HUMAN:IKKB

Species (Taxon ID)	Homo sapiens (Human). (9606)
Gene Name(s)	IKBKB (synonyms: IKKB)
Protein Name(s)	Inhibitor of nuclear factor kappa-B kinase subunit beta I-kappa-B-kinase beta IKK-B IKK-beta IkBKB I-kappa-B kinase 2 IKK2 Nuclear factor NF-kappa-B inhibitor kinase beta NFKBIKB
External Links
UniProt	O14920
EMBL	AF029684 AF080158 AF031416 AK302723 AK303528 AK316418 AY663108 AC083973 BC006231
CCDS	CCDS55228.1 CCDS56535.1 CCDS6128.1
RefSeq	NP_001177649.1 NP_001229707.1 NP_001547.1
UniGene	Hs.597664
PDB	3BRT 3BRV 4E3C 4KIK
PDBsum	3BRT 3BRV 4E3C 4KIK
ProteinModelPortal	O14920
SMR	O14920
BioGrid	109767
DIP	DIP-27527N
IntAct	O14920
MINT	MINT-107608
STRING	9606.ENSP00000339151
BindingDB	O14920
ChEMBL	CHEMBL1991
DrugBank	DB06151 DB00945 DB01169 DB00995 DB00244 DB00795
GuidetoPHARMACOLOGY	2039
PhosphoSite	O14920
MaxQB	O14920
PaxDb	O14920
PRIDE	O14920
DNASU	3551
Ensembl	ENST00000416505 ENST00000519735 ENST00000520810 ENST00000520835
GeneID	3551
KEGG	hsa:3551
UCSC	uc003xow.2 uc011lcq.2 uc011lcr.2
CTD	3551
GeneCards	GC08P042146
HGNC	HGNC:5960
HPA	CAB004447 HPA001249
MIM	603258 615592
neXtProt	NX_O14920
Orphanet	397787
PharmGKB	PA29776
eggNOG	COG0515
GeneTree	ENSGT00770000120525
HOGENOM	HOG000038048
HOVERGEN	HBG018241
InParanoid	O14920
KO	K07209
OMA	WINEINI
OrthoDB	EOG7FBRH3
PhylomeDB	O14920
TreeFam	TF324269
BRENDA	2.7.11.10
Reactome	REACT_118563 REACT_118656 REACT_12555 REACT_13415 REACT_13696 REACT_163994 REACT_21281 REACT_22442 REACT_24918 REACT_24969 REACT_25039 REACT_25354 REACT_25374 REACT_75776
SABIO-RK	O14920
SignaLink	O14920
ChiTaRS	IKBKB
EvolutionaryTrace	O14920
GeneWiki	IKK2
GenomeRNAi	3551
NextBio	13864
PRO	PR:O14920
Proteomes	UP000005640
Bgee	O14920
CleanEx	HS_IKBKB
ExpressionAtlas	O14920
Genevestigator	O14920
GO	GO:0035631 GO:0005737 GO:0009898 GO:0005829 GO:0008385 GO:0045121 GO:0005634 GO:0005524 GO:0008384 GO:0046982 GO:0042803 GO:0004672 GO:0019901 GO:0004674 GO:0097110 GO:0001782 GO:0071356 GO:0038095 GO:0007249 GO:0007252 GO:0006954 GO:0045087 GO:0002755 GO:0002756 GO:0043066 GO:0048011 GO:0035872 GO:0070423 GO:2001259 GO:0043123 GO:0051092 GO:0010765 GO:0045944 GO:0045893 GO:0032481 GO:0006468 GO:0009615 GO:0042501 GO:0050852 GO:0034166 GO:0034134 GO:0034138 GO:0034142 GO:0034146 GO:0034162 GO:0002224 GO:0038123 GO:0038124 GO:0035666
InterPro	IPR022007 IPR011009 IPR000719 IPR008271 IPR000626 IPR029071
Pfam	PF12179 PF00069
SUPFAM	SSF54236 SSF56112
PROSITE	PS50011 PS00108

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
	GO:0006302	double-strand break repair	PMID:21490922^[1]	ECO:0000315			P		Fig 4D,F. IKKβ knockdown cells exhibited a significant reduction in the repair of IR-induced DSBs. Fig 5. The DSB repair function was completely restored in MCF-7/IKKbeta(-) after transfection with either WT-IKKβ or SSEE-IKKβ compared to MCF-7 cells.	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:30337470^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0007249	I-kappaB kinase/NF-kappaB signaling	PMID:15383541^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0072659	protein localization to plasma membrane	PMID:25816133^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:2000008) causally_upstream_of:(GO:1903140) has_regulation_target:(UniProtKB:O00501) has_input:(UniProtKB:Q13464) results_in_development_of:(GO:0005923)	Seeded From UniProt	complete
involved_in	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity	PMID:25816133^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:2000008) causally_upstream_of:(GO:1903140) has_regulation_target:(UniProtKB:Q13464)	Seeded From UniProt	complete
involved_in	GO:0007249	I-kappaB kinase/NF-kappaB signaling	PMID:25816133^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:2000008) causally_upstream_of:(GO:1903140)	Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	PMID:25816133^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:2000008) causally_upstream_of:(GO:1903140)	Seeded From UniProt	complete
involved_in	GO:0030866	cortical actin cytoskeleton organization	PMID:25816133^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	happens_during:(GO:0033209) occurs_in:(CL:2000008)	Seeded From UniProt	complete
involved_in	GO:1903347	negative regulation of bicellular tight junction assembly	PMID:25816133^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:2000008)	Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:25816133^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:2000008)	Seeded From UniProt	complete
involved_in	GO:1903140	regulation of establishment of endothelial barrier	PMID:25816133^[4]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	occurs_in:(CL:2000008)	Seeded From UniProt	complete
involved_in	GO:0042325	regulation of phosphorylation	PMID:26212789^[5]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:Q96PG8) part_of:(GO:0006915)	Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:15084260^[6]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:15084260^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:15084260^[6]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23453807^[7]	ECO:0000314	direct assay evidence used in manual assertion		P	has_regulation_target:(UniProtKB:O60313)	Seeded From UniProt	complete
part_of	GO:0035631	CD40 receptor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O88351	C		Seeded From UniProt	complete
part_of	GO:0009898	cytoplasmic side of plasma membrane	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O88351	C		Seeded From UniProt	complete
involved_in	GO:0071356	cellular response to tumor necrosis factor	PMID:23091055^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	PMID:23091055^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:23091055^[8]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9813230^[9]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9346485^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045893	positive regulation of transcription, DNA-templated	PMID:9346484^[11]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	PMID:23091055^[8]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21399639^[12]	ECO:0000314	direct assay evidence used in manual assertion		P	has_direct_input:(UniProtKB:P23396)	Seeded From UniProt	complete
enables	GO:0019901	protein kinase binding	PMID:12492477^[13]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O43283	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:20434986^[14]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	PMID:9346484^[11]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	PMID:20434986^[14]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000540281 RGD:621375 UniProtKB:O14920	P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000540281 UniProtKB:O14920 UniProtKB:O15111	P		Seeded From UniProt	complete
involved_in	GO:0033209	tumor necrosis factor-mediated signaling pathway	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338071 PANTHER:PTN000540281 UniProtKB:O14920	P		Seeded From UniProt	complete
involved_in	GO:0018105	peptidyl-serine phosphorylation	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024222 FB:FBgn0086657 MGI:MGI:1929658 PANTHER:PTN001491808 UniProtKB:O14920 UniProtKB:Q9UHD2	P		Seeded From UniProt	complete
part_of	GO:0008385	IkappaB kinase complex	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000540281 RGD:1306661 RGD:621375	C		Seeded From UniProt	complete
contributes_to	GO:0008384	IkappaB kinase activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338071 PANTHER:PTN000540281 RGD:1306661	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:21873635^[15]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0024222 FB:FBgn0086657 MGI:MGI:1929658 PANTHER:PTN001491808 UniProtKB:O14920 UniProtKB:Q9UHD2	F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:23613522^[16]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	PMID:18692471^[17]	ECO:0000269	experimental evidence used in manual assertion		F		Seeded From UniProt	complete
enables	GO:0097110	scaffold protein binding	PMID:23776175^[18]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:15790681^[19]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:23776406^[20]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14920	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:21423167^[21]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14920	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	PMID:16319058^[22]	ECO:0000353	physical interaction evidence used in manual assertion	UniProtKB:O14920	F		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000052	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
involved_in	GO:0007252	I-kappaB phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008384	P		Seeded From UniProt	complete
involved_in	GO:0007252	I-kappaB phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008384	P		Seeded From UniProt	complete
involved_in	GO:0007252	I-kappaB phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008384	P		Seeded From UniProt	complete
involved_in	GO:0007252	I-kappaB phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008384	P		Seeded From UniProt	complete
involved_in	GO:0007252	I-kappaB phosphorylation	GO_REF:0000108	ECO:0000364	evidence based on logical inference from manual annotation used in automatic assertion	GO:0008384	P		Seeded From UniProt	complete
involved_in	GO:0007252	I-kappaB phosphorylation	GO_REF:0000108	ECO:0000366	evidence based on logical inference from automatic annotation used in automatic assertion	GO:0008384	P		Seeded From UniProt	complete
enables	GO:0004672	protein kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719	F		Seeded From UniProt	complete
involved_in	GO:0006468	protein phosphorylation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000719 InterPro:IPR008271	P		Seeded From UniProt	complete
enables	GO:0008384	IkappaB kinase activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR022007	F		Seeded From UniProt	complete
enables	GO:0008384	IkappaB kinase activity	GO_REF:0000003	ECO:0000501	evidence used in automatic assertion	EC:2.7.11.10	F		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	PMID:18626576^[23] Reactome:R-HSA-445989	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:18626576^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0009615	response to virus	PMID:18626576^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0008385	IkappaB kinase complex	PMID:18626576^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0008384	IkappaB kinase activity	PMID:18626576^[23] Reactome:R-HSA-5684275 Reactome:R-HSA-5684267	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0007249	I-kappaB kinase/NF-kappaB signaling	PMID:18626576^[23] Reactome:R-HSA-5357956	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:18626576^[23]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070498	interleukin-1-mediated signaling pathway	Reactome:R-HSA-9020702	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051403	stress-activated MAPK cascade	Reactome:R-HSA-450294	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050852	T cell receptor signaling pathway	Reactome:R-HSA-202403	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Reactome:R-HSA-937039	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0043066	negative regulation of apoptotic process	Reactome:R-HSA-193639	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0038095	Fc-epsilon receptor signaling pathway	Reactome:R-HSA-2454202	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	Reactome:R-HSA-937061	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010803	regulation of tumor necrosis factor-mediated signaling pathway	Reactome:R-HSA-5357905	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	Reactome:R-HSA-975119 Reactome:R-HSA-937032 Reactome:R-HSA-937029 Reactome:R-HSA-933539 Reactome:R-HSA-933530 Reactome:R-HSA-9014343 Reactome:R-HSA-8863895 Reactome:R-HSA-5684275 Reactome:R-HSA-5684267 Reactome:R-HSA-5626962 Reactome:R-HSA-5609665 Reactome:R-HSA-5607742 Reactome:R-HSA-5357831 Reactome:R-HSA-5357776 Reactome:R-HSA-5262921 Reactome:R-HSA-5228840 Reactome:R-HSA-5228811 Reactome:R-HSA-451561 Reactome:R-HSA-2730876 Reactome:R-HSA-209087 Reactome:R-HSA-202541 Reactome:R-HSA-202534 Reactome:R-HSA-202500 Reactome:R-HSA-193705 Reactome:R-HSA-193703 Reactome:R-HSA-193641 Reactome:R-HSA-168910 Reactome:R-HSA-168184 Reactome:R-HSA-168140 Reactome:R-HSA-1168638	ECO:0000304	author statement supported by traceable reference used in manual assertion		C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	Reactome:R-HSA-5357831 Reactome:R-HSA-5228811 Reactome:R-HSA-209087 Reactome:R-HSA-202541 Reactome:R-HSA-168140	ECO:0000304	author statement supported by traceable reference used in manual assertion		F		Seeded From UniProt	complete
involved_in	GO:0002756	MyD88-independent toll-like receptor signaling pathway	Reactome:R-HSA-168927	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	Reactome:R-HSA-1236974	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0002223	stimulatory C-type lectin receptor signaling pathway	Reactome:R-HSA-5621481	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0016740	transferase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0808	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
enables	GO:0004674	protein serine/threonine kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0723	F		Seeded From UniProt	complete
enables	GO:0016301	kinase activity	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
involved_in	GO:0016032	viral process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0945	P		Seeded From UniProt	complete
involved_in	GO:0016310	phosphorylation	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0418	P		Seeded From UniProt	complete
enables	GO:0000166	nucleotide binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0547	F		Seeded From UniProt	complete
enables	GO:0005524	ATP binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0067	F		Seeded From UniProt	complete
part_of	GO:0045121	membrane raft	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0370	C		Seeded From UniProt	complete
	GO:0004674	protein serine/threonine kinase activity	PMID:25636800^[24]	ECO:0000314			F		Figure 3E shows a higher ratio of pMAVS to MAVS when concentration of TBK1 is increased.	complete CACAO 11220
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ Wu, L et al. (2011) IKKβ regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells. PLoS ONE 6 e18447 PubMed GONUTS page
↑ Cardinez, C et al. (2018) Gain-of-function mutation causes human combined immune deficiency. J. Exp. Med. 215 2715-2724 PubMed GONUTS page
↑ Lamkanfi, M et al. (2004) INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. J. Biol. Chem. 279 51729-38 PubMed GONUTS page
↑ ^4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Clark, PR et al. (2015) Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases. PLoS ONE 10 e0120075 PubMed GONUTS page
↑ Xie, W et al. (2015) Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA. Autophagy 11 1623-35 PubMed GONUTS page
↑ ^6.0 ^6.1 ^6.2 Hu, MC et al. (2004) IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117 225-37 PubMed GONUTS page
↑ Müller-Rischart, AK et al. (2013) The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO. Mol. Cell 49 908-21 PubMed GONUTS page
↑ ^8.0 ^8.1 ^8.2 ^8.3 Wang, W et al. (2012) The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling. J. Biol. Chem. 287 42856-66 PubMed GONUTS page
↑ Hu, MC & Wang, Y (1998) IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes. Gene 222 31-40 PubMed GONUTS page
↑ Woronicz, JD et al. (1997) IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science 278 866-9 PubMed GONUTS page
↑ ^11.0 ^11.1 Mercurio, F et al. (1997) IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science 278 860-6 PubMed GONUTS page
↑ Wan, F et al. (2011) IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7. Nat. Immunol. 12 335-43 PubMed GONUTS page
↑ Masaki, M et al. (2003) Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically. Eur. J. Biochem. 270 76-83 PubMed GONUTS page
↑ ^14.0 ^14.1 Cui, J et al. (2010) NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell 141 483-96 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ Karim, ZA et al. (2013) IκB kinase phosphorylation of SNAP-23 controls platelet secretion. Blood 121 4567-74 PubMed GONUTS page
↑ Suzuki, K & Verma, IM (2008) Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation. Cell 134 485-95 PubMed GONUTS page
↑ Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page
↑ Bettelli, E et al. (2005) Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc. Natl. Acad. Sci. U.S.A. 102 5138-43 PubMed GONUTS page
↑ Polley, S et al. (2013) A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. PLoS Biol. 11 e1001581 PubMed GONUTS page
↑ Xu, G et al. (2011) Crystal structure of inhibitor of κB kinase β. Nature 472 325-30 PubMed GONUTS page
↑ Bernier, M et al. (2006) Binding of manumycin A inhibits IkappaB kinase beta activity. J. Biol. Chem. 281 2551-61 PubMed GONUTS page
↑ ^23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 Solt, LA & May, MJ (2008) The IkappaB kinase complex: master regulator of NF-kappaB signaling. Immunol. Res. 42 3-18 PubMed GONUTS page
↑ Liu, S et al. (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 347 aaa2630 PubMed GONUTS page

[PMID:21490922-1] Wu, L et al. (2011) IKKβ regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells. PLoS ONE 6 e18447 PubMed GONUTS page

[PMID:30337470-2] Cardinez, C et al. (2018) Gain-of-function mutation causes human combined immune deficiency. J. Exp. Med. 215 2715-2724 PubMed GONUTS page

[PMID:15383541-3] Lamkanfi, M et al. (2004) INCA, a novel human caspase recruitment domain protein that inhibits interleukin-1beta generation. J. Biol. Chem. 279 51729-38 PubMed GONUTS page

[PMID:25816133-4] 4.0 ^4.1 ^4.2 ^4.3 ^4.4 ^4.5 ^4.6 ^4.7 Clark, PR et al. (2015) Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases. PLoS ONE 10 e0120075 PubMed GONUTS page

[PMID:26212789-5] Xie, W et al. (2015) Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA. Autophagy 11 1623-35 PubMed GONUTS page

[PMID:15084260-6] 6.0 ^6.1 ^6.2 Hu, MC et al. (2004) IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117 225-37 PubMed GONUTS page

[PMID:23453807-7] Müller-Rischart, AK et al. (2013) The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO. Mol. Cell 49 908-21 PubMed GONUTS page

[PMID:23091055-8] 8.0 ^8.1 ^8.2 ^8.3 Wang, W et al. (2012) The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling. J. Biol. Chem. 287 42856-66 PubMed GONUTS page

[PMID:9813230-9] Hu, MC & Wang, Y (1998) IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes. Gene 222 31-40 PubMed GONUTS page

[PMID:9346485-10] Woronicz, JD et al. (1997) IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science 278 866-9 PubMed GONUTS page

[PMID:9346484-11] 11.0 ^11.1 Mercurio, F et al. (1997) IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science 278 860-6 PubMed GONUTS page

[PMID:21399639-12] Wan, F et al. (2011) IKKβ phosphorylation regulates RPS3 nuclear translocation and NF-κB function during infection with Escherichia coli strain O157:H7. Nat. Immunol. 12 335-43 PubMed GONUTS page

[PMID:12492477-13] Masaki, M et al. (2003) Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically. Eur. J. Biochem. 270 76-83 PubMed GONUTS page

[PMID:20434986-14] 14.0 ^14.1 Cui, J et al. (2010) NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways. Cell 141 483-96 PubMed GONUTS page

[PMID:21873635-15] 15.0 ^15.1 ^15.2 ^15.3 ^15.4 ^15.5 ^15.6 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:23613522-16] Karim, ZA et al. (2013) IκB kinase phosphorylation of SNAP-23 controls platelet secretion. Blood 121 4567-74 PubMed GONUTS page

[PMID:18692471-17] Suzuki, K & Verma, IM (2008) Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation. Cell 134 485-95 PubMed GONUTS page

[PMID:23776175-18] Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page

[PMID:15790681-19] Bettelli, E et al. (2005) Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells. Proc. Natl. Acad. Sci. U.S.A. 102 5138-43 PubMed GONUTS page

[PMID:23776406-20] Polley, S et al. (2013) A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. PLoS Biol. 11 e1001581 PubMed GONUTS page

[PMID:21423167-21] Xu, G et al. (2011) Crystal structure of inhibitor of κB kinase β. Nature 472 325-30 PubMed GONUTS page

[PMID:16319058-22] Bernier, M et al. (2006) Binding of manumycin A inhibits IkappaB kinase beta activity. J. Biol. Chem. 281 2551-61 PubMed GONUTS page

[PMID:18626576-23] 23.0 ^23.1 ^23.2 ^23.3 ^23.4 ^23.5 ^23.6 Solt, LA & May, MJ (2008) The IkappaB kinase complex: master regulator of NF-kappaB signaling. Immunol. Res. 42 3-18 PubMed GONUTS page

[PMID:25636800-24] Liu, S et al. (2015) Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. Science 347 aaa2630 PubMed GONUTS page

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HUMAN:IKKB

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