HUMAN:BAD

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	BAD (synonyms: BBC6, BCL2L8)
Protein Name(s)	Bcl2-associated agonist of cell death BAD Bcl-2-binding component 6 Bcl-2-like protein 8 Bcl2-L-8 Bcl-xL/Bcl-2-associated death promoter Bcl2 antagonist of cell death
External Links
UniProt	Q92934
EMBL	U66879 AF021792 AF031523 AK291863 BT006678 CR541935 CR541959 AB451254 AB451378 CH471076 BC001901 BC095431
CCDS	CCDS8065.1
RefSeq	NP_004313.1 NP_116784.1
UniGene	Hs.370254
PDB	1G5J
PDBsum	1G5J
ProteinModelPortal	Q92934
SMR	Q92934
BioGrid	107048
DIP	DIP-29184N
IntAct	Q92934
MINT	MINT-216253
STRING	9606.ENSP00000309103
BindingDB	Q92934
ChEMBL	CHEMBL3817
PhosphoSite	Q92934
DMDM	17371773
MaxQB	Q92934
PaxDb	Q92934
PeptideAtlas	Q92934
PRIDE	Q92934
DNASU	572
Ensembl	ENST00000309032 ENST00000394532
GeneID	572
KEGG	hsa:572
UCSC	uc001nzc.3
CTD	572
GeneCards	GC11M064037
HGNC	HGNC:936
HPA	CAB004205 HPA028185
MIM	603167
neXtProt	NX_Q92934
PharmGKB	PA25236
eggNOG	NOG43412
GeneTree	ENSGT00390000010740
HOGENOM	HOG000095169
HOVERGEN	HBG001653
InParanoid	Q92934
KO	K02158
OMA	GEAGHQQ
OrthoDB	EOG7MD4RF
PhylomeDB	Q92934
TreeFam	TF102001
Reactome	REACT_12564 REACT_13638 REACT_147727 REACT_330
ChiTaRS	BAD
EvolutionaryTrace	Q92934
GeneWiki	Bcl-2-associated_death_promoter
GenomeRNAi	572
NextBio	2331
PMAP-CutDB	Q92934
PRO	PR:Q92934
Proteomes	UP000005640
Bgee	Q92934
CleanEx	HS_BAD
ExpressionAtlas	Q92934
Genevestigator	Q92934
GO	GO:0005829 GO:0005741 GO:0005739 GO:0008656 GO:0008289 GO:0005543 GO:0019901 GO:0097202 GO:0006919 GO:0046031 GO:0006915 GO:0097190 GO:0046034 GO:0060154 GO:0071247 GO:0071456 GO:0071396 GO:0071260 GO:0071316 GO:0019221 GO:0007173 GO:0097191 GO:0097192 GO:0008625 GO:0038095 GO:0008543 GO:0006007 GO:0042593 GO:0045087 GO:0097193 GO:0008630 GO:0048011 GO:0048015 GO:0046931 GO:0043065 GO:0060139 GO:0010508 GO:0045579 GO:0043280 GO:0050679 GO:0033133 GO:0032024 GO:0035774 GO:2001244 GO:0010918 GO:1901216 GO:1900740 GO:0045862 GO:0090200 GO:0045582 GO:2000078 GO:0046902 GO:0001836 GO:0043200 GO:0051592 GO:0042493 GO:0032355 GO:0045471 GO:0051384 GO:0009749 GO:0042542 GO:0034201 GO:0032570 GO:0033574 GO:0019050 GO:0044342
InterPro	IPR018868
Pfam	PF10514

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0097202	activation of cysteine-type endopeptidase activity	PMID:18387192^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045862	positive regulation of proteolysis	PMID:18387192^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:2000078	positive regulation of type B pancreatic cell development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61337	P		Seeded From UniProt	complete
involved_in	GO:0097193	intrinsic apoptotic signaling pathway	PMID:18676776^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	PMID:18852119^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	PMID:17289999^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(UniProtKB:Q13794)	Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:20810912^[5]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071316	cellular response to nicotine	PMID:18676776^[2]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	PMID:19593445^[6]	ECO:0000270	expression pattern evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050679	positive regulation of epithelial cell proliferation	PMID:19593445^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046931	pore complex assembly	PMID:21081150^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046931	pore complex assembly	PMID:19667065^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046902	regulation of mitochondrial membrane permeability	PMID:20700721^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046034	ATP metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61337	P		Seeded From UniProt	complete
involved_in	GO:0046031	ADP metabolic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61337	P		Seeded From UniProt	complete
involved_in	GO:0044342	type B pancreatic cell proliferation	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61337	P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:18402937^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:17289999^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_participant:(UniProtKB:Q13794)	Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	PMID:9388232^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61337	P		Seeded From UniProt	complete
involved_in	GO:0033133	positive regulation of glucokinase activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61337	P		Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61337	P		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:17270021^[12]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q86V86	F		Seeded From UniProt	complete
involved_in	GO:0010918	positive regulation of mitochondrial membrane potential	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61337	P		Seeded From UniProt	complete
enables	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	PMID:18402937^[10]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0008289	lipid binding	PMID:19667065^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q61337	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:19667065^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:20700721^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	PMID:20700721^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005543	phospholipid binding	PMID:21081150^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0097202	activation of cysteine-type endopeptidase activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002004008 UniProtKB:Q92934	P		Seeded From UniProt	complete
involved_in	GO:0097193	intrinsic apoptotic signaling pathway	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002004008 UniProtKB:Q92934	P		Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002004008 UniProtKB:Q92934	P		Seeded From UniProt	complete
involved_in	GO:0071456	cellular response to hypoxia	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002004008 UniProtKB:Q92934	P		Seeded From UniProt	complete
involved_in	GO:0046902	regulation of mitochondrial membrane permeability	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002004008 UniProtKB:Q92934	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096330 PANTHER:PTN002004008	F		Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN002004008 UniProtKB:Q92934	F		Seeded From UniProt	complete
enables	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096330 PANTHER:PTN002004008 UniProtKB:Q92934	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096330 PANTHER:PTN002004008 RGD:620103 UniProtKB:Q92934	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096330 PANTHER:PTN002004008 RGD:620103 UniProtKB:Q92934	C		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1096330 PANTHER:PTN002004008	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:1904710	positive regulation of granulosa cell apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:1901216	positive regulation of neuron death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
enables	GO:0071889	14-3-3 protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	F		Seeded From UniProt	complete
involved_in	GO:0071247	cellular response to chromate	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0051384	response to glucocorticoid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0045471	response to ethanol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
enables	GO:0043422	protein kinase B binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	F		Seeded From UniProt	complete
involved_in	GO:0043200	response to amino acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0042542	response to hydrogen peroxide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0034201	response to oleic acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0033574	response to testosterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0032355	response to estradiol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
enables	GO:0030346	protein phosphatase 2B binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	F		Seeded From UniProt	complete
involved_in	GO:0021987	cerebral cortex development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0009749	response to glucose	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0009725	response to hormone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:0007283	spermatogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	C		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O35147 ensembl:ENSRNOP00000028712	P		Seeded From UniProt	complete
involved_in	GO:2000078	positive regulation of type B pancreatic cell development	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:1902220	positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0071396	cellular response to lipid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0060154	cellular process regulating host cell cycle in response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0060139	positive regulation of apoptotic process by virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	F		Seeded From UniProt	complete
involved_in	GO:0046034	ATP metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0046031	ADP metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0045582	positive regulation of T cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0045579	positive regulation of B cell differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0044342	type B pancreatic cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0042593	glucose homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0033133	positive regulation of glucokinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0032024	positive regulation of insulin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
enables	GO:0019903	protein phosphatase binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	F		Seeded From UniProt	complete
involved_in	GO:0019221	cytokine-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0019050	suppression by virus of host apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0010918	positive regulation of mitochondrial membrane potential	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
enables	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	F		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0008283	cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0006007	glucose catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	C		Seeded From UniProt	complete
involved_in	GO:0001836	release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q61337 ensembl:ENSMUSP00000025910	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR018868	P		Seeded From UniProt	complete
involved_in	GO:0010508	positive regulation of autophagy	PMID:18309324^[14]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	has_regulation_target:(UniProtKB:P10415)\|has_regulation_target:(UniProtKB:Q07817-1)	Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:7834748^[15]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
	GO:1990051	activation of protein kinase C activity	PMID:9388241^[16]	ECO:0000314			P		Figure 2	complete CACAO 9429
involved_in	GO:2001244	positive regulation of intrinsic apoptotic signaling pathway	Reactome:R-HSA-111453	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	Reactome:R-HSA-111447	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-2399941 Reactome:R-HSA-205075 Reactome:R-HSA-139906 Reactome:R-HSA-139905 Reactome:R-HSA-139899	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	Reactome:R-HSA-508162 Reactome:R-HSA-139905 Reactome:R-HSA-139897	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0001844	protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	Reactome:R-HSA-139905	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005741	mitochondrial outer membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1000 UniProtKB-SubCell:SL-0172	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Ketteler, R et al. (2008) A pathway sensor for genome-wide screens of intracellular proteolytic cleavage. Genome Biol. 9 R64 PubMed GONUTS page
↑ ^2.0 ^2.1 Zhang, J et al. (2009) Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer. Am. J. Respir. Cell Mol. Biol. 40 135-46 PubMed GONUTS page
↑ Co, NN et al. (2008) Oncogene AF1q enhances doxorubicin-induced apoptosis through BAD-mediated mitochondrial apoptotic pathway. Mol. Cancer Ther. 7 3160-8 PubMed GONUTS page
↑ ^4.0 ^4.1 Willis, SN et al. (2007) Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 315 856-9 PubMed GONUTS page
↑ Chen, B et al. (2010) Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. Am. J. Physiol., Cell Physiol. 299 C968-76 PubMed GONUTS page
↑ ^6.0 ^6.1 Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page
↑ ^7.0 ^7.1 Polzien, L et al. (2011) Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part. Biochim. Biophys. Acta 1810 162-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 Polzien, L et al. (2009) Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation. J. Biol. Chem. 284 28004-20 PubMed GONUTS page
↑ ^9.0 ^9.1 ^9.2 Cerioni, L & Cantoni, O (2010) Assessing Bad sub-cellular localization under conditions associated with prevention or promotion of mitochondrial permeability transition-dependent toxicity. Methods Mol. Biol. 648 291-301 PubMed GONUTS page
↑ ^10.0 ^10.1 Chen, J et al. (2008) Anti-apoptotic actions of vasopressin in H32 neurons involve MAP kinase transactivation and Bad phosphorylation. Exp. Neurol. 211 529-38 PubMed GONUTS page
↑ Ottilie, S et al. (1997) Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins. J. Biol. Chem. 272 30866-72 PubMed GONUTS page
↑ Popivanova, BK et al. (2007) Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis. Cancer Sci. 98 321-8 PubMed GONUTS page
↑ ^13.00 ^13.01 ^13.02 ^13.03 ^13.04 ^13.05 ^13.06 ^13.07 ^13.08 ^13.09 ^13.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Galluzzi, L et al. (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15 1113-23 PubMed GONUTS page
↑ Yang, E et al. (1995) Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80 285-91 PubMed GONUTS page
↑ Gray, MO et al. (1997) A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death. J. Biol. Chem. 272 30945-51 PubMed GONUTS page

[PMID:18387192-1] 1.0 ^1.1 Ketteler, R et al. (2008) A pathway sensor for genome-wide screens of intracellular proteolytic cleavage. Genome Biol. 9 R64 PubMed GONUTS page

[PMID:18676776-2] 2.0 ^2.1 Zhang, J et al. (2009) Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer. Am. J. Respir. Cell Mol. Biol. 40 135-46 PubMed GONUTS page

[PMID:18852119-3] Co, NN et al. (2008) Oncogene AF1q enhances doxorubicin-induced apoptosis through BAD-mediated mitochondrial apoptotic pathway. Mol. Cancer Ther. 7 3160-8 PubMed GONUTS page

[PMID:17289999-4] 4.0 ^4.1 Willis, SN et al. (2007) Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 315 856-9 PubMed GONUTS page

[PMID:20810912-5] Chen, B et al. (2010) Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts. Am. J. Physiol., Cell Physiol. 299 C968-76 PubMed GONUTS page

[PMID:19593445-6] 6.0 ^6.1 Smith, AJ et al. (2009) Expression of the Bcl-2 protein BAD promotes prostate cancer growth. PLoS ONE 4 e6224 PubMed GONUTS page

[PMID:21081150-7] 7.0 ^7.1 Polzien, L et al. (2011) Pore-forming activity of BAD is regulated by specific phosphorylation and structural transitions of the C-terminal part. Biochim. Biophys. Acta 1810 162-9 PubMed GONUTS page

[PMID:19667065-8] 8.0 ^8.1 ^8.2 Polzien, L et al. (2009) Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation. J. Biol. Chem. 284 28004-20 PubMed GONUTS page

[PMID:20700721-9] 9.0 ^9.1 ^9.2 Cerioni, L & Cantoni, O (2010) Assessing Bad sub-cellular localization under conditions associated with prevention or promotion of mitochondrial permeability transition-dependent toxicity. Methods Mol. Biol. 648 291-301 PubMed GONUTS page

[PMID:18402937-10] 10.0 ^10.1 Chen, J et al. (2008) Anti-apoptotic actions of vasopressin in H32 neurons involve MAP kinase transactivation and Bad phosphorylation. Exp. Neurol. 211 529-38 PubMed GONUTS page

[PMID:9388232-11] Ottilie, S et al. (1997) Dimerization properties of human BAD. Identification of a BH-3 domain and analysis of its binding to mutant BCL-2 and BCL-XL proteins. J. Biol. Chem. 272 30866-72 PubMed GONUTS page

[PMID:17270021-12] Popivanova, BK et al. (2007) Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis. Cancer Sci. 98 321-8 PubMed GONUTS page

[PMID:21873635-13] 13.00 ^13.01 ^13.02 ^13.03 ^13.04 ^13.05 ^13.06 ^13.07 ^13.08 ^13.09 ^13.10 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:18309324-14] Galluzzi, L et al. (2008) No death without life: vital functions of apoptotic effectors. Cell Death Differ. 15 1113-23 PubMed GONUTS page

[PMID:7834748-15] Yang, E et al. (1995) Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80 285-91 PubMed GONUTS page

[PMID:9388241-16] Gray, MO et al. (1997) A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death. J. Biol. Chem. 272 30945-51 PubMed GONUTS page

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