MOUSE:TLR4

Species (Taxon ID)	Mus musculus (Mouse). (10090)
Gene Name(s)	Tlr4 (synonyms: Lps)
Protein Name(s)	Toll-like receptor 4
External Links
UniProt	Q9QUK6
EMBL	AF095353 AF110133 AF185285 AF177767 AK014533
CCDS	CCDS18271.1
RefSeq	NP_067272.1
UniGene	Mm.38049
PDB	2Z64 3VQ1 3VQ2
PDBsum	2Z64 3VQ1 3VQ2
ProteinModelPortal	Q9QUK6
SMR	Q9QUK6
BioGrid	204224
DIP	DIP-38573N
IntAct	Q9QUK6
STRING	10090.ENSMUSP00000045770
BindingDB	Q9QUK6
ChEMBL	CHEMBL3038514
PhosphoSite	Q9QUK6
PRIDE	Q9QUK6
Ensembl	ENSMUST00000048096
GeneID	21898
KEGG	mmu:21898
UCSC	uc008thv.1
CTD	7099
MGI	MGI:96824
eggNOG	NOG249751
GeneTree	ENSGT00760000119006
HOGENOM	HOG000037951
HOVERGEN	HBG018823
InParanoid	Q9QUK6
KO	K10160
OMA	RCEIETI
OrthoDB	EOG7ZKS9G
PhylomeDB	Q9QUK6
TreeFam	TF351113
Reactome	REACT_196636 REACT_198539 REACT_225463 REACT_226192 REACT_230045 REACT_246719
EvolutionaryTrace	Q9QUK6
NextBio	301436
PRO	PR:Q9QUK6
Proteomes	UP000000589
Bgee	Q9QUK6
CleanEx	MM_TLR4
ExpressionAtlas	Q9QUK6
Genevestigator	Q9QUK6
GO	GO:0009897 GO:0005887 GO:0046696 GO:0048471 GO:0001875 GO:0004888 GO:0002218 GO:0000187 GO:0007250 GO:0002322 GO:0071222 GO:0071223 GO:0071260 GO:0050829 GO:0032497 GO:0007252 GO:0045087 GO:0032609 GO:0060729 GO:0031663 GO:0042116 GO:0045576 GO:0002755 GO:0070373 GO:0032689 GO:0032700 GO:0032707 GO:0032715 GO:0032720 GO:0002537 GO:0030890 GO:0032722 GO:0070374 GO:0043123 GO:0032727 GO:0045359 GO:0032728 GO:0032729 GO:0045362 GO:0032732 GO:0032733 GO:0045084 GO:0032735 GO:0045368 GO:0045410 GO:0032755 GO:0045416 GO:0046330 GO:0050671 GO:0060907 GO:0045348 GO:0042346 GO:0051092 GO:0045429 GO:0051770 GO:0070430 GO:0070434 GO:0010572 GO:0032874 GO:0045944 GO:0042535 GO:0032760 GO:0050707 GO:0050727 GO:0009617 GO:0032496 GO:0034142
Gene3D	3.40.50.10140
InterPro	IPR000483 IPR001611 IPR000157 IPR027168 IPR017241
PANTHER	PTHR24365:SF230
Pfam	PF13855 PF01582
PIRSF	PIRSF037595
SMART	SM00082 SM00255
SUPFAM	SSF52200
PROSITE	PS50104

Annotations

Qualifier	GO ID	GO term name	Reference	ECO ID	ECO term name	with/from	Aspect	Extension	Notes	Status
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:28096568^[1]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000129)	Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	PMID:28096568^[1]	ECO:0000314	direct assay evidence used in manual assertion		C	part_of:(CL:0000129) part_of:(GO:0071222)	Seeded From UniProt	complete
involved_in	GO:0120163	negative regulation of cold-induced thermogenesis	PMID:26370079^[2]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:20037584^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404) regulates_expression_of:(ENSEMBL:ENSMUSG00000027398)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:20037584^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9EPW9	P	regulates_o_occurs_in:(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404) regulates_expression_of:(ENSEMBL:ENSMUSG00000029380)\|regulates_o_occurs_in(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404) regulates_expression_of:(ENSEMBL:ENSMUSG00000058427)\|regulates_o_occurs_in(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404) regulates_expression_of:(ENSEMBL:ENSMUSG00000019122)\|regulates_o_occurs_in(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404) regulates_expression_of:(ENSEMBL:ENSMUSG00000035042)	Seeded From UniProt	complete
involved_in	GO:0035666	TRIF-dependent toll-like receptor signaling pathway	PMID:20037584^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9EPW9	P	occurs_in:(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404)	Seeded From UniProt	complete
involved_in	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	PMID:20037584^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9EPW9	P	occurs_in:(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404)	Seeded From UniProt	complete
involved_in	GO:0050729	positive regulation of inflammatory response	PMID:20037584^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:O00206	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:1903428	positive regulation of reactive oxygen species biosynthetic process	PMID:20037584^[3]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000235) positively_regulates:(GO:0002269) part_of:(GO:0071404)	Seeded From UniProt	complete
involved_in	GO:0043032	positive regulation of macrophage activation	PMID:20037584^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9Y2C9	P	part_of:(GO:0050729)	Seeded From UniProt	complete
involved_in	GO:0140052	cellular response to oxidised low-density lipoprotein particle stimulus	PMID:20037584^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9Y2C9	P	occurs_in:(CL:0000235) part_of:(GO:1900017)	Seeded From UniProt	complete
involved_in	GO:1900017	positive regulation of cytokine production involved in inflammatory response	PMID:20037584^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:Q9Y2C9	P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
involved_in	GO:1903223	positive regulation of oxidative stress-induced neuron death	PMID:20037584^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	P	regulates_o_occurs_in:(CL:0000540) occurs_in:(CL:0000129)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:20037584^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	P	regulates_o_occurs_in:(CL:0000129) regulates_expression_of:(ENSEMBL:ENSMUSG00000035042)	Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	PMID:20037584^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	P	regulates_o_occurs_in:(CL:0000129) regulates_expression_of:(ENSEMBL:ENSMUSG00000027398) part_of:(GO:1904646)	Seeded From UniProt	complete
involved_in	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:20037584^[3]	ECO:0000316	genetic interaction evidence used in manual assertion	UniProtKB:P05067:PRO_0000000092	P	part_of:(GO:1904646) regulates_o_occurs_in:(CL:0000129) positively_regulates:(GO:0070997)	Seeded From UniProt	complete
involved_in	GO:0050702	interleukin-1 beta secretion	PMID:23812099^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly	PMID:23812099^[4]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	PMID:20051628^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0070373	negative regulation of ERK1 and ERK2 cascade	PMID:20051628^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0060729	intestinal epithelial structure maintenance	PMID:20051628^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	PMID:15356140^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0050727	regulation of inflammatory response	PMID:18203139^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045944	positive regulation of transcription by RNA polymerase II	PMID:15356140^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032760	positive regulation of tumor necrosis factor production	PMID:15356140^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:15356140^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	PMID:12421970^[8]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032735	positive regulation of interleukin-12 production	PMID:15356140^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032733	positive regulation of interleukin-10 production	PMID:15356140^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032732	positive regulation of interleukin-1 production	PMID:15356140^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032729	positive regulation of interferon-gamma production	PMID:18203139^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032728	positive regulation of interferon-beta production	PMID:15356140^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032727	positive regulation of interferon-alpha production	PMID:15356140^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032722	positive regulation of chemokine production	PMID:15356140^[6]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032720	negative regulation of tumor necrosis factor production	PMID:20051628^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	PMID:20051628^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032715	negative regulation of interleukin-6 production	PMID:18203139^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032707	negative regulation of interleukin-23 production	PMID:18203139^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032700	negative regulation of interleukin-17 production	PMID:18203139^[7]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032700	negative regulation of interleukin-17 production	PMID:20051628^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032689	negative regulation of interferon-gamma production	PMID:20051628^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0010572	positive regulation of platelet activation	PMID:16514062^[9]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0000187	activation of MAPK activity	PMID:20051628^[5]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0046696	lipopolysaccharide receptor complex	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O00206	C		Seeded From UniProt	complete
involved_in	GO:0045576	mast cell activation	PMID:11490012^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045576	mast cell activation	PMID:11739561^[11]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045410	positive regulation of interleukin-6 biosynthetic process	PMID:11490012^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045368	positive regulation of interleukin-13 biosynthetic process	PMID:11490012^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0045362	positive regulation of interleukin-1 biosynthetic process	PMID:11490012^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0042116	macrophage activation	PMID:10835634^[12]	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
involved_in	GO:0007250	activation of NF-kappaB-inducing kinase activity	PMID:11490012^[10]	ECO:0000303	author statement without traceable support used in manual assertion		P		Seeded From UniProt	complete
enables	GO:0001875	lipopolysaccharide receptor activity	GO_REF:0000024	ECO:0000250	sequence similarity evidence used in manual assertion	UniProtKB:O00206	F		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	MGI:MGI:96824 PANTHER:PTN000687406	P		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687652 RGD:1303030 RGD:3870 RGD:735138	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687652 UniProtKB:O00206	C		Seeded From UniProt	complete
involved_in	GO:0002224	toll-like receptor signaling pathway	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687652 RGD:1303030 RGD:3870 RGD:735138 RGD:735171	P		Seeded From UniProt	complete
enables	GO:0001875	lipopolysaccharide receptor activity	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687407 UniProtKB:O00206	F		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	PMID:21873635^[13]	ECO:0000318	biological aspect of ancestor evidence used in manual assertion	PANTHER:PTN000687407 RGD:3870 UniProtKB:O00206	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904646	cellular response to amyloid-beta	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1904467	regulation of tumor necrosis factor secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1903974	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071346	cellular response to interferon-gamma	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071223	cellular response to lipoteichoic acid	PMID:10549626^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860885	P	occurs_in:(CL:0000581)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:14691481^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860755	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:10880523^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:24740015^[17]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	PMID:10880523^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070542	response to fatty acid	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070434	positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	PMID:18261938^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070430	positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	PMID:18261938^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0070374	positive regulation of ERK1 and ERK2 cascade	PMID:18261938^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0060907	positive regulation of macrophage cytokine production	PMID:10549626^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860885	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051930	regulation of sensory perception of pain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0051091	positive regulation of DNA-binding transcription factor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050965	detection of temperature stimulus involved in sensory perception of pain	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050829	defense response to Gram-negative bacterium	PMID:15661922^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860885	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050729	positive regulation of inflammatory response	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0050671	positive regulation of lymphocyte proliferation	PMID:10607756^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860885	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	F		Seeded From UniProt	complete
part_of	GO:0046696	lipopolysaccharide receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046330	positive regulation of JNK cascade	PMID:16260493^[21]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1346877	P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046330	positive regulation of JNK cascade	PMID:18261938^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0046330	positive regulation of JNK cascade	PMID:16260493^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045471	response to ethanol	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045429	positive regulation of nitric oxide biosynthetic process	PMID:10549626^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860885	P	regulates_o_occurs_in:(CL:0000581)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045416	positive regulation of interleukin-8 biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045359	positive regulation of interferon-beta biosynthetic process	PMID:15661922^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860885	P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045348	positive regulation of MHC class II biosynthetic process	PMID:10549626^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860885	P	regulates_o_occurs_in:(CL:0000236)	Seeded From UniProt	complete
colocalizes_with	GO:0045121	membrane raft	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0045084	positive regulation of interleukin-12 biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
enables	GO:0043548	phosphatidylinositol 3-kinase binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043388	positive regulation of DNA binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:19734906^[22]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:18261938^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	PMID:16260493^[21]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000057)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0043065	positive regulation of apoptotic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	P		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0042116	macrophage activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032874	positive regulation of stress-activated MAPK cascade	PMID:18261938^[18]	ECO:0000314	direct assay evidence used in manual assertion		P	regulates_o_occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	PMID:14691481^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860755	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	PMID:10623794^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857718	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	PMID:10607756^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860885	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	PMID:10549626^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860885	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032760	positive regulation of tumor necrosis factor production	PMID:18261938^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032757	positive regulation of interleukin-8 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032755	positive regulation of interleukin-6 production	PMID:14691481^[15]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860755	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032755	positive regulation of interleukin-6 production	PMID:10549626^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860885	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032755	positive regulation of interleukin-6 production	PMID:18261938^[18]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032733	positive regulation of interleukin-10 production	PMID:21609717^[24]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032722	positive regulation of chemokine production	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032609	interferon-gamma production	PMID:11489994^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1270861	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032497	detection of lipopolysaccharide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	PMID:11489994^[25]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1270861	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	PMID:12055258^[26]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857718	P	occurs_in:(EMAPA:16138)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	PMID:10607756^[20]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860885	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	PMID:10549626^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860885	P	occurs_in:(CL:0000581)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	PMID:10229796^[27]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857718 MGI:MGI:1860755	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0032496	response to lipopolysaccharide	GO_REF:0000008	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031663	lipopolysaccharide-mediated signaling pathway	PMID:10880523^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1341909	P	occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031663	lipopolysaccharide-mediated signaling pathway	PMID:10880523^[16]	ECO:0000316	genetic interaction evidence used in manual assertion	MGI:MGI:1194924 MGI:MGI:1321404	P	occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031663	lipopolysaccharide-mediated signaling pathway	PMID:10880523^[16]	ECO:0000314	direct assay evidence used in manual assertion		P	occurs_in:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0031663	lipopolysaccharide-mediated signaling pathway	PMID:10880523^[16]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
NOT\|acts_upstream_of_or_within	GO:0031663	lipopolysaccharide-mediated signaling pathway	PMID:10880523^[16]	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
part_of	GO:0031226	intrinsic component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0030890	positive regulation of B cell proliferation	PMID:10549626^[14]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860885	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0014002	astrocyte development	PMID:22577135^[28]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0010628	positive regulation of gene expression	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	C		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	C		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0009617	response to bacterium	PMID:11294571^[29]	ECO:0000315	mutant phenotype evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007252	I-kappaB phosphorylation	PMID:18820689^[30]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860885	P	occurs_in:(CL:0000235)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0007252	I-kappaB phosphorylation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006979	response to oxidative stress	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0006691	leukotriene metabolic process	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002758	innate immune response-activating signal transduction	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002730	regulation of dendritic cell cytokine production	PMID:19047410^[31]	ECO:0000314	direct assay evidence used in manual assertion		P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002537	nitric oxide production involved in inflammatory response	PMID:10623794^[23]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1857718	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002322	B cell proliferation involved in immune response	PMID:10880523^[16]	ECO:0000315	mutant phenotype evidence used in manual assertion		P	acts_on_population_of:(CL:0000236)	Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002224	toll-like receptor signaling pathway	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	P		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0002218	activation of innate immune response	PMID:15661922^[19]	ECO:0000315	mutant phenotype evidence used in manual assertion	MGI:MGI:1860885	P		Seeded From UniProt	complete
enables	GO:0001875	lipopolysaccharide receptor activity	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	F		Seeded From UniProt	complete
acts_upstream_of_or_within	GO:0001774	microglial cell activation	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	P		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	UniProtKB:O00206	F		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	GO_REF:0000096	ECO:0000266	sequence orthology evidence used in manual assertion	RGD:3870	F		Seeded From UniProt	complete
involved_in	GO:1904646	cellular response to amyloid-beta	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
involved_in	GO:1903974	positive regulation of cellular response to macrophage colony-stimulating factor stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
involved_in	GO:1901224	positive regulation of NIK/NF-kappaB signaling	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
involved_in	GO:0071346	cellular response to interferon-gamma	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
involved_in	GO:0071260	cellular response to mechanical stimulus	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
involved_in	GO:0071222	cellular response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
involved_in	GO:0051092	positive regulation of NF-kappaB transcription factor activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
involved_in	GO:0050718	positive regulation of interleukin-1 beta secretion	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
part_of	GO:0048471	perinuclear region of cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	C		Seeded From UniProt	complete
enables	GO:0046982	protein heterodimerization activity	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	F		Seeded From UniProt	complete
part_of	GO:0046696	lipopolysaccharide receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	C		Seeded From UniProt	complete
involved_in	GO:0045416	positive regulation of interleukin-8 biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
involved_in	GO:0045084	positive regulation of interleukin-12 biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
part_of	GO:0043235	receptor complex	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	C		Seeded From UniProt	complete
enables	GO:0042802	identical protein binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	F		Seeded From UniProt	complete
involved_in	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
involved_in	GO:0042116	macrophage activation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
involved_in	GO:0032757	positive regulation of interleukin-8 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
involved_in	GO:0032755	positive regulation of interleukin-6 production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
involved_in	GO:0032722	positive regulation of chemokine production	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
involved_in	GO:0032497	detection of lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
involved_in	GO:0032496	response to lipopolysaccharide	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
part_of	GO:0031226	intrinsic component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	C		Seeded From UniProt	complete
involved_in	GO:0010628	positive regulation of gene expression	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
part_of	GO:0009986	cell surface	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	C		Seeded From UniProt	complete
part_of	GO:0009897	external side of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	C		Seeded From UniProt	complete
involved_in	GO:0007252	I-kappaB phosphorylation	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
involved_in	GO:0006909	phagocytosis	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	P		Seeded From UniProt	complete
part_of	GO:0005887	integral component of plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	C		Seeded From UniProt	complete
part_of	GO:0005737	cytoplasm	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	C		Seeded From UniProt	complete
enables	GO:0005102	signaling receptor binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	F		Seeded From UniProt	complete
part_of	GO:0001891	phagocytic cup	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	C		Seeded From UniProt	complete
enables	GO:0001530	lipopolysaccharide binding	GO_REF:0000107	ECO:0000265	sequence orthology evidence used in automatic assertion	UniProtKB:O00206 ensembl:ENSP00000494590	F		Seeded From UniProt	complete
involved_in	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027168	P		Seeded From UniProt	complete
enables	GO:0004888	transmembrane signaling receptor activity	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027168	F		Seeded From UniProt	complete
involved_in	GO:0007165	signal transduction	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR000157	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027168	C		Seeded From UniProt	complete
involved_in	GO:0034142	toll-like receptor 4 signaling pathway	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027168	P		Seeded From UniProt	complete
involved_in	GO:0042116	macrophage activation	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027168	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027168	P		Seeded From UniProt	complete
part_of	GO:0046696	lipopolysaccharide receptor complex	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027168	C		Seeded From UniProt	complete
involved_in	GO:0050707	regulation of cytokine secretion	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027168	P		Seeded From UniProt	complete
involved_in	GO:0050829	defense response to Gram-negative bacterium	GO_REF:0000002	ECO:0000256	match to sequence model evidence used in automatic assertion	InterPro:IPR027168	P		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	PMID:15356140^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
involved_in	GO:0032497	detection of lipopolysaccharide	PMID:15356140^[6]	ECO:0000304	author statement supported by traceable reference used in manual assertion		P		Seeded From UniProt	complete
part_of	GO:0005768	endosome	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0967	C		Seeded From UniProt	complete
part_of	GO:0005886	plasma membrane	GO_REF:0000037 GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-1003 UniProtKB-SubCell:SL-0039	C		Seeded From UniProt	complete
involved_in	GO:0045087	innate immune response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0399	P		Seeded From UniProt	complete
part_of	GO:0016020	membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0472	C		Seeded From UniProt	complete
involved_in	GO:0006954	inflammatory response	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0395	P		Seeded From UniProt	complete
part_of	GO:0016021	integral component of membrane	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0812	C		Seeded From UniProt	complete
involved_in	GO:0002376	immune system process	GO_REF:0000037	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-KW:KW-0391	P		Seeded From UniProt	complete
part_of	GO:0005769	early endosome	GO_REF:0000039	ECO:0000322	imported manually asserted information used in automatic assertion	UniProtKB-SubCell:SL-0094	C		Seeded From UniProt	complete
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Notes

References

See Help:References for how to manage references in GONUTS.

↑ ^1.0 ^1.1 Cunha, C et al. (2016) Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization. Mediators Inflamm. 2016 6986175 PubMed GONUTS page
↑ Okla, M et al. (2015) Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress. J. Biol. Chem. 290 26476-90 PubMed GONUTS page
↑ ^3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Stewart, CR et al. (2010) CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat. Immunol. 11 155-61 PubMed GONUTS page
↑ ^4.0 ^4.1 Sheedy, FJ et al. (2013) CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat. Immunol. 14 812-20 PubMed GONUTS page
↑ ^5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 González-Navajas, JM et al. (2010) TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice. J. Clin. Invest. 120 570-81 PubMed GONUTS page
↑ ^6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 Olson, JK & Miller, SD (2004) Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J. Immunol. 173 3916-24 PubMed GONUTS page
↑ ^7.0 ^7.1 ^7.2 ^7.3 ^7.4 Marta, M et al. (2008) Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis. Eur. J. Immunol. 38 565-75 PubMed GONUTS page
↑ Schilling, D et al. (2002) Toll-like receptor 4 and Toll-IL-1 receptor domain-containing adapter protein (TIRAP)/myeloid differentiation protein 88 adapter-like (Mal) contribute to maximal IL-6 expression in macrophages. J. Immunol. 169 5874-80 PubMed GONUTS page
↑ Ståhl, AL et al. (2006) Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome. Blood 108 167-76 PubMed GONUTS page
↑ ^10.0 ^10.1 ^10.2 ^10.3 ^10.4 Supajatura, V et al. (2001) Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4. J. Immunol. 167 2250-6 PubMed GONUTS page
↑ McCurdy, JD et al. (2001) Toll-like receptor 4-mediated activation of murine mast cells. J. Leukoc. Biol. 70 977-84 PubMed GONUTS page
↑ Arbour, NC et al. (2000) TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat. Genet. 25 187-91 PubMed GONUTS page
↑ ^13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page
↑ ^14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 Takeuchi, O et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11 443-51 PubMed GONUTS page
↑ ^15.0 ^15.1 ^15.2 He, YW et al. (2004) The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. Nat. Immunol. 5 88-97 PubMed GONUTS page
↑ ^16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 Ogata, H et al. (2000) The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J. Exp. Med. 192 23-9 PubMed GONUTS page
↑ Festuccia, WT et al. (2014) Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide. PLoS ONE 9 e95432 PubMed GONUTS page
↑ ^18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 Kim, YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28 246-57 PubMed GONUTS page
↑ ^19.0 ^19.1 ^19.2 O'Connell, RM et al. (2005) Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1. J. Immunol. 174 1602-7 PubMed GONUTS page
↑ ^20.0 ^20.1 ^20.2 Takeuchi, O et al. (2000) Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. Int. Immunol. 12 113-7 PubMed GONUTS page
↑ ^21.0 ^21.1 ^21.2 Shim, JH et al. (2005) TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 19 2668-81 PubMed GONUTS page
↑ Chang, M et al. (2009) Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat. Immunol. 10 1089-95 PubMed GONUTS page
↑ ^23.0 ^23.1 Ohashi, K et al. (2000) Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J. Immunol. 164 558-61 PubMed GONUTS page
↑ Liu, Y et al. (2011) MicroRNA-98 negatively regulates IL-10 production and endotoxin tolerance in macrophages after LPS stimulation. FEBS Lett. 585 1963-8 PubMed GONUTS page
↑ ^25.0 ^25.1 Poltorak, A et al. (2001) A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice. J. Immunol. 167 2106-11 PubMed GONUTS page
↑ Fierer, J et al. (2002) The role of lipopolysaccharide binding protein in resistance to Salmonella infections in mice. J. Immunol. 168 6396-403 PubMed GONUTS page
↑ Vogel, SN et al. (1999) Cutting edge: functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for a dominant negative mutation. J. Immunol. 162 5666-70 PubMed GONUTS page
↑ Ryu, MJ et al. (2012) Oncogenic Kras expression in postmitotic neurons leads to S100A8-S100A9 protein overexpression and gliosis. J. Biol. Chem. 287 22948-58 PubMed GONUTS page
↑ Bihl, F et al. (2001) LPS-hyporesponsiveness of mnd mice is associated with a mutation in Toll-like receptor 4. Genes Immun. 2 56-9 PubMed GONUTS page
↑ Hiratsuka, S et al. (2008) The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. Nat. Cell Biol. 10 1349-55 PubMed GONUTS page
↑ Kamda, JD & Singer, SM (2009) Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia. Infect. Immun. 77 685-93 PubMed GONUTS page

[PMID:28096568-1] 1.0 ^1.1 Cunha, C et al. (2016) Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization. Mediators Inflamm. 2016 6986175 PubMed GONUTS page

[PMID:26370079-2] Okla, M et al. (2015) Activation of Toll-like receptor 4 (TLR4) attenuates adaptive thermogenesis via endoplasmic reticulum stress. J. Biol. Chem. 290 26476-90 PubMed GONUTS page

[PMID:20037584-3] 3.00 ^3.01 ^3.02 ^3.03 ^3.04 ^3.05 ^3.06 ^3.07 ^3.08 ^3.09 ^3.10 ^3.11 ^3.12 Stewart, CR et al. (2010) CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat. Immunol. 11 155-61 PubMed GONUTS page

[PMID:23812099-4] 4.0 ^4.1 Sheedy, FJ et al. (2013) CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat. Immunol. 14 812-20 PubMed GONUTS page

[PMID:20051628-5] 5.0 ^5.1 ^5.2 ^5.3 ^5.4 ^5.5 ^5.6 ^5.7 González-Navajas, JM et al. (2010) TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice. J. Clin. Invest. 120 570-81 PubMed GONUTS page

[PMID:15356140-6] 6.00 ^6.01 ^6.02 ^6.03 ^6.04 ^6.05 ^6.06 ^6.07 ^6.08 ^6.09 ^6.10 ^6.11 Olson, JK & Miller, SD (2004) Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J. Immunol. 173 3916-24 PubMed GONUTS page

[PMID:18203139-7] 7.0 ^7.1 ^7.2 ^7.3 ^7.4 Marta, M et al. (2008) Unexpected regulatory roles of TLR4 and TLR9 in experimental autoimmune encephalomyelitis. Eur. J. Immunol. 38 565-75 PubMed GONUTS page

[PMID:12421970-8] Schilling, D et al. (2002) Toll-like receptor 4 and Toll-IL-1 receptor domain-containing adapter protein (TIRAP)/myeloid differentiation protein 88 adapter-like (Mal) contribute to maximal IL-6 expression in macrophages. J. Immunol. 169 5874-80 PubMed GONUTS page

[PMID:16514062-9] Ståhl, AL et al. (2006) Lipopolysaccharide from enterohemorrhagic Escherichia coli binds to platelets through TLR4 and CD62 and is detected on circulating platelets in patients with hemolytic uremic syndrome. Blood 108 167-76 PubMed GONUTS page

[PMID:11490012-10] 10.0 ^10.1 ^10.2 ^10.3 ^10.4 Supajatura, V et al. (2001) Protective roles of mast cells against enterobacterial infection are mediated by Toll-like receptor 4. J. Immunol. 167 2250-6 PubMed GONUTS page

[PMID:11739561-11] McCurdy, JD et al. (2001) Toll-like receptor 4-mediated activation of murine mast cells. J. Leukoc. Biol. 70 977-84 PubMed GONUTS page

[PMID:10835634-12] Arbour, NC et al. (2000) TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat. Genet. 25 187-91 PubMed GONUTS page

[PMID:21873635-13] 13.0 ^13.1 ^13.2 ^13.3 ^13.4 ^13.5 Gaudet, P et al. (2011) Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics 12 449-62 PubMed GONUTS page

[PMID:10549626-14] 14.0 ^14.1 ^14.2 ^14.3 ^14.4 ^14.5 ^14.6 ^14.7 Takeuchi, O et al. (1999) Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11 443-51 PubMed GONUTS page

[PMID:14691481-15] 15.0 ^15.1 ^15.2 He, YW et al. (2004) The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. Nat. Immunol. 5 88-97 PubMed GONUTS page

[PMID:10880523-16] 16.0 ^16.1 ^16.2 ^16.3 ^16.4 ^16.5 ^16.6 ^16.7 Ogata, H et al. (2000) The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J. Exp. Med. 192 23-9 PubMed GONUTS page

[PMID:24740015-17] Festuccia, WT et al. (2014) Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide. PLoS ONE 9 e95432 PubMed GONUTS page

[PMID:18261938-18] 18.0 ^18.1 ^18.2 ^18.3 ^18.4 ^18.5 ^18.6 ^18.7 Kim, YG et al. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28 246-57 PubMed GONUTS page

[PMID:15661922-19] 19.0 ^19.1 ^19.2 O'Connell, RM et al. (2005) Immune activation of type I IFNs by Listeria monocytogenes occurs independently of TLR4, TLR2, and receptor interacting protein 2 but involves TNFR-associated NF kappa B kinase-binding kinase 1. J. Immunol. 174 1602-7 PubMed GONUTS page

[PMID:10607756-20] 20.0 ^20.1 ^20.2 Takeuchi, O et al. (2000) Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades. Int. Immunol. 12 113-7 PubMed GONUTS page

[PMID:16260493-21] 21.0 ^21.1 ^21.2 Shim, JH et al. (2005) TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo. Genes Dev. 19 2668-81 PubMed GONUTS page

[PMID:19734906-22] Chang, M et al. (2009) Peli1 facilitates TRIF-dependent Toll-like receptor signaling and proinflammatory cytokine production. Nat. Immunol. 10 1089-95 PubMed GONUTS page

[PMID:10623794-23] 23.0 ^23.1 Ohashi, K et al. (2000) Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J. Immunol. 164 558-61 PubMed GONUTS page

[PMID:21609717-24] Liu, Y et al. (2011) MicroRNA-98 negatively regulates IL-10 production and endotoxin tolerance in macrophages after LPS stimulation. FEBS Lett. 585 1963-8 PubMed GONUTS page

[PMID:11489994-25] 25.0 ^25.1 Poltorak, A et al. (2001) A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice. J. Immunol. 167 2106-11 PubMed GONUTS page

[PMID:12055258-26] Fierer, J et al. (2002) The role of lipopolysaccharide binding protein in resistance to Salmonella infections in mice. J. Immunol. 168 6396-403 PubMed GONUTS page

[PMID:10229796-27] Vogel, SN et al. (1999) Cutting edge: functional characterization of the effect of the C3H/HeJ defect in mice that lack an Lpsn gene: in vivo evidence for a dominant negative mutation. J. Immunol. 162 5666-70 PubMed GONUTS page

[PMID:22577135-28] Ryu, MJ et al. (2012) Oncogenic Kras expression in postmitotic neurons leads to S100A8-S100A9 protein overexpression and gliosis. J. Biol. Chem. 287 22948-58 PubMed GONUTS page

[PMID:11294571-29] Bihl, F et al. (2001) LPS-hyporesponsiveness of mnd mice is associated with a mutation in Toll-like receptor 4. Genes Immun. 2 56-9 PubMed GONUTS page

[PMID:18820689-30] Hiratsuka, S et al. (2008) The S100A8-serum amyloid A3-TLR4 paracrine cascade establishes a pre-metastatic phase. Nat. Cell Biol. 10 1349-55 PubMed GONUTS page

[PMID:19047410-31] Kamda, JD & Singer, SM (2009) Phosphoinositide 3-kinase-dependent inhibition of dendritic cell interleukin-12 production by Giardia lamblia. Infect. Immun. 77 685-93 PubMed GONUTS page

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MOUSE:TLR4

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