GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.

Have any questions? Please email us at ecoliwiki@gmail.com

CHICK:A5HNF6

From GONUTS
Jump to: navigation, search
Species (Taxon ID) Gallus gallus (Chicken). (9031)
Gene Name(s) MYD88
Protein Name(s) Myeloid differentiation primary response protein MyD88
External Links
UniProt A5HNF6
EMBL EF011109
EF544486
AJ851640
RefSeq NP_001026133.1
UniGene Gga.17397
ProteinModelPortal A5HNF6
SMR A5HNF6
STRING 9031.ENSGALP00000009551
PaxDb A5HNF6
Ensembl ENSGALT00000044477
GeneID 420420
KEGG gga:420420
CTD 4615
eggNOG NOG70664
GeneTree ENSGT00510000048324
HOVERGEN HBG052547
InParanoid A5HNF6
KO K04729
PhylomeDB A5HNF6
Reactome REACT_197234
REACT_197235
REACT_197463
REACT_204054
REACT_237695
REACT_245541
REACT_24954
REACT_25089
REACT_255374
REACT_258049
REACT_261022
REACT_27197
REACT_27254
REACT_27259
NextBio 20823331
PRO PR:A5HNF6
Proteomes UP000000539
ExpressionAtlas A5HNF6
GO GO:0005737
GO:0005829
GO:0005634
GO:0005886
GO:0070935
GO:0035419
GO:0071260
GO:0050830
GO:0090557
GO:0016064
GO:0006954
GO:0045087
GO:0031663
GO:0002755
GO:0044130
GO:0045080
GO:0032740
GO:0032747
GO:0032755
GO:0046330
GO:0050671
GO:0042346
GO:0051092
GO:0032760
GO:0050727
GO:0070555
GO:0002238
GO:0032494
GO:0009615
GO:0035681
GO:0034134
GO:0035682
GO:0034142
GO:0034146
GO:0034154
GO:0002224
GO:0045351
Gene3D 1.10.533.10
3.40.50.10140
InterPro IPR011029
IPR000488
IPR017281
IPR000157
Pfam PF00531
PF01582
PIRSF PIRSF037756
SMART SM00005
SM00255
SUPFAM SSF47986
SSF52200
PROSITE PS50017
PS50104

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status

involved_in

GO:0002224

toll-like receptor signaling pathway

PMID:19776194[1]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002755

MyD88-dependent toll-like receptor signaling pathway

PMID:20053507[2]

ECO:0000303

author statement without traceable support used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:1901224

positive regulation of NIK/NF-kappaB signaling

PMID:18582498[3]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:18582498[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

PMID:18582498[3]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0003674

molecular_function

GO_REF:0000015

ECO:0000307

no biological data found used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:2000341

regulation of chemokine (C-X-C motif) ligand 2 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:2000338

regulation of chemokine (C-X-C motif) ligand 1 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:1902622

regulation of neutrophil migration

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:1900017

positive regulation of cytokine production involved in inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0140052

cellular response to oxidised low-density lipoprotein particle stimulus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0090557

establishment of endothelial intestinal barrier

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0050727

regulation of inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0050671

positive regulation of lymphocyte proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0046330

positive regulation of JNK cascade

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0045351

type I interferon biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0045080

positive regulation of chemokine biosynthetic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0044130

negative regulation of growth of symbiont in host

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0042127

regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

enables

GO:0035325

Toll-like receptor binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

F

Seeded From UniProt

complete

involved_in

GO:0032760

positive regulation of tumor necrosis factor production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0032755

positive regulation of interleukin-6 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0032747

positive regulation of interleukin-23 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0032740

positive regulation of interleukin-17 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0032680

regulation of tumor necrosis factor production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0032675

regulation of interleukin-6 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0032494

response to peptidoglycan

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0031663

lipopolysaccharide-mediated signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0016064

immunoglobulin mediated immune response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0010468

regulation of gene expression

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0009682

induced systemic resistance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0009615

response to virus

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0007166

cell surface receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

C

Seeded From UniProt

complete

involved_in

GO:0002755

MyD88-dependent toll-like receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0002238

response to molecule of fungal origin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:P22366
ensembl:ENSMUSP00000035092

P

Seeded From UniProt

complete

involved_in

GO:0002755

MyD88-dependent toll-like receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017281

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000157
InterPro:IPR000488
InterPro:IPR034249

P

Seeded From UniProt

complete

involved_in

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017281

P

Seeded From UniProt

complete

enables

GO:0070976

TIR domain binding

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR017281

F

Seeded From UniProt

complete

involved_in

GO:0002224

toll-like receptor signaling pathway

PMID:12814703[4]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-GGA-977238

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005829

cytosol

Reactome:R-GGA-977238

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0002755

MyD88-dependent toll-like receptor signaling pathway

Reactome:R-GGA-977240

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0005634

nucleus

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0539
UniProtKB-SubCell:SL-0191

C

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0963
UniProtKB-SubCell:SL-0086

C

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0395

P

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

  1. Lu, Y et al. (2009) Expression profiles of genes in Toll-like receptor-mediated signaling of broilers infected with Clostridium perfringens. Clin. Vaccine Immunol. 16 1639-47 PubMed GONUTS page
  2. Li, P et al. (2010) Up-regulation of the MyD88-dependent pathway of TLR signaling in spleen and caecum of young chickens infected with Salmonella serovar Pullorum. Vet. Microbiol. 143 346-51 PubMed GONUTS page
  3. 3.0 3.1 3.2 Qiu, Y et al. (2008) Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88 (MyD88). Dev. Comp. Immunol. 32 1522-30 PubMed GONUTS page
  4. Lynn, DJ et al. (2003) In silico identification of components of the Toll-like receptor (TLR) signaling pathway in clustered chicken expressed sequence tags (ESTs). Vet. Immunol. Immunopathol. 93 177-84 PubMed GONUTS page