HUMAN:P2RX7

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	P2RX7
Protein Name(s)	P2X purinoceptor 7 P2X7 ATP receptor P2Z receptor Purinergic receptor
External Links
UniProt	Q99572
EMBL	Y09561 Y12851 Y12852 Y12853 Y12854 Y12855 AY847298 AY847299 AY847300 AY847301 AY847302 AY847303 AY847304 AK290405 AK294126 AC069209 AC079602 Z98941 BC007679 BC011913
CCDS	CCDS9213.1
RefSeq	NP_002553.3
UniGene	Hs.729169
ProteinModelPortal	Q99572
SMR	Q99572
IntAct	Q99572
MINT	MINT-3972963
STRING	9606.ENSP00000261826
BindingDB	Q99572
ChEMBL	CHEMBL4805
GuidetoPHARMACOLOGY	484
TCDB	1.A.7.1.3
PhosphoSite	Q99572
DMDM	395398617
PaxDb	Q99572
PRIDE	Q99572
Ensembl	ENST00000328963 ENST00000535250 ENST00000535600 ENST00000541022 ENST00000541716
GeneID	5027
KEGG	hsa:5027
UCSC	uc001tzm.3
CTD	5027
GeneCards	GC12P121570
HGNC	HGNC:8537
HPA	HPA034968 HPA044141
MIM	602566
neXtProt	NX_Q99572
PharmGKB	PA32866
eggNOG	NOG38999
GeneTree	ENSGT00390000016028
HOGENOM	HOG000232042
HOVERGEN	HBG053086
InParanoid	Q99572
KO	K05220
OrthoDB	EOG78PV92
TreeFam	TF328633
Reactome	REACT_75808
SignaLink	Q99572
ChiTaRS	P2RX7
GeneWiki	P2RX7
GenomeRNAi	5027
NextBio	13635968
PRO	PR:Q99572
Proteomes	UP000005640
Bgee	Q99572
CleanEx	HS_P2RX7
ExpressionAtlas	Q99572
Genevestigator	Q99572
GO	GO:0032059 GO:0005737 GO:0005639 GO:0005887 GO:0016020 GO:0005886 GO:0005524 GO:0004931 GO:0001530 GO:0042803 GO:0001614 GO:0005102 GO:0097190 GO:0032060 GO:0098655 GO:0006812 GO:0007166 GO:0045087 GO:0051899 GO:0045779 GO:0043409 GO:0035872 GO:0046931 GO:0030501 GO:0010524 GO:0045919 GO:0051495 GO:0050718 GO:0035590 GO:0051709 GO:0002028 GO:0033198 GO:0019233
Gene3D	2.60.490.10
InterPro	IPR003050 IPR027309 IPR001429
PANTHER	PTHR10125 PTHR10125:SF13
Pfam	PF00864
PRINTS	PR01314 PR01307
TIGRFAMs	TIGR00863
PROSITE	PS01212

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0010628	positive regulation of gene expression	PMID:22898868^[1]	ECO:0000315			P		Figure 4-P2X7R expression causes overexpression of the key glycolytic enzymes G3PDH and PFK.	complete CACAO 5234
	GO:0045821	positive regulation of glycolysis	PMID:22898868^[1]	ECO:0000315			P		From figure 1 it shows that P2X7R expression stimulates cell metabolism	complete CACAO 5347
involved_in	GO:0002931	response to ischemia	PMID:12849743^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0046931	pore complex assembly	PMID:25651887^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:Q4KMQ2)	Seeded From UniProt	complete
involved_in	GO:0045794	negative regulation of cell volume	PMID:25651887^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1904172	positive regulation of bleb assembly	PMID:25651887^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0017121	plasma membrane phospholipid scrambling	PMID:25651887^[3]	ECO:0000314	direct assay evidence used in manual assertion		P	has_input:(CHEBI:18303)	Seeded From UniProt	complete
involved_in	GO:0035590	purinergic nucleotide receptor signaling pathway	PMID:25651887^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034767	positive regulation of ion transmembrane transport	PMID:25651887^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q4KMQ2)	Seeded From UniProt	complete
involved_in	GO:0045821	positive regulation of glycolytic process	PMID:22898868^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:22898868^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:12107182^[4]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0032060	bleb assembly	PMID:12107182^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0097190	apoptotic signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64663	P		Seeded From UniProt	complete
involved_in	GO:0051899	membrane depolarization	PMID:9038151^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051709	regulation of killing of cells of other organism	PMID:17785580^[6]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051495	positive regulation of cytoskeleton organization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64663	P		Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	PMID:17036048^[7]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	PMID:18089587^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0046931	pore complex assembly	PMID:9038151^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045919	positive regulation of cytolysis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64663	P		Seeded From UniProt	complete
involved_in	GO:0045779	negative regulation of bone resorption	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z1M0	P		Seeded From UniProt	complete
involved_in	GO:0043409	negative regulation of MAPK cascade	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z1M0	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:17895406^[9]	ECO:0000303	author statement without traceable support used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0033198	response to ATP	PMID:9038151^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032060	bleb assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64663	P		Seeded From UniProt	complete
part_of	GO:0032059	bleb	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64663	C		Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z1M0	P		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z1M0	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	PMID:17785580^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0010524	positive regulation of calcium ion transport into cytosol	PMID:9038151^[5]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64663	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:9038151^[5]	ECO:0000305	curator inference used in manual assertion	GO:0001614	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17785580^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64663	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64663	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	PMID:9038151^[5]	ECO:0000305	curator inference used in manual assertion	GO:0001614	F		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	PMID:17785580^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64663	F		Seeded From UniProt	complete
enables	GO:0004931	extracellularly ATP-gated cation channel activity	PMID:9038151^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002028	regulation of sodium ion transport	PMID:17785580^[6]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q64663	P		Seeded From UniProt	complete
enables	GO:0001614	purinergic nucleotide receptor activity	PMID:9038151^[5]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Z1M0	F		Seeded From UniProt	complete
enables	GO:0035381	ATP-gated ion channel activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000012953 dictyBase:DDB_G0272004	F		Seeded From UniProt	complete
involved_in	GO:0034220	ion transmembrane transport	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000012953 UniProtKB:Q99571	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000012953 RGD:620251 ZFIN:ZDB-GENE-020806-2	C		Seeded From UniProt	complete
involved_in	GO:0006812	cation transport	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1097160 MGI:MGI:1339957 PANTHER:PTN000012953 ZFIN:ZDB-GENE-000427-3 ZFIN:ZDB-GENE-020806-2 ZFIN:ZDB-GENE-030319-3 ZFIN:ZDB-GENE-030319-4 ZFIN:ZDB-GENE-030319-5 ZFIN:ZDB-GENE-030319-6 ZFIN:ZDB-GENE-030319-7	P		Seeded From UniProt	complete
part_of	GO:0005639	integral component of nuclear inner membrane	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000804619 RGD:3241	C		Seeded From UniProt	complete
enables	GO:0004931	extracellularly ATP-gated cation channel activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1097160 MGI:MGI:1338859 MGI:MGI:1339957 MGI:MGI:2137026 MGI:MGI:2665170 PANTHER:PTN000804619 RGD:3240 RGD:3241 RGD:3243 RGD:620251 RGD:620253 RGD:620256 RGD:62073 UniProtKB:Q99571 UniProtKB:Q99572 UniProtKB:Q9UBL9 ZFIN:ZDB-GENE-020806-2 ZFIN:ZDB-GENE-030319-2 ZFIN:ZDB-GENE-030319-3 ZFIN:ZDB-GENE-030319-6 ZFIN:ZDB-GENE-030319-7	F		Seeded From UniProt	complete
enables	GO:0001614	purinergic nucleotide receptor activity	PMID:21873635^[10]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1098235 PANTHER:PTN000012953 RGD:3241 RGD:62073 UniProtKB:P51575 UniProtKB:Q99571 UniProtKB:Q99572	F		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004931	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0004931	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004931	P		Seeded From UniProt	complete
involved_in	GO:0060079	excitatory postsynaptic potential	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0004931	P		Seeded From UniProt	complete
part_of	GO:0098793	presynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0016079	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0060079	C		Seeded From UniProt	complete
part_of	GO:0098794	postsynapse	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0060079	C		Seeded From UniProt	complete
involved_in	GO:0050717	positive regulation of interleukin-1 alpha secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0050715	positive regulation of cytokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0050714	positive regulation of protein secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0048873	homeostasis of number of cells within a tissue	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0048705	skeletal system morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0046931	pore complex assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0046513	ceramide biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0045794	negative regulation of cell volume	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0045779	negative regulation of bone resorption	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0045778	positive regulation of ossification	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0045332	phospholipid translocation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
part_of	GO:0045202	synapse	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	C		Seeded From UniProt	complete
involved_in	GO:0043410	positive regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0043409	negative regulation of MAPK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0043132	NAD transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0043085	positive regulation of catalytic activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0043029	T cell homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	C		Seeded From UniProt	complete
involved_in	GO:0042493	response to drug	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0042098	T cell proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	F		Seeded From UniProt	complete
involved_in	GO:0034405	response to fluid shear stress	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0033198	response to ATP	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0032963	collagen metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0032731	positive regulation of interleukin-1 beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0032308	positive regulation of prostaglandin secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0032060	bleb assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0031668	cellular response to extracellular stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
part_of	GO:0031594	neuromuscular junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	C		Seeded From UniProt	complete
involved_in	GO:0030501	positive regulation of bone mineralization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0030163	protein catabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0019233	sensory perception of pain	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0016485	protein processing	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0016079	synaptic vesicle exocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	C		Seeded From UniProt	complete
enables	GO:0015267	channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	F		Seeded From UniProt	complete
involved_in	GO:0014070	response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0014054	positive regulation of gamma-aminobutyric acid secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0014049	positive regulation of glutamate secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0012501	programmed cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0010467	gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0010043	response to zinc ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0010033	response to organic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	C		Seeded From UniProt	complete
involved_in	GO:0009617	response to bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0009612	response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0008219	cell death	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0007009	plasma membrane organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0007005	mitochondrion organization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0006900	vesicle budding from membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0006884	cell volume homeostasis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0006816	calcium ion transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0006812	cation transport	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0006649	phospholipid transfer to membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0006509	membrane protein ectodomain proteolysis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
part_of	GO:0005911	cell-cell junction	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	C		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	C		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	F		Seeded From UniProt	complete
enables	GO:0004931	extracellularly ATP-gated cation channel activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	F		Seeded From UniProt	complete
involved_in	GO:0001934	positive regulation of protein phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0001916	positive regulation of T cell mediated cytotoxicity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0001845	phagolysosome assembly	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	F		Seeded From UniProt	complete
involved_in	GO:0000902	cell morphogenesis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0097191	extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0072593	reactive oxygen species metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0071407	cellular response to organic cyclic compound	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0071359	cellular response to dsRNA	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0070230	positive regulation of lymphocyte apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0051901	positive regulation of mitochondrial depolarization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0051602	response to electrical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0051592	response to calcium ion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0051259	protein complex oligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0051209	release of sequestered calcium ion into cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9Z1M0 ensembl:ENSMUSP00000098303	P		Seeded From UniProt	complete
enables	GO:0001614	purinergic nucleotide receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001429 InterPro:IPR003050	F		Seeded From UniProt	complete
enables	GO:0004931	extracellularly ATP-gated cation channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001429	F		Seeded From UniProt	complete
enables	GO:0005216	ion channel activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003050	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003050	F		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001429	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003050	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR003050	C		Seeded From UniProt	complete
involved_in	GO:0033198	response to ATP	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001429	P		Seeded From UniProt	complete
involved_in	GO:0098655	cation transmembrane transport	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001429	P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:17299767^[11] Reactome:R-HSA-877198 Reactome:R-HSA-877187 Reactome:R-HSA-419490 Reactome:R-HSA-139855	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	part_of:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:1905114	cell surface receptor signaling pathway involved in cell-cell signaling	PMID:12151016^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0000129) part_of:(GO:0035585) has_agent:(CL:0000127)	Seeded From UniProt	complete
involved_in	GO:0070588	calcium ion transmembrane transport	PMID:12151016^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0000129) part_of:(GO:0035585) part_of:(GO:1905114)	Seeded From UniProt	complete
involved_in	GO:0035585	calcium-mediated signaling using extracellular calcium source	PMID:12151016^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0071318	cellular response to ATP	PMID:12151016^[12]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	occurs_in:(CL:0000129) part_of:(GO:0035585)	Seeded From UniProt	complete
involved_in	GO:0007596	blood coagulation	Reactome:R-HSA-109582	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0006811	ion transport	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0406	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 ^1.2 ^1.3 Amoroso, F et al. (2012) The P2X7 receptor is a key modulator of aerobic glycolysis. Cell Death Dis 3 e370 PubMed GONUTS page
↑ Cavaliere, F et al. (2003) Up-regulation of P2X2, P2X4 receptor and ischemic cell death: prevention by P2 antagonists. Neuroscience 120 85-98 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Ousingsawat, J et al. (2015) Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages. Nat Commun 6 6245 PubMed GONUTS page
↑ ^4.0 ^4.1 Wilson, HL et al. (2002) Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus. J. Biol. Chem. 277 34017-23 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Rassendren, F et al. (1997) The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA. J. Biol. Chem. 272 5482-6 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 ^6.4 Guo, C et al. (2007) Evidence for functional P2X4/P2X7 heteromeric receptors. Mol. Pharmacol. 72 1447-56 PubMed GONUTS page
↑ Pelegrin, P & Surprenant, A (2006) Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J. 25 5071-82 PubMed GONUTS page
↑ Warren, AY et al. (2008) Interleukin-1 beta secretion from cord blood mononuclear cells in vitro involves P2X 7 receptor activation. Reprod Sci 15 189-94 PubMed GONUTS page
↑ Dubyak, GR (2007) Go it alone no more--P2X7 joins the society of heteromeric ATP-gated receptor channels. Mol. Pharmacol. 72 1402-5 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Ohsawa, K et al. (2007) Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis. Glia 55 604-16 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 James, G & Butt, AM (2002) P2Y and P2X purinoceptor mediated Ca2+ signalling in glial cell pathology in the central nervous system. Eur. J. Pharmacol. 447 247-60 PubMed GONUTS page

[PMID:22898868-1] 1.0 ^1.1 ^1.2 ^1.3 Amoroso, F et al. (2012) The P2X7 receptor is a key modulator of aerobic glycolysis. Cell Death Dis 3 e370 PubMed GONUTS page

[PMID:12849743-2] Cavaliere, F et al. (2003) Up-regulation of P2X2, P2X4 receptor and ischemic cell death: prevention by P2 antagonists. Neuroscience 120 85-98 PubMed GONUTS page

[PMID:25651887-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 ^3.5 Ousingsawat, J et al. (2015) Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages. Nat Commun 6 6245 PubMed GONUTS page

[PMID:12107182-4] 4.0 ^4.1 Wilson, HL et al. (2002) Epithelial membrane proteins induce membrane blebbing and interact with the P2X7 receptor C terminus. J. Biol. Chem. 277 34017-23 PubMed GONUTS page

[PMID:9038151-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 Rassendren, F et al. (1997) The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA. J. Biol. Chem. 272 5482-6 PubMed GONUTS page

[PMID:17785580-6] 6.0 ^6.1 ^6.2 ^6.3 ^6.4 Guo, C et al. (2007) Evidence for functional P2X4/P2X7 heteromeric receptors. Mol. Pharmacol. 72 1447-56 PubMed GONUTS page

[PMID:17036048-7] Pelegrin, P & Surprenant, A (2006) Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J. 25 5071-82 PubMed GONUTS page

[PMID:18089587-8] Warren, AY et al. (2008) Interleukin-1 beta secretion from cord blood mononuclear cells in vitro involves P2X 7 receptor activation. Reprod Sci 15 189-94 PubMed GONUTS page

[PMID:17895406-9] Dubyak, GR (2007) Go it alone no more--P2X7 joins the society of heteromeric ATP-gated receptor channels. Mol. Pharmacol. 72 1402-5 PubMed GONUTS page

[PMID:21873635-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 ^10.5 ^10.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17299767-11] Ohsawa, K et al. (2007) Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis. Glia 55 604-16 PubMed GONUTS page

[PMID:12151016-12] 12.0 ^12.1 ^12.2 ^12.3 James, G & Butt, AM (2002) P2Y and P2X purinoceptor mediated Ca2+ signalling in glial cell pathology in the central nervous system. Eur. J. Pharmacol. 447 247-60 PubMed GONUTS page

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HUMAN:P2RX7

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