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MOUSE:JAK2

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Species (Taxon ID) Mus musculus (Mouse). (10090)
Gene Name(s) Jak2
Protein Name(s) Tyrosine-protein kinase JAK2

Janus kinase 2 JAK-2

External Links
UniProt Q62120
EMBL L16956
BC054807
BC059834
M33423
PIR A47511
B39577
JH0114
RefSeq NP_001041642.1
NP_032439.2
UniGene Mm.275839
PDB 2HDX
4GL9
PDBsum 2HDX
4GL9
ProteinModelPortal Q62120
SMR Q62120
BioGrid 200857
DIP DIP-320N
IntAct Q62120
MINT MINT-188474
BindingDB Q62120
ChEMBL CHEMBL1649049
PhosphoSite Q62120
MaxQB Q62120
PaxDb Q62120
PRIDE Q62120
GeneID 16452
KEGG mmu:16452
CTD 3717
MGI MGI:96629
eggNOG COG0515
HOGENOM HOG000049158
HOVERGEN HBG006195
InParanoid Q62120
KO K04447
PhylomeDB Q62120
BRENDA 2.7.10.2
Reactome REACT_169390
REACT_188529
REACT_198614
REACT_198645
ChiTaRS Jak2
EvolutionaryTrace Q62120
NextBio 289717
PRO PR:Q62120
Proteomes UP000000589
CleanEx MM_JAK2
Genevestigator Q62120
GO GO:0005901
GO:0005737
GO:0005856
GO:0005829
GO:0012505
GO:0045121
GO:0016363
GO:0005634
GO:0005524
GO:0005131
GO:0020037
GO:0042393
GO:0035401
GO:0005143
GO:0004715
GO:0004672
GO:0019901
GO:0004713
GO:0006919
GO:0097296
GO:0042977
GO:0000186
GO:0031103
GO:0030154
GO:0071549
GO:0071222
GO:0019221
GO:0007167
GO:0030218
GO:0097191
GO:0007186
GO:0060396
GO:0035409
GO:0009755
GO:0034050
GO:0060333
GO:0035722
GO:0035556
GO:0008631
GO:0007259
GO:0060397
GO:0061180
GO:0031959
GO:0030099
GO:0043066
GO:0008285
GO:0022408
GO:0043392
GO:0045822
GO:0018108
GO:0048008
GO:2001235
GO:0050867
GO:0045597
GO:0030335
GO:0008284
GO:0010811
GO:0007204
GO:0043388
GO:0060399
GO:0050729
GO:0032024
GO:0032731
GO:0045429
GO:0051770
GO:0050731
GO:0014068
GO:0032516
GO:0033160
GO:0051091
GO:0045944
GO:0032760
GO:0042517
GO:0042523
GO:0046777
GO:0050727
GO:0046677
GO:0097012
GO:0033194
GO:0070671
GO:0032496
GO:0006979
GO:0034612
GO:0007165
GO:0007262
GO:0033209
GO:0007260
GO:0042508
GO:0042503
Gene3D 3.30.505.10
InterPro IPR019749
IPR019748
IPR000299
IPR011009
IPR000719
IPR017441
IPR001245
IPR000980
IPR008266
IPR020635
IPR016251
IPR020693
Pfam PF07714
PF00017
PIRSF PIRSF000636
PRINTS PR01823
PR01825
PR00109
SMART SM00295
SM00252
SM00219
SUPFAM SSF47031
SSF55550
SSF56112
PROSITE PS50057
PS00107
PS50011
PS00109
PS50001

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0019221

cytokine-mediated signaling pathway

PMID:23526587[1]

ECO:0000314

P

JAK2 is essential to naive t cell homing. Figure 2C demonstrates that silencing JAK1/2 proteins severely inhibited the ability of chemokine-mediated t cell signaling. This indicated by the naive t-cell's inability to migrate through a chemokine gradient.

complete
CACAO 7284

GO:0035166

post-embryonic hemopoiesis

PMID:23544085[2]

ECO:0000315

P

Figure 3: B) Representative peripheral blood films from both genotypes showing the presence of anemia, thrombocytopenia, and poikilocytosis in the Jak2 cKO mice, but not the controls. (C) Histologic sections of spleen found an abnormal splenic architecture in the Jak2 cKO mice characterized by atrophied and disorganized white pulp.(D) Representative bone marrow sections from both genotypes indicating increased adipose deposits in the Jak2 cKO mice, but not the controls. (E) Representative liver sections showing diffuse centrolobular vacuolar degeneration in the Jak2 cKO tissue, but not in the control tissue.

complete
CACAO 9822

involved_in

GO:0120162

positive regulation of cold-induced thermogenesis

PMID:26515423[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0035166

post-embryonic hemopoiesis

PMID:23544085[2]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097296

activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway

PMID:12426001[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0097012

response to granulocyte macrophage colony-stimulating factor

PMID:18424709[5]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0070671

response to interleukin-12

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O60674

P

Seeded From UniProt

complete

involved_in

GO:0060399

positive regulation of growth hormone receptor signaling pathway

PMID:17761766[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060397

growth hormone receptor signaling pathway via JAK-STAT

PMID:8923468[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0060396

growth hormone receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O60674

P

Seeded From UniProt

complete

involved_in

GO:0060333

interferon-gamma-mediated signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0051770

positive regulation of nitric-oxide synthase biosynthetic process

PMID:10600756[8]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051770

positive regulation of nitric-oxide synthase biosynthetic process

PMID:12426001[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051091

positive regulation of DNA-binding transcription factor activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0050867

positive regulation of cell activation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

PMID:7782332[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0050729

positive regulation of inflammatory response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0050727

regulation of inflammatory response

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O60674

P

Seeded From UniProt

complete

involved_in

GO:0048008

platelet-derived growth factor receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0045822

negative regulation of heart contraction

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0045597

positive regulation of cell differentiation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0045429

positive regulation of nitric oxide biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0043388

positive regulation of DNA binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

PMID:8923468[7]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007260

tyrosine phosphorylation of STAT protein

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0035722

interleukin-12-mediated signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O60674

P

Seeded From UniProt

complete

involved_in

GO:0034612

response to tumor necrosis factor

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O60674

P

Seeded From UniProt

complete

involved_in

GO:0033209

tumor necrosis factor-mediated signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O60674

P

Seeded From UniProt

complete

involved_in

GO:0033194

response to hydroperoxide

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0032760

positive regulation of tumor necrosis factor production

PMID:12426001[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032731

positive regulation of interleukin-1 beta production

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0032516

positive regulation of phosphoprotein phosphatase activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

PMID:11536325[10]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032024

positive regulation of insulin secretion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0031959

mineralocorticoid receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0031103

axon regeneration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0030335

positive regulation of cell migration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0022408

negative regulation of cell-cell adhesion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O60674

F

Seeded From UniProt

complete

part_of

GO:0016363

nuclear matrix

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

C

Seeded From UniProt

complete

involved_in

GO:0014068

positive regulation of phosphatidylinositol 3-kinase signaling

PMID:7782332[9]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010811

positive regulation of cell-substrate adhesion

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O60674

P

Seeded From UniProt

complete

involved_in

GO:0009755

hormone-mediated signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0008631

intrinsic apoptotic signaling pathway in response to oxidative stress

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0007204

positive regulation of cytosolic calcium ion concentration

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0006979

response to oxidative stress

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0006919

activation of cysteine-type endopeptidase activity involved in apoptotic process

PMID:12426001[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O60674

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O60674

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

C

Seeded From UniProt

complete

enables

GO:0005131

growth hormone receptor binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

F

Seeded From UniProt

complete

involved_in

GO:0000186

activation of MAPKK activity

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q62689

P

Seeded From UniProt

complete

involved_in

GO:0060397

growth hormone receptor signaling pathway via JAK-STAT

PMID:20304997[11]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0046777

protein autophosphorylation

PMID:20304997[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042976

activation of Janus kinase activity

PMID:20304997[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042531

positive regulation of tyrosine phosphorylation of STAT protein

PMID:15156153[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042393

histone binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O60674

F

Seeded From UniProt

complete

involved_in

GO:0035409

histone H3-Y41 phosphorylation

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O60674

P

Seeded From UniProt

complete

enables

GO:0035401

histone kinase activity (H3-Y41 specific)

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O60674

F

Seeded From UniProt

complete

involved_in

GO:0030218

erythrocyte differentiation

PMID:9590173[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030218

erythrocyte differentiation

PMID:9590174[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0020037

heme binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O60674

F

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

PMID:9590173[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

PMID:9590174[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:9590173[13]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:9590174[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:15156153[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:O60674

C

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:20304997[11]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0035409

histone H3-Y41 phosphorylation

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001231348
UniProtKB:O60674

P

Seeded From UniProt

complete

enables

GO:0035401

histone kinase activity (H3-Y41 specific)

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001231348
UniProtKB:O60674

F

Seeded From UniProt

complete

involved_in

GO:0030218

erythrocyte differentiation

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96629
PANTHER:PTN002401049

P

Seeded From UniProt

complete

involved_in

GO:0019221

cytokine-mediated signaling pathway

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96629
MGI:MGI:99928
PANTHER:PTN002401049
RGD:2940
UniProtKB:O60674

P

Seeded From UniProt

complete

involved_in

GO:0007260

tyrosine phosphorylation of STAT protein

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

MGI:MGI:96629
PANTHER:PTN002401049
RGD:2939

P

Seeded From UniProt

complete

enables

GO:0005131

growth hormone receptor binding

PMID:21873635[15]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN001231348
RGD:2939

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:9111318[16]

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:8400282[17]

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:7961995[18]

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:7538110[19]

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:7527668[20]

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:10822380[21]

ECO:0000269

experimental evidence used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:2001235

positive regulation of apoptotic signaling pathway

PMID:15012602[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1904707

positive regulation of vascular smooth muscle cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1904037

positive regulation of epithelial cell apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:1902728

positive regulation of growth factor dependent skeletal muscle satellite cell proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0099527

postsynapse to nucleus signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

part_of

GO:0098978

glutamatergic synapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

C

Seeded From UniProt

complete

part_of

GO:0098794

postsynapse

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0097191

extrinsic apoptotic signaling pathway

PMID:12426001[4]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0000235)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071549

cellular response to dexamethasone stimulus

PMID:21606371[23]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0071222

cellular response to lipopolysaccharide

PMID:21606371[23]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0070671

response to interleukin-12

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0061180

mammary gland epithelium development

PMID:12040017[24]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

results_in_development_of:(EMAPA:17760)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060548

negative regulation of cell death

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060397

growth hormone receptor signaling pathway via JAK-STAT

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060396

growth hormone receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0060333

interferon-gamma-mediated signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051770

positive regulation of nitric-oxide synthase biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

enables

GO:0051428

peptide hormone receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0051091

positive regulation of DNA-binding transcription factor activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050867

positive regulation of cell activation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050804

modulation of chemical synaptic transmission

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050729

positive regulation of inflammatory response

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0050727

regulation of inflammatory response

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0048008

platelet-derived growth factor receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046777

protein autophosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046677

response to antibiotic

PMID:16280321[25]

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0046425

regulation of receptor signaling pathway via JAK-STAT

PMID:12147240[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045944

positive regulation of transcription by RNA polymerase II

PMID:20530874[27]

ECO:0000316

genetic interaction evidence used in manual assertion

MGI:MGI:1933533

P

  • regulates_o_occurs_in:(CL:0000235)
  • has_regulation_target:(MGI:MGI:96562)
  • has_regulation_target:(MGI:MGI:96561)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045822

negative regulation of heart contraction

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045597

positive regulation of cell differentiation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045429

positive regulation of nitric oxide biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0045428

regulation of nitric oxide biosynthetic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

PMID:12388746[28]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:17759)

Seeded From UniProt

complete

enables

GO:0043560

insulin receptor substrate binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

F

Seeded From UniProt

complete

enables

GO:0043548

phosphatidylinositol 3-kinase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043524

negative regulation of neuron apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043392

negative regulation of DNA binding

PMID:12388746[28]

ECO:0000314

direct assay evidence used in manual assertion

P

  • regulates_o_occurs_in:(EMAPA:17759)
  • regulates_o_occurs_in:(CL:0000066)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043388

positive regulation of DNA binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043066

negative regulation of apoptotic process

PMID:12147240[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0043065

positive regulation of apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

F

Seeded From UniProt

complete

enables

GO:0042393

histone binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

F

Seeded From UniProt

complete

enables

GO:0042169

SH2 domain binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0036016

cellular response to interleukin-3

PMID:8378315[29]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035722

interleukin-12-mediated signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035556

intracellular signal transduction

PMID:8022486[30]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0000084)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0035409

histone H3-Y41 phosphorylation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

P

Seeded From UniProt

complete

enables

GO:0035401

histone kinase activity (H3-Y41 specific)

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034612

response to tumor necrosis factor

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0034050

host programmed cell death induced by symbiont

PMID:12426001[4]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033209

tumor necrosis factor-mediated signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0033194

response to hydroperoxide

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

enables

GO:0033130

acetylcholine receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032731

positive regulation of interleukin-1 beta production

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032516

positive regulation of phosphoprotein phosphatase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0032024

positive regulation of insulin secretion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031959

mineralocorticoid receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

enables

GO:0031702

type 1 angiotensin receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0031103

axon regeneration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030335

positive regulation of cell migration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030154

cell differentiation

PMID:11821424[31]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0030099

myeloid cell differentiation

PMID:15354294[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3045147

P

results_in_acquisition_of_features_of:(CL:0000547)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0022408

negative regulation of cell-cell adhesion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

enables

GO:0020037

heme binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

F

Seeded From UniProt

complete

enables

GO:0019901

protein kinase binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019221

cytokine-mediated signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0018108

peptidyl-tyrosine phosphorylation

PMID:10872802[33]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0016363

nuclear matrix

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

C

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010811

positive regulation of cell-substrate adhesion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0010667

negative regulation of cardiac muscle cell apoptotic process

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0009755

hormone-mediated signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008631

intrinsic apoptotic signaling pathway in response to oxidative stress

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008285

negative regulation of cell population proliferation

PMID:11821424[31]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0008284

positive regulation of cell population proliferation

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

enables

GO:0008022

protein C-terminus binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007260

tyrosine phosphorylation of STAT protein

PMID:11821424[31]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007260

tyrosine phosphorylation of STAT protein

PMID:12388746[28]

ECO:0000314

direct assay evidence used in manual assertion

P

has_participant:(MGI:MGI:103036)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007260

tyrosine phosphorylation of STAT protein

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007259

receptor signaling pathway via JAK-STAT

PMID:15354294[32]

ECO:0000315

mutant phenotype evidence used in manual assertion

MGI:MGI:3045147

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007259

receptor signaling pathway via JAK-STAT

PMID:11821424[31]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007259

receptor signaling pathway via JAK-STAT

PMID:21606371[23]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007259

receptor signaling pathway via JAK-STAT

PMID:12147240[26]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007259

receptor signaling pathway via JAK-STAT

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007204

positive regulation of cytosolic calcium ion concentration

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007186

G protein-coupled receptor signaling pathway

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0007167

enzyme linked receptor protein signaling pathway

PMID:8022486[30]

ECO:0000314

direct assay evidence used in manual assertion

P

occurs_in:(CL:0000084)

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0006979

response to oxidative stress

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

part_of

GO:0005925

focal adhesion

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

C

Seeded From UniProt

complete

part_of

GO:0005901

caveola

PMID:12388746[28]

ECO:0000314

direct assay evidence used in manual assertion

C

part_of:(EMAPA:17759)

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

C

Seeded From UniProt

complete

part_of

GO:0005654

nucleoplasm

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

C

Seeded From UniProt

complete

enables

GO:0005143

interleukin-12 receptor binding

PMID:11489994[34]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:P97378

F

Seeded From UniProt

complete

enables

GO:0005131

growth hormone receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

F

Seeded From UniProt

complete

enables

GO:0005102

signaling receptor binding

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:15012602[22]

ECO:0000315

mutant phenotype evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:8378315[29]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:12147240[26]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

PMID:10872802[33]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

UniProtKB:O60674

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0000186

activation of MAPKK activity

GO_REF:0000096

ECO:0000266

sequence orthology evidence used in manual assertion

RGD:2939

P

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266

F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020635

F

Seeded From UniProt

complete

enables

GO:0004715

non-membrane spanning protein tyrosine kinase activity

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016251
InterPro:IPR020693

F

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR016251
InterPro:IPR017441
InterPro:IPR020693

F

Seeded From UniProt

complete

part_of

GO:0005856

cytoskeleton

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000299

C

Seeded From UniProt

complete

involved_in

GO:0006468

protein phosphorylation

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000719
InterPro:IPR001245
InterPro:IPR008266
InterPro:IPR016251
InterPro:IPR020635
InterPro:IPR020693

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016251
InterPro:IPR020693

C

Seeded From UniProt

complete

involved_in

GO:0035556

intracellular signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR016251
InterPro:IPR020693

P

Seeded From UniProt

complete

enables

GO:0042393

histone binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR020693

F

Seeded From UniProt

complete

enables

GO:0004715

non-membrane spanning protein tyrosine kinase activity

GO_REF:0000003

ECO:0000501

evidence used in automatic assertion

EC:2.7.10.2

F

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-NUL-8950050
Reactome:R-NUL-879922
Reactome:R-NUL-1067645
Reactome:R-MMU-9032476
Reactome:R-MMU-9030353
Reactome:R-MMU-9030346
Reactome:R-MMU-9029162
Reactome:R-MMU-9029152
Reactome:R-MMU-9029147
Reactome:R-MMU-9029146
Reactome:R-MMU-9027436
Reactome:R-MMU-9027429
Reactome:R-MMU-9027268
Reactome:R-MMU-9027266
Reactome:R-MMU-9012656
Reactome:R-MMU-9012653
Reactome:R-MMU-9012652
Reactome:R-MMU-9006466
Reactome:R-MMU-9006329
Reactome:R-MMU-9006327
Reactome:R-MMU-9006326
Reactome:R-MMU-8950723
Reactome:R-MMU-8950679
Reactome:R-MMU-8950612
Reactome:R-MMU-8950442
Reactome:R-MMU-877301
Reactome:R-MMU-2672295
Reactome:R-MMU-2671877
Reactome:R-MMU-2671854
Reactome:R-MMU-2671852
Reactome:R-MMU-2671843
Reactome:R-MMU-2671841
Reactome:R-MMU-2671836
Reactome:R-MMU-2671832
Reactome:R-MMU-2671831
Reactome:R-MMU-2671830
Reactome:R-MMU-2671740
Reactome:R-MMU-2671739
Reactome:R-MMU-2586558
Reactome:R-MMU-2586557
Reactome:R-MMU-2586548
Reactome:R-MMU-209310
Reactome:R-MMU-1169250
Reactome:R-MMU-1169240
Reactome:R-MMU-1169229
Reactome:R-MMU-1169206
Reactome:R-MMU-1169194
Reactome:R-MMU-1169142
Reactome:R-MMU-1168927
Reactome:R-MMU-1168923
Reactome:R-MMU-1168910

ECO:0000304

author statement supported by traceable reference used in manual assertion



















































C

Seeded From UniProt

complete

enables

GO:0004715

non-membrane spanning protein tyrosine kinase activity

Reactome:R-MMU-1169206
Reactome:R-MMU-1168923

ECO:0000304

author statement supported by traceable reference used in manual assertion


F

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

Reactome:R-MMU-9012653
Reactome:R-MMU-9006327
Reactome:R-MMU-2671843
Reactome:R-MMU-2671836
Reactome:R-MMU-2671830
Reactome:R-MMU-2586557
Reactome:R-MMU-2586548

ECO:0000304

author statement supported by traceable reference used in manual assertion







F

Seeded From UniProt

complete

enables

GO:0004672

protein kinase activity

Reactome:R-MMU-2671740

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

acts_upstream_of_or_within

GO:0019221

cytokine-mediated signaling pathway

PMID:12147240[26]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:12147240[26]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0004713

protein tyrosine kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0829

F

Seeded From UniProt

complete

involved_in

GO:0002250

adaptive immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-1064

P

Seeded From UniProt

complete

enables

GO:0005524

ATP binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0067

F

Seeded From UniProt

complete

enables

GO:0000166

nucleotide binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0547

F

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

enables

GO:0016740

transferase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0808

F

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

involved_in

GO:0016310

phosphorylation

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

P

Seeded From UniProt

complete

involved_in

GO:0006325

chromatin organization

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0156

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

enables

GO:0016301

kinase activity

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0418

F

Seeded From UniProt

complete

enables

GO:0046872

metal ion binding

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0479

F

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472

C

Seeded From UniProt

complete

part_of

GO:0012505

endomembrane system

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0147

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

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  2. 2.0 2.1 Park, SO et al. (2013) Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans. PLoS ONE 8 e59675 PubMed GONUTS page
  3. Shi, SY et al. (2016) JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice. Diabetologia 59 187-96 PubMed GONUTS page
  4. 4.0 4.1 4.2 4.3 4.4 4.5 Rojas, M et al. () Activation of JAK2/STAT1-alpha-dependent signaling events during Mycobacterium tuberculosis-induced macrophage apoptosis. Cell. Immunol. 217 58-66 PubMed GONUTS page
  5. Sebastián, C et al. (2008) Deacetylase activity is required for STAT5-dependent GM-CSF functional activity in macrophages and differentiation to dendritic cells. J. Immunol. 180 5898-906 PubMed GONUTS page
  6. Loesch, K et al. (2007) Endoplasmic reticulum-associated degradation of growth hormone receptor in Janus kinase 2-deficient cells. Endocrinology 148 5955-65 PubMed GONUTS page
  7. 7.0 7.1 Yi, W et al. (1996) Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase. Mol. Endocrinol. 10 1425-43 PubMed GONUTS page
  8. Cruz, MT et al. (1999) Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells. Am. J. Physiol. 277 C1050-7 PubMed GONUTS page
  9. 9.0 9.1 Argetsinger, LS et al. (1995) Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J. Biol. Chem. 270 14685-92 PubMed GONUTS page
  10. Dell'Albani, P et al. (2001) JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures. J. Neurosci. Res. 65 417-24 PubMed GONUTS page
  11. 11.0 11.1 11.2 11.3 Argetsinger, LS et al. (2010) Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity. Mol. Endocrinol. 24 1062-76 PubMed GONUTS page
  12. 12.0 12.1 Kamakura, S et al. (2004) Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat. Cell Biol. 6 547-54 PubMed GONUTS page
  13. 13.0 13.1 13.2 Parganas, E et al. (1998) Jak2 is essential for signaling through a variety of cytokine receptors. Cell 93 385-95 PubMed GONUTS page
  14. 14.0 14.1 14.2 Neubauer, H et al. (1998) Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93 397-409 PubMed GONUTS page
  15. 15.0 15.1 15.2 15.3 15.4 15.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  16. Feng, J et al. (1997) Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop. Mol. Cell. Biol. 17 2497-501 PubMed GONUTS page
  17. Damen, JE et al. (1993) Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein. Blood 82 2296-303 PubMed GONUTS page
  18. Miura, Y et al. (1994) Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor. J. Biol. Chem. 269 29962-9 PubMed GONUTS page
  19. He, TC et al. (1995) Erythropoietin-induced recruitment of Shc via a receptor phosphotyrosine-independent, Jak2-associated pathway. J. Biol. Chem. 270 11055-61 PubMed GONUTS page
  20. Miura, O et al. (1994) Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor. Blood 84 4135-41 PubMed GONUTS page
  21. Zochodne, B et al. (2000) Epo regulates erythroid proliferation and differentiation through distinct signaling pathways: implication for erythropoiesis and Friend virus-induced erythroleukemia. Oncogene 19 2296-304 PubMed GONUTS page
  22. 22.0 22.1 Auernhammer, CJ et al. (2004) The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells. J. Endocrinol. 180 479-86 PubMed GONUTS page
  23. 23.0 23.1 23.2 Bhattacharyya, S et al. (2011) Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation. Proc. Natl. Acad. Sci. U.S.A. 108 9554-9 PubMed GONUTS page
  24. Shillingford, JM et al. (2002) Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis. Mol. Endocrinol. 16 1309-21 PubMed GONUTS page
  25. Shang, L & Tomasi, TB (2006) The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. J. Biol. Chem. 281 1876-84 PubMed GONUTS page
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