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PMID:16055554
| Citation |
Takeuchi, O, Fisher, J, Suh, H, Harada, H, Malynn, BA and Korsmeyer, SJ (2005) Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc. Natl. Acad. Sci. U.S.A. 102:11272-7 |
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| Abstract |
B cell homeostasis is maintained by a balance between the continual generation of new cells and their elimination. Here we show proapoptotic BCL-2 family members BAX and BAK are essential for regulating the number of B cells at both immature and mature developmental stages. BAX and BAK are critical mediators of B cell death induced by multiple stimuli. In addition, BAX- and BAK-deficient B cells display defective cell cycle progression to B cell receptor crosslinking and lipopolysaccharide, but not to CpG-DNA. Furthermore, inducible deletion of Bax and Bak in adult mice results in the development of severe autoimmune disease. |
| Links |
PubMed PMC1183578 Online version:10.1073/pnas.0504783102 |
| Keywords |
Animals; Apoptosis/immunology; Apoptosis Regulatory Proteins/genetics; Apoptosis Regulatory Proteins/immunology; Autoimmune Diseases/immunology; B-Lymphocytes/immunology; Flow Cytometry; Fluoresceins; Immunohistochemistry; Membrane Proteins/genetics; Membrane Proteins/immunology; Mice; Mice, Knockout; Proto-Oncogene Proteins/genetics; Proto-Oncogene Proteins/immunology; Succinimides; bcl-2 Homologous Antagonist-Killer Protein/genetics; bcl-2 Homologous Antagonist-Killer Protein/immunology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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