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PMID:12235208
| Citation |
Pasparakis, M, Schmidt-Supprian, M and Rajewsky, K (2002) IkappaB kinase signaling is essential for maintenance of mature B cells. J. Exp. Med. 196:743-52 |
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| Abstract |
Nuclear factor (NF)-kappaB proteins play crucial roles in immune responses and cellular survival. Activation of NF-kappaB is mediated by the IkappaB kinase (IKK) complex, which is composed of two kinases, IKK1 and IKK2, and a regulatory subunit termed NF-kappaB essential modulator (NEMO). IKK2- and NEMO-deficient mice die at early embryonic stages. We therefore used conditional gene targeting to evaluate the role of these proteins in B cells in adult mice. B lineage-specific disruption of either IKK signaling by deletion of NEMO, or of IKK2-specific signals by ablation of IKK2 activity leads to the disappearance of mature B lymphocytes. We conclude that maintenance of mature B cells depends on IKK-mediated activation of NF-kappaB. |
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| Keywords |
Animals; Antigens, CD19/physiology; B-Lymphocytes/physiology; Flow Cytometry; I-kappa B Kinase; Integrases/physiology; Mice; NF-kappa B/physiology; Protein-Serine-Threonine Kinases/physiology; Viral Proteins/physiology |
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Significance
Annotations
| Gene product | Qualifier | GO ID | GO term name | Evidence Code | with/from | Aspect | Notes | Status |
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