CHICK:MYD88

Species (Taxon ID)	Gallus gallus (Chicken). (9031)
Gene Name(s)	MYD88
Protein Name(s)	Myeloid differentiation primary response protein MyD88
External Links
UniProt	A5HNF6
EMBL	EF011109 EF544486 AJ851640
RefSeq	NP_001026133.1
UniGene	Gga.17397
ProteinModelPortal	A5HNF6
SMR	A5HNF6
STRING	9031.ENSGALP00000009551
PaxDb	A5HNF6
Ensembl	ENSGALT00000044477
GeneID	420420
KEGG	gga:420420
CTD	4615
eggNOG	NOG70664
GeneTree	ENSGT00510000048324
HOVERGEN	HBG052547
InParanoid	A5HNF6
KO	K04729
PhylomeDB	A5HNF6
Reactome	REACT_197234 REACT_197235 REACT_197463 REACT_204054 REACT_237695 REACT_245541 REACT_24954 REACT_25089 REACT_255374 REACT_258049 REACT_261022 REACT_27197 REACT_27254 REACT_27259
NextBio	20823331
PRO	PR:A5HNF6
Proteomes	UP000000539
ExpressionAtlas	A5HNF6
GO	GO:0005737 GO:0005829 GO:0005634 GO:0005886 GO:0070935 GO:0035419 GO:0071260 GO:0050830 GO:0090557 GO:0016064 GO:0006954 GO:0045087 GO:0031663 GO:0002755 GO:0044130 GO:0045080 GO:0032740 GO:0032747 GO:0032755 GO:0046330 GO:0050671 GO:0042346 GO:0051092 GO:0032760 GO:0050727 GO:0070555 GO:0002238 GO:0032494 GO:0009615 GO:0035681 GO:0034134 GO:0035682 GO:0034142 GO:0034146 GO:0034154 GO:0002224 GO:0045351
Gene3D	1.10.533.10 3.40.50.10140
InterPro	IPR011029 IPR000488 IPR017281 IPR000157
Pfam	PF00531 PF01582
PIRSF	PIRSF037756
SMART	SM00005 SM00255
SUPFAM	SSF47986 SSF52200
PROSITE	PS50017 PS50104

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Notes	Status
involved_in	GO:0002224	toll-like receptor signaling pathway	PMID:19776194^[1]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	PMID:20053507^[2]	ECO:0000303	author statement without traceable support used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:18582498^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:18582498^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:18582498^[3]	ECO:0000314	direct assay evidence used in manual assertion		C	Seeded From UniProt	complete
enables	GO:0003674	molecular_function	GO_REF:0000015	ECO:0000307	no biological data found used in manual assertion		F	Seeded From UniProt	complete
involved_in	GO:2000341	regulation of chemokine (C-X-C motif) ligand 2 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:2000338	regulation of chemokine (C-X-C motif) ligand 1 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:1902622	regulation of neutrophil migration	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:1900017	positive regulation of cytokine production involved in inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0090557	establishment of endothelial intestinal barrier	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0050671	positive regulation of lymphocyte proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0045351	type I interferon biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0045080	positive regulation of chemokine biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0044130	negative regulation of growth of symbiont in host	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0042127	regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
enables	GO:0035325	Toll-like receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	F	Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0032747	positive regulation of interleukin-23 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0032740	positive regulation of interleukin-17 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0032680	regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0032675	regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0032494	response to peptidoglycan	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0016064	immunoglobulin mediated immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0010468	regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0009682	induced systemic resistance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0007166	cell surface receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	C	Seeded From UniProt	complete
involved_in	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0002238	response to molecule of fungal origin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:P22366 ensembl:ENSMUSP00000035092	P	Seeded From UniProt	complete
involved_in	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017281	P	Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000157 InterPro:IPR000488 InterPro:IPR034249	P	Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017281	P	Seeded From UniProt	complete
enables	GO:0070976	TIR domain binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR017281	F	Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	PMID:12814703^[4]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-GGA-977238	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-GGA-977238	ECO:0000304	author statement supported by traceable reference used in manual assertion		C	Seeded From UniProt	complete
involved_in	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Reactome:R-GGA-977240	ECO:0000304	author statement supported by traceable reference used in manual assertion		P	Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P	Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C	Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P	Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C	Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P	Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Lu, Y et al. (2009) Expression profiles of genes in Toll-like receptor-mediated signaling of broilers infected with Clostridium perfringens. Clin. Vaccine Immunol. 16 1639-47 PubMed GONUTS page
↑ Li, P et al. (2010) Up-regulation of the MyD88-dependent pathway of TLR signaling in spleen and caecum of young chickens infected with Salmonella serovar Pullorum. Vet. Microbiol. 143 346-51 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 Qiu, Y et al. (2008) Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88 (MyD88). Dev. Comp. Immunol. 32 1522-30 PubMed GONUTS page
↑ Lynn, DJ et al. (2003) In silico identification of components of the Toll-like receptor (TLR) signaling pathway in clustered chicken expressed sequence tags (ESTs). Vet. Immunol. Immunopathol. 93 177-84 PubMed GONUTS page

[PMID:19776194-1] Lu, Y et al. (2009) Expression profiles of genes in Toll-like receptor-mediated signaling of broilers infected with Clostridium perfringens. Clin. Vaccine Immunol. 16 1639-47 PubMed GONUTS page

[PMID:20053507-2] Li, P et al. (2010) Up-regulation of the MyD88-dependent pathway of TLR signaling in spleen and caecum of young chickens infected with Salmonella serovar Pullorum. Vet. Microbiol. 143 346-51 PubMed GONUTS page

[PMID:18582498-3] 3.0 ^3.1 ^3.2 Qiu, Y et al. (2008) Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88 (MyD88). Dev. Comp. Immunol. 32 1522-30 PubMed GONUTS page

[PMID:12814703-4] Lynn, DJ et al. (2003) In silico identification of components of the Toll-like receptor (TLR) signaling pathway in clustered chicken expressed sequence tags (ESTs). Vet. Immunol. Immunopathol. 93 177-84 PubMed GONUTS page

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CHICK:MYD88

Contents

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Notes

References

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