GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
MOUSE:JAK2
Contents
Annotations
Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
---|---|---|---|---|---|---|---|---|---|---|
GO:0019221 |
cytokine-mediated signaling pathway |
ECO:0000314 |
P |
JAK2 is essential to naive t cell homing. Figure 2C demonstrates that silencing JAK1/2 proteins severely inhibited the ability of chemokine-mediated t cell signaling. This indicated by the naive t-cell's inability to migrate through a chemokine gradient. |
complete | |||||
GO:0035166 |
post-embryonic hemopoiesis |
ECO:0000315 |
P |
Figure 3: B) Representative peripheral blood films from both genotypes showing the presence of anemia, thrombocytopenia, and poikilocytosis in the Jak2 cKO mice, but not the controls. (C) Histologic sections of spleen found an abnormal splenic architecture in the Jak2 cKO mice characterized by atrophied and disorganized white pulp.(D) Representative bone marrow sections from both genotypes indicating increased adipose deposits in the Jak2 cKO mice, but not the controls. (E) Representative liver sections showing diffuse centrolobular vacuolar degeneration in the Jak2 cKO tissue, but not in the control tissue. |
complete | |||||
involved_in |
GO:0120162 |
positive regulation of cold-induced thermogenesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035166 |
post-embryonic hemopoiesis |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097296 |
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0097012 |
response to granulocyte macrophage colony-stimulating factor |
ECO:0000303 |
author statement without traceable support used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0070671 |
response to interleukin-12 |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060399 |
positive regulation of growth hormone receptor signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060397 |
growth hormone receptor signaling pathway via JAK-STAT |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060396 |
growth hormone receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060333 |
interferon-gamma-mediated signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051770 |
positive regulation of nitric-oxide synthase biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051770 |
positive regulation of nitric-oxide synthase biosynthetic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050867 |
positive regulation of cell activation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050731 |
positive regulation of peptidyl-tyrosine phosphorylation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050729 |
positive regulation of inflammatory response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0050727 |
regulation of inflammatory response |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0048008 |
platelet-derived growth factor receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045822 |
negative regulation of heart contraction |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045597 |
positive regulation of cell differentiation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045429 |
positive regulation of nitric oxide biosynthetic process |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0043388 |
positive regulation of DNA binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042531 |
positive regulation of tyrosine phosphorylation of STAT protein |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007260 |
tyrosine phosphorylation of STAT protein |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035722 |
interleukin-12-mediated signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0034612 |
response to tumor necrosis factor |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0033209 |
tumor necrosis factor-mediated signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0033194 |
response to hydroperoxide |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032760 |
positive regulation of tumor necrosis factor production |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032731 |
positive regulation of interleukin-1 beta production |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032516 |
positive regulation of phosphoprotein phosphatase activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032496 |
response to lipopolysaccharide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0032024 |
positive regulation of insulin secretion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031959 |
mineralocorticoid receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0031103 |
axon regeneration |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030335 |
positive regulation of cell migration |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0022408 |
negative regulation of cell-cell adhesion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0019901 |
protein kinase binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016363 |
nuclear matrix |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0014068 |
positive regulation of phosphatidylinositol 3-kinase signaling |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0010811 |
positive regulation of cell-substrate adhesion |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0009755 |
hormone-mediated signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008631 |
intrinsic apoptotic signaling pathway in response to oxidative stress |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006979 |
response to oxidative stress |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006919 |
activation of cysteine-type endopeptidase activity involved in apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0005131 |
growth hormone receptor binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0000186 |
activation of MAPKK activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0060397 |
growth hormone receptor signaling pathway via JAK-STAT |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0046777 |
protein autophosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042976 |
activation of Janus kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0042531 |
positive regulation of tyrosine phosphorylation of STAT protein |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042393 |
histone binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035409 |
histone H3-Y41 phosphorylation |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0035401 |
histone kinase activity (H3-Y41 specific) |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030218 |
erythrocyte differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0030218 |
erythrocyte differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0020037 |
heme binding |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007165 |
signal transduction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0007165 |
signal transduction |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035409 |
histone H3-Y41 phosphorylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001231348 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0035401 |
histone kinase activity (H3-Y41 specific) |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001231348 |
F |
Seeded From UniProt |
complete | ||
involved_in |
GO:0030218 |
erythrocyte differentiation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96629 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0019221 |
cytokine-mediated signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96629 |
P |
Seeded From UniProt |
complete | ||
involved_in |
GO:0007260 |
tyrosine phosphorylation of STAT protein |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:96629 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0005131 |
growth hormone receptor binding |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN001231348 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000269 |
experimental evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:2001235 |
positive regulation of apoptotic signaling pathway |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:1904707 |
positive regulation of vascular smooth muscle cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:1904037 |
positive regulation of epithelial cell apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:1902728 |
positive regulation of growth factor dependent skeletal muscle satellite cell proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0099527 |
postsynapse to nucleus signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0098978 |
glutamatergic synapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0098794 |
postsynapse |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0097191 |
extrinsic apoptotic signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0000235) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0071549 |
cellular response to dexamethasone stimulus |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0071222 |
cellular response to lipopolysaccharide |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0070671 |
response to interleukin-12 |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0061180 |
mammary gland epithelium development |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
results_in_development_of:(EMAPA:17760) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0060548 |
negative regulation of cell death |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0060397 |
growth hormone receptor signaling pathway via JAK-STAT |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0060396 |
growth hormone receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0060333 |
interferon-gamma-mediated signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0051770 |
positive regulation of nitric-oxide synthase biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0051428 |
peptide hormone receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0051091 |
positive regulation of DNA-binding transcription factor activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0050867 |
positive regulation of cell activation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0050804 |
modulation of chemical synaptic transmission |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0050729 |
positive regulation of inflammatory response |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0050727 |
regulation of inflammatory response |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0048008 |
platelet-derived growth factor receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0046777 |
protein autophosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0046677 |
response to antibiotic |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0046425 |
regulation of receptor signaling pathway via JAK-STAT |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000316 |
genetic interaction evidence used in manual assertion |
MGI:MGI:1933533 |
P |
|
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0045822 |
negative regulation of heart contraction |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045597 |
positive regulation of cell differentiation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045429 |
positive regulation of nitric oxide biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0045428 |
regulation of nitric oxide biosynthetic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0045121 |
membrane raft |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:17759) |
Seeded From UniProt |
complete | ||
enables |
GO:0043560 |
insulin receptor substrate binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0043548 |
phosphatidylinositol 3-kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043524 |
negative regulation of neuron apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043392 |
negative regulation of DNA binding |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
|
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043388 |
positive regulation of DNA binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0043066 |
negative regulation of apoptotic process |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0043065 |
positive regulation of apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0042802 |
identical protein binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042393 |
histone binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0042169 |
SH2 domain binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0036016 |
cellular response to interleukin-3 |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0035722 |
interleukin-12-mediated signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0035556 |
intracellular signal transduction |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0000084) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0035409 |
histone H3-Y41 phosphorylation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0035401 |
histone kinase activity (H3-Y41 specific) |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0034612 |
response to tumor necrosis factor |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0034050 |
host programmed cell death induced by symbiont |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0033209 |
tumor necrosis factor-mediated signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0033194 |
response to hydroperoxide |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0033130 |
acetylcholine receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0032731 |
positive regulation of interleukin-1 beta production |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0032516 |
positive regulation of phosphoprotein phosphatase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0032024 |
positive regulation of insulin secretion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0031959 |
mineralocorticoid receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0031702 |
type 1 angiotensin receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0031103 |
axon regeneration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0030335 |
positive regulation of cell migration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0030154 |
cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0030099 |
myeloid cell differentiation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3045147 |
P |
results_in_acquisition_of_features_of:(CL:0000547) |
Seeded From UniProt |
complete | |
acts_upstream_of_or_within |
GO:0022408 |
negative regulation of cell-cell adhesion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0020037 |
heme binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0019901 |
protein kinase binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0019221 |
cytokine-mediated signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0018108 |
peptidyl-tyrosine phosphorylation |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0016363 |
nuclear matrix |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
C |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0010811 |
positive regulation of cell-substrate adhesion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0010667 |
negative regulation of cardiac muscle cell apoptotic process |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0009755 |
hormone-mediated signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008631 |
intrinsic apoptotic signaling pathway in response to oxidative stress |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0008285 |
negative regulation of cell population proliferation |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0008284 |
positive regulation of cell population proliferation |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0008022 |
protein C-terminus binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007260 |
tyrosine phosphorylation of STAT protein |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007260 |
tyrosine phosphorylation of STAT protein |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
has_participant:(MGI:MGI:103036) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007260 |
tyrosine phosphorylation of STAT protein |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007259 |
receptor signaling pathway via JAK-STAT |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
MGI:MGI:3045147 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007259 |
receptor signaling pathway via JAK-STAT |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007259 |
receptor signaling pathway via JAK-STAT |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007259 |
receptor signaling pathway via JAK-STAT |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
acts_upstream_of_or_within |
GO:0007259 |
receptor signaling pathway via JAK-STAT |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007204 |
positive regulation of cytosolic calcium ion concentration |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007186 |
G protein-coupled receptor signaling pathway |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0007167 |
enzyme linked receptor protein signaling pathway |
ECO:0000314 |
direct assay evidence used in manual assertion |
P |
occurs_in:(CL:0000084) |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0006979 |
response to oxidative stress |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0005925 |
focal adhesion |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005901 |
caveola |
ECO:0000314 |
direct assay evidence used in manual assertion |
C |
part_of:(EMAPA:17759) |
Seeded From UniProt |
complete | ||
part_of |
GO:0005886 |
plasma membrane |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
C |
Seeded From UniProt |
complete | ||
part_of |
GO:0005654 |
nucleoplasm |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
C |
Seeded From UniProt |
complete | ||
enables |
GO:0005143 |
interleukin-12 receptor binding |
ECO:0000353 |
physical interaction evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005131 |
growth hormone receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
F |
Seeded From UniProt |
complete | ||
enables |
GO:0005102 |
signaling receptor binding |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000315 |
mutant phenotype evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000314 |
direct assay evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0000186 |
activation of MAPKK activity |
ECO:0000266 |
sequence orthology evidence used in manual assertion |
RGD:2939 |
P |
Seeded From UniProt |
complete | ||
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004715 |
non-membrane spanning protein tyrosine kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000719 |
F |
Seeded From UniProt |
complete | ||
part_of |
GO:0005856 |
cytoskeleton |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
InterPro:IPR000719 |
P |
Seeded From UniProt |
complete | ||
part_of |
GO:0016020 |
membrane |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0035556 |
intracellular signal transduction |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0042393 |
histone binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0004715 |
non-membrane spanning protein tyrosine kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005829 |
cytosol |
Reactome:R-NUL-8950050 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
C |
Seeded From UniProt |
complete | |
enables |
GO:0004715 |
non-membrane spanning protein tyrosine kinase activity |
Reactome:R-MMU-1169206 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
F |
Seeded From UniProt |
complete | |
enables |
GO:0004713 |
protein tyrosine kinase activity |
Reactome:R-MMU-9012653 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
|
F |
Seeded From UniProt |
complete | |
enables |
GO:0004672 |
protein kinase activity |
Reactome:R-MMU-2671740 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
F |
Seeded From UniProt |
complete | ||
acts_upstream_of_or_within |
GO:0019221 |
cytokine-mediated signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0004713 |
protein tyrosine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002250 |
adaptive immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
involved_in |
GO:0045087 |
innate immune response |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
involved_in |
GO:0002376 |
immune system process |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
involved_in |
GO:0006325 |
chromatin organization |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
enables |
GO:0046872 |
metal ion binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
part_of |
GO:0016020 |
membrane |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
part_of |
GO:0012505 |
endomembrane system |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ Pérez-Rivero, G et al. (2013) Janus kinases 1 and 2 regulate chemokine-mediated integrin activation and naïve T-cell homing. Eur. J. Immunol. 43 1745-57 PubMed GONUTS page
- ↑ 2.0 2.1 Park, SO et al. (2013) Conditional deletion of Jak2 reveals an essential role in hematopoiesis throughout mouse ontogeny: implications for Jak2 inhibition in humans. PLoS ONE 8 e59675 PubMed GONUTS page
- ↑ Shi, SY et al. (2016) JAK2 promotes brown adipose tissue function and is required for diet- and cold-induced thermogenesis in mice. Diabetologia 59 187-96 PubMed GONUTS page
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 Rojas, M et al. () Activation of JAK2/STAT1-alpha-dependent signaling events during Mycobacterium tuberculosis-induced macrophage apoptosis. Cell. Immunol. 217 58-66 PubMed GONUTS page
- ↑ Sebastián, C et al. (2008) Deacetylase activity is required for STAT5-dependent GM-CSF functional activity in macrophages and differentiation to dendritic cells. J. Immunol. 180 5898-906 PubMed GONUTS page
- ↑ Loesch, K et al. (2007) Endoplasmic reticulum-associated degradation of growth hormone receptor in Janus kinase 2-deficient cells. Endocrinology 148 5955-65 PubMed GONUTS page
- ↑ 7.0 7.1 Yi, W et al. (1996) Growth hormone receptor cytoplasmic domain differentially promotes tyrosine phosphorylation of signal transducers and activators of transcription 5b and 3 by activated JAK2 kinase. Mol. Endocrinol. 10 1425-43 PubMed GONUTS page
- ↑ Cruz, MT et al. (1999) Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells. Am. J. Physiol. 277 C1050-7 PubMed GONUTS page
- ↑ 9.0 9.1 Argetsinger, LS et al. (1995) Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J. Biol. Chem. 270 14685-92 PubMed GONUTS page
- ↑ Dell'Albani, P et al. (2001) JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures. J. Neurosci. Res. 65 417-24 PubMed GONUTS page
- ↑ 11.0 11.1 11.2 11.3 Argetsinger, LS et al. (2010) Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity. Mol. Endocrinol. 24 1062-76 PubMed GONUTS page
- ↑ 12.0 12.1 Kamakura, S et al. (2004) Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat. Cell Biol. 6 547-54 PubMed GONUTS page
- ↑ 13.0 13.1 13.2 Parganas, E et al. (1998) Jak2 is essential for signaling through a variety of cytokine receptors. Cell 93 385-95 PubMed GONUTS page
- ↑ 14.0 14.1 14.2 Neubauer, H et al. (1998) Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell 93 397-409 PubMed GONUTS page
- ↑ 15.0 15.1 15.2 15.3 15.4 15.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Feng, J et al. (1997) Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop. Mol. Cell. Biol. 17 2497-501 PubMed GONUTS page
- ↑ Damen, JE et al. (1993) Erythropoietin stimulates the tyrosine phosphorylation of Shc and its association with Grb2 and a 145-Kd tyrosine phosphorylated protein. Blood 82 2296-303 PubMed GONUTS page
- ↑ Miura, Y et al. (1994) Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor. J. Biol. Chem. 269 29962-9 PubMed GONUTS page
- ↑ He, TC et al. (1995) Erythropoietin-induced recruitment of Shc via a receptor phosphotyrosine-independent, Jak2-associated pathway. J. Biol. Chem. 270 11055-61 PubMed GONUTS page
- ↑ Miura, O et al. (1994) Induction of tyrosine phosphorylation of Vav and expression of Pim-1 correlates with Jak2-mediated growth signaling from the erythropoietin receptor. Blood 84 4135-41 PubMed GONUTS page
- ↑ Zochodne, B et al. (2000) Epo regulates erythroid proliferation and differentiation through distinct signaling pathways: implication for erythropoiesis and Friend virus-induced erythroleukemia. Oncogene 19 2296-304 PubMed GONUTS page
- ↑ 22.0 22.1 Auernhammer, CJ et al. (2004) The oncostatin M receptor/gp130 ligand murine oncostatin M induces apoptosis in adrenocortical Y-1 tumor cells. J. Endocrinol. 180 479-86 PubMed GONUTS page
- ↑ 23.0 23.1 23.2 Bhattacharyya, S et al. (2011) Glucocorticoids target suppressor of cytokine signaling 1 (SOCS1) and type 1 interferons to regulate Toll-like receptor-induced STAT1 activation. Proc. Natl. Acad. Sci. U.S.A. 108 9554-9 PubMed GONUTS page
- ↑ Shillingford, JM et al. (2002) Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis. Mol. Endocrinol. 16 1309-21 PubMed GONUTS page
- ↑ Shang, L & Tomasi, TB (2006) The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons. J. Biol. Chem. 281 1876-84 PubMed GONUTS page
- ↑ 26.0 26.1 26.2 26.3 26.4 26.5 Olsen, H et al. (2002) Effects of hyperactive Janus kinase 2 signaling in mammary epithelial cells. Biochem. Biophys. Res. Commun. 296 139-44 PubMed GONUTS page
- ↑ De Domenico, I et al. (2010) Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice. J. Clin. Invest. 120 2395-405 PubMed GONUTS page
- ↑ 28.0 28.1 28.2 28.3 Park, DS et al. (2002) Caveolin-1-deficient mice show accelerated mammary gland development during pregnancy, premature lactation, and hyperactivation of the Jak-2/STAT5a signaling cascade. Mol. Biol. Cell 13 3416-30 PubMed GONUTS page
- ↑ 29.0 29.1 Silvennoinen, O et al. (1993) Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. Proc. Natl. Acad. Sci. U.S.A. 90 8429-33 PubMed GONUTS page
- ↑ 30.0 30.1 Witthuhn, BA et al. (1994) Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370 153-7 PubMed GONUTS page
- ↑ 31.0 31.1 31.2 31.3 Xie, J et al. (2002) Role of tyrosine kinase Jak2 in prolactin-induced differentiation and growth of mammary epithelial cells. J. Biol. Chem. 277 14020-30 PubMed GONUTS page
- ↑ 32.0 32.1 Krempler, A et al. (2004) Generation of a conditional knockout allele for the Janus kinase 2 (Jak2) gene in mice. Genesis 40 52-7 PubMed GONUTS page
- ↑ 33.0 33.1 Iseki, M et al. (2000) Molecular cloning of the mouse APS as a member of the Lnk family adaptor proteins. Biochem. Biophys. Res. Commun. 272 45-54 PubMed GONUTS page
- ↑ Poltorak, A et al. (2001) A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice. J. Immunol. 167 2106-11 PubMed GONUTS page
a
c
- GO:0005901 ! caveola
- GO:0036016 ! cellular response to interleukin-3
- GO:0071222 ! cellular response to lipopolysaccharide
- GO:0071549 ! cellular response to dexamethasone stimulus
- GO:0030154 ! cell differentiation
- GO:0007259 ! cell surface receptor signaling pathway via JAK-STAT
- Chordata
- GO:0006325 ! chromatin organization
- Craniata
- GO:0019221 ! cytokine-mediated signaling pathway
- GO:0005737 ! cytoplasm
- GO:0005856 ! cytoskeleton
- GO:0005829 ! cytosol
e
g
h
i
- GO:0042802 ! identical protein binding
- GO:0002376 ! immune system process
- GO:0045087 ! innate immune response
- GO:0043560 ! insulin receptor substrate binding
- GO:0035722 ! interleukin-12-mediated signaling pathway
- GO:0005143 ! interleukin-12 receptor binding
- GO:0035556 ! intracellular signal transduction
- GO:0008631 ! intrinsic apoptotic signaling pathway in response to oxidative stress
m
n
- GO:0045822 ! negative regulation of heart contraction
- GO:0008285 ! negative regulation of cell population proliferation
- GO:0010667 ! negative regulation of cardiac muscle cell apoptotic process
- GO:0043066 ! negative regulation of apoptotic process
- GO:0043392 ! negative regulation of DNA binding
- GO:0043524 ! negative regulation of neuron apoptotic process
- GO:0022408 ! negative regulation of cell-cell adhesion
- GO:0004715 ! non-membrane spanning protein tyrosine kinase activity
- GO:0016363 ! nuclear matrix
- GO:0031959 ! nuclear receptor-mediated mineralocorticoid signaling pathway
- GO:0005654 ! nucleoplasm
- GO:0000166 ! nucleotide binding
- GO:0005634 ! nucleus
o
- GO:0000186 ! obsolete activation of MAPKK activity
- GO:0097296 ! obsolete activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
- GO:0006919 ! obsolete activation of cysteine-type endopeptidase activity involved in apoptotic process
- GO:0035409 ! obsolete histone H3-Y41 phosphorylation
- GO:0060548 ! obsolete negative regulation of cell death
- GO:0032516 ! obsolete positive regulation of phosphoprotein phosphatase activity
- GO:0051770 ! obsolete positive regulation of nitric-oxide synthase biosynthetic process
- GO:0014068 ! obsolete positive regulation of phosphatidylinositol 3-kinase signaling
- GO:0008022 ! obsolete protein C-terminus binding
p
- GO:0051428 ! peptide hormone receptor binding
- GO:0018108 ! peptidyl-tyrosine phosphorylation
- GO:0043548 ! phosphatidylinositol 3-kinase binding
- GO:0016310 ! phosphorylation
- GO:0005886 ! plasma membrane
- GO:0048008 ! platelet-derived growth factor receptor signaling pathway
- GO:0010811 ! positive regulation of cell-substrate adhesion
- GO:0050729 ! positive regulation of inflammatory response
- GO:0043065 ! positive regulation of apoptotic process
- GO:0045597 ! positive regulation of cell differentiation
- GO:0045429 ! positive regulation of nitric oxide biosynthetic process
- GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation
- GO:0030335 ! positive regulation of cell migration
- GO:0043388 ! positive regulation of DNA binding
- GO:2001235 ! positive regulation of apoptotic signaling pathway
- GO:0042531 ! positive regulation of tyrosine phosphorylation of STAT protein
- GO:0008284 ! positive regulation of cell population proliferation
- GO:0050867 ! positive regulation of cell activation
- GO:0051091 ! positive regulation of DNA-binding transcription factor activity
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:1904707 ! positive regulation of vascular associated smooth muscle cell proliferation
- GO:1904037 ! positive regulation of epithelial cell apoptotic process
- GO:1902728 ! positive regulation of growth factor dependent skeletal muscle satellite cell proliferation
- GO:0032760 ! positive regulation of tumor necrosis factor production
- GO:0060399 ! positive regulation of growth hormone receptor signaling pathway
- GO:0032731 ! positive regulation of interleukin-1 beta production
- GO:0120162 ! positive regulation of cold-induced thermogenesis
- GO:0007204 ! positive regulation of cytosolic calcium ion concentration
- GO:0032024 ! positive regulation of insulin secretion
- GO:0035166 ! post-embryonic hemopoiesis
- GO:0098794 ! postsynapse
- GO:0099527 ! postsynapse to nucleus signaling pathway
- GO:0046777 ! protein autophosphorylation
- GO:0019901 ! protein kinase binding
- GO:0004672 ! protein kinase activity
- GO:0006468 ! protein phosphorylation
- GO:0004713 ! protein tyrosine kinase activity
r
- GO:0050727 ! regulation of inflammatory response
- GO:0046425 ! regulation of receptor signaling pathway via JAK-STAT
- GO:0045428 ! regulation of nitric oxide biosynthetic process
- GO:0046677 ! response to antibiotic
- GO:0034612 ! response to tumor necrosis factor
- GO:0006979 ! response to oxidative stress
- GO:0033194 ! response to hydroperoxide
- GO:0032496 ! response to lipopolysaccharide
- GO:0070671 ! response to interleukin-12
- GO:0097012 ! response to granulocyte macrophage colony-stimulating factor
- Rodentia
s
t