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HUMAN:TLR2

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Species (Taxon ID) Homo sapiens (Human). (9606)
Gene Name(s) TLR2 (synonyms: TIL4)
Protein Name(s) Toll-like receptor 2

Toll/interleukin-1 receptor-like protein 4

External Links
UniProt O60603
EMBL AF051152
U88878
AB445624
DQ012265
DQ012266
DQ012267
DQ012268
DQ012269
DQ012270
DQ012271
CH471056
CH471056
BC033756
AF502291
CCDS CCDS3784.1
RefSeq NP_003255.2
XP_005263250.1
XP_005263251.1
XP_005263252.1
XP_005263253.1
XP_005263254.1
UniGene Hs.519033
PDB 1FYW
1FYX
1O77
2Z7X
2Z80
PDBsum 1FYW
1FYX
1O77
2Z7X
2Z80
ProteinModelPortal O60603
SMR O60603
BioGrid 112952
DIP DIP-35138N
IntAct O60603
MINT MINT-3000106
STRING 9606.ENSP00000260010
BindingDB O60603
ChEMBL CHEMBL4163
DrugBank DB00045
GuidetoPHARMACOLOGY 1752
PhosphoSite O60603
PaxDb O60603
PRIDE O60603
DNASU 7097
Ensembl ENST00000260010
GeneID 7097
KEGG hsa:7097
UCSC uc003inq.3
CTD 7097
GeneCards GC04P154612
HGNC HGNC:11848
MIM 246300
603028
neXtProt NX_O60603
PharmGKB PA36550
eggNOG NOG251801
GeneTree ENSGT00760000119006
HOGENOM HOG000110611
HOVERGEN HBG108574
InParanoid O60603
KO K10159
OMA LGNPYKT
OrthoDB EOG7SBNN7
PhylomeDB O60603
TreeFam TF351113
Reactome REACT_115897
REACT_6788
REACT_8005
REACT_8006
SignaLink O60603
EvolutionaryTrace O60603
GeneWiki TLR_2
GenomeRNAi 7097
NextBio 27765
PRO PR:O60603
Proteomes UP000005640
Bgee O60603
CleanEx HS_TLR2
ExpressionAtlas O60603
Genevestigator O60603
GO GO:0044297
GO:0042995
GO:0009986
GO:0005737
GO:0009897
GO:0005887
GO:0005886
GO:0035354
GO:0035355
GO:0042498
GO:0001875
GO:0070891
GO:0042834
GO:0046982
GO:0004872
GO:0008329
GO:0004888
GO:0042497
GO:0006915
GO:0002752
GO:0071221
GO:0071726
GO:0071223
GO:0071224
GO:0071727
GO:0032289
GO:0042892
GO:0050830
GO:0042496
GO:0042495
GO:0007252
GO:0006955
GO:0052063
GO:0006954
GO:0045087
GO:0006691
GO:0031663
GO:0001774
GO:0002755
GO:0008285
GO:0044130
GO:0032695
GO:0032700
GO:0046209
GO:0032722
GO:0050715
GO:0050729
GO:0032728
GO:0032733
GO:0032735
GO:0032741
GO:0032755
GO:0032757
GO:0002687
GO:0060907
GO:0042346
GO:0051092
GO:0045429
GO:0051770
GO:0048714
GO:0034123
GO:0045944
GO:0042535
GO:0032760
GO:0030177
GO:0070542
GO:0001666
GO:0032868
GO:0002238
GO:0032570
GO:0009636
GO:0007165
GO:0034134
GO:0034142
GO:0002224
GO:0038123
GO:0038124
Gene3D 3.40.50.10140
InterPro IPR000483
IPR001611
IPR003591
IPR000157
IPR027185
IPR017241
PANTHER PTHR24365:SF17
Pfam PF13855
PF01582
PIRSF PIRSF037595
SMART SM00369
SM00082
SM00255
SUPFAM SSF52200
PROSITE PS51450
PS50104

Annotations

Qualifier GO ID GO term name Reference ECO ID ECO term name with/from Aspect Extension Notes Status
GO:0002374

cytokine secretion involved in immune response

PMID:20441518[1]

ECO:0000315

P

Figure 2. The Effect of TLR2 on cytokine production as an immune response to Borrelia burgdorferi shown through experimentation on stimulated PBMCs.

complete
CACAO 6509

involved_in

GO:0071346

cellular response to interferon-gamma

PMID:11672593[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0001540

amyloid-beta binding

PMID:22198949[3]

ECO:0000314

direct assay evidence used in manual assertion

F

occurs_in:(CL:0000129)

Seeded From UniProt

complete

GO:0045893

positive regulation of transcription, DNA-templated

PMID:24585880[4]

ECO:0000314

P

TLR2 when stimulated with LTA increase expression of mRNA of Tyrosine receptor kinase A (TrkA) as shown in figure 3D and which is further translated to protein as shown in figure 3E.

complete
CACAO 9647

involved_in

GO:2000484

positive regulation of interleukin-8 secretion

PMID:22198949[3]

ECO:0000316

genetic interaction evidence used in manual assertion

ComplexPortal:CPX-1134

P

  • occurs_in:(CL:0002321)
  • occurs_in:(CL:1000497)
  • part_of:(GO:1904646)

Seeded From UniProt

complete

GO:0032613

interleukin-10 production

PMID:23826189[5]

ECO:0000314

P

Figure 2A: TLR 2 was collected in two samples via extraction of mononuclear cells. One sample was stimulated with a TLR agonist, while the other was not. Levels of Interleukin 10 were measured in both. Upon stimulation of the TLR2 receptor, more interleukin 10 was observed in the sample.

complete
CACAO 9869

enables

GO:0044877

protein-containing complex binding

PMID:22198949[3]

ECO:0000353

physical interaction evidence used in manual assertion

ComplexPortal:CPX-1134

F

occurs_in:(CL:0000129)

Seeded From UniProt

complete

involved_in

GO:0071223

cellular response to lipoteichoic acid

PMID:26649771[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:26649771[6]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0001775

cell activation

PMID:15294986[7]

ECO:0000314

direct assay evidence used in manual assertion

P

has_direct_input:(CHEBI:134411)|has_direct_input:(CHEBI:46889)

Seeded From UniProt

complete

enables

GO:0001540

amyloid-beta binding

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QUN7

F

occurs_in:(CL:0000129)

Seeded From UniProt

complete

involved_in

GO:0051964

negative regulation of synapse assembly

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QUN7

P

occurs_in:(UBERON:0000955)

Seeded From UniProt

complete

involved_in

GO:0050765

negative regulation of phagocytosis

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QUN7

P

  • occurs_in:(UBERON:0000956)
  • has_regulation_target:(UniProtKB:P05067:PRO_0000000092)

Seeded From UniProt

complete

involved_in

GO:0032640

tumor necrosis factor production

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QUN7

P

  • has_agent:(CL:0002092)
  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0014005

microglia development

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QUN7

P

  • has_agent:(CL:0002092)
  • occurs_in:(UBERON:0002421)

Seeded From UniProt

complete

involved_in

GO:0007612

learning

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QUN7

P

occurs_in:(UBERON:0000955)

Seeded From UniProt

complete

involved_in

GO:0010628

positive regulation of gene expression

PMID:23817958[8]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071727

cellular response to triacyl bacterial lipopeptide

PMID:16880211[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071726

cellular response to diacyl bacterial lipopeptide

PMID:16880211[9]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005794

Golgi apparatus

PMID:16880211[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

PMID:16880211[9]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0035325

Toll-like receptor binding

PMID:16880211[9]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:Q15399
UniProtKB:Q9Y2C9

F

Seeded From UniProt

complete

enables

GO:0001530

lipopolysaccharide binding

PMID:11274165[10]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0031226

intrinsic component of plasma membrane

PMID:11274165[10]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0002374

cytokine secretion involved in immune response

PMID:20441518[1]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032613

interleukin-10 production

PMID:23826189[5]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:21618349[11]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051770

positive regulation of nitric-oxide synthase biosynthetic process

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QUN7

P

Seeded From UniProt

complete

involved_in

GO:0050729

positive regulation of inflammatory response

PMID:19740627[12]

ECO:0000305

curator inference used in manual assertion

GO:1901224

P

Seeded From UniProt

complete

involved_in

GO:0045944

positive regulation of transcription by RNA polymerase II

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QUN7

P

Seeded From UniProt

complete

involved_in

GO:1901224

positive regulation of NIK/NF-kappaB signaling

PMID:19740627[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0034123

positive regulation of toll-like receptor signaling pathway

PMID:17128265[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032760

positive regulation of tumor necrosis factor production

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QUN7

P

Seeded From UniProt

complete

involved_in

GO:0032757

positive regulation of interleukin-8 production

PMID:19740627[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032757

positive regulation of interleukin-8 production

PMID:17128265[13]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032755

positive regulation of interleukin-6 production

PMID:19740627[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0032741

positive regulation of interleukin-18 production

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QUN7

P

Seeded From UniProt

complete

involved_in

GO:0032735

positive regulation of interleukin-12 production

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QUN7

P

Seeded From UniProt

complete

involved_in

GO:0032728

positive regulation of interferon-beta production

GO_REF:0000024

ECO:0000250

sequence similarity evidence used in manual assertion

UniProtKB:Q9QUN7

P

Seeded From UniProt

complete

involved_in

GO:0032722

positive regulation of chemokine production

PMID:19740627[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0030177

positive regulation of Wnt signaling pathway

PMID:16601243[14]

ECO:0000315

mutant phenotype evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0007252

I-kappaB phosphorylation

PMID:19740627[12]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

PMID:19740627[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005737

cytoplasm

PMID:19740627[12]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

involved_in

GO:0050830

defense response to Gram-positive bacterium

PMID:11521063[15]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0042834

peptidoglycan binding

PMID:11986301[16]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

PMID:12443841[17]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0008329

signaling pattern recognition receptor activity

PMID:10384090[18]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:1903974

positive regulation of cellular response to macrophage colony-stimulating factor stimulus

PMID:11672593[2]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031226

intrinsic component of plasma membrane

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000687557
UniProtKB:O60603

C

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000687652
RGD:1303030
RGD:3870
RGD:735138

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000687652
UniProtKB:O00206

C

Seeded From UniProt

complete

involved_in

GO:0002224

toll-like receptor signaling pathway

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000687652
RGD:1303030
RGD:3870
RGD:735138
RGD:735171

P

Seeded From UniProt

complete

involved_in

GO:0002224

toll-like receptor signaling pathway

PMID:21873635[19]

ECO:0000318

biological aspect of ancestor evidence used in manual assertion

PANTHER:PTN000687557
RGD:735138

P

Seeded From UniProt

complete

involved_in

GO:0071727

cellular response to triacyl bacterial lipopeptide

PMID:19931471[20]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071726

cellular response to diacyl bacterial lipopeptide

PMID:19931471[20]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0071223

cellular response to lipoteichoic acid

PMID:12594207[21]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0051092

positive regulation of NF-kappaB transcription factor activity

PMID:12594207[21]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0046982

protein heterodimerization activity

PMID:17889651[22]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

enables

GO:0042497

triacyl lipopeptide binding

PMID:17889651[22]

ECO:0000314

direct assay evidence used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0042496

detection of diacyl bacterial lipopeptide

PMID:19931471[20]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0042495

detection of triacyl bacterial lipopeptide

PMID:19931471[20]

ECO:0000314

direct assay evidence used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0035354

Toll-like receptor 1-Toll-like receptor 2 protein complex

PMID:17889651[22]

ECO:0000314

direct assay evidence used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0042802

identical protein binding

PMID:23155421[23]

ECO:0000353

physical interaction evidence used in manual assertion

UniProtKB:O60603

F

Seeded From UniProt

complete

involved_in

GO:0031663

lipopolysaccharide-mediated signaling pathway

GO_REF:0000108

ECO:0000364

evidence based on logical inference from manual annotation used in automatic assertion

GO:0001875

P

Seeded From UniProt

complete

enables

GO:0071723

lipopeptide binding

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

F

Seeded From UniProt

complete

involved_in

GO:0070542

response to fatty acid

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

P

Seeded From UniProt

complete

involved_in

GO:0048714

positive regulation of oligodendrocyte differentiation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

P

Seeded From UniProt

complete

involved_in

GO:0046209

nitric oxide metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

P

Seeded From UniProt

complete

part_of

GO:0044297

cell body

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

C

Seeded From UniProt

complete

part_of

GO:0042995

cell projection

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

C

Seeded From UniProt

complete

involved_in

GO:0032868

response to insulin

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

P

Seeded From UniProt

complete

involved_in

GO:0032733

positive regulation of interleukin-10 production

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

P

Seeded From UniProt

complete

involved_in

GO:0032570

response to progesterone

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

P

Seeded From UniProt

complete

involved_in

GO:0032496

response to lipopolysaccharide

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

P

Seeded From UniProt

complete

involved_in

GO:0032493

response to bacterial lipoprotein

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

P

Seeded From UniProt

complete

involved_in

GO:0032289

central nervous system myelin formation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

P

Seeded From UniProt

complete

part_of

GO:0009986

cell surface

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

C

Seeded From UniProt

complete

involved_in

GO:0009636

response to toxic substance

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

P

Seeded From UniProt

complete

involved_in

GO:0008285

negative regulation of cell population proliferation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

P

Seeded From UniProt

complete

involved_in

GO:0006691

leukotriene metabolic process

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

P

Seeded From UniProt

complete

involved_in

GO:0002224

toll-like receptor signaling pathway

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

P

Seeded From UniProt

complete

involved_in

GO:0001774

microglial cell activation

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

P

Seeded From UniProt

complete

involved_in

GO:0001666

response to hypoxia

GO_REF:0000107

ECO:0000265

sequence orthology evidence used in automatic assertion

UniProtKB:E9PTD9
ensembl:ENSRNOP00000013025

P

Seeded From UniProt

complete

involved_in

GO:0002237

response to molecule of bacterial origin

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027185

P

Seeded From UniProt

complete

involved_in

GO:0002755

MyD88-dependent toll-like receptor signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027185

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027185

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR000157

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027185

C

Seeded From UniProt

complete

involved_in

GO:0034134

toll-like receptor 2 signaling pathway

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027185

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027185

P

Seeded From UniProt

complete

involved_in

GO:0050707

regulation of cytokine secretion

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027185

P

Seeded From UniProt

complete

involved_in

GO:0050729

positive regulation of inflammatory response

GO_REF:0000002

ECO:0000256

match to sequence model evidence used in automatic assertion

InterPro:IPR027185

P

Seeded From UniProt

complete

involved_in

GO:0007165

signal transduction

PMID:10426996[24]
PMID:10426995[25]
PMID:11044375[26]

ECO:0000304

author statement supported by traceable reference used in manual assertion



P

Seeded From UniProt

complete

involved_in

GO:0006955

immune response

PMID:10426995[25]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0006915

apoptotic process

PMID:10426996[24]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0005887

integral component of plasma membrane

PMID:9435236[27]

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

enables

GO:0038023

signaling receptor activity

PMID:10426995[25]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0071221

cellular response to bacterial lipopeptide

PMID:15356140[28]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

PMID:15356140[28]

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

enables

GO:0001875

lipopolysaccharide receptor activity

PMID:11518816[29]

ECO:0000304

author statement supported by traceable reference used in manual assertion

F

Seeded From UniProt

complete

involved_in

GO:0043312

neutrophil degranulation

Reactome:R-HSA-6798695

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0038124

toll-like receptor TLR6:TLR2 signaling pathway

Reactome:R-HSA-168188

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0038123

toll-like receptor TLR1:TLR2 signaling pathway

Reactome:R-HSA-168179

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0030667

secretory granule membrane

Reactome:R-HSA-6798743

ECO:0000304

author statement supported by traceable reference used in manual assertion

C

Seeded From UniProt

complete

part_of

GO:0005886

plasma membrane

Reactome:R-HSA-937079
Reactome:R-HSA-937059
Reactome:R-HSA-937022
Reactome:R-HSA-6798743
Reactome:R-HSA-5602672
Reactome:R-HSA-5602606
Reactome:R-HSA-5602383
Reactome:R-HSA-5602353
Reactome:R-HSA-5432814
Reactome:R-HSA-2559414
Reactome:R-HSA-2262777
Reactome:R-HSA-2262775
Reactome:R-HSA-2201322
Reactome:R-HSA-2201316
Reactome:R-HSA-1974676
Reactome:R-HSA-168951
Reactome:R-HSA-168950
Reactome:R-HSA-166363
Reactome:R-HSA-166362
Reactome:R-HSA-166286
Reactome:R-HSA-166284
Reactome:R-HSA-166119
Reactome:R-HSA-166091
Reactome:R-HSA-166082
Reactome:R-HSA-166072

ECO:0000304

author statement supported by traceable reference used in manual assertion

























C

Seeded From UniProt

complete

involved_in

GO:0002755

MyD88-dependent toll-like receptor signaling pathway

Reactome:R-HSA-166058

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

involved_in

GO:0002224

toll-like receptor signaling pathway

Reactome:R-HSA-168898

ECO:0000304

author statement supported by traceable reference used in manual assertion

P

Seeded From UniProt

complete

part_of

GO:0031410

cytoplasmic vesicle

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0968

C

Seeded From UniProt

complete

involved_in

GO:0045087

innate immune response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0399

P

Seeded From UniProt

complete

involved_in

GO:0006954

inflammatory response

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0395

P

Seeded From UniProt

complete

part_of

GO:0016021

integral component of membrane

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0812

C

Seeded From UniProt

complete

involved_in

GO:0002376

immune system process

GO_REF:0000037

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0391

P

Seeded From UniProt

complete

part_of

GO:0016020

membrane

GO_REF:0000037
GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-KW:KW-0472
UniProtKB-SubCell:SL-0162

C

Seeded From UniProt

complete

part_of

GO:0045121

membrane raft

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0370

C

Seeded From UniProt

complete

part_of

GO:0030670

phagocytic vesicle membrane

GO_REF:0000039

ECO:0000322

imported manually asserted information used in automatic assertion

UniProtKB-SubCell:SL-0205

C

Seeded From UniProt

complete

Notes

References

See Help:References for how to manage references in GONUTS.

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  2. 2.0 2.1 Mita, Y et al. (2001) Toll-like receptor 2 and 4 surface expressions on human monocytes are modulated by interferon-gamma and macrophage colony-stimulating factor. Immunol. Lett. 78 97-101 PubMed GONUTS page
  3. 3.0 3.1 3.2 Liu, S et al. (2012) TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation. J. Immunol. 188 1098-107 PubMed GONUTS page
  4. Prencipe, G et al. (2014) Nerve growth factor downregulates inflammatory response in human monocytes through TrkA. J. Immunol. 192 3345-54 PubMed GONUTS page
  5. 5.0 5.1 Cardoso, EC et al. (2013) TLR7/TLR8 Activation Restores Defective Cytokine Secretion by Myeloid Dendritic Cells but Not by Plasmacytoid Dendritic Cells in HIV-Infected Pregnant Women and Newborns. PLoS ONE 8 e67036 PubMed GONUTS page
  6. 6.0 6.1 Kim, JH et al. (2015) Expression of Beta-Defensin 131 Promotes an Innate Immune Response in Human Prostate Epithelial Cells. PLoS ONE 10 e0144776 PubMed GONUTS page
  7. Schröder, NW et al. (2004) Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses. J. Immunol. 173 2683-91 PubMed GONUTS page
  8. Gieseke, F et al. (2013) Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation. Eur. J. Immunol. 43 2741-9 PubMed GONUTS page
  9. 9.0 9.1 9.2 9.3 9.4 Triantafilou, M et al. (2006) Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. J. Biol. Chem. 281 31002-11 PubMed GONUTS page
  10. 10.0 10.1 da Silva Correia, J et al. (2001) Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2. J. Biol. Chem. 276 21129-35 PubMed GONUTS page
  11. Ben-Ali, M et al. (2011) Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family. Hum. Mutat. 32 643-52 PubMed GONUTS page
  12. 12.0 12.1 12.2 12.3 12.4 12.5 12.6 12.7 Yu, N et al. (2009) Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9. J. Dermatol. Sci. 56 113-20 PubMed GONUTS page
  13. 13.0 13.1 Lee, J et al. (2006) Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat. Cell Biol. 8 1327-36 PubMed GONUTS page
  14. Blumenthal, A et al. (2006) The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood 108 965-73 PubMed GONUTS page
  15. Dziarski, R & Gupta, D (2000) Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive bacteria and activation of chemokine genes. J. Endotoxin Res. 6 401-5 PubMed GONUTS page
  16. Iwaki, D et al. (2002) The extracellular toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus. J. Biol. Chem. 277 24315-20 PubMed GONUTS page
  17. Kawai, K et al. (2002) Expression of functional Toll-like receptor 2 on human epidermal keratinocytes. J. Dermatol. Sci. 30 185-94 PubMed GONUTS page
  18. Yoshimura, A et al. (1999) Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J. Immunol. 163 1-5 PubMed GONUTS page
  19. 19.0 19.1 19.2 19.3 19.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
  20. 20.0 20.1 20.2 20.3 Kang, JY et al. (2009) Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. Immunity 31 873-84 PubMed GONUTS page
  21. 21.0 21.1 Schröder, NW et al. (2003) Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. J. Biol. Chem. 278 15587-94 PubMed GONUTS page
  22. 22.0 22.1 22.2 Jin, MS et al. (2007) Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130 1071-82 PubMed GONUTS page
  23. Godfroy, JI 3rd et al. (2012) Isolated Toll-like receptor transmembrane domains are capable of oligomerization. PLoS ONE 7 e48875 PubMed GONUTS page
  24. 24.0 24.1 Aliprantis, AO et al. (1999) Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 285 736-9 PubMed GONUTS page
  25. 25.0 25.1 25.2 Brightbill, HD et al. (1999) Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 285 732-6 PubMed GONUTS page
  26. Muzio, M et al. (2000) Toll-like receptor family and signalling pathway. Biochem. Soc. Trans. 28 563-6 PubMed GONUTS page
  27. Rock, FL et al. (1998) A family of human receptors structurally related to Drosophila Toll. Proc. Natl. Acad. Sci. U.S.A. 95 588-93 PubMed GONUTS page
  28. 28.0 28.1 Olson, JK & Miller, SD (2004) Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J. Immunol. 173 3916-24 PubMed GONUTS page
  29. Hallman, M et al. (2001) Toll-like receptors as sensors of pathogens. Pediatr. Res. 50 315-21 PubMed GONUTS page