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CHICK:IKKA
Contents
| Species (Taxon ID) | Gallus gallus (Chicken). (9031) | |
| Gene Name(s) | CHUK (synonyms: IKKA) | |
| Protein Name(s) | Inhibitor of nuclear factor kappa-B kinase subunit alpha
I kappa-B kinase alpha IKK-A IKK-alpha IkBKA IkappaB kinase Conserved helix-loop-helix ubiquitous kinase Nuclear factor NF-kappa-B inhibitor kinase alpha NFKBIKA | |
| External Links | ||
| UniProt | Q5ZJB4 | |
| EMBL | AJ720520 | |
| RefSeq | NP_001012922.1 | |
| UniGene | Gga.5483 | |
| ProteinModelPortal | Q5ZJB4 | |
| STRING | 9031.ENSGALP00000005196 | |
| PaxDb | Q5ZJB4 | |
| GeneID | 423669 | |
| KEGG | gga:423669 | |
| CTD | 1147 | |
| eggNOG | COG0515 | |
| HOGENOM | HOG000038048 | |
| HOVERGEN | HBG018241 | |
| InParanoid | Q5ZJB4 | |
| KO | K04467 | |
| PhylomeDB | Q5ZJB4 | |
| Reactome | REACT_197120 REACT_25145 REACT_25296 REACT_75885 REACT_75895 | |
| NextBio | 20826106 | |
| PRO | PR:Q5ZJB4 | |
| Proteomes | UP000000539 | |
| GO | GO:0005829 GO:0005634 GO:0005886 GO:0005524 GO:0008384 GO:0046982 GO:0042803 GO:0002218 GO:0035419 GO:0007250 GO:0071356 GO:0045087 GO:0002755 GO:0045944 GO:0035681 GO:0034134 GO:0035682 GO:0034138 GO:0034142 GO:0034146 GO:0034154 GO:0002224 | |
| InterPro | IPR022007 IPR011009 IPR000719 IPR017441 IPR002290 IPR008271 | |
| Pfam | PF12179 PF00069 | |
| SMART | SM00220 | |
| SUPFAM | SSF56112 | |
| PROSITE | PS00107 PS50011 PS00108 | |
Annotations
| Qualifier | GO ID | GO term name | Reference | ECO ID | ECO term name | with/from | Aspect | Extension | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|---|
|
involved_in |
GO:0071356 |
cellular response to tumor necrosis factor |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0046982 |
protein heterodimerization activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0042803 |
protein homodimerization activity |
ECO:0000250 |
sequence similarity evidence used in manual assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0051092 |
positive regulation of NF-kappaB transcription factor activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000540281 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0045944 |
positive regulation of transcription by RNA polymerase II |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000540281 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0033209 |
tumor necrosis factor-mediated signaling pathway |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1338071 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0018105 |
peptidyl-serine phosphorylation |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0024222 |
P |
Seeded From UniProt |
complete | ||
|
part_of |
GO:0008385 |
IkappaB kinase complex |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
PANTHER:PTN000540281 |
C |
Seeded From UniProt |
complete | ||
|
contributes_to |
GO:0008384 |
IkappaB kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
MGI:MGI:1338071 |
F |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000318 |
biological aspect of ancestor evidence used in manual assertion |
FB:FBgn0024222 |
F |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007252 |
I-kappaB phosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008384 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007252 |
I-kappaB phosphorylation |
ECO:0000364 |
evidence based on logical inference from manual annotation used in automatic assertion |
GO:0008384 |
P |
Seeded From UniProt |
complete | ||
|
involved_in |
GO:0007252 |
I-kappaB phosphorylation |
ECO:0000366 |
evidence based on logical inference from automatic annotation used in automatic assertion |
GO:0008384 |
P |
Seeded From UniProt |
complete | ||
|
enables |
GO:0004672 |
protein kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0006468 |
protein phosphorylation |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008384 |
IkappaB kinase activity |
ECO:0000256 |
match to sequence model evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0008384 |
IkappaB kinase activity |
ECO:0000501 |
evidence used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0002224 |
toll-like receptor signaling pathway |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005829 |
cytosol |
Reactome:R-GGA-1169563 |
ECO:0000304 |
author statement supported by traceable reference used in manual assertion |
C |
Seeded From UniProt |
complete | ||
|
enables |
GO:0016301 |
kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005634 |
nucleus |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
|
enables |
GO:0000166 |
nucleotide binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0004674 |
protein serine/threonine kinase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0005524 |
ATP binding |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
enables |
GO:0016740 |
transferase activity |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
F |
Seeded From UniProt |
complete | |||
|
involved_in |
GO:0016310 |
phosphorylation |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
P |
Seeded From UniProt |
complete | |||
|
part_of |
GO:0005737 |
cytoplasm |
ECO:0000322 |
imported manually asserted information used in automatic assertion |
C |
Seeded From UniProt |
complete | |||
Notes
References
See Help:References for how to manage references in GONUTS.
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
- ↑ Lynn, DJ et al. (2003) In silico identification of components of the Toll-like receptor (TLR) signaling pathway in clustered chicken expressed sequence tags (ESTs). Vet. Immunol. Immunopathol. 93 177-84 PubMed GONUTS page
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- GO:0018105 ! peptidyl-serine phosphorylation
- Phasianidae
- Phasianinae
- GO:0016310 ! phosphorylation
- GO:0051092 ! positive regulation of NF-kappaB transcription factor activity
- GO:0045944 ! positive regulation of transcription by RNA polymerase II
- GO:0046982 ! protein heterodimerization activity
- GO:0042803 ! protein homodimerization activity
- GO:0004672 ! protein kinase activity
- GO:0006468 ! protein phosphorylation
- GO:0004674 ! protein serine/threonine kinase activity
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