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PMID:10363969
| Citation |
Schorr, K, Li, M, Bar-Peled, U, Lewis, A, Heredia, A, Lewis, B, Knudson, CM, Korsmeyer, SJ, Jäger, R, Weiher, H and Furth, PA (1999) Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivo. Cancer Res. 59:2541-5 |
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| Abstract |
The impact of gain of Bcl-2 function on mammary epithelial cell survival was compared with loss of Bax function during the two stages of mammary gland involution. Bcl-2 gain of function reduced apoptosis 50% during the first stage and increased cell survival 70% during the second stage. Complete loss of Bax reduced apoptosis by 20% during the first stage without second stage effect. Partial loss of Bax was ineffective but increased cell survival 2.4-fold when combined with Bcl-2 gain. Gain of Bcl-2 function is more potent than loss of Bax function in regulating mammary epithelial cell survival in vivo. |
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| Keywords |
Animals; Apoptosis/physiology; Cell Survival; Epithelial Cells/physiology; Female; Mammary Glands, Animal/cytology; Mammary Glands, Animal/metabolism; Mice; Proto-Oncogene Proteins/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; bcl-2-Associated X Protein |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
References
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