GONUTS has been updated to MW1.31 Most things seem to be working but be sure to report problems.
Category:GO:0008385 ! IkappaB kinase complex
name: IkappaB kinase complex
namespace: cellular_component
def: "A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:ma, PMID:12055104, PMID:20300203]
synonym: "heterotrimeric IKK complex" EXACT [GOC:bf]
synonym: "IKK complex" EXACT []
synonym: "trimeric IKK complex" EXACT [PMID:21173796]
is_a: GO:1902554 ! serine/threonine protein kinase complex
relationship: part_of: GO:0005829 ! cytosol
AmiGO
<GOterm>GO:0008385</GOterm>
Gene Ontology Home
The contents of this box are automatically generated. You can help by adding information to the "Notes"
Usage Notes
References
See Help:References for how to manage references in GONUTS.
