MOUSE:BID

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Bid
Protein Name(s)	BH3-interacting domain death agonist p22 BID BID BH3-interacting domain death agonist p15 p15 BID BH3-interacting domain death agonist p13 p13 BID BH3-interacting domain death agonist p11 p11 BID
External Links
UniProt	P70444
EMBL	U75506 AK045731 AK051076 AK052356 AK077657 AK161235 BC002031
CCDS	CCDS20486.1
RefSeq	NP_031570.2 XP_006505471.1 XP_006505472.1 XP_006505473.1 XP_006505474.1 XP_006507182.1 XP_006507183.1 XP_006507184.1
UniGene	Mm.235081
PDB	1DDB 2VOI
PDBsum	1DDB 2VOI
ProteinModelPortal	P70444
SMR	P70444
BioGrid	198349
DIP	DIP-29808N
IntAct	P70444
MINT	MINT-143107
STRING	10090.ENSMUSP00000004560
PhosphoSite	P70444
MaxQB	P70444
PaxDb	P70444
PRIDE	P70444
Ensembl	ENSMUST00000004560 ENSMUST00000160684
GeneID	12122
KEGG	mmu:12122
UCSC	uc009dnv.1
CTD	637
MGI	MGI:108093
eggNOG	NOG78659
GeneTree	ENSGT00390000002868
HOGENOM	HOG000010016
HOVERGEN	HBG001703
InParanoid	P70444
KO	K04726
OMA	RDVFRTT
OrthoDB	EOG73V6MW
PhylomeDB	P70444
TreeFam	TF102047
Reactome	REACT_202639 REACT_208000 REACT_210929 REACT_223399
EvolutionaryTrace	P70444
NextBio	280439
PMAP-CutDB	P70444
PRO	PR:P70444
Proteomes	UP000000589
Bgee	P70444
CleanEx	MM_BID
ExpressionAtlas	P70444
Genevestigator	P70444
GO	GO:0005737 GO:0005829 GO:0070062 GO:0032592 GO:0016020 GO:0005739 GO:0031625 GO:0006919 GO:0008637 GO:0007420 GO:0090150 GO:0097191 GO:0034349 GO:0097284 GO:0097345 GO:2001238 GO:0032464 GO:0090200 GO:0051260 GO:0006626 GO:0042127 GO:2000045 GO:1902108 GO:0032459 GO:0001836 GO:0032355 GO:0042770
InterPro	IPR020728 IPR010479
Pfam	PF06393
PIRSF	PIRSF038018
PROSITE	PS01259

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0001836	release of cytochrome c from mitochondria	PMID:18084238^[1]	ECO:0000314			P		Figures 6a and 6b shows by comparison of % cytochrome release in multiple proteins, that tBID is capable of release of cytochrome c from mitochondria in a mouse liver.	complete CACAO 5090
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:P55957	C		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	PMID:18084238^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	PMID:21041309^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P70444	P		Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	PMID:10950869^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O08734	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	PMID:10950869^[3]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0032592	integral component of mitochondrial membrane	PMID:10950869^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032464	positive regulation of protein homooligomerization	PMID:21041309^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032459	regulation of protein oligomerization	PMID:20850011^[4]	ECO:0000314	direct assay evidence used in manual assertion		P	has_participant:(UniProtKB:Q07812)	Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	PMID:20392206^[5]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q96J02	F		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002860227 UniProtKB:P55957	P		Seeded From UniProt	complete
involved_in	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002860227 UniProtKB:P55957	P		Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108093 PANTHER:PTN002860227 UniProtKB:P55957	P		Seeded From UniProt	complete
involved_in	GO:0008637	apoptotic mitochondrial changes	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108093 PANTHER:PTN002860227 RGD:620160 UniProtKB:P55957	P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108093 PANTHER:PTN002860227	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108093 PANTHER:PTN002860227 RGD:620160 UniProtKB:P55957	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:108093 PANTHER:PTN002860227 RGD:620160	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55957	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55957	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001235	positive regulation of apoptotic signaling pathway	PMID:8918887^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000271	positive regulation of fibroblast apoptotic process	PMID:8918887^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000045	regulation of G1/S transition of mitotic cell cycle	PMID:15855651^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158671	P	regulates_o_occurs_in:(EMAPA:16846) regulates_o_occurs_in:(CL:0000182)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	PMID:26219591^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5428930	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process	PMID:23744079^[10]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1929260 MGI:MGI:99702	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process	PMID:14963330^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:99702	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097345	mitochondrial outer membrane permeabilization	PMID:20436477^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1929260	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097284	hepatocyte apoptotic process	PMID:20436477^[12]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1929260 MGI:MGI:95484	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0097191	extrinsic apoptotic signaling pathway	PMID:10476969^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158671	P	occurs_in:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090200	positive regulation of release of cytochrome c from mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55957	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090150	establishment of protein localization to membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55957	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:8918887^[7]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:P10417 UniProtKB:Q07813 UniProtKB:Q64373	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	PMID:8918887^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55957	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	PMID:8918887^[7]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:88138	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042775	mitochondrial ATP synthesis coupled electron transport	PMID:26219591^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5428930	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042127	regulation of cell population proliferation	PMID:15855651^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0034263	positive regulation of autophagy in response to ER overload	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620160	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032464	positive regulation of protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55957	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032461	positive regulation of protein oligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55957	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:8918887^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:23744079^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010918	positive regulation of mitochondrial membrane potential	PMID:26219591^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:5428930	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:12011074^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158671	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006626	protein targeting to mitochondrion	PMID:11369777^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158671	P	has_participant:(MGI:MGI:99702)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:8918887^[7]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11980919^[16]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16985) part_of:(CL:0000540)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11369777^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846) part_of:(CL:0000182)	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55957	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620160	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55957	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:18614015^[17]	ECO:0007005	high throughput direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:11369777^[15]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(EMAPA:16846) part_of:(CL:0000182)	Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620160	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001836	release of cytochrome c from mitochondria	PMID:11369777^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2158671	P	occurs_in:(EMAPA:16846) occurs_in:(CL:0000182)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:P55957	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:620160	P		Seeded From UniProt	complete
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55957 ensembl:ENSP00000318822	P		Seeded From UniProt	complete
involved_in	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55957 ensembl:ENSP00000318822	P		Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55957 ensembl:ENSP00000318822	P		Seeded From UniProt	complete
involved_in	GO:0090150	establishment of protein localization to membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55957 ensembl:ENSP00000318822	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55957 ensembl:ENSP00000318822	P		Seeded From UniProt	complete
involved_in	GO:0032464	positive regulation of protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55957 ensembl:ENSP00000318822	P		Seeded From UniProt	complete
involved_in	GO:0032461	positive regulation of protein oligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55957 ensembl:ENSP00000318822	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55957 ensembl:ENSP00000318822	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55957 ensembl:ENSP00000318822	C		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P55957 ensembl:ENSP00000318822	P		Seeded From UniProt	complete
involved_in	GO:0034349	glial cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLT6 ensembl:ENSRNOP00000016776	P		Seeded From UniProt	complete
involved_in	GO:0034263	positive regulation of autophagy in response to ER overload	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLT6 ensembl:ENSRNOP00000016776	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLT6 ensembl:ENSRNOP00000016776	P		Seeded From UniProt	complete
involved_in	GO:0007420	brain development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLT6 ensembl:ENSRNOP00000016776	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLT6 ensembl:ENSRNOP00000016776	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLT6 ensembl:ENSRNOP00000016776	C		Seeded From UniProt	complete
involved_in	GO:0002931	response to ischemia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLT6 ensembl:ENSRNOP00000016776	P		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9JLT6 ensembl:ENSRNOP00000016776	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010479	C		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR020728 InterPro:IPR036834	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR010479	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:9873064^[18]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0042770	signal transduction in response to DNA damage	PMID:18309324^[19]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0031966	mitochondrial membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0171	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Flanagan, AM & Letai, A (2008) BH3 domains define selective inhibitory interactions with BHRF-1 and KSHV BCL-2. Cell Death Differ. 15 580-8 PubMed GONUTS page
↑ ^2.0 ^2.1 Du, H et al. (2011) BH3 domains other than Bim and Bid can directly activate Bax/Bak. J. Biol. Chem. 286 491-501 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Wei, MC et al. (2000) tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev. 14 2060-71 PubMed GONUTS page
↑ Montessuit, S et al. (2010) Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization. Cell 142 889-901 PubMed GONUTS page
↑ Azakir, BA et al. (2010) The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid. FEBS J. 277 1319-30 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 ^7.5 ^7.6 Wang, K et al. (1996) BID: a novel BH3 domain-only death agonist. Genes Dev. 10 2859-69 PubMed GONUTS page
↑ ^8.0 ^8.1 Bai, L et al. (2005) Deletion of Bid impedes cell proliferation and hepatic carcinogenesis. Am. J. Pathol. 166 1523-32 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Maryanovich, M et al. (2015) An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate. Nat Commun 6 7901 PubMed GONUTS page
↑ ^10.0 ^10.1 Shamas-Din, A et al. (2013) tBid undergoes multiple conformational changes at the membrane required for Bax activation. J. Biol. Chem. 288 22111-27 PubMed GONUTS page
↑ Chipuk, JE et al. (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303 1010-4 PubMed GONUTS page
↑ ^12.0 ^12.1 Zaltsman, Y et al. (2010) MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria. Nat. Cell Biol. 12 553-62 PubMed GONUTS page
↑ Yin, XM et al. (1999) Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 400 886-91 PubMed GONUTS page
↑ Li, S et al. (2002) Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis. J. Biol. Chem. 277 26912-20 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 Zhao, Y et al. (2001) Activation of pro-death Bcl-2 family proteins and mitochondria apoptosis pathway in tumor necrosis factor-alpha-induced liver injury. J. Biol. Chem. 276 27432-40 PubMed GONUTS page
↑ Putcha, GV et al. (2002) Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. J. Cell Biol. 157 441-53 PubMed GONUTS page
↑ Pagliarini, DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell 134 112-23 PubMed GONUTS page
↑ Gross, A et al. (1999) Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J. Biol. Chem. 274 1156-63 PubMed GONUTS page
↑ Galluzzi, L et al. (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15 1113-23 PubMed GONUTS page

[PMID:18084238-1] 1.0 ^1.1 Flanagan, AM & Letai, A (2008) BH3 domains define selective inhibitory interactions with BHRF-1 and KSHV BCL-2. Cell Death Differ. 15 580-8 PubMed GONUTS page

[PMID:21041309-2] 2.0 ^2.1 Du, H et al. (2011) BH3 domains other than Bim and Bid can directly activate Bax/Bak. J. Biol. Chem. 286 491-501 PubMed GONUTS page

[PMID:10950869-3] 3.0 ^3.1 ^3.2 Wei, MC et al. (2000) tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev. 14 2060-71 PubMed GONUTS page

[PMID:20850011-4] Montessuit, S et al. (2010) Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization. Cell 142 889-901 PubMed GONUTS page

[PMID:20392206-5] Azakir, BA et al. (2010) The ubiquitin ligase Itch mediates the antiapoptotic activity of epidermal growth factor by promoting the ubiquitylation and degradation of the truncated C-terminal portion of Bid. FEBS J. 277 1319-30 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 ^6.5 ^6.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

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MOUSE:BID

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