MOUSE:ASC

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Pycard (synonyms: Asc)
Protein Name(s)	Apoptosis-associated speck-like protein containing a CARD mASC PYD and CARD domain-containing protein
External Links
UniProt	Q9EPB4
EMBL	AB032249 AF310104 AK009852 AK007742 AK018682 BC008252
CCDS	CCDS21888.1
RefSeq	NP_075747.3
UniGene	Mm.24163
ProteinModelPortal	Q9EPB4
SMR	Q9EPB4
DIP	DIP-27619N
IntAct	Q9EPB4
STRING	10090.ENSMUSP00000033056
PhosphoSite	Q9EPB4
MaxQB	Q9EPB4
PaxDb	Q9EPB4
PRIDE	Q9EPB4
DNASU	66824
Ensembl	ENSMUST00000033056
GeneID	66824
KEGG	mmu:66824
UCSC	uc009jxu.2
CTD	29108
MGI	MGI:1931465
eggNOG	NOG39139
GeneTree	ENSGT00440000033973
HOGENOM	HOG000034090
HOVERGEN	HBG018739
InParanoid	Q9EPB4
KO	K12799
OMA	MGCTRDA
OrthoDB	EOG786H4P
PhylomeDB	Q9EPB4
TreeFam	TF337882
Reactome	REACT_198644 REACT_198662
NextBio	322743
PRO	PR:Q9EPB4
Proteomes	UP000000589
Bgee	Q9EPB4
CleanEx	MM_PYCARD
ExpressionAtlas	Q9EPB4
Genevestigator	Q9EPB4
GO	GO:0097169 GO:0005737 GO:0005829 GO:0005783 GO:0005576 GO:0005739 GO:0043025 GO:0072559 GO:0005634 GO:0016505 GO:0042803 GO:0032090 GO:0006919 GO:0002218 GO:0006915 GO:0006954 GO:0045087 GO:0032611 GO:0044351 GO:0002277 GO:0030838 GO:0042104 GO:0002588 GO:0090197 GO:0043280 GO:0002230 GO:0070374 GO:0032729 GO:0050718 GO:0032755 GO:0050766 GO:2000406 GO:0042981 GO:0010506 GO:0043281 GO:0050727 GO:0031647 GO:0032314 GO:0009617
Gene3D	1.10.533.10
InterPro	IPR001315 IPR004020 IPR011029
Pfam	PF00619 PF02758
SUPFAM	SSF47986
PROSITE	PS50209 PS50824

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0097202	activation of cysteine-type endopeptidase activity	PMID:23302887^[1]	ECO:0000315			P		As seen in figure 1, ASC, a type of inflammasome adaptor protein, is essential for WNV-induced IL-1beta maturation and caspase 1 activation. This implies that ASC is a critical component of the WNV-induced inflammasome and that the production of IL-1beta is dependent on ASC.	complete CACAO 6903
enables	GO:0046983	protein dimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ULZ3	F		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
involved_in	GO:1900016	negative regulation of cytokine production involved in inflammatory response	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:24407287^[2]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	PMID:24407287^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0097202	activation of cysteine-type endopeptidase activity	PMID:23302887^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ULZ3	F		Seeded From UniProt	complete
enables	GO:0032090	Pyrin domain binding	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ULZ3	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ULZ3	C		Seeded From UniProt	complete
involved_in	GO:2000406	positive regulation of T cell migration	PMID:21892172^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0097169	AIM2 inflammasome complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ULZ3	C		Seeded From UniProt	complete
involved_in	GO:0090197	positive regulation of chemokine secretion	PMID:21487011^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0072559	NLRP3 inflammasome complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9ULZ3	C		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:21487011^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050766	positive regulation of phagocytosis	PMID:21892172^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	PMID:19158675^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0044351	macropinocytosis	PMID:21892172^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042104	positive regulation of activated T cell proliferation	PMID:21892172^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:21892172^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	PMID:21892172^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043087	regulation of GTPase activity	PMID:21892172^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0031647	regulation of protein stability	PMID:21892172^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0030838	positive regulation of actin filament polymerization	PMID:21892172^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21892172^[3]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0002588	positive regulation of antigen processing and presentation of peptide antigen via MHC class II	PMID:21892172^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002277	myeloid dendritic cell activation involved in immune response	PMID:21892172^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002230	positive regulation of defense response to virus by host	PMID:19158675^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	PMID:19158675^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0097153	cysteine-type endopeptidase activity involved in apoptotic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019972 MGI:MGI:107739 MGI:MGI:109383 MGI:MGI:1261423 MGI:MGI:97295 PANTHER:PTN000047947 UniProtKB:P42574 UniProtKB:Q14790	F		Seeded From UniProt	complete
involved_in	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000048016 UniProtKB:P55211	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0010501 FB:FBgn0020381 FB:FBgn0026404 FB:FBgn0028381 FB:FBgn0033659 MGI:MGI:107739 MGI:MGI:109383 MGI:MGI:1261423 MGI:MGI:1277950 MGI:MGI:1312922 PANTHER:PTN000047947 RGD:2274 RGD:2275 RGD:61867 RGD:620945 RGD:69274 UniProtKB:O15519 UniProtKB:P42574 UniProtKB:P55210 UniProtKB:P55211 UniProtKB:Q14790 WB:WBGene00000417	P		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[6]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0019972 FB:FBgn0020381 FB:FBgn0026404 FB:FBgn0028381 FB:FBgn0033051 MGI:MGI:107739 MGI:MGI:1261423 MGI:MGI:1336166 MGI:MGI:97295 PANTHER:PTN000047947 RGD:2274 RGD:2275 RGD:61867 RGD:620945 RGD:70967 UniProtKB:O15519 UniProtKB:P31944 UniProtKB:Q95ND5 UniProtKB:Q9ULZ3 WB:WBGene00000417	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001242	regulation of intrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001181	positive regulation of interleukin-10 secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2001056	positive regulation of cysteine-type endopeptidase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000778	positive regulation of interleukin-6 secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:2000484	positive regulation of interleukin-8 secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1900016	negative regulation of cytokine production involved in inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
part_of	GO:0097169	AIM2 inflammasome complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090200	positive regulation of release of cytochrome c from mitochondria	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0090197	positive regulation of chemokine secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
part_of	GO:0072559	NLRP3 inflammasome complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	C		Seeded From UniProt	complete
part_of	GO:0072558	NLRP1 inflammasome complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071901	negative regulation of protein serine/threonine kinase activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071347	cellular response to interleukin-1	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
enables	GO:0070700	BMP receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051607	defense response to virus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051260	protein homooligomerization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050870	positive regulation of T cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050727	regulation of inflammatory response	PMID:22297845^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3686870	P	regulates_o_has_participant:(EMAPA:16846)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050727	regulation of inflammatory response	PMID:22002608^[8]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3686870	P	regulates_o_has_participant:(EMAPA:18939)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050718	positive regulation of interleukin-1 beta secretion	PMID:22002608^[8]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:107700 MGI:MGI:2653833	P	regulates_o_occurs_in:(CL:0002476)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050718	positive regulation of interleukin-1 beta secretion	PMID:23997220^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3686870	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046330	positive regulation of JNK cascade	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628637	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043281	regulation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:15190255^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3046932	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628637	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628637	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042981	regulation of apoptotic process	PMID:15190255^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3046932	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628637	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032688	negative regulation of interferon-beta production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032611	interleukin-1 beta production	PMID:19158679^[11]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:2686159 MGI:MGI:96543 MGI:MGI:96544	P		Seeded From UniProt	complete
enables	GO:0032090	Pyrin domain binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	F		Seeded From UniProt	complete
enables	GO:0017024	myosin I binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	F		Seeded From UniProt	complete
enables	GO:0016505	peptidase activator activity involved in apoptotic process	PMID:11139337^[12]	ECO:0000266	sequence orthology evidence used in manual assertion	RefSeq:NM_013258	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010506	regulation of autophagy	PMID:24581500^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3686870	P	regulates_o_occurs_in:(CL:0000160)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009617	response to bacterium	PMID:24581500^[13]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3686870	P	occurs_in:(CL:0000328)	Seeded From UniProt	complete
colocalizes_with	GO:0008385	IkappaB kinase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006954	inflammatory response	PMID:15190255^[10]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3046932	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	PMID:17008311^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:3686870	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006915	apoptotic process	PMID:11139337^[12]	ECO:0000266	sequence orthology evidence used in manual assertion	RefSeq:NM_013258	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	PMID:11139337^[12]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:19158679^[11]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	C		Seeded From UniProt	complete
part_of	GO:0005576	extracellular region	PMID:15190255^[10]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0005523	tropomyosin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	F		Seeded From UniProt	complete
enables	GO:0005138	interleukin-6 receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002821	positive regulation of adaptive immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002218	activation of innate immune response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	F		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:628637	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001773	myeloid dendritic cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	P		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9ULZ3	C		Seeded From UniProt	complete
enables	GO:0044325	ion channel binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V8L1 ensembl:ENSRNOP00000026699	F		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V8L1 ensembl:ENSRNOP00000026699	P		Seeded From UniProt	complete
part_of	GO:0043025	neuronal cell body	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V8L1 ensembl:ENSRNOP00000026699	C		Seeded From UniProt	complete
part_of	GO:0032991	protein-containing complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V8L1 ensembl:ENSRNOP00000026699	C		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:G3V8L1 ensembl:ENSRNOP00000026699	F		Seeded From UniProt	complete
involved_in	GO:2001242	regulation of intrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:2001181	positive regulation of interleukin-10 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:2001056	positive regulation of cysteine-type endopeptidase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:2000778	positive regulation of interleukin-6 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:2000484	positive regulation of interleukin-8 secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:1900016	negative regulation of cytokine production involved in inflammatory response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
part_of	GO:0097169	AIM2 inflammasome complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	C		Seeded From UniProt	complete
involved_in	GO:0090200	positive regulation of release of cytochrome c from mitochondria	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:0090197	positive regulation of chemokine secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
part_of	GO:0072559	NLRP3 inflammasome complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	C		Seeded From UniProt	complete
part_of	GO:0072558	NLRP1 inflammasome complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	C		Seeded From UniProt	complete
involved_in	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:0071901	negative regulation of protein serine/threonine kinase activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:0071347	cellular response to interleukin-1	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
enables	GO:0070700	BMP receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	F		Seeded From UniProt	complete
involved_in	GO:0070374	positive regulation of ERK1 and ERK2 cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:0051607	defense response to virus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:0051260	protein homooligomerization	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:0050870	positive regulation of T cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
enables	GO:0046983	protein dimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	F		Seeded From UniProt	complete
involved_in	GO:0046330	positive regulation of JNK cascade	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:0043280	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:0043065	positive regulation of apoptotic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	F		Seeded From UniProt	complete
involved_in	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:0032688	negative regulation of interferon-beta production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
enables	GO:0032090	Pyrin domain binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	F		Seeded From UniProt	complete
involved_in	GO:0032088	negative regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
enables	GO:0019899	enzyme binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	F		Seeded From UniProt	complete
enables	GO:0017024	myosin I binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	F		Seeded From UniProt	complete
involved_in	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
part_of	GO:0008385	IkappaB kinase complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	C		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	C		Seeded From UniProt	complete
part_of	GO:0005730	nucleolus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	C		Seeded From UniProt	complete
enables	GO:0005523	tropomyosin binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	F		Seeded From UniProt	complete
enables	GO:0005138	interleukin-6 receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	F		Seeded From UniProt	complete
involved_in	GO:0002821	positive regulation of adaptive immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
involved_in	GO:0002218	activation of innate immune response	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
enables	GO:0002020	protease binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	F		Seeded From UniProt	complete
involved_in	GO:0001773	myeloid dendritic cell activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	P		Seeded From UniProt	complete
part_of	GO:0000139	Golgi membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:Q9ULZ3 ensembl:ENSP00000247470	C		Seeded From UniProt	complete
enables	GO:0004197	cysteine-type endopeptidase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002398	F		Seeded From UniProt	complete
involved_in	GO:0006508	proteolysis	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR002398	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033516	P		Seeded From UniProt	complete
involved_in	GO:0042981	regulation of apoptotic process	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR001315	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR033516	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-MMU-877388 Reactome:R-MMU-877385	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
part_of	GO:0005739	mitochondrion	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0496 UniProtKB-SubCell:SL-0173	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
part_of	GO:0005783	endoplasmic reticulum	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0256 UniProtKB-SubCell:SL-0095	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
involved_in	GO:0006915	apoptotic process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0053	P		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Kumar, M et al. (2013) Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis. J. Virol. 87 3655-67 PubMed GONUTS page
↑ ^2.0 ^2.1 Dowling, JK et al. (2014) Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation. J. Biol. Chem. 289 6429-37 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 Ippagunta, SK et al. (2011) The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization. Nat. Immunol. 12 1010-6 PubMed GONUTS page
↑ ^4.0 ^4.1 Taxman, DJ et al. (2011) The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome. J. Biol. Chem. 286 19605-16 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 Hornung, V et al. (2009) AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458 514-8 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 ^6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Henao-Mejia, J et al. (2012) Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482 179-85 PubMed GONUTS page
↑ ^8.0 ^8.1 Kayagaki, N et al. (2011) Non-canonical inflammasome activation targets caspase-11. Nature 479 117-21 PubMed GONUTS page
↑ Shah, S et al. (2013) Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-β and AIM2 inflammasome-dependent IL-1β production via its ESX-1 secretion system. J. Immunol. 191 3514-8 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 Mariathasan, S et al. (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430 213-8 PubMed GONUTS page
↑ ^11.0 ^11.1 Bürckstümmer, T et al. (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 10 266-72 PubMed GONUTS page
↑ ^12.0 ^12.1 ^12.2 Masumoto, J et al. (2001) Murine ortholog of ASC, a CARD-containing protein, self-associates and exhibits restricted distribution in developing mouse embryos. Exp. Cell Res. 262 128-33 PubMed GONUTS page
↑ ^13.0 ^13.1 Wlodarska, M et al. (2014) NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell 156 1045-59 PubMed GONUTS page
↑ Kanneganti, TD et al. (2006) Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J. Biol. Chem. 281 36560-8 PubMed GONUTS page

[PMID:23302887-1] 1.0 ^1.1 Kumar, M et al. (2013) Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis. J. Virol. 87 3655-67 PubMed GONUTS page

[PMID:24407287-2] 2.0 ^2.1 Dowling, JK et al. (2014) Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation. J. Biol. Chem. 289 6429-37 PubMed GONUTS page

[PMID:21892172-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 Ippagunta, SK et al. (2011) The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization. Nat. Immunol. 12 1010-6 PubMed GONUTS page

[PMID:21487011-4] 4.0 ^4.1 Taxman, DJ et al. (2011) The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome. J. Biol. Chem. 286 19605-16 PubMed GONUTS page

[PMID:19158675-5] 5.0 ^5.1 ^5.2 Hornung, V et al. (2009) AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458 514-8 PubMed GONUTS page

[PMID:21873635-6] 6.0 ^6.1 ^6.2 ^6.3 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:22297845-7] Henao-Mejia, J et al. (2012) Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature 482 179-85 PubMed GONUTS page

[PMID:22002608-8] 8.0 ^8.1 Kayagaki, N et al. (2011) Non-canonical inflammasome activation targets caspase-11. Nature 479 117-21 PubMed GONUTS page

[PMID:23997220-9] Shah, S et al. (2013) Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-β and AIM2 inflammasome-dependent IL-1β production via its ESX-1 secretion system. J. Immunol. 191 3514-8 PubMed GONUTS page

[PMID:15190255-10] 10.0 ^10.1 ^10.2 ^10.3 Mariathasan, S et al. (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430 213-8 PubMed GONUTS page

[PMID:19158679-11] 11.0 ^11.1 Bürckstümmer, T et al. (2009) An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 10 266-72 PubMed GONUTS page

[PMID:11139337-12] 12.0 ^12.1 ^12.2 Masumoto, J et al. (2001) Murine ortholog of ASC, a CARD-containing protein, self-associates and exhibits restricted distribution in developing mouse embryos. Exp. Cell Res. 262 128-33 PubMed GONUTS page

[PMID:24581500-13] 13.0 ^13.1 Wlodarska, M et al. (2014) NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell 156 1045-59 PubMed GONUTS page

[PMID:17008311-14] Kanneganti, TD et al. (2006) Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J. Biol. Chem. 281 36560-8 PubMed GONUTS page

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