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PMID:10597216
| Citation |
Lee, JH, Takahashi, T, Yasuhara, N, Inazawa, J, Kamada, S and Tsujimoto, Y (1999) Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death. Oncogene 18:6183-90 |
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| Abstract |
Bcl-2 is the best characterized inhibitor of apoptosis, although the molecular basis of this action is not fully understood. Using a protein interaction cloning procedure, we identified a human gene designated as bis (mapped to chromosome 10q25) that encoded a novel Bcl-2-interacting protein. Bis protein showed no significant homology with Bcl-2 family proteins and had no prominent functional motif. Co-immunoprecipitation analysis confirmed that Bis interacted with Bcl-2 in vivo. DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis. These results suggest that Bis is a novel modulator of cellular anti-apoptotic activity that functions through its interaction with Bcl-2. |
| Links |
PubMed Online version:10.1038/sj.onc.1203043 |
| Keywords |
Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Apoptosis/physiology; B-Lymphocytes/chemistry; Binding Sites; Carrier Proteins/genetics; Carrier Proteins/isolation & purification; Carrier Proteins/metabolism; Chromosome Mapping; Chromosomes, Human, Pair 10/genetics; Cloning, Molecular; DNA, Complementary/genetics; Genes; Humans; Mice; Molecular Sequence Data; Organ Specificity; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2/physiology; Sequence Alignment; Sequence Homology, Amino Acid |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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See also
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