MOUSE:NEMO

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Ikbkg (synonyms: Nemo)
Protein Name(s)	NF-kappa-B essential modulator NEMO IkB kinase-associated protein 1 IKKAP1 mFIP-3 Inhibitor of nuclear factor kappa-B kinase subunit gamma I-kappa-B kinase subunit gamma IKK-gamma IKKG IkB kinase subunit gamma NF-kappa-B essential modifier
External Links
UniProt	O88522
EMBL	AF069542 AF326207 AF513109 AK154095 AL669976 CH466650
CCDS	CCDS41023.1
RefSeq	NP_001154895.1 NP_034677.2 XP_006527913.1 XP_006527914.1 XP_006527915.1
UniGene	Mm.12967
PDB	2V4H 2ZVN 2ZVO 3F89 3JSV 4OWF
PDBsum	2V4H 2ZVN 2ZVO 3F89 3JSV 4OWF
ProteinModelPortal	O88522
SMR	O88522
BioGrid	200602
DIP	DIP-29811N
IntAct	O88522
MINT	MINT-143245
STRING	10090.ENSMUSP00000004330
PhosphoSite	O88522
MaxQB	O88522
PaxDb	O88522
PRIDE	O88522
Ensembl	ENSMUST00000114127 ENSMUST00000114128 ENSMUST00000114133 ENSMUST00000164101
GeneID	16151
KEGG	mmu:16151
UCSC	uc009toz.2
CTD	8517
MGI	MGI:1338074
eggNOG	NOG138369
GeneTree	ENSGT00530000063808
HOGENOM	HOG000293233
HOVERGEN	HBG000417
InParanoid	O88522
KO	K07210
TreeFam	TF326608
Reactome	REACT_198543 REACT_198546 REACT_199121 REACT_202898 REACT_204812 REACT_205561 REACT_205717 REACT_211125 REACT_219800 REACT_222971 REACT_224208 REACT_225145 REACT_226192 REACT_237946
EvolutionaryTrace	O88522
NextBio	288945
PRO	PR:O88522
Proteomes	UP000000589
Bgee	O88522
CleanEx	MM_IKBKG
ExpressionAtlas	O88522
Genevestigator	O88522
GO	GO:0005737 GO:0008385 GO:0005634 GO:0070530 GO:0046872 GO:0046982 GO:0042803 GO:0007250 GO:0001782 GO:0006974 GO:1902236 GO:0010628 GO:0043123 GO:0051092 GO:0045944 GO:0006351
InterPro	IPR021063
Pfam	PF11577

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6K9	P		Seeded From UniProt	complete
involved_in	GO:0016239	positive regulation of macroautophagy	PMID:23778976^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	part_of:(GO:0043276)	Seeded From UniProt	complete
involved_in	GO:0043276	anoikis	PMID:23778976^[1]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:23453807^[2]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O60260	P	has_regulation_target:(UniProtKB:P58281) occurs_in:(CL:0000530)	Seeded From UniProt	complete
involved_in	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	PMID:23453807^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6K9	F		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6K9	P		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:Q9Y6K9	F		Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:1338074 MGI:MGI:1918898 PANTHER:PTN001268347	F		Seeded From UniProt	complete
involved_in	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001268361 UniProtKB:Q9Y6K9	P		Seeded From UniProt	complete
part_of	GO:0008385	IkappaB kinase complex	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN001268361 RGD:735223 UniProtKB:Q9Y6K9	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0041205 MGI:MGI:1338074 PANTHER:PTN001268347 RGD:628886 UniProtKB:Q9Y6K9	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	PMID:21873635^[3]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	FB:FBgn0041205 PANTHER:PTN001268347 RGD:628886 UniProtKB:Q9Y6K9	C		Seeded From UniProt	complete
enables	GO:1990450	linear polyubiquitin binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K9	F		Seeded From UniProt	complete
part_of	GO:0072686	mitotic spindle	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K9	C		Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	PMID:17702576^[4]	ECO:0000314	direct assay evidence used in manual assertion		F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051650	establishment of vesicle localization	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K9	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K9	P		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K9	F		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735223	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045944	positive regulation of transcription by RNA polymerase II	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K9	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:17702576^[4]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K9	P		Seeded From UniProt	complete
enables	GO:0042975	peroxisome proliferator activated receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735223	F		Seeded From UniProt	complete
enables	GO:0042803	protein homodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K9	F		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K9	F		Seeded From UniProt	complete
enables	GO:0031625	ubiquitin protein ligase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K9	F		Seeded From UniProt	complete
enables	GO:0019904	protein domain specific binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K9	F		Seeded From UniProt	complete
part_of	GO:0008385	IkappaB kinase complex	PMID:23776175^[5]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K9	C		Seeded From UniProt	complete
part_of	GO:0008385	IkappaB kinase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735223	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007250	activation of NF-kappaB-inducing kinase activity	PMID:14654787^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K9	P		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K9	C		Seeded From UniProt	complete
part_of	GO:0005829	cytosol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:735223	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	PMID:14654787^[6]	ECO:0000314	direct assay evidence used in manual assertion		C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K9	C		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K9	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001782	B cell homeostasis	PMID:12235208^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:2679024	P		Seeded From UniProt	complete
part_of	GO:0000922	spindle pole	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K9	C		Seeded From UniProt	complete
part_of	GO:0000151	ubiquitin ligase complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:Q9Y6K9	C		Seeded From UniProt	complete
enables	GO:0070530	K63-linked polyubiquitin modification-dependent protein binding	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR034735	F		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0963 UniProtKB-SubCell:SL-0086	C		Seeded From UniProt	complete
involved_in	GO:0006974	cellular response to DNA damage stimulus	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0227	P		Seeded From UniProt	complete
enables	GO:0046872	metal ion binding	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0479	F		Seeded From UniProt	complete
part_of	GO:0005634	nucleus	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0539 UniProtKB-SubCell:SL-0191	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Chen, N & Debnath, J (2013) IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway. Autophagy 9 1214-27 PubMed GONUTS page
↑ ^2.0 ^2.1 Müller-Rischart, AK et al. (2013) The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO. Mol. Cell 49 908-21 PubMed GONUTS page
↑ ^3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^4.0 ^4.1 Zhu, G et al. (2007) Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP. Curr. Biol. 17 1438-43 PubMed GONUTS page
↑ Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page
↑ ^6.0 ^6.1 Iha, H et al. (2003) Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signaling. Oncogene 22 8912-23 PubMed GONUTS page
↑ Pasparakis, M et al. (2002) IkappaB kinase signaling is essential for maintenance of mature B cells. J. Exp. Med. 196 743-52 PubMed GONUTS page

[PMID:23778976-1] 1.0 ^1.1 Chen, N & Debnath, J (2013) IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway. Autophagy 9 1214-27 PubMed GONUTS page

[PMID:23453807-2] 2.0 ^2.1 Müller-Rischart, AK et al. (2013) The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO. Mol. Cell 49 908-21 PubMed GONUTS page

[PMID:21873635-3] 3.0 ^3.1 ^3.2 ^3.3 ^3.4 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:17702576-4] 4.0 ^4.1 Zhu, G et al. (2007) Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP. Curr. Biol. 17 1438-43 PubMed GONUTS page

[PMID:23776175-5] Dauphinee, SM et al. (2013) SASH1 is a scaffold molecule in endothelial TLR4 signaling. J. Immunol. 191 892-901 PubMed GONUTS page

[PMID:14654787-6] 6.0 ^6.1 Iha, H et al. (2003) Segregation of NF-kappaB activation through NEMO/IKKgamma by Tax and TNFalpha: implications for stimulus-specific interruption of oncogenic signaling. Oncogene 22 8912-23 PubMed GONUTS page

[PMID:12235208-7] Pasparakis, M et al. (2002) IkappaB kinase signaling is essential for maintenance of mature B cells. J. Exp. Med. 196 743-52 PubMed GONUTS page

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MOUSE:NEMO

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