assay evidence used in manual assertion

C

  • part_of:(EMAPA:18271)
  • part_of:(CL:0000209)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:10486519[105]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:17331)

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:10464378[106]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2192

C

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002904

positive regulation of B cell apoptotic process

PMID:11604501[107]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:97250

P

regulates_o_occurs_in:(CL:0000236)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002358

B cell homeostatic proliferation

PMID:7569956[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002352

B cell negative selection

PMID:16055554[28]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0002262

myeloid cell homeostasis

PMID:15967824[11]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001974

blood vessel remodeling

PMID:15955981[12]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161

P

has_participant:(EMAPA:16198)|has_participant:(EMAPA:32743)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001844

protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

PMID:12952892[43]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001836

release of cytochrome c from mitochondria

PMID:17052454[108]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:108093

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001836

release of cytochrome c from mitochondria

PMID:14963330[14]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:98834

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001836

release of cytochrome c from mitochondria

PMID:9560217[84]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001836

release of cytochrome c from mitochondria

PMID:14623868[33]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001836

release of cytochrome c from mitochondria

PMID:14614769[27]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001836

release of cytochrome c from mitochondria

PMID:12925707[18]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001836

release of cytochrome c from mitochondria

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001822

kidney development

PMID:9241272[44]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:88138

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001783

B cell apoptotic process

PMID:16055554[28]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161

P

occurs_in:(CL:0000236)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001783

B cell apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:Q07812

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001782

B cell homeostasis

PMID:15967824[11]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001782

B cell homeostasis

PMID:16055554[28]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001777

T cell homeostatic proliferation

PMID:9241272[44]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

acts_on_population_of:(CL:0000051)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001777

T cell homeostatic proliferation

PMID:7569956[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001776

leukocyte homeostasis

PMID:15967824[11]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1197519

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001776

leukocyte homeostasis

PMID:11163212[23]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1097161

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001764

neuron migration

PMID:15590937[59]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

  • occurs_in:(EMAPA:35277)
  • results_in_movement_of:(CL:0000117)|occurs_in(EMAPA:35276)
  • results_in_movement_of:(CL:0000117)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001541

ovarian follicle development

PMID:10894153[82]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:2176699

P

results_in_development_of:(EMAPA:30755)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0001541

ovarian follicle development

PMID:17244737[109]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:1857429

P

results_in_development_of:(EMAPA:35627)

Seeded From UniProt

complete

involved_in

GO:2001244

positive regulation of intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:1990117

B cell receptor apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:1902512

positive regulation of apoptotic DNA fragmentation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:1900103

positive regulation of endoplasmic reticulum unfolded protein response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:0097193

intrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:0097191

extrinsic apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:0097190

apoptotic signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

part_of

GO:0097144

BAX complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

C

Seeded From UniProt

complete

part_of

GO:0097136

Bcl-2 family protein complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

C

Seeded From UniProt

complete

involved_in

GO:0090200

positive regulation of release of cytochrome c from mitochondria

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

part_of

GO:0071944

cell periphery

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

C

Seeded From UniProt

complete

involved_in

GO:0070059

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

enables

GO:0051434

BH3 domain binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

F

Seeded From UniProt

complete

involved_in

GO:0051260

protein homooligomerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:0051259

protein complex oligomerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

F

Seeded From UniProt

complete

part_of

GO:0046930

pore complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

C

Seeded From UniProt

complete

involved_in

GO:0043653

mitochondrial fragmentation involved in apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:0043525

positive regulation of neuron apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:0043497

regulation of protein heterodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:0043496

regulation of protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

enables

GO:0042803

protein homodimerization activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

F

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

F

Seeded From UniProt

complete

involved_in

GO:0032976

release of matrix enzymes from mitochondria

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:0032461

positive regulation of protein oligomerization

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:0032091

negative regulation of protein binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

enables

GO:0015267

channel activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

F

Seeded From UniProt

complete

involved_in

GO:0010248

establishment or maintenance of transmembrane electrochemical gradient

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:0009636

response to toxic substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:0008637

apoptotic mitochondrial changes

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:0008635

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

enables

GO:0008289

lipid binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

F

Seeded From UniProt

complete

involved_in

GO:0008053

mitochondrial fusion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

C

Seeded From UniProt

complete

part_of

GO:0005789

endoplasmic reticulum membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

C

Seeded From UniProt

complete

part_of

GO:0005783

endoplasmic reticulum

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

C

Seeded From UniProt

complete

part_of

GO:0005757

mitochondrial permeability transition pore complex

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

C

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

C

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

C

Seeded From UniProt

complete

part_of

GO:0005635

nuclear envelope

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

C

Seeded From UniProt

complete

involved_in

GO:0001836

release of cytochrome c from mitochondria

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:0001783

B cell apoptotic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:Q07812
ensembl:ENSP00000293288

P

Seeded From UniProt

complete

involved_in

GO:0042981

regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020717
InterPro:IPR020726
InterPro:IPR020728
InterPro:IPR026298
InterPro:IPR036834

P

Seeded From UniProt

complete

involved_in

GO:0043065

positive regulation of apoptotic process

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR026304

P

Seeded From UniProt

complete

involved_in

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:16735463[110]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001241

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand

PMID:8358790[80]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:26299946[111]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q07813-1

F

Seeded From UniProt

complete

part_of

GO:0005741

mitochondrial outer membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1000
UniProtKB-SubCell:SL-0172

C

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

involved_in

GO:0016032

viral process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0945

P

Seeded From UniProt

complete

part_of

GO:0005739

mitochondrion

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0496

C

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0053

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. 1.0 1.1 1.2 1.3 Knudson, CM et al. (1995) Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270 96-9 PubMed GONUTS page
  2. Llambi, F et al. (2016) BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation. Cell 165 421-33 PubMed GONUTS page
  3. D'Orsi, B et al. (2016) Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury. J. Neurosci. 36 4564-78 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 Gotoh, T et al. (2004) hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria. Cell Death Differ. 11 390-402 PubMed GONUTS page
  5. Ekholm-Reed, S et al. (2013) Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1. Mol. Cell. Biol. 33 3627-43 PubMed GONUTS page
  6. Tan, KO et al. (2001) MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains. J. Biol. Chem. 276 2802-7 PubMed GONUTS page
  7. 7.0 7.1 7.2 7.3 7.4 7.5 7.6 7.7 7.8 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  8. 8.0 8.1 8.2 Young, C et al. (2003) Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain. Cell Death Differ. 10 1148-55 PubMed GONUTS page
  9. Suzuki, H et al. (2008) Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways. Dev. Biol. 318 133-42 PubMed GONUTS page
  10. Whelan, RS et al. (2012) Bax regulates primary necrosis through mitochondrial dynamics. Proc. Natl. Acad. Sci. U.S.A. 109 6566-71 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 11.4 11.5 11.6 11.7 11.8 Hutcheson, J et al. (2005) Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis. J. Exp. Med. 201 1949-60 PubMed GONUTS page
  12. 12.0 12.1 12.2 Hahn, P et al. (2005) Persistent fetal ocular vasculature in mice deficient in bax and bak. Arch. Ophthalmol. 123 797-802 PubMed GONUTS page
  13. Shamas-Din, A et al. (2013) tBid undergoes multiple conformational changes at the membrane required for Bax activation. J. Biol. Chem. 288 22111-27 PubMed GONUTS page
  14. 14.0 14.1 14.2 Chipuk, JE et al. (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303 1010-4 PubMed GONUTS page
  15. 15.0 15.1 15.2 Cregan, SP et al. (1999) Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons. J. Neurosci. 19 7860-9 PubMed GONUTS page
  16. Lum, JJ et al. (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120 237-48 PubMed GONUTS page
  17. 17.0 17.1 17.2 Dong, H et al. (2003) Enhanced oligodendrocyte survival after spinal cord injury in Bax-deficient mice and mice with delayed Wallerian degeneration. J. Neurosci. 23 8682-91 PubMed GONUTS page
  18. 18.0 18.1 18.2 18.3 18.4 18.5 Valentijn, AJ et al. (2003) Spatial and temporal changes in Bax subcellular localization during anoikis. J. Cell Biol. 162 599-612 PubMed GONUTS page
  19. Mu, J et al. (2003) Apoptosis and related proteins in placenta of intrauterine fetal death in prostaglandin f receptor-deficient mice. Biol. Reprod. 68 1968-74 PubMed GONUTS page
  20. 20.0 20.1 Cleland, MM et al. (2011) Bcl-2 family interaction with the mitochondrial morphogenesis machinery. Cell Death Differ. 18 235-47 PubMed GONUTS page
  21. 21.0 21.1 Ruiz-Vela, A et al. (2005) Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep. 6 379-85 PubMed GONUTS page
  22. 22.0 22.1 22.2 22.3 22.4 Zong, WX et al. (2003) Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J. Cell Biol. 162 59-69 PubMed GONUTS page
  23. 23.0 23.1 23.2 23.3 Lindsten, T et al. (2000) The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol. Cell 6 1389-99 PubMed GONUTS page
  24. 24.0 24.1 Schorr, K et al. (1999) Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo. Cancer Res. 59 2541-5 PubMed GONUTS page
  25. 25.0 25.1 Mosinger Ogilvie, J et al. (1998) Suppression of developmental retinal cell death but not of photoreceptor degeneration in Bax-deficient mice. Invest. Ophthalmol. Vis. Sci. 39 1713-20 PubMed GONUTS page
  26. Ross, AJ et al. (2001) BCLW mediates survival of postmitotic Sertoli cells by regulating BAX activity. Dev. Biol. 239 295-308 PubMed GONUTS page
  27. 27.0 27.1 27.2 Heimlich, G et al. (2004) Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6. Biochem. J. 378 247-55 PubMed GONUTS page
  28. 28.0 28.1 28.2 28.3 Takeuchi, O et al. (2005) Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc. Natl. Acad. Sci. U.S.A. 102 11272-7 PubMed GONUTS page
  29. de Rivero Vaccari, JC et al. (2006) NMDA receptors promote survival in somatosensory relay nuclei by inhibiting Bax-dependent developmental cell death. Proc. Natl. Acad. Sci. U.S.A. 103 16971-6 PubMed GONUTS page
  30. Laforet, GA et al. (2001) Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease. J. Neurosci. 21 9112-23 PubMed GONUTS page
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