HUMAN:TLR2

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	TLR2 (synonyms: TIL4)
Protein Name(s)	Toll-like receptor 2 Toll/interleukin-1 receptor-like protein 4
External Links
UniProt	O60603
EMBL	AF051152 U88878 AB445624 DQ012265 DQ012266 DQ012267 DQ012268 DQ012269 DQ012270 DQ012271 CH471056 CH471056 BC033756 AF502291
CCDS	CCDS3784.1
RefSeq	NP_003255.2 XP_005263250.1 XP_005263251.1 XP_005263252.1 XP_005263253.1 XP_005263254.1
UniGene	Hs.519033
PDB	1FYW 1FYX 1O77 2Z7X 2Z80
PDBsum	1FYW 1FYX 1O77 2Z7X 2Z80
ProteinModelPortal	O60603
SMR	O60603
BioGrid	112952
DIP	DIP-35138N
IntAct	O60603
MINT	MINT-3000106
STRING	9606.ENSP00000260010
BindingDB	O60603
ChEMBL	CHEMBL4163
DrugBank	DB00045
GuidetoPHARMACOLOGY	1752
PhosphoSite	O60603
PaxDb	O60603
PRIDE	O60603
DNASU	7097
Ensembl	ENST00000260010
GeneID	7097
KEGG	hsa:7097
UCSC	uc003inq.3
CTD	7097
GeneCards	GC04P154612
HGNC	HGNC:11848
MIM	246300 603028
neXtProt	NX_O60603
PharmGKB	PA36550
eggNOG	NOG251801
GeneTree	ENSGT00760000119006
HOGENOM	HOG000110611
HOVERGEN	HBG108574
InParanoid	O60603
KO	K10159
OMA	LGNPYKT
OrthoDB	EOG7SBNN7
PhylomeDB	O60603
TreeFam	TF351113
Reactome	REACT_115897 REACT_6788 REACT_8005 REACT_8006
SignaLink	O60603
EvolutionaryTrace	O60603
GeneWiki	TLR_2
GenomeRNAi	7097
NextBio	27765
PRO	PR:O60603
Proteomes	UP000005640
Bgee	O60603
CleanEx	HS_TLR2
ExpressionAtlas	O60603
Genevestigator	O60603
GO	GO:0044297 GO:0042995 GO:0009986 GO:0005737 GO:0009897 GO:0005887 GO:0005886 GO:0035354 GO:0035355 GO:0042498 GO:0001875 GO:0070891 GO:0042834 GO:0046982 GO:0004872 GO:0008329 GO:0004888 GO:0042497 GO:0006915 GO:0002752 GO:0071221 GO:0071726 GO:0071223 GO:0071224 GO:0071727 GO:0032289 GO:0042892 GO:0050830 GO:0042496 GO:0042495 GO:0007252 GO:0006955 GO:0052063 GO:0006954 GO:0045087 GO:0006691 GO:0031663 GO:0001774 GO:0002755 GO:0008285 GO:0044130 GO:0032695 GO:0032700 GO:0046209 GO:0032722 GO:0050715 GO:0050729 GO:0032728 GO:0032733 GO:0032735 GO:0032741 GO:0032755 GO:0032757 GO:0002687 GO:0060907 GO:0042346 GO:0051092 GO:0045429 GO:0051770 GO:0048714 GO:0034123 GO:0045944 GO:0042535 GO:0032760 GO:0030177 GO:0070542 GO:0001666 GO:0032868 GO:0002238 GO:0032570 GO:0009636 GO:0007165 GO:0034134 GO:0034142 GO:0002224 GO:0038123 GO:0038124
Gene3D	3.40.50.10140
InterPro	IPR000483 IPR001611 IPR003591 IPR000157 IPR027185 IPR017241
PANTHER	PTHR24365:SF17
Pfam	PF13855 PF01582
PIRSF	PIRSF037595
SMART	SM00369 SM00082 SM00255
SUPFAM	SSF52200
PROSITE	PS51450 PS50104

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0071346	cellular response to interferon-gamma	PMID:11672593^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	PMID:22198949^[2]	ECO:0000314	direct assay evidence used in manual assertion		F	occurs_in:(CL:0000129)	Seeded From UniProt	complete
	GO:0045893	positive regulation of transcription, DNA-templated	PMID:24585880^[3]	ECO:0000314			P		TLR2 when stimulated with LTA increase expression of mRNA of Tyrosine receptor kinase A (TrkA) as shown in figure 3D and which is further translated to protein as shown in figure 3E.	complete CACAO 9647
involved_in	GO:2000484	positive regulation of interleukin-8 secretion	PMID:22198949^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	ComplexPortal:CPX-1134	P	occurs_in:(CL:0002321) occurs_in:(CL:1000497) part_of:(GO:1904646)	Seeded From UniProt	complete
	GO:0001819	interleukin-10 production	PMID:23826189^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Figure 2A	complete CACAO 9869
enables	GO:0044877	protein-containing complex binding	PMID:22198949^[2]	ECO:0000353	physical interaction evidence used in manual assertion	ComplexPortal:CPX-1134	F	occurs_in:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0071223	cellular response to lipoteichoic acid	PMID:26649771^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:26649771^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	has_input:(UniProtKB:P59861) happens_during:(GO:0071223)	Seeded From UniProt	complete
involved_in	GO:0001775	cell activation	PMID:15294986^[6]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(CHEBI:134411)\|has_direct_input:(CHEBI:46889)	Seeded From UniProt	complete
enables	GO:0001540	amyloid-beta binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUN7	F	occurs_in:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0051964	negative regulation of synapse assembly	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUN7	P	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0050765	negative regulation of phagocytosis	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUN7	P	occurs_in:(UBERON:0000956) has_regulation_target:(UniProtKB:P05067:PRO_0000000092)	Seeded From UniProt	complete
involved_in	GO:0032640	tumor necrosis factor production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUN7	P	has_agent:(CL:0002092) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0014005	microglia development	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUN7	P	has_agent:(CL:0002092) occurs_in:(UBERON:0002421)	Seeded From UniProt	complete
involved_in	GO:0007612	learning	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUN7	P	occurs_in:(UBERON:0000955)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23817958^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:0000134) has_regulation_target:(UniProtKB:O00182)	Seeded From UniProt	complete
involved_in	GO:0071727	cellular response to triacyl bacterial lipopeptide	PMID:16880211^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071726	cellular response to diacyl bacterial lipopeptide	PMID:16880211^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005794	Golgi apparatus	PMID:16880211^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	PMID:16880211^[8]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0035325	Toll-like receptor binding	PMID:16880211^[8]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:Q15399 UniProtKB:Q9Y2C9	F		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	PMID:11274165^[9]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0031226	intrinsic component of plasma membrane	PMID:11274165^[9]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002720	positive regulation of cytokine production involved in immune response	PMID:20441518^[10]	ECO:0000314	direct assay evidence used in manual assertion		P		Fig 2	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:21618349^[11]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUN7	P		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:19740627^[12]	ECO:0000305	curator inference used in manual assertion	GO:1901224	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUN7	P		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	PMID:19740627^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0034123	positive regulation of toll-like receptor signaling pathway	PMID:17128265^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUN7	P		Seeded From UniProt	complete
involved_in	GO:0032757	positive regulation of interleukin-8 production	PMID:19740627^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032757	positive regulation of interleukin-8 production	PMID:17128265^[13]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:19740627^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032741	positive regulation of interleukin-18 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUN7	P		Seeded From UniProt	complete
involved_in	GO:0032735	positive regulation of interleukin-12 production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUN7	P		Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9QUN7	P		Seeded From UniProt	complete
involved_in	GO:0032722	positive regulation of chemokine production	PMID:19740627^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030177	positive regulation of Wnt signaling pathway	PMID:16601243^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007252	I-kappaB phosphorylation	PMID:19740627^[12]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:19740627^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19740627^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0050830	defense response to Gram-positive bacterium	PMID:11521063^[15]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042834	peptidoglycan binding	PMID:11986301^[16]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	PMID:12443841^[17]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008329	signaling pattern recognition receptor activity	PMID:10384090^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:1903974	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	PMID:11672593^[1]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031226	intrinsic component of plasma membrane	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687557 UniProtKB:O60603	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687652 RGD:1303030 RGD:3870 RGD:735138	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687652 UniProtKB:O00206	C		Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687652 RGD:1303030 RGD:3870 RGD:735138 RGD:735171	P		Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	PMID:21873635^[19]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687557 RGD:735138	P		Seeded From UniProt	complete
involved_in	GO:0071727	cellular response to triacyl bacterial lipopeptide	PMID:19931471^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071726	cellular response to diacyl bacterial lipopeptide	PMID:19931471^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071223	cellular response to lipoteichoic acid	PMID:12594207^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:12594207^[21]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:17889651^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0042497	triacyl lipopeptide binding	PMID:17889651^[22]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0042496	detection of diacyl bacterial lipopeptide	PMID:19931471^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042495	detection of triacyl bacterial lipopeptide	PMID:19931471^[20]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0035354	Toll-like receptor 1-Toll-like receptor 2 protein complex	PMID:17889651^[22]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23155421^[23]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O60603	F		Seeded From UniProt	complete
involved_in	GO:0031663	lipopolysaccharide-mediated signaling pathway	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0001875	P		Seeded From UniProt	complete
enables	GO:0071723	lipopeptide binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	F		Seeded From UniProt	complete
involved_in	GO:0070542	response to fatty acid	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	P		Seeded From UniProt	complete
involved_in	GO:0048714	positive regulation of oligodendrocyte differentiation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	P		Seeded From UniProt	complete
involved_in	GO:0046209	nitric oxide metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	P		Seeded From UniProt	complete
part_of	GO:0044297	cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	C		Seeded From UniProt	complete
part_of	GO:0042995	cell projection	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	C		Seeded From UniProt	complete
involved_in	GO:0032868	response to insulin	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	P		Seeded From UniProt	complete
involved_in	GO:0032733	positive regulation of interleukin-10 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	P		Seeded From UniProt	complete
involved_in	GO:0032570	response to progesterone	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	P		Seeded From UniProt	complete
involved_in	GO:0032493	response to bacterial lipoprotein	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	P		Seeded From UniProt	complete
involved_in	GO:0032289	central nervous system myelin formation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	C		Seeded From UniProt	complete
involved_in	GO:0009636	response to toxic substance	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	P		Seeded From UniProt	complete
involved_in	GO:0008285	negative regulation of cell population proliferation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	P		Seeded From UniProt	complete
involved_in	GO:0006691	leukotriene metabolic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	P		Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	P		Seeded From UniProt	complete
involved_in	GO:0001774	microglial cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	P		Seeded From UniProt	complete
involved_in	GO:0001666	response to hypoxia	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:E9PTD9 ensembl:ENSRNOP00000013025	P		Seeded From UniProt	complete
involved_in	GO:0002237	response to molecule of bacterial origin	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027185	P		Seeded From UniProt	complete
involved_in	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027185	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027185	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000157	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027185	C		Seeded From UniProt	complete
involved_in	GO:0034134	toll-like receptor 2 signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027185	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027185	P		Seeded From UniProt	complete
involved_in	GO:0050707	regulation of cytokine secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027185	P		Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027185	P		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	PMID:10426996^[24] PMID:10426995^[25] PMID:11044375^[26]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006955	immune response	PMID:10426995^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:10426996^[24]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:9435236^[27]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0038023	signaling receptor activity	PMID:10426995^[25]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0071221	cellular response to bacterial lipopeptide	PMID:15356140^[28]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:15356140^[28]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001875	lipopolysaccharide receptor activity	PMID:11518816^[29]	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0043312	neutrophil degranulation	Reactome:R-HSA-6798695	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway	Reactome:R-HSA-168188	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway	Reactome:R-HSA-168179	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0030667	secretory granule membrane	Reactome:R-HSA-6798743	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	Reactome:R-HSA-937079 Reactome:R-HSA-937059 Reactome:R-HSA-937022 Reactome:R-HSA-6798743 Reactome:R-HSA-5602672 Reactome:R-HSA-5602606 Reactome:R-HSA-5602383 Reactome:R-HSA-5602353 Reactome:R-HSA-5432814 Reactome:R-HSA-2559414 Reactome:R-HSA-2262777 Reactome:R-HSA-2262775 Reactome:R-HSA-2201322 Reactome:R-HSA-2201316 Reactome:R-HSA-1974676 Reactome:R-HSA-168951 Reactome:R-HSA-168950 Reactome:R-HSA-166363 Reactome:R-HSA-166362 Reactome:R-HSA-166286 Reactome:R-HSA-166284 Reactome:R-HSA-166119 Reactome:R-HSA-166091 Reactome:R-HSA-166082 Reactome:R-HSA-166072	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Reactome:R-HSA-166058	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	Reactome:R-HSA-168898	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0031410	cytoplasmic vesicle	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0968	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472 UniProtKB-SubCell:SL-0162	C		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0370	C		Seeded From UniProt	complete
part_of	GO:0030670	phagocytic vesicle membrane	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0205	C		Seeded From UniProt	complete
edit table

Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Mita, Y et al. (2001) Toll-like receptor 2 and 4 surface expressions on human monocytes are modulated by interferon-gamma and macrophage colony-stimulating factor. Immunol. Lett. 78 97-101 PubMed GONUTS page
↑ ^2.0 ^2.1 ^2.2 Liu, S et al. (2012) TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation. J. Immunol. 188 1098-107 PubMed GONUTS page
↑ Prencipe, G et al. (2014) Nerve growth factor downregulates inflammatory response in human monocytes through TrkA. J. Immunol. 192 3345-54 PubMed GONUTS page
↑ Cardoso, EC et al. (2013) TLR7/TLR8 Activation Restores Defective Cytokine Secretion by Myeloid Dendritic Cells but Not by Plasmacytoid Dendritic Cells in HIV-Infected Pregnant Women and Newborns. PLoS ONE 8 e67036 PubMed GONUTS page
↑ ^5.0 ^5.1 Kim, JH et al. (2015) Expression of Beta-Defensin 131 Promotes an Innate Immune Response in Human Prostate Epithelial Cells. PLoS ONE 10 e0144776 PubMed GONUTS page
↑ Schröder, NW et al. (2004) Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses. J. Immunol. 173 2683-91 PubMed GONUTS page
↑ Gieseke, F et al. (2013) Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation. Eur. J. Immunol. 43 2741-9 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 ^8.4 Triantafilou, M et al. (2006) Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. J. Biol. Chem. 281 31002-11 PubMed GONUTS page
↑ ^9.0 ^9.1 da Silva Correia, J et al. (2001) Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2. J. Biol. Chem. 276 21129-35 PubMed GONUTS page
↑ Oosting, M et al. (2010) Recognition of Borrelia burgdorferi by NOD2 is central for the induction of an inflammatory reaction. J. Infect. Dis. 201 1849-58 PubMed GONUTS page
↑ Ben-Ali, M et al. (2011) Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family. Hum. Mutat. 32 643-52 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 Yu, N et al. (2009) Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9. J. Dermatol. Sci. 56 113-20 PubMed GONUTS page
↑ ^13.0 ^13.1 Lee, J et al. (2006) Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat. Cell Biol. 8 1327-36 PubMed GONUTS page
↑ Blumenthal, A et al. (2006) The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood 108 965-73 PubMed GONUTS page
↑ Dziarski, R & Gupta, D (2000) Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive bacteria and activation of chemokine genes. J. Endotoxin Res. 6 401-5 PubMed GONUTS page
↑ Iwaki, D et al. (2002) The extracellular toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus. J. Biol. Chem. 277 24315-20 PubMed GONUTS page
↑ Kawai, K et al. (2002) Expression of functional Toll-like receptor 2 on human epidermal keratinocytes. J. Dermatol. Sci. 30 185-94 PubMed GONUTS page
↑ Yoshimura, A et al. (1999) Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J. Immunol. 163 1-5 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 ^19.3 ^19.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 ^20.3 Kang, JY et al. (2009) Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. Immunity 31 873-84 PubMed GONUTS page
↑ ^21.0 ^21.1 Schröder, NW et al. (2003) Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. J. Biol. Chem. 278 15587-94 PubMed GONUTS page
↑ ^22.0 ^22.1 ^22.2 Jin, MS et al. (2007) Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130 1071-82 PubMed GONUTS page
↑ Godfroy, JI 3rd et al. (2012) Isolated Toll-like receptor transmembrane domains are capable of oligomerization. PLoS ONE 7 e48875 PubMed GONUTS page
↑ ^24.0 ^24.1 Aliprantis, AO et al. (1999) Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 285 736-9 PubMed GONUTS page
↑ ^25.0 ^25.1 ^25.2 Brightbill, HD et al. (1999) Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 285 732-6 PubMed GONUTS page
↑ Muzio, M et al. (2000) Toll-like receptor family and signalling pathway. Biochem. Soc. Trans. 28 563-6 PubMed GONUTS page
↑ Rock, FL et al. (1998) A family of human receptors structurally related to Drosophila Toll. Proc. Natl. Acad. Sci. U.S.A. 95 588-93 PubMed GONUTS page
↑ ^28.0 ^28.1 Olson, JK & Miller, SD (2004) Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J. Immunol. 173 3916-24 PubMed GONUTS page
↑ Hallman, M et al. (2001) Toll-like receptors as sensors of pathogens. Pediatr. Res. 50 315-21 PubMed GONUTS page

[PMID:11672593-1] 1.0 ^1.1 Mita, Y et al. (2001) Toll-like receptor 2 and 4 surface expressions on human monocytes are modulated by interferon-gamma and macrophage colony-stimulating factor. Immunol. Lett. 78 97-101 PubMed GONUTS page

[PMID:22198949-2] 2.0 ^2.1 ^2.2 Liu, S et al. (2012) TLR2 is a primary receptor for Alzheimer's amyloid β peptide to trigger neuroinflammatory activation. J. Immunol. 188 1098-107 PubMed GONUTS page

[PMID:24585880-3] Prencipe, G et al. (2014) Nerve growth factor downregulates inflammatory response in human monocytes through TrkA. J. Immunol. 192 3345-54 PubMed GONUTS page

[PMID:23826189-4] Cardoso, EC et al. (2013) TLR7/TLR8 Activation Restores Defective Cytokine Secretion by Myeloid Dendritic Cells but Not by Plasmacytoid Dendritic Cells in HIV-Infected Pregnant Women and Newborns. PLoS ONE 8 e67036 PubMed GONUTS page

[PMID:26649771-5] 5.0 ^5.1 Kim, JH et al. (2015) Expression of Beta-Defensin 131 Promotes an Innate Immune Response in Human Prostate Epithelial Cells. PLoS ONE 10 e0144776 PubMed GONUTS page

[PMID:15294986-6] Schröder, NW et al. (2004) Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses. J. Immunol. 173 2683-91 PubMed GONUTS page

[PMID:23817958-7] Gieseke, F et al. (2013) Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation. Eur. J. Immunol. 43 2741-9 PubMed GONUTS page

[PMID:16880211-8] 8.0 ^8.1 ^8.2 ^8.3 ^8.4 Triantafilou, M et al. (2006) Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. J. Biol. Chem. 281 31002-11 PubMed GONUTS page

[PMID:11274165-9] 9.0 ^9.1 da Silva Correia, J et al. (2001) Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2. J. Biol. Chem. 276 21129-35 PubMed GONUTS page

[PMID:20441518-10] Oosting, M et al. (2010) Recognition of Borrelia burgdorferi by NOD2 is central for the induction of an inflammatory reaction. J. Infect. Dis. 201 1849-58 PubMed GONUTS page

[PMID:21618349-11] Ben-Ali, M et al. (2011) Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family. Hum. Mutat. 32 643-52 PubMed GONUTS page

[PMID:19740627-12] 12.0 ^12.1 ^12.2 ^12.3 ^12.4 ^12.5 ^12.6 ^12.7 Yu, N et al. (2009) Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9. J. Dermatol. Sci. 56 113-20 PubMed GONUTS page

[PMID:17128265-13] 13.0 ^13.1 Lee, J et al. (2006) Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat. Cell Biol. 8 1327-36 PubMed GONUTS page

[PMID:16601243-14] Blumenthal, A et al. (2006) The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood 108 965-73 PubMed GONUTS page

[PMID:11521063-15] Dziarski, R & Gupta, D (2000) Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive bacteria and activation of chemokine genes. J. Endotoxin Res. 6 401-5 PubMed GONUTS page

[PMID:11986301-16] Iwaki, D et al. (2002) The extracellular toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus. J. Biol. Chem. 277 24315-20 PubMed GONUTS page

[PMID:12443841-17] Kawai, K et al. (2002) Expression of functional Toll-like receptor 2 on human epidermal keratinocytes. J. Dermatol. Sci. 30 185-94 PubMed GONUTS page

[PMID:10384090-18] Yoshimura, A et al. (1999) Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J. Immunol. 163 1-5 PubMed GONUTS page

[PMID:21873635-19] 19.0 ^19.1 ^19.2 ^19.3 ^19.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:19931471-20] 20.0 ^20.1 ^20.2 ^20.3 Kang, JY et al. (2009) Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer. Immunity 31 873-84 PubMed GONUTS page

[PMID:12594207-21] 21.0 ^21.1 Schröder, NW et al. (2003) Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. J. Biol. Chem. 278 15587-94 PubMed GONUTS page

[PMID:17889651-22] 22.0 ^22.1 ^22.2 Jin, MS et al. (2007) Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130 1071-82 PubMed GONUTS page

[PMID:23155421-23] Godfroy, JI 3rd et al. (2012) Isolated Toll-like receptor transmembrane domains are capable of oligomerization. PLoS ONE 7 e48875 PubMed GONUTS page

[PMID:10426996-24] 24.0 ^24.1 Aliprantis, AO et al. (1999) Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science 285 736-9 PubMed GONUTS page

[PMID:10426995-25] 25.0 ^25.1 ^25.2 Brightbill, HD et al. (1999) Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science 285 732-6 PubMed GONUTS page

[PMID:11044375-26] Muzio, M et al. (2000) Toll-like receptor family and signalling pathway. Biochem. Soc. Trans. 28 563-6 PubMed GONUTS page

[PMID:9435236-27] Rock, FL et al. (1998) A family of human receptors structurally related to Drosophila Toll. Proc. Natl. Acad. Sci. U.S.A. 95 588-93 PubMed GONUTS page

[PMID:15356140-28] 28.0 ^28.1 Olson, JK & Miller, SD (2004) Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J. Immunol. 173 3916-24 PubMed GONUTS page

[PMID:11518816-29] Hallman, M et al. (2001) Toll-like receptors as sensors of pathogens. Pediatr. Res. 50 315-21 PubMed GONUTS page

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HUMAN:TLR2

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